- Adam Empie Papers, 1811/2004, bulk 1811/18501
- Alexander Brown Papers (I), 1815/19101
- Amos Koontz Papers I, 1809/1965, bulk 1936/19651
- Armistead-Cocke Papers, 1680/19171
- Austin-Twyman Papers, 1765/19391
- Baird Family Papers, 1656/1922, bulk 1656/18481
- Blow Family Papers, 1613/1960, bulk 1770/18751
- Bozarth Brothers Account Book, 1907-1913, 1907/19131
- Bozarth and Warburton Journal, 1907/19101
- Bozarth and Warburton Ledger, 1898/19101
- Byers Family Papers, 1806/19291
- C. L. Worthington Papers, 1752/19381
- Cabell Family Papers, 1693/1913, bulk 1743/18231
- Chappelear Collection, 1788/19591
- Civil War Collection, 1856/19381