{"links":{"self":"https://arvasarchive.org/catalog.json?f%5Bdate_range%5D%5B%5D=1839\u0026f%5Brepository%5D%5B%5D=University+of+Virginia%2C+Special+Collections+Dept.\u0026page=112","prev":"https://arvasarchive.org/catalog.json?f%5Bdate_range%5D%5B%5D=1839\u0026f%5Brepository%5D%5B%5D=University+of+Virginia%2C+Special+Collections+Dept.\u0026page=111","next":"https://arvasarchive.org/catalog.json?f%5Bdate_range%5D%5B%5D=1839\u0026f%5Brepository%5D%5B%5D=University+of+Virginia%2C+Special+Collections+Dept.\u0026page=113","last":"https://arvasarchive.org/catalog.json?f%5Bdate_range%5D%5B%5D=1839\u0026f%5Brepository%5D%5B%5D=University+of+Virginia%2C+Special+Collections+Dept.\u0026page=129"},"meta":{"pages":{"current_page":112,"next_page":113,"prev_page":111,"total_pages":129,"limit_value":10,"offset_value":1110,"total_count":1284,"first_page?":false,"last_page?":false}},"data":[{"id":"viu_repositories_3_resources_206_c03","type":"Series","attributes":{"title":"Series 3. 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Manuscripts and miscellaneous, 1820/1946","Carter Glass Papers, 1820/1946","English"],"parent_unittitles_ssm":["Carter Glass Papers, 1820/1946"],"parent_unittitles_tesim":["Carter Glass Papers, 1820/1946"],"normalized_date_ssm":["1820/1946"],"unitdate_inclusive_ssm":["1820-1946"],"level_ssm":["Series"],"level_ssim":["Series"],"component_level_isim":[1],"sort_isi":4212,"repository_ssim":["University of Virginia, Special Collections Dept."],"collection_ssim":["Carter Glass Papers, 1820/1946"],"has_online_content_ssim":["false"],"child_component_count_isi":13,"parent_access_restrict_tesm":["This collection is open for research. Restrictions apply to veterans claims."],"parent_access_terms_tesm":["There are no restrictions in this collection except for veterans claims."],"language_ssim":["English"],"date_range_isim":[1820,1821,1822,1823,1824,1825,1826,1827,1828,1829,1830,1831,1832,1833,1834,1835,1836,1837,1838,1839,1840,1841,1842,1843,1844,1845,1846,1847,1848,1849,1850,1851,1852,1853,1854,1855,1856,1857,1858,1859,1860,1861,1862,1863,1864,1865,1866,1867,1868,1869,1870,1871,1872,1873,1874,1875,1876,1877,1878,1879,1880,1881,1882,1883,1884,1885,1886,1887,1888,1889,1890,1891,1892,1893,1894,1895,1896,1897,1898,1899,1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935,1936,1937,1938,1939,1940,1941,1942,1943,1944,1945,1946],"_nest_path_":"/components#2","timestamp":"2026-08-14T22:53:58.310Z","collection":{"numFound":1,"start":0,"numFoundExact":true,"docs":[{"id":"viu_repositories_3_resources_206","ead_ssi":"viu_repositories_3_resources_206","_root_":"viu_repositories_3_resources_206","_nest_parent_":"viu_repositories_3_resources_206","ead_source_url_ssi":"data/oai/UVA/repositories_3_resources_206.xml","aspace_url_ssi":"https://archives.lib.virginia.edu/ark:/59853/146110","title_filing_ssi":"Glass, Carter, papers","title_ssm":["Carter Glass Papers"],"title_tesim":["Carter Glass Papers"],"unitdate_ssm":["1820-1946"],"unitdate_inclusive_ssm":["1820-1946"],"normalized_date_ssm":["1820/1946"],"normalized_title_ssm":["Carter Glass Papers, 1820/1946"],"text":["Carter Glass Papers, 1820/1946","MSS 2913","Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","/repositories/3/resources/206","Virginia -- Politics and government -- 20th century","Banks and banking -- United States","Judges -- Selection and appointment","Depressions -- 1929 -- United States","Labor laws and legislation -- United States","World War, 1939-1945","World War, 1914-1918","This collection is open for research. Restrictions apply to veterans claims.","The collection is arranged into four series: Series 1. Banking: Subseries banking correspondence,  banking printed, Series 2. Correspondence: Subseries legislative, military, political, topical, greeting cards, business and related cards, honors, constituent (patronage, praise),veterans claim (restricted), and veterinary (farming), Series 3. Manuscripts and miscellaneous, Series 4. Printed and miscellaneous: Subseries newspaper clippings, articles, bills, reports and photographs, speeches, and election tickets.","Due to the large size of this collection these categories are meant as general guidelines and some cross over of subjects can be expected throughout the series. Similarly,further searching may be necessary if an area of research is not found in the identified series of the guide, for example military correspondence is located chronologically throughout the collection and as a subseries.","Series 1 Banking Correspondence is in boxes 1-43, 171-177; Banking Printed is in boxes 44-47; Series 2 Correspondence: Legislative Correspondence is in boxes 47-105, 178-180; Military Correspondence is in boxes 105-109; Political Correspondence is in boxes 109-143, 180-183; Topical Correspondence is in boxes 143-169; 183-193; Greeting Cards are in boxes 169-170; Honors are in box 170; Constituent Correspondence is in boxes 194-220; Patronage Correspondence is in boxes 220-249; Praise for Carter Glass is in boxes 250-258; Invitations are in boxes 259-264; Veteran's Claims (restricted) are in boxes 265-268; Veterinarian and farming (cows) are in box 269; Series 3 Manuscripts and Miscellaneous are in box 270; Series 4 Printed(including newspaper articles, photographs, and speeches) are in boxes 271-279; Letterbooks for 1918-1919 are in boxes 281-282.","Carter Glass (January 4, 1858 – May 28, 1946) was born on January 4, 1858, in Lynchburg, Virginia, to Robert Henry Glass and Augusta Elizabeth Christian. He became a newspaper publisher (like his father)and after hearing a speech by William Jenning Bryan in 1896, entered politics in 1902 as a Democrat in the United States House of Representatives and was re-elected to eight terms. He was a United States Senator from Lynchburg, Virginia from 1920 until his death in 1946.  In 1913, he became Chairman of the House Committee on Banking and Currency, where he worked with President Woodrow Wilson to pass the Glass-Owen Federal Reserve Act and he went on to pass the Glass-Steagall Act in 1932 and the Banking Act in 1933 that made banking more stable in the United States. In 1918, President Wilson appointed him Secretary of the Treasury, where he marketed Victory Liberty Loans for World War I debts.  At the 1920 Democratic National Convention Glass was nominated for President of the United States. Many of his supporters have said that at 5'4 inches tall, his speeches and political prowess made him seem larger than life.","Carter Glass became an apprentice printer to his father when he was 13 years old, and continued his education through reading literature in his father's library. At the age of 22, Glass became a reporter, a job he had long sought, for the \"Lynchburg News\". He rose to become the morning newspaper's editor by 1887. After acquiring the afternoon \"Daily Advance\", the competing \"Daily Republican\",  he became Lynchburg's sole newspaper publisher. The \"Lynchburg News and Advance\" is the successor publication to his newspapers.","Carter Glass played a major role in the establishment of the U.S. financial regulatory system, helping to establish the Federal Reserve System and the Federal Deposit Insurance Corporation. He co-sponsored the 1933 Banking Act, also known as the Glass–Steagall Act, which created the Federal Deposit Insurance Corporation and enforced the separation of investment banking firms and commercial banks. His banking reforms (Banking Act of 1913, Glass Steagall Act 1932, Banking Act of 1933) earned him gratitude across the country, landing him on the cover of Time Magazine twice, and honoring him with many degrees from universities.  Prior to Glass's reforms, the country's banking system was chaotic and regulated by bankers. The Glass-Steagall bill restricted banks from engaging in invesment banking. The country had suffered eight recessions between 1890 and 1914. Portions of the Glass-Steagall bill were repealed in 1999, allowing banks to combine their own investment activity with commercial banking and possibly contributing to the recession in 2008.","Not as well-publicized was Carter Glass's lifelong opposition to voting rights for African Americans. One of Glass's first political exploits was helping craft the revised 1902 Virginia Constitution to bar [African American] citizens from voting. The 1902 Constitution instituted a poll tax and required bulk payment after a voter missed elections, making voting a luxury. The Constitution also required that voters pass a literacy test with their performance graded by the registrar. When questioned as to whether these measures were potentially discriminatory, Glass exclaimed, \"Discrimination! Why that is exactly what we propose. To remove every [African American] voter who can be gotten rid of, legally, without materially impairing the numerical strength of the white electorate.\" Indeed, the number of African Americans qualified to vote dropped from 147,000 to 21,000 immediately. More than 50 years after it was ratified, the Lynchburg senator remained opposed to the 15th Amendment to the U.S. Constitution, which granted African Americans the right to vote. He said in the 1920's it \"constituted an attempt to destroy white civilization in nearly one-third of the nation and to erect on its ruins an Ethiopian state ignorant, profligate, corrupt, controlled by manumitted slaves.\" Glass was in step with his white constituents in Virginia, where African Americans did not receive equal voting rights until the 1960s. In 1928, during a debate involving prohibition, Glass said, \"people of the original thirteen Southern States curse and deride and spit upon the Fifteenth Amendment — and have no intention of letting the [African American] vote\" all the while maintaining Virginia was complying with the law.","Carter Glass remained one of the strongest advocates of segregation and continued to dedicate much of his political career to the perpetuation of Jim Crow laws in the South. He sponsored massive resistance legislation along with Virginia Senator Harry F. Byrd of Winchester, another Virginia newspaperman who shared many of Glass's political views. Both Glass and Byrd were opposed to Roosevelt's New Deal policies. Each was a strong supporter of fiscal conservatism and states' rights. Carter Glass supported President Roosevelt but later criticized his policies, including the New Deal, attempts to pack the Supreme Court, third term presidency, and nominations for Federal Judgeships.","Glass had suffered from ill health throughout his life, and usually walked on tip toes because he believed that would help with his indigestion. He kept his seat in his final term in the Senate even though he was not able to be in attendance. He died in his hotel apartment in Washington, D.C., on May 28, 1946. His funeral in Lynchburg was attended by the Chief Justice, the Secretary of State, 11 Senators, 11 House members, and other notables. History remembers Carter Glass as the Father of the Federal Reserve Act but today history also considers his role in the 1902 Constitution that disenfranchised virtually every black voter in the state. The reduction in African American votes helped him politically and put him in a postion to create the banking reform legislation. Nationally, Glass might have been the architect of financial reform that stabilized the nation's banking system, but at home, historian J. Douglas Smith calls him, \"the architect of disenfranchisement in the Old Dominion.\" Harvard University named their business school, Glass House, after Carter Glass achievements in banking, but they have now changed the name to Cash House, for James Cash, the first African American tenured professor at Harvard.","Sources: \nWikipedia\nJoe Stinnett, retired editor of The News \u0026 Advance and The Roanoke Times.\nThe Roanoke Times","The Carter Glass papers, 1820-1946, 141 cubic feet, consist of correspondence, manuscripts, newspaper articles, photographs, speeches, and printed materials from his work in the Banking and Currency Committee, the Secretary of the Treasury (1918-1920), and the United States Senate (1920-1946). Subjects include: The Federal Reserve Banking Act of 1913, the Federal Reserve system, and the Banking Act of 1933 (1932 Glass-Steagall Act).","Other topics include international, national and state issues reflected in the politics of this time period including opposition to the National Industrial Recovery Act; National Labor Relations Act; Bank Holding Company Bill; Office of Price Administration; World Wars I and II; League of Nations; World Court; Democratic Party platforms and policies; presidential elections of 1912, 1920, 1924, 1928, and 1940; Senator Huey P. Long; Franklin D. Roosevelt and the New Deal; attempted packing of the Supreme Court; neutrality legislation; disarmament; regulation of the coal industry; (business) products and services; child labor; anti-lynching law; immigration restriction (especially Chinese in Hawaii); Muscle Shoals; trade with Russia; diplomatic relations with the Vatican; Four-Power Treaty; soldiers' bonus bill; tariffs and protectionism; and national defense.","Virginia topics of concern to Glass or his constituents include poll tax elimination; African American suffrage; women's suffrage; highways; intrastate commerce; University of Virginia Board of Visitors;  Woodrow Wilson Foundation; national Patrick Henry shrine at \"Red Hill\"; gubernatorial election of 1924; Bishop James Cannon, Jr., prohibition and the Anti-saloon League; Skyline Drive; Spotsylvania Battlefield Park; Virginia Fight For Freedom Committee; operation of the Lynchburg News and Advance; and patronage requests from Lynchburg, Roanoke, and Bedford, Campbell, Floyd, Montgomery, and Roanoke Counties, Va.","Miscellaneous items of interest include a letter describing the early life of Booker T. Washington, election tickets for 1848, a 1906 recipe book, and letters concerning Glass' belief in the Baconian theory of Shakespeare authorship.","Among the many correspondents are Edwin A. Alderman, Newton Baker, Ray Stannard Baker, Alben Barkley, Bernard Baruch, William E. Borah, Chester Bowles, John Stewart Bryan, William Jennings Bryan, Harry F. Byrd, Richard E. Byrd, Calvin Coolidge, John W. Daniel, Josephus Daniels, Colgate W. Darden, Westmoreland Davis, Frederic A. Delano, the Democratic National Committee, Marriner S. Eccles, James A. Farley, Henry Ford, Douglas Southall Freeman, James A. Garfield, Samuel Gompers, Cary T. Grayson, Charles S. Hamlin, William P.G. Harding, Warren G. Harding, George L. Harrison, J. Edgar Hoover,Herbert Hoover, Edwin M. House, Cordell Hull, Harold Ickes, Hugh S. Johnson, Jesse Jones, Joseph P. Kennedy, Russell C. Leffingwell, Walter Lippmann, Huey Long, William Gibbs McAdoo, George Walter Mapp, Andrew Mellon, Eugene and Agnes Meyer, Andrew J. Montague, R. Walton Moore, Henry Morgenthau, Jr., Robert L. Owen, George C. Peery, Edmund Platt, John Garland Pollard, A. Willis Robertson, Eleanor Roosevelt, Franklin Delano Roosevelt, Dave E. Satterfield, C. Bascom Slemp, Rixey Smith, Billy Sunday, Claude A. Swanson, Harry S. Truman, Joseph P. Tumulty, Oscar W. Underwood, Samuel Untermeyer, Arthur H. Vandenberg, Robert F. Wagner, Henry A. Wallace, Paul Moritz Warburg, Richard S. Whaley, William Allen White, John Skelton Williams, Henry Parker Willis, , Edith Bolling Wilson, Woodrow Wilson, Clifton A. Woodrum, and Walter Wyatt.","There are no restrictions in this collection except for veterans claims.","Albert and Shirley Small Special Collections Library","English"],"collection_title_tesim":["Carter Glass Papers, 1820/1946"],"collection_ssim":["Carter Glass Papers, 1820/1946"],"level_ssm":["collection"],"level_ssim":["Collection"],"unitid_ssm":["MSS 2913","Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","/repositories/3/resources/206"],"unitid_tesim":["MSS 2913","Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","/repositories/3/resources/206"],"repository_ssm":["University of Virginia, Special Collections Dept."],"repository_ssim":["University of Virginia, Special Collections Dept."],"geogname_ssm":["Virginia -- Politics and government -- 20th century"],"geogname_ssim":["Virginia -- Politics and government -- 20th century"],"places_ssim":["Virginia -- Politics and government -- 20th century"],"creator_corpname_ssim":["Albert and Shirley Small Special Collections Library"],"creators_ssim":["Albert and Shirley Small Special Collections Library"],"access_terms_ssm":["There are no restrictions in this collection except for veterans claims."],"acqinfo_ssim":["This collection was a gift from the Glass family to the Small Special Collections Library at the University of Virginia in 1948."],"access_subjects_ssim":["Banks and banking -- United States","Judges -- Selection and appointment","Depressions -- 1929 -- United States","Labor laws and legislation -- United States","World War, 1939-1945","World War, 1914-1918"],"access_subjects_ssm":["Banks and banking -- United States","Judges -- Selection and appointment","Depressions -- 1929 -- United States","Labor laws and legislation -- United States","World War, 1939-1945","World War, 1914-1918"],"has_online_content_ssim":["false"],"extent_ssm":["141 Cubic Feet 285 document boxes, 3 oversize flat boxes"],"extent_tesim":["141 Cubic Feet 285 document boxes, 3 oversize flat boxes"],"date_range_isim":[1820,1821,1822,1823,1824,1825,1826,1827,1828,1829,1830,1831,1832,1833,1834,1835,1836,1837,1838,1839,1840,1841,1842,1843,1844,1845,1846,1847,1848,1849,1850,1851,1852,1853,1854,1855,1856,1857,1858,1859,1860,1861,1862,1863,1864,1865,1866,1867,1868,1869,1870,1871,1872,1873,1874,1875,1876,1877,1878,1879,1880,1881,1882,1883,1884,1885,1886,1887,1888,1889,1890,1891,1892,1893,1894,1895,1896,1897,1898,1899,1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935,1936,1937,1938,1939,1940,1941,1942,1943,1944,1945,1946],"accessrestrict_html_tesm":["\u003cp\u003eThis collection is open for research. Restrictions apply to veterans claims.\u003c/p\u003e  "],"accessrestrict_heading_ssm":["Conditions Governing Access"],"accessrestrict_tesim":["This collection is open for research. Restrictions apply to veterans claims."],"arrangement_html_tesm":["\u003cp\u003eThe collection is arranged into four series: Series 1. Banking: Subseries banking correspondence,  banking printed, Series 2. Correspondence: Subseries legislative, military, political, topical, greeting cards, business and related cards, honors, constituent (patronage, praise),veterans claim (restricted), and veterinary (farming), Series 3. Manuscripts and miscellaneous, Series 4. Printed and miscellaneous: Subseries newspaper clippings, articles, bills, reports and photographs, speeches, and election tickets. \u003c/p\u003e","\u003cp\u003eDue to the large size of this collection these categories are meant as general guidelines and some cross over of subjects can be expected throughout the series. Similarly,further searching may be necessary if an area of research is not found in the identified series of the guide, for example military correspondence is located chronologically throughout the collection and as a subseries.\u003c/p\u003e","\u003cp\u003eSeries 1 Banking Correspondence is in boxes 1-43, 171-177; Banking Printed is in boxes 44-47; Series 2 Correspondence: Legislative Correspondence is in boxes 47-105, 178-180; Military Correspondence is in boxes 105-109; Political Correspondence is in boxes 109-143, 180-183; Topical Correspondence is in boxes 143-169; 183-193; Greeting Cards are in boxes 169-170; Honors are in box 170; Constituent Correspondence is in boxes 194-220; Patronage Correspondence is in boxes 220-249; Praise for Carter Glass is in boxes 250-258; Invitations are in boxes 259-264; Veteran's Claims (restricted) are in boxes 265-268; Veterinarian and farming (cows) are in box 269; Series 3 Manuscripts and Miscellaneous are in box 270; Series 4 Printed(including newspaper articles, photographs, and speeches) are in boxes 271-279; Letterbooks for 1918-1919 are in boxes 281-282.\u003c/p\u003e  "],"arrangement_heading_ssm":["Arrangement"],"arrangement_tesim":["The collection is arranged into four series: Series 1. Banking: Subseries banking correspondence,  banking printed, Series 2. Correspondence: Subseries legislative, military, political, topical, greeting cards, business and related cards, honors, constituent (patronage, praise),veterans claim (restricted), and veterinary (farming), Series 3. Manuscripts and miscellaneous, Series 4. Printed and miscellaneous: Subseries newspaper clippings, articles, bills, reports and photographs, speeches, and election tickets.","Due to the large size of this collection these categories are meant as general guidelines and some cross over of subjects can be expected throughout the series. Similarly,further searching may be necessary if an area of research is not found in the identified series of the guide, for example military correspondence is located chronologically throughout the collection and as a subseries.","Series 1 Banking Correspondence is in boxes 1-43, 171-177; Banking Printed is in boxes 44-47; Series 2 Correspondence: Legislative Correspondence is in boxes 47-105, 178-180; Military Correspondence is in boxes 105-109; Political Correspondence is in boxes 109-143, 180-183; Topical Correspondence is in boxes 143-169; 183-193; Greeting Cards are in boxes 169-170; Honors are in box 170; Constituent Correspondence is in boxes 194-220; Patronage Correspondence is in boxes 220-249; Praise for Carter Glass is in boxes 250-258; Invitations are in boxes 259-264; Veteran's Claims (restricted) are in boxes 265-268; Veterinarian and farming (cows) are in box 269; Series 3 Manuscripts and Miscellaneous are in box 270; Series 4 Printed(including newspaper articles, photographs, and speeches) are in boxes 271-279; Letterbooks for 1918-1919 are in boxes 281-282."],"bioghist_html_tesm":["\u003cp\u003e Carter Glass (January 4, 1858 – May 28, 1946) was born on January 4, 1858, in Lynchburg, Virginia, to Robert Henry Glass and Augusta Elizabeth Christian. He became a newspaper publisher (like his father)and after hearing a speech by William Jenning Bryan in 1896, entered politics in 1902 as a Democrat in the United States House of Representatives and was re-elected to eight terms. He was a United States Senator from Lynchburg, Virginia from 1920 until his death in 1946.  In 1913, he became Chairman of the House Committee on Banking and Currency, where he worked with President Woodrow Wilson to pass the Glass-Owen Federal Reserve Act and he went on to pass the Glass-Steagall Act in 1932 and the Banking Act in 1933 that made banking more stable in the United States. In 1918, President Wilson appointed him Secretary of the Treasury, where he marketed Victory Liberty Loans for World War I debts.  At the 1920 Democratic National Convention Glass was nominated for President of the United States. Many of his supporters have said that at 5'4 inches tall, his speeches and political prowess made him seem larger than life.\u003c/p\u003e","\u003cp\u003eCarter Glass became an apprentice printer to his father when he was 13 years old, and continued his education through reading literature in his father's library. At the age of 22, Glass became a reporter, a job he had long sought, for the \"Lynchburg News\". He rose to become the morning newspaper's editor by 1887. After acquiring the afternoon \"Daily Advance\", the competing \"Daily Republican\",  he became Lynchburg's sole newspaper publisher. The \"Lynchburg News and Advance\" is the successor publication to his newspapers. \u003c/p\u003e","\u003cp\u003e  Carter Glass played a major role in the establishment of the U.S. financial regulatory system, helping to establish the Federal Reserve System and the Federal Deposit Insurance Corporation. He co-sponsored the 1933 Banking Act, also known as the Glass–Steagall Act, which created the Federal Deposit Insurance Corporation and enforced the separation of investment banking firms and commercial banks. His banking reforms (Banking Act of 1913, Glass Steagall Act 1932, Banking Act of 1933) earned him gratitude across the country, landing him on the cover of Time Magazine twice, and honoring him with many degrees from universities.  Prior to Glass's reforms, the country's banking system was chaotic and regulated by bankers. The Glass-Steagall bill restricted banks from engaging in invesment banking. The country had suffered eight recessions between 1890 and 1914. Portions of the Glass-Steagall bill were repealed in 1999, allowing banks to combine their own investment activity with commercial banking and possibly contributing to the recession in 2008.\n \u003c/p\u003e","\u003cp\u003eNot as well-publicized was Carter Glass's lifelong opposition to voting rights for African Americans. One of Glass's first political exploits was helping craft the revised 1902 Virginia Constitution to bar [African American] citizens from voting. The 1902 Constitution instituted a poll tax and required bulk payment after a voter missed elections, making voting a luxury. The Constitution also required that voters pass a literacy test with their performance graded by the registrar. When questioned as to whether these measures were potentially discriminatory, Glass exclaimed, \"Discrimination! Why that is exactly what we propose. To remove every [African American] voter who can be gotten rid of, legally, without materially impairing the numerical strength of the white electorate.\" Indeed, the number of African Americans qualified to vote dropped from 147,000 to 21,000 immediately. More than 50 years after it was ratified, the Lynchburg senator remained opposed to the 15th Amendment to the U.S. Constitution, which granted African Americans the right to vote. He said in the 1920's it \"constituted an attempt to destroy white civilization in nearly one-third of the nation and to erect on its ruins an Ethiopian state ignorant, profligate, corrupt, controlled by manumitted slaves.\" Glass was in step with his white constituents in Virginia, where African Americans did not receive equal voting rights until the 1960s. In 1928, during a debate involving prohibition, Glass said, \"people of the original thirteen Southern States curse and deride and spit upon the Fifteenth Amendment — and have no intention of letting the [African American] vote\" all the while maintaining Virginia was complying with the law.\u003c/p\u003e","\u003cp\u003e\nCarter Glass remained one of the strongest advocates of segregation and continued to dedicate much of his political career to the perpetuation of Jim Crow laws in the South. He sponsored massive resistance legislation along with Virginia Senator Harry F. Byrd of Winchester, another Virginia newspaperman who shared many of Glass's political views. Both Glass and Byrd were opposed to Roosevelt's New Deal policies. Each was a strong supporter of fiscal conservatism and states' rights. Carter Glass supported President Roosevelt but later criticized his policies, including the New Deal, attempts to pack the Supreme Court, third term presidency, and nominations for Federal Judgeships.\u003c/p\u003e","\u003cp\u003eGlass had suffered from ill health throughout his life, and usually walked on tip toes because he believed that would help with his indigestion. He kept his seat in his final term in the Senate even though he was not able to be in attendance. He died in his hotel apartment in Washington, D.C., on May 28, 1946. His funeral in Lynchburg was attended by the Chief Justice, the Secretary of State, 11 Senators, 11 House members, and other notables. History remembers Carter Glass as the Father of the Federal Reserve Act but today history also considers his role in the 1902 Constitution that disenfranchised virtually every black voter in the state. The reduction in African American votes helped him politically and put him in a postion to create the banking reform legislation. Nationally, Glass might have been the architect of financial reform that stabilized the nation's banking system, but at home, historian J. Douglas Smith calls him, \"the architect of disenfranchisement in the Old Dominion.\" Harvard University named their business school, Glass House, after Carter Glass achievements in banking, but they have now changed the name to Cash House, for James Cash, the first African American tenured professor at Harvard.\u003c/p\u003e","\u003cp\u003eSources: \nWikipedia\nJoe Stinnett, retired editor of The News \u0026amp; Advance and The Roanoke Times.\nThe Roanoke Times\u003c/p\u003e  "],"bioghist_heading_ssm":["Biographical / Historical"],"bioghist_tesim":["Carter Glass (January 4, 1858 – May 28, 1946) was born on January 4, 1858, in Lynchburg, Virginia, to Robert Henry Glass and Augusta Elizabeth Christian. He became a newspaper publisher (like his father)and after hearing a speech by William Jenning Bryan in 1896, entered politics in 1902 as a Democrat in the United States House of Representatives and was re-elected to eight terms. He was a United States Senator from Lynchburg, Virginia from 1920 until his death in 1946.  In 1913, he became Chairman of the House Committee on Banking and Currency, where he worked with President Woodrow Wilson to pass the Glass-Owen Federal Reserve Act and he went on to pass the Glass-Steagall Act in 1932 and the Banking Act in 1933 that made banking more stable in the United States. In 1918, President Wilson appointed him Secretary of the Treasury, where he marketed Victory Liberty Loans for World War I debts.  At the 1920 Democratic National Convention Glass was nominated for President of the United States. Many of his supporters have said that at 5'4 inches tall, his speeches and political prowess made him seem larger than life.","Carter Glass became an apprentice printer to his father when he was 13 years old, and continued his education through reading literature in his father's library. At the age of 22, Glass became a reporter, a job he had long sought, for the \"Lynchburg News\". He rose to become the morning newspaper's editor by 1887. After acquiring the afternoon \"Daily Advance\", the competing \"Daily Republican\",  he became Lynchburg's sole newspaper publisher. The \"Lynchburg News and Advance\" is the successor publication to his newspapers.","Carter Glass played a major role in the establishment of the U.S. financial regulatory system, helping to establish the Federal Reserve System and the Federal Deposit Insurance Corporation. He co-sponsored the 1933 Banking Act, also known as the Glass–Steagall Act, which created the Federal Deposit Insurance Corporation and enforced the separation of investment banking firms and commercial banks. His banking reforms (Banking Act of 1913, Glass Steagall Act 1932, Banking Act of 1933) earned him gratitude across the country, landing him on the cover of Time Magazine twice, and honoring him with many degrees from universities.  Prior to Glass's reforms, the country's banking system was chaotic and regulated by bankers. The Glass-Steagall bill restricted banks from engaging in invesment banking. The country had suffered eight recessions between 1890 and 1914. Portions of the Glass-Steagall bill were repealed in 1999, allowing banks to combine their own investment activity with commercial banking and possibly contributing to the recession in 2008.","Not as well-publicized was Carter Glass's lifelong opposition to voting rights for African Americans. One of Glass's first political exploits was helping craft the revised 1902 Virginia Constitution to bar [African American] citizens from voting. The 1902 Constitution instituted a poll tax and required bulk payment after a voter missed elections, making voting a luxury. The Constitution also required that voters pass a literacy test with their performance graded by the registrar. When questioned as to whether these measures were potentially discriminatory, Glass exclaimed, \"Discrimination! Why that is exactly what we propose. To remove every [African American] voter who can be gotten rid of, legally, without materially impairing the numerical strength of the white electorate.\" Indeed, the number of African Americans qualified to vote dropped from 147,000 to 21,000 immediately. More than 50 years after it was ratified, the Lynchburg senator remained opposed to the 15th Amendment to the U.S. Constitution, which granted African Americans the right to vote. He said in the 1920's it \"constituted an attempt to destroy white civilization in nearly one-third of the nation and to erect on its ruins an Ethiopian state ignorant, profligate, corrupt, controlled by manumitted slaves.\" Glass was in step with his white constituents in Virginia, where African Americans did not receive equal voting rights until the 1960s. In 1928, during a debate involving prohibition, Glass said, \"people of the original thirteen Southern States curse and deride and spit upon the Fifteenth Amendment — and have no intention of letting the [African American] vote\" all the while maintaining Virginia was complying with the law.","Carter Glass remained one of the strongest advocates of segregation and continued to dedicate much of his political career to the perpetuation of Jim Crow laws in the South. He sponsored massive resistance legislation along with Virginia Senator Harry F. Byrd of Winchester, another Virginia newspaperman who shared many of Glass's political views. Both Glass and Byrd were opposed to Roosevelt's New Deal policies. Each was a strong supporter of fiscal conservatism and states' rights. Carter Glass supported President Roosevelt but later criticized his policies, including the New Deal, attempts to pack the Supreme Court, third term presidency, and nominations for Federal Judgeships.","Glass had suffered from ill health throughout his life, and usually walked on tip toes because he believed that would help with his indigestion. He kept his seat in his final term in the Senate even though he was not able to be in attendance. He died in his hotel apartment in Washington, D.C., on May 28, 1946. His funeral in Lynchburg was attended by the Chief Justice, the Secretary of State, 11 Senators, 11 House members, and other notables. History remembers Carter Glass as the Father of the Federal Reserve Act but today history also considers his role in the 1902 Constitution that disenfranchised virtually every black voter in the state. The reduction in African American votes helped him politically and put him in a postion to create the banking reform legislation. Nationally, Glass might have been the architect of financial reform that stabilized the nation's banking system, but at home, historian J. Douglas Smith calls him, \"the architect of disenfranchisement in the Old Dominion.\" Harvard University named their business school, Glass House, after Carter Glass achievements in banking, but they have now changed the name to Cash House, for James Cash, the first African American tenured professor at Harvard.","Sources: \nWikipedia\nJoe Stinnett, retired editor of The News \u0026 Advance and The Roanoke Times.\nThe Roanoke Times"],"prefercite_html_tesm":["\u003cp\u003eMSS 2913, Carter Glass papers, Small Special Collections Library, University of Virginia.\u003c/p\u003e  "],"prefercite_tesim":["MSS 2913, Carter Glass papers, Small Special Collections Library, University of Virginia."],"scopecontent_html_tesm":["\u003cp\u003eThe Carter Glass papers, 1820-1946, 141 cubic feet, consist of correspondence, manuscripts, newspaper articles, photographs, speeches, and printed materials from his work in the Banking and Currency Committee, the Secretary of the Treasury (1918-1920), and the United States Senate (1920-1946). Subjects include: The Federal Reserve Banking Act of 1913, the Federal Reserve system, and the Banking Act of 1933 (1932 Glass-Steagall Act).  \u003c/p\u003e","\u003cp\u003eOther topics include international, national and state issues reflected in the politics of this time period including opposition to the National Industrial Recovery Act; National Labor Relations Act; Bank Holding Company Bill; Office of Price Administration; World Wars I and II; League of Nations; World Court; Democratic Party platforms and policies; presidential elections of 1912, 1920, 1924, 1928, and 1940; Senator Huey P. Long; Franklin D. Roosevelt and the New Deal; attempted packing of the Supreme Court; neutrality legislation; disarmament; regulation of the coal industry; (business) products and services; child labor; anti-lynching law; immigration restriction (especially Chinese in Hawaii); Muscle Shoals; trade with Russia; diplomatic relations with the Vatican; Four-Power Treaty; soldiers' bonus bill; tariffs and protectionism; and national defense.\u003c/p\u003e","\u003cp\u003eVirginia topics of concern to Glass or his constituents include poll tax elimination; African American suffrage; women's suffrage; highways; intrastate commerce; University of Virginia Board of Visitors;  Woodrow Wilson Foundation; national Patrick Henry shrine at \"Red Hill\"; gubernatorial election of 1924; Bishop James Cannon, Jr., prohibition and the Anti-saloon League; Skyline Drive; Spotsylvania Battlefield Park; Virginia Fight For Freedom Committee; operation of the Lynchburg News and Advance; and patronage requests from Lynchburg, Roanoke, and Bedford, Campbell, Floyd, Montgomery, and Roanoke Counties, Va.\u003c/p\u003e","\u003cp\u003eMiscellaneous items of interest include a letter describing the early life of Booker T. Washington, election tickets for 1848, a 1906 recipe book, and letters concerning Glass' belief in the Baconian theory of Shakespeare authorship.\u003c/p\u003e","\u003cp\u003eAmong the many correspondents are Edwin A. Alderman, Newton Baker, Ray Stannard Baker, Alben Barkley, Bernard Baruch, William E. Borah, Chester Bowles, John Stewart Bryan, William Jennings Bryan, Harry F. Byrd, Richard E. Byrd, Calvin Coolidge, John W. Daniel, Josephus Daniels, Colgate W. Darden, Westmoreland Davis, Frederic A. Delano, the Democratic National Committee, Marriner S. Eccles, James A. Farley, Henry Ford, Douglas Southall Freeman, James A. Garfield, Samuel Gompers, Cary T. Grayson, Charles S. Hamlin, William P.G. Harding, Warren G. Harding, George L. Harrison, J. Edgar Hoover,Herbert Hoover, Edwin M. House, Cordell Hull, Harold Ickes, Hugh S. Johnson, Jesse Jones, Joseph P. Kennedy, Russell C. Leffingwell, Walter Lippmann, Huey Long, William Gibbs McAdoo, George Walter Mapp, Andrew Mellon, Eugene and Agnes Meyer, Andrew J. Montague, R. Walton Moore, Henry Morgenthau, Jr., Robert L. Owen, George C. Peery, Edmund Platt, John Garland Pollard, A. Willis Robertson, Eleanor Roosevelt, Franklin Delano Roosevelt, Dave E. Satterfield, C. Bascom Slemp, Rixey Smith, Billy Sunday, Claude A. Swanson, Harry S. Truman, Joseph P. Tumulty, Oscar W. Underwood, Samuel Untermeyer, Arthur H. Vandenberg, Robert F. Wagner, Henry A. Wallace, Paul Moritz Warburg, Richard S. Whaley, William Allen White, John Skelton Williams, Henry Parker Willis, , Edith Bolling Wilson, Woodrow Wilson, Clifton A. Woodrum, and Walter Wyatt.\u003c/p\u003e  "],"scopecontent_heading_ssm":["Scope and Contents"],"scopecontent_tesim":["The Carter Glass papers, 1820-1946, 141 cubic feet, consist of correspondence, manuscripts, newspaper articles, photographs, speeches, and printed materials from his work in the Banking and Currency Committee, the Secretary of the Treasury (1918-1920), and the United States Senate (1920-1946). Subjects include: The Federal Reserve Banking Act of 1913, the Federal Reserve system, and the Banking Act of 1933 (1932 Glass-Steagall Act).","Other topics include international, national and state issues reflected in the politics of this time period including opposition to the National Industrial Recovery Act; National Labor Relations Act; Bank Holding Company Bill; Office of Price Administration; World Wars I and II; League of Nations; World Court; Democratic Party platforms and policies; presidential elections of 1912, 1920, 1924, 1928, and 1940; Senator Huey P. Long; Franklin D. Roosevelt and the New Deal; attempted packing of the Supreme Court; neutrality legislation; disarmament; regulation of the coal industry; (business) products and services; child labor; anti-lynching law; immigration restriction (especially Chinese in Hawaii); Muscle Shoals; trade with Russia; diplomatic relations with the Vatican; Four-Power Treaty; soldiers' bonus bill; tariffs and protectionism; and national defense.","Virginia topics of concern to Glass or his constituents include poll tax elimination; African American suffrage; women's suffrage; highways; intrastate commerce; University of Virginia Board of Visitors;  Woodrow Wilson Foundation; national Patrick Henry shrine at \"Red Hill\"; gubernatorial election of 1924; Bishop James Cannon, Jr., prohibition and the Anti-saloon League; Skyline Drive; Spotsylvania Battlefield Park; Virginia Fight For Freedom Committee; operation of the Lynchburg News and Advance; and patronage requests from Lynchburg, Roanoke, and Bedford, Campbell, Floyd, Montgomery, and Roanoke Counties, Va.","Miscellaneous items of interest include a letter describing the early life of Booker T. Washington, election tickets for 1848, a 1906 recipe book, and letters concerning Glass' belief in the Baconian theory of Shakespeare authorship.","Among the many correspondents are Edwin A. Alderman, Newton Baker, Ray Stannard Baker, Alben Barkley, Bernard Baruch, William E. Borah, Chester Bowles, John Stewart Bryan, William Jennings Bryan, Harry F. Byrd, Richard E. Byrd, Calvin Coolidge, John W. Daniel, Josephus Daniels, Colgate W. Darden, Westmoreland Davis, Frederic A. Delano, the Democratic National Committee, Marriner S. Eccles, James A. Farley, Henry Ford, Douglas Southall Freeman, James A. Garfield, Samuel Gompers, Cary T. Grayson, Charles S. Hamlin, William P.G. Harding, Warren G. Harding, George L. Harrison, J. Edgar Hoover,Herbert Hoover, Edwin M. House, Cordell Hull, Harold Ickes, Hugh S. Johnson, Jesse Jones, Joseph P. Kennedy, Russell C. Leffingwell, Walter Lippmann, Huey Long, William Gibbs McAdoo, George Walter Mapp, Andrew Mellon, Eugene and Agnes Meyer, Andrew J. Montague, R. Walton Moore, Henry Morgenthau, Jr., Robert L. Owen, George C. Peery, Edmund Platt, John Garland Pollard, A. Willis Robertson, Eleanor Roosevelt, Franklin Delano Roosevelt, Dave E. Satterfield, C. Bascom Slemp, Rixey Smith, Billy Sunday, Claude A. Swanson, Harry S. Truman, Joseph P. Tumulty, Oscar W. Underwood, Samuel Untermeyer, Arthur H. Vandenberg, Robert F. Wagner, Henry A. Wallace, Paul Moritz Warburg, Richard S. Whaley, William Allen White, John Skelton Williams, Henry Parker Willis, , Edith Bolling Wilson, Woodrow Wilson, Clifton A. Woodrum, and Walter Wyatt."],"userestrict_html_tesm":["\u003cp\u003eThere are no restrictions in this collection except for veterans claims.\u003c/p\u003e  "],"userestrict_heading_ssm":["Conditions Governing Use"],"userestrict_tesim":["There are no restrictions in this collection except for veterans claims."],"corpname_ssim":["Albert and Shirley Small Special Collections Library"],"names_ssim":["Albert and Shirley Small Special Collections Library"],"language_ssim":["English"],"descrules_ssm":["Describing Archives: A Content Standard"],"total_component_count_is":4648,"online_item_count_is":0,"component_level_isim":[0],"sort_isi":0,"timestamp":"2026-08-14T22:53:58.310Z"}]}},"label":"Breadcrumbs"}}},"links":{"self":"https://arvasarchive.org/catalog/viu_repositories_3_resources_206_c03"}},{"id":"viu_repositories_3_resources_941_c04","type":"Series","attributes":{"title":"Series 4: Currency, 1839/1875","abstract_or_scope":{"id":"https://arvasarchive.org/catalog/viu_repositories_3_resources_941_c04#abstract_or_scope","type":"document_value","attributes":{"value":"\u003cp\u003eSeries 4: Currency (1839-1875; approx. 1.5 cubic feet) contains currency predominately from the Civil War period (1861-1865) issued by the United States and the Confederate States, including currency notes, fractional currency notes, postage currency notes, postage stamps, bonds, and treasury warrants. In addition, it also contains currency issued by southern states and local governments, southern banks (with the addition of the Farmers and Merchants Bank, Washington, D.C.), and corporate entities based in the south.\u003c/p\u003e","label":"Abstract Or Scope"}},"breadcrumbs":{"id":"https://arvasarchive.org/catalog/viu_repositories_3_resources_941_c04#breadcrumbs","type":"document_value","attributes":{"value":{"ref_ssi":"viu_repositories_3_resources_941_c04","ref_ssm":["viu_repositories_3_resources_941_c04"],"id":"viu_repositories_3_resources_941_c04","ead_ssi":"viu_repositories_3_resources_941","_root_":"viu_repositories_3_resources_941","_nest_parent_":"viu_repositories_3_resources_941","parent_ssi":"viu_repositories_3_resources_941","parent_ssim":["John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/1865"],"parent_ids_ssim":["viu_repositories_3_resources_941"],"title_filing_ssi":"Series 4: Currency","title_ssm":["Series 4: Currency"],"title_tesim":["Series 4: Currency"],"normalized_title_ssm":["Series 4: Currency, 1839/1875"],"text":["Series 4: Currency, 1839/1875","John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/1865","Series 4 is arranged chronologically within the following subseries.  \n \nSubseries A: United States of America (USA) Fractional Currency Notes \nSubseries B: United States of America (USA) Post-Civil War Fractional Currency Notes  \nSubseries C: United States of America (USA) Postage Currency Notes \nSubseries D: Note Issued by a Private Bank in the United States \nSubseries E: Confederate States of America (CSA) Currency Notes \nSubseries F: Confederate States of America (CSA) Postage Stamps \nSubseries G: Confederate States of America (CSA) Bonds \nSubseries H: Notes Issued by Confederate States, Cities, and Counties \nSubseries I: Treasury Warrants Issued by the State of Texas and Limestone County, Texas \nSubseries J: Notes Issued by Southern Banks and Other Corporate Entities","Series 4: Currency (1839-1875; approx. 1.5 cubic feet) contains currency predominately from the Civil War period (1861-1865) issued by the United States and the Confederate States, including currency notes, fractional currency notes, postage currency notes, postage stamps, bonds, and treasury warrants. In addition, it also contains currency issued by southern states and local governments, southern banks (with the addition of the Farmers and Merchants Bank, Washington, D.C.), and corporate entities based in the south."],"parent_unittitles_ssm":["John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/1865"],"parent_unittitles_tesim":["John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/1865"],"normalized_date_ssm":["1839/1875"],"unitdate_inclusive_ssm":["1839-1875"],"level_ssm":["Series"],"level_ssim":["Series"],"component_level_isim":[1],"sort_isi":10006,"repository_ssim":["University of Virginia, Special Collections Dept."],"collection_ssim":["John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/1865"],"has_online_content_ssim":["false"],"child_component_count_isi":10,"parent_access_restrict_tesm":["The collection is open for research."],"date_range_isim":[1839,1840,1841,1842,1843,1844,1845,1846,1847,1848,1849,1850,1851,1852,1853,1854,1855,1856,1857,1858,1859,1860,1861,1862,1863,1864,1865,1866,1867,1868,1869,1870,1871,1872,1873,1874,1875],"arrangement_html_tesm":["\u003cp\u003eSeries 4 is arranged chronologically within the following subseries.  \n \nSubseries A: United States of America (USA) Fractional Currency Notes \nSubseries B: United States of America (USA) Post-Civil War Fractional Currency Notes  \nSubseries C: United States of America (USA) Postage Currency Notes \nSubseries D: Note Issued by a Private Bank in the United States \nSubseries E: Confederate States of America (CSA) Currency Notes \nSubseries F: Confederate States of America (CSA) Postage Stamps \nSubseries G: Confederate States of America (CSA) Bonds \nSubseries H: Notes Issued by Confederate States, Cities, and Counties \nSubseries I: Treasury Warrants Issued by the State of Texas and Limestone County, Texas \nSubseries J: Notes Issued by Southern Banks and Other Corporate Entities\u003c/p\u003e"],"arrangement_heading_ssm":["Arrangement"],"arrangement_tesim":["Series 4 is arranged chronologically within the following subseries.  \n \nSubseries A: United States of America (USA) Fractional Currency Notes \nSubseries B: United States of America (USA) Post-Civil War Fractional Currency Notes  \nSubseries C: United States of America (USA) Postage Currency Notes \nSubseries D: Note Issued by a Private Bank in the United States \nSubseries E: Confederate States of America (CSA) Currency Notes \nSubseries F: Confederate States of America (CSA) Postage Stamps \nSubseries G: Confederate States of America (CSA) Bonds \nSubseries H: Notes Issued by Confederate States, Cities, and Counties \nSubseries I: Treasury Warrants Issued by the State of Texas and Limestone County, Texas \nSubseries J: Notes Issued by Southern Banks and Other Corporate Entities"],"scopecontent_html_tesm":["\u003cp\u003eSeries 4: Currency (1839-1875; approx. 1.5 cubic feet) contains currency predominately from the Civil War period (1861-1865) issued by the United States and the Confederate States, including currency notes, fractional currency notes, postage currency notes, postage stamps, bonds, and treasury warrants. In addition, it also contains currency issued by southern states and local governments, southern banks (with the addition of the Farmers and Merchants Bank, Washington, D.C.), and corporate entities based in the south.\u003c/p\u003e"],"scopecontent_heading_ssm":["Scope and Contents"],"scopecontent_tesim":["Series 4: Currency (1839-1875; approx. 1.5 cubic feet) contains currency predominately from the Civil War period (1861-1865) issued by the United States and the Confederate States, including currency notes, fractional currency notes, postage currency notes, postage stamps, bonds, and treasury warrants. In addition, it also contains currency issued by southern states and local governments, southern banks (with the addition of the Farmers and Merchants Bank, Washington, D.C.), and corporate entities based in the south."],"_nest_path_":"/components#3","timestamp":"2026-08-14T22:54:19.132Z","collection":{"numFound":1,"start":0,"numFoundExact":true,"docs":[{"id":"viu_repositories_3_resources_941","ead_ssi":"viu_repositories_3_resources_941","_root_":"viu_repositories_3_resources_941","_nest_parent_":"viu_repositories_3_resources_941","ead_source_url_ssi":"data/oai/UVA/repositories_3_resources_941.xml","aspace_url_ssi":"https://archives.lib.virginia.edu/ark:/59853/189095","title_filing_ssi":"Nau, John L. III, Civil War History Collection","title_ssm":["John L. Nau III Civil War History Collection"],"title_tesim":["John L. Nau III Civil War History Collection"],"unitdate_ssm":["1806-1988","1861-1865"],"unitdate_inclusive_ssm":["1806-1988"],"unitdate_bulk_ssim":["1861-1865"],"normalized_date_ssm":["1806/1988, bulk 1861/1865"],"normalized_title_ssm":["John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/1865"],"text":["John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/1865","MSS 16459","Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","/repositories/3/resources/941","United States --  History  -- Civil War, 1861-1865","United States -- History -- Civil War, 1861-1865 -- Personal narratives","letters (correspondence)","Photograph albums","photographs","newspapers","Good.","The collection is open for research.","The John L. Nau III Civil War History Collection (1806-1988; bulk 1861-1865; 133 cubic feet) has been arranged into five series, Series 1: Materials Related to the Civil War Experiences of Soldiers, Officers, and Civilians (1806-1988; approx. 83 cubic feet); Series 2: Photographs and Prints (circa 1848-1939; approx. 34 cubic feet); Series 3: Government Military Records (1855-1913; approx. 9 cubic feet); Series 4: Currency (1839-1875; approx. 1.5 cubic feet); and Series 5: Newspapers and Print Materials (1846-1913; approx. 5.25 cubic feet).","The John L. Nau III Civil War History Collection contains offensive or harmful language and imagery. This includes—but is not limited to—correspondence and diary entries that express racist views; photographs of enslaved people forced into inhumane conditions by enslavers; descriptions of violence and battle experiences; photographs of deceased soldiers; and correspondence containing explicit descriptions of sex. The purpose of this note is to give users the opportunity to decide whether they need or want to view these materials, or at least, to mentally or emotionally prepare themselves to view the materials.","The donor's accession numbering system has been preserved to maintain access to collection metadata or descriptive information. Each file title in this finding aid includes the donor accession number at the end of the title and each corresponding physical folder or item is also labeled with the donor accession number.","Donor accession numbers are comprised of letters denoting document or photograph format followed by a four-digit number that denotes the number of the accession. The following examples can be found in the collection: DA0001 (meaning document - autograph), DC0001.001 (document - currency), DL0001 (document - letter), DN0003 (document - newspaper), DOR0001 (document - order), DOT0001 (document - other), DR0002 (document - requisition), PA0184 (photograph - ambrotype), PC0200 (photograph - carte de visite), PD0007 (photograph - daguerreotype), POT0012 (photograph - other), and PT0003 (photograph - tintype).","These donor accession numbers can be used to search the donation listing spreadsheet for corresponding metadata. This spreadsheet is available to download directly from the finding aid below, under External Documents.","About External Document MSS 16459 John L. Nau II Civil War History Collection - Donation Listing (View and Download Below)","Upon accession of the John L. Nau III Civil War History Collection, the donor provided a spreadsheet donation listing containing metadata and sellers' descriptions associated with collection materials. The spreadsheet can be downloaded below, under the External Documents heading.","Please note that many descriptions contained in this spreadsheet are drawn from sellers' language used by dealers and auction houses and contain biased and qualitative descriptions. In addition, many descriptions contain offensive, racist, and archaic language, some quoted directly from collection materials (also see the above Content Warning).","Please also note there may be some materials listed in the donor spreadsheet that are not present in the collection. The Small Library's finding aid is the definitive listing of materials available to researchers.","Suggestions for Using the Donation Listing Spreadsheet","Materials found in the finding aid can be identified in the spreadsheet using the keyboard shortcut Control + F. If searching for materials discovered in the finding aid, it is recommended to search using donor accession numbers. (For more on this, see the above note on Alphanumeric Designations).","Please note that the spreadsheet does not contain additional descriptive information for all materials listed in the finding aid.","Researchers can use the spreadsheet to explore the collection in many ways, including the following:","- To conduct subject-based searches (e.g., regiments, battles, and military functions, and experiences such as sickness).","- To identify photographs of women, Black soldiers, and Native American soldiers.","- To identify correspondence in Series 1 authored by women and contained within personal papers attributed to men. Series 1 contains a significant amount of correspondence written by women to male relatives and friends. An example includes the many letters written by Mary Stanton to her husband Courtland Stanton, which are found with the Courtland Stanton (DL0011) papers. Another example are the letters of Lucy Britton and Martha Britton found with the Britton Family (DL0100) papers.","- To distinguish between duplicate titles and donor accession numbers in Series 1. Secondary collections such as the papers of Amos Garrison (DL0068) and Albert R. Whitney (DL0269) contain duplicate file titles, and descriptions in the spreadsheet may allow researchers to learn more about the exact nature of the materials they contain.","- To distinguish between portraits of unknown subjects in Series 2. Searching for a particular portrait of an unknown subject using the donor accession number may provide researchers with a description of the portrait, including details such as uniform and rank of the subject.","About External Documents MSS 16459 John L. Nau II Civil War History Collection - Transcripts (View and Download Below)","Transcript files are titled by donor accession number. (See above note titled Alphanumeric Designations).","Please be aware that these transcripts may contain mistakes. They are not intended to be a replacement for the original materials or their digital surrogates.","The Nau Collection was processed from October 2021 to March 2023. Because it is an artificial collection with no original order, it was arranged into series to emphasize the provenance of collection materials and to restore materials attributed to or associated with the same individual. Provenance was determined by the archival materials themselves as well as by donor metadata. Additional resources consulted during processing included The National Park Service's online Civil War Soldiers and Sailors Database (https://www.nps.gov/civilwar/soldiers-and-sailors-database.htm); Grover C. Criswell and Clarence L. Criswell's Confederate and Southern State Currency, vol. 1, (Pass-A-Grille, Florida: Criswell's Publications, 1957); John H. Eicher and David J. Eicher's Civil War High Commands (Stanford, California: Stanford University Press, 2001); and the Library of Congress's online newspapers database (https://www.loc.gov/newspapers/).","Efforts were made to restore materials to record creators and keep these materials together. However, there are some exceptions, particularly in relation to high-profile historical figures. For example, materials relating to Robert E. Lee and William Tecumseh Sherman can be found in Series 1, 2, and 3.","File titles have been devised by the archivist and each contains a donor accession number (see note titled Alphanumeric Designations). Wherever possible or applicable, titles attributed to materials by record creators are included.","The John L. Nau III Civil War History Collection (1806-1988, bulk 1861-1865; 133 cubic feet) contains Civil War-era correspondence, service records, pension records, artifacts, photographs, military records (including orders, requisitions, and correspondence), currency, newspapers, and other print materials.","The collection primarily contains the correspondence, records, and photographs of white soldiers and officers who fought in the Civil War, including white officers serving in the United States Colored Troops (USCT). Additionally, the collection includes some correspondence and portraits of white women as well as a small number of portraits of Black soldiers (including PT0322, a family portrait, and a young Ben Brown, PC0836.0001) and Native American soldiers (including Frederick L. Rainbow, PT0424.0001).","Albert and Shirley Small Special Collections Library","The John L. Nau III Civil War History Collection is predominantly in English. A small number of materials are in Spanish, French, Swedish, and German, and this is indicated at the file level."],"collection_title_tesim":["John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/1865"],"collection_ssim":["John L. Nau III Civil War History Collection, 1806/1988, bulk 1861/1865"],"level_ssm":["collection"],"level_ssim":["Collection"],"unitid_ssm":["MSS 16459","Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource 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Key","/repositories/3/resources/941"],"unitid_tesim":["MSS 16459","Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival 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Virginia, Special Collections Dept."],"geogname_ssm":["United States --  History  -- Civil War, 1861-1865","United States -- History -- Civil War, 1861-1865 -- Personal narratives"],"geogname_ssim":["United States --  History  -- Civil War, 1861-1865","United States -- History -- Civil War, 1861-1865 -- Personal narratives"],"places_ssim":["United States --  History  -- Civil War, 1861-1865","United States -- History -- Civil War, 1861-1865 -- Personal narratives"],"creator_corpname_ssim":["Albert and Shirley Small Special Collections Library"],"creators_ssim":["Albert and Shirley Small Special Collections Library"],"acqinfo_ssim":["The John L. Nau III Civil War History Collection was acquired and donated by John L. Nau III. It was accessioned by the Albert and Shirley Small Special Collections Library on September 3, 2019 (2019-0149) and in an additional accession in October 2019 (2019-0231)."],"access_subjects_ssim":["letters (correspondence)","Photograph albums","photographs","newspapers"],"access_subjects_ssm":["letters (correspondence)","Photograph albums","photographs","newspapers"],"has_online_content_ssim":["true"],"physdesc_tesim":["Good."],"extent_ssm":["133 Cubic Feet 255 boxes; 9 framed items"],"extent_tesim":["133 Cubic Feet 255 boxes; 9 framed items"],"genreform_ssim":["letters (correspondence)","Photograph albums","photographs","newspapers"],"date_range_isim":[1806,1807,1808,1809,1810,1811,1812,1813,1814,1815,1816,1817,1818,1819,1820,1821,1822,1823,1824,1825,1826,1827,1828,1829,1830,1831,1832,1833,1834,1835,1836,1837,1838,1839,1840,1841,1842,1843,1844,1845,1846,1847,1848,1849,1850,1851,1852,1853,1854,1855,1856,1857,1858,1859,1860,1861,1862,1863,1864,1865,1866,1867,1868,1869,1870,1871,1872,1873,1874,1875,1876,1877,1878,1879,1880,1881,1882,1883,1884,1885,1886,1887,1888,1889,1890,1891,1892,1893,1894,1895,1896,1897,1898,1899,1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935,1936,1937,1938,1939,1940,1941,1942,1943,1944,1945,1946,1947,1948,1949,1950,1951,1952,1953,1954,1955,1956,1957,1958,1959,1960,1961,1962,1963,1964,1965,1966,1967,1968,1969,1970,1971,1972,1973,1974,1975,1976,1977,1978,1979,1980,1981,1982,1983,1984,1985,1986,1987,1988],"accessrestrict_html_tesm":["\u003cp\u003eThe collection is open for research.\u003c/p\u003e  "],"accessrestrict_heading_ssm":["Conditions Governing Access"],"accessrestrict_tesim":["The collection is open for research."],"arrangement_html_tesm":["\u003cp\u003eThe John L. Nau III Civil War History Collection (1806-1988; bulk 1861-1865; 133 cubic feet) has been arranged into five series, Series 1: Materials Related to the Civil War Experiences of Soldiers, Officers, and Civilians (1806-1988; approx. 83 cubic feet); Series 2: Photographs and Prints (circa 1848-1939; approx. 34 cubic feet); Series 3: Government Military Records (1855-1913; approx. 9 cubic feet); Series 4: Currency (1839-1875; approx. 1.5 cubic feet); and Series 5: Newspapers and Print Materials (1846-1913; approx. 5.25 cubic feet).\u003c/p\u003e  "],"arrangement_heading_ssm":["Arrangement"],"arrangement_tesim":["The John L. Nau III Civil War History Collection (1806-1988; bulk 1861-1865; 133 cubic feet) has been arranged into five series, Series 1: Materials Related to the Civil War Experiences of Soldiers, Officers, and Civilians (1806-1988; approx. 83 cubic feet); Series 2: Photographs and Prints (circa 1848-1939; approx. 34 cubic feet); Series 3: Government Military Records (1855-1913; approx. 9 cubic feet); Series 4: Currency (1839-1875; approx. 1.5 cubic feet); and Series 5: Newspapers and Print Materials (1846-1913; approx. 5.25 cubic feet)."],"odd_html_tesm":["\u003cp\u003eThe John L. Nau III Civil War History Collection contains offensive or harmful language and imagery. This includes—but is not limited to—correspondence and diary entries that express racist views; photographs of enslaved people forced into inhumane conditions by enslavers; descriptions of violence and battle experiences; photographs of deceased soldiers; and correspondence containing explicit descriptions of sex. The purpose of this note is to give users the opportunity to decide whether they need or want to view these materials, or at least, to mentally or emotionally prepare themselves to view the materials.\u003c/p\u003e  ","\u003cp\u003eThe donor's accession numbering system has been preserved to maintain access to collection metadata or descriptive information. Each file title in this finding aid includes the donor accession number at the end of the title and each corresponding physical folder or item is also labeled with the donor accession number. \u003c/p\u003e","\u003cp\u003eDonor accession numbers are comprised of letters denoting document or photograph format followed by a four-digit number that denotes the number of the accession. The following examples can be found in the collection: DA0001 (meaning document - autograph), DC0001.001 (document - currency), DL0001 (document - letter), DN0003 (document - newspaper), DOR0001 (document - order), DOT0001 (document - other), DR0002 (document - requisition), PA0184 (photograph - ambrotype), PC0200 (photograph - carte de visite), PD0007 (photograph - daguerreotype), POT0012 (photograph - other), and PT0003 (photograph - tintype).\u003c/p\u003e","\u003cp\u003eThese donor accession numbers can be used to search the donation listing spreadsheet for corresponding metadata. This spreadsheet is available to download directly from the finding aid below, under External Documents.\u003c/p\u003e  ","\u003cp\u003e\u003cemph render=\"bold\"\u003eAbout External Document MSS 16459 John L. Nau II Civil War History Collection - Donation Listing (View and Download Below)\u003c/emph\u003e\u003c/p\u003e","\u003cp\u003eUpon accession of the John L. Nau III Civil War History Collection, the donor provided a spreadsheet donation listing containing metadata and sellers' descriptions associated with collection materials. The spreadsheet can be downloaded below, under the External Documents heading.\u003c/p\u003e","\u003cp\u003ePlease note that many descriptions contained in this spreadsheet are drawn from sellers' language used by dealers and auction houses and contain biased and qualitative descriptions. In addition, many descriptions contain offensive, racist, and archaic language, some quoted directly from collection materials (also see the above Content Warning). \u003c/p\u003e","\u003cp\u003ePlease also note there may be some materials listed in the donor spreadsheet that are not present in the collection. The Small Library's finding aid is the definitive listing of materials available to researchers.\u003c/p\u003e","\u003cp\u003e\n\u003cemph render=\"bold\"\u003eSuggestions for Using the Donation Listing Spreadsheet\u003c/emph\u003e\u003c/p\u003e","\u003cp\u003eMaterials found in the finding aid can be identified in the spreadsheet using the keyboard shortcut Control + F. If searching for materials discovered in the finding aid, it is recommended to search using donor accession numbers. (For more on this, see the above note on Alphanumeric Designations). \u003c/p\u003e","\u003cp\u003ePlease note that the spreadsheet does not contain additional descriptive information for all materials listed in the finding aid.\u003c/p\u003e","\u003cp\u003eResearchers can use the spreadsheet to explore the collection in many ways, including the following: \u003c/p\u003e","\u003cp\u003e- To conduct subject-based searches (e.g., regiments, battles, and military functions, and experiences such as sickness).\u003c/p\u003e","\u003cp\u003e- To identify photographs of women, Black soldiers, and Native American soldiers.\u003c/p\u003e","\u003cp\u003e- To identify correspondence in Series 1 authored by women and contained within personal papers attributed to men. Series 1 contains a significant amount of correspondence written by women to male relatives and friends. An example includes the many letters written by Mary Stanton to her husband Courtland Stanton, which are found with the Courtland Stanton (DL0011) papers. Another example are the letters of Lucy Britton and Martha Britton found with the Britton Family (DL0100) papers.\u003c/p\u003e","\u003cp\u003e- To distinguish between duplicate titles and donor accession numbers in Series 1. Secondary collections such as the papers of Amos Garrison (DL0068) and Albert R. Whitney (DL0269) contain duplicate file titles, and descriptions in the spreadsheet may allow researchers to learn more about the exact nature of the materials they contain.\u003c/p\u003e","\u003cp\u003e- To distinguish between portraits of unknown subjects in Series 2. Searching for a particular portrait of an unknown subject using the donor accession number may provide researchers with a description of the portrait, including details such as uniform and rank of the subject.\u003c/p\u003e","\u003cp\u003e\n\u003cemph render=\"bold\"\u003eAbout External Documents MSS 16459 John L. Nau II Civil War History Collection - Transcripts (View and Download Below)\u003c/emph\u003e\u003c/p\u003e","\u003cp\u003eTranscript files are titled by donor accession number. (See above note titled Alphanumeric Designations).\u003c/p\u003e","\u003cp\u003ePlease be aware that these transcripts may contain mistakes. They are not intended to be a replacement for the original materials or their digital surrogates.\u003c/p\u003e  "],"odd_heading_ssm":["Content Warning","Alphanumeric Designations","Important Information about External Documents"],"odd_tesim":["The John L. Nau III Civil War History Collection contains offensive or harmful language and imagery. This includes—but is not limited to—correspondence and diary entries that express racist views; photographs of enslaved people forced into inhumane conditions by enslavers; descriptions of violence and battle experiences; photographs of deceased soldiers; and correspondence containing explicit descriptions of sex. The purpose of this note is to give users the opportunity to decide whether they need or want to view these materials, or at least, to mentally or emotionally prepare themselves to view the materials.","The donor's accession numbering system has been preserved to maintain access to collection metadata or descriptive information. Each file title in this finding aid includes the donor accession number at the end of the title and each corresponding physical folder or item is also labeled with the donor accession number.","Donor accession numbers are comprised of letters denoting document or photograph format followed by a four-digit number that denotes the number of the accession. The following examples can be found in the collection: DA0001 (meaning document - autograph), DC0001.001 (document - currency), DL0001 (document - letter), DN0003 (document - newspaper), DOR0001 (document - order), DOT0001 (document - other), DR0002 (document - requisition), PA0184 (photograph - ambrotype), PC0200 (photograph - carte de visite), PD0007 (photograph - daguerreotype), POT0012 (photograph - other), and PT0003 (photograph - tintype).","These donor accession numbers can be used to search the donation listing spreadsheet for corresponding metadata. This spreadsheet is available to download directly from the finding aid below, under External Documents.","About External Document MSS 16459 John L. Nau II Civil War History Collection - Donation Listing (View and Download Below)","Upon accession of the John L. Nau III Civil War History Collection, the donor provided a spreadsheet donation listing containing metadata and sellers' descriptions associated with collection materials. The spreadsheet can be downloaded below, under the External Documents heading.","Please note that many descriptions contained in this spreadsheet are drawn from sellers' language used by dealers and auction houses and contain biased and qualitative descriptions. In addition, many descriptions contain offensive, racist, and archaic language, some quoted directly from collection materials (also see the above Content Warning).","Please also note there may be some materials listed in the donor spreadsheet that are not present in the collection. The Small Library's finding aid is the definitive listing of materials available to researchers.","Suggestions for Using the Donation Listing Spreadsheet","Materials found in the finding aid can be identified in the spreadsheet using the keyboard shortcut Control + F. If searching for materials discovered in the finding aid, it is recommended to search using donor accession numbers. (For more on this, see the above note on Alphanumeric Designations).","Please note that the spreadsheet does not contain additional descriptive information for all materials listed in the finding aid.","Researchers can use the spreadsheet to explore the collection in many ways, including the following:","- To conduct subject-based searches (e.g., regiments, battles, and military functions, and experiences such as sickness).","- To identify photographs of women, Black soldiers, and Native American soldiers.","- To identify correspondence in Series 1 authored by women and contained within personal papers attributed to men. Series 1 contains a significant amount of correspondence written by women to male relatives and friends. An example includes the many letters written by Mary Stanton to her husband Courtland Stanton, which are found with the Courtland Stanton (DL0011) papers. Another example are the letters of Lucy Britton and Martha Britton found with the Britton Family (DL0100) papers.","- To distinguish between duplicate titles and donor accession numbers in Series 1. Secondary collections such as the papers of Amos Garrison (DL0068) and Albert R. Whitney (DL0269) contain duplicate file titles, and descriptions in the spreadsheet may allow researchers to learn more about the exact nature of the materials they contain.","- To distinguish between portraits of unknown subjects in Series 2. Searching for a particular portrait of an unknown subject using the donor accession number may provide researchers with a description of the portrait, including details such as uniform and rank of the subject.","About External Documents MSS 16459 John L. Nau II Civil War History Collection - Transcripts (View and Download Below)","Transcript files are titled by donor accession number. (See above note titled Alphanumeric Designations).","Please be aware that these transcripts may contain mistakes. They are not intended to be a replacement for the original materials or their digital surrogates."],"prefercite_html_tesm":["\u003cp\u003eJohn L. Nau III Civil War History Collection, MSS 16459, box number, [if applicable] folder number, donor accession number, Albert and Shirley Small Special Collections Library, University of Virginia.\u003c/p\u003e  "],"prefercite_tesim":["John L. Nau III Civil War History Collection, MSS 16459, box number, [if applicable] folder number, donor accession number, Albert and Shirley Small Special Collections Library, University of Virginia."],"processinfo_html_tesm":["\u003cp\u003eThe Nau Collection was processed from October 2021 to March 2023. Because it is an artificial collection with no original order, it was arranged into series to emphasize the provenance of collection materials and to restore materials attributed to or associated with the same individual. Provenance was determined by the archival materials themselves as well as by donor metadata. Additional resources consulted during processing included The National Park Service's online \u003cemph render=\"italic\"\u003eCivil War Soldiers and Sailors Database\u003c/emph\u003e (https://www.nps.gov/civilwar/soldiers-and-sailors-database.htm); Grover C. Criswell and Clarence L. Criswell's \u003cemph render=\"italic\"\u003eConfederate and Southern State Currency\u003c/emph\u003e, vol. 1, (Pass-A-Grille, Florida: Criswell's Publications, 1957); John H. Eicher and David J. Eicher's \u003cemph render=\"italic\"\u003eCivil War High Commands\u003c/emph\u003e (Stanford, California: Stanford University Press, 2001); and the Library of Congress's online newspapers database (https://www.loc.gov/newspapers/).\u003c/p\u003e","\u003cp\u003eEfforts were made to restore materials to record creators and keep these materials together. However, there are some exceptions, particularly in relation to high-profile historical figures. For example, materials relating to Robert E. Lee and William Tecumseh Sherman can be found in Series 1, 2, and 3. \u003c/p\u003e","\u003cp\u003eFile titles have been devised by the archivist and each contains a donor accession number (see note titled Alphanumeric Designations). Wherever possible or applicable, titles attributed to materials by record creators are included. \u003c/p\u003e  "],"processinfo_heading_ssm":["Processing Information"],"processinfo_tesim":["The Nau Collection was processed from October 2021 to March 2023. Because it is an artificial collection with no original order, it was arranged into series to emphasize the provenance of collection materials and to restore materials attributed to or associated with the same individual. Provenance was determined by the archival materials themselves as well as by donor metadata. Additional resources consulted during processing included The National Park Service's online Civil War Soldiers and Sailors Database (https://www.nps.gov/civilwar/soldiers-and-sailors-database.htm); Grover C. Criswell and Clarence L. Criswell's Confederate and Southern State Currency, vol. 1, (Pass-A-Grille, Florida: Criswell's Publications, 1957); John H. Eicher and David J. Eicher's Civil War High Commands (Stanford, California: Stanford University Press, 2001); and the Library of Congress's online newspapers database (https://www.loc.gov/newspapers/).","Efforts were made to restore materials to record creators and keep these materials together. However, there are some exceptions, particularly in relation to high-profile historical figures. For example, materials relating to Robert E. Lee and William Tecumseh Sherman can be found in Series 1, 2, and 3.","File titles have been devised by the archivist and each contains a donor accession number (see note titled Alphanumeric Designations). Wherever possible or applicable, titles attributed to materials by record creators are included."],"scopecontent_html_tesm":["\u003cp\u003eThe John L. Nau III Civil War History Collection (1806-1988, bulk 1861-1865; 133 cubic feet) contains Civil War-era correspondence, service records, pension records, artifacts, photographs, military records (including orders, requisitions, and correspondence), currency, newspapers, and other print materials. \u003c/p\u003e","\u003cp\u003eThe collection primarily contains the correspondence, records, and photographs of white soldiers and officers who fought in the Civil War, including white officers serving in the United States Colored Troops (USCT). Additionally, the collection includes some correspondence and portraits of white women as well as a small number of portraits of Black soldiers (including PT0322, a family portrait, and a young Ben Brown, PC0836.0001) and Native American soldiers (including Frederick L. Rainbow, PT0424.0001). \u003c/p\u003e  "],"scopecontent_heading_ssm":["Scope and Contents"],"scopecontent_tesim":["The John L. Nau III Civil War History Collection (1806-1988, bulk 1861-1865; 133 cubic feet) contains Civil War-era correspondence, service records, pension records, artifacts, photographs, military records (including orders, requisitions, and correspondence), currency, newspapers, and other print materials.","The collection primarily contains the correspondence, records, and photographs of white soldiers and officers who fought in the Civil War, including white officers serving in the United States Colored Troops (USCT). Additionally, the collection includes some correspondence and portraits of white women as well as a small number of portraits of Black soldiers (including PT0322, a family portrait, and a young Ben Brown, PC0836.0001) and Native American soldiers (including Frederick L. Rainbow, PT0424.0001)."],"corpname_ssim":["Albert and Shirley Small Special Collections Library"],"names_ssim":["Albert and Shirley Small Special Collections Library"],"language_ssim":["The John L. Nau III Civil War History Collection is predominantly in English. A small number of materials are in Spanish, French, Swedish, and German, and this is indicated at the file level."],"descrules_ssm":["Describing Archives: A Content Standard"],"total_component_count_is":10302,"online_item_count_is":5,"component_level_isim":[0],"sort_isi":0,"timestamp":"2026-08-14T22:54:19.132Z"}]}},"label":"Breadcrumbs"}}},"links":{"self":"https://arvasarchive.org/catalog/viu_repositories_3_resources_941_c04"}},{"id":"viu_repositories_3_resources_1396_c04","type":"Series","attributes":{"title":"Series 4. Financial and Legal papers, 1794/1910","abstract_or_scope":{"id":"https://arvasarchive.org/catalog/viu_repositories_3_resources_1396_c04#abstract_or_scope","type":"document_value","attributes":{"value":"\u003cp\u003eA. Indentures, deeds, plats, receipts, tax statements,petitions, and wills. B. Letters about debt collection. C.Stocks D. Receipt for goods and services for Watts family\u003c/p\u003e","label":"Abstract Or Scope"}},"breadcrumbs":{"id":"https://arvasarchive.org/catalog/viu_repositories_3_resources_1396_c04#breadcrumbs","type":"document_value","attributes":{"value":{"ref_ssi":"viu_repositories_3_resources_1396_c04","ref_ssm":["viu_repositories_3_resources_1396_c04"],"id":"viu_repositories_3_resources_1396_c04","ead_ssi":"viu_repositories_3_resources_1396","_root_":"viu_repositories_3_resources_1396","_nest_parent_":"viu_repositories_3_resources_1396","parent_ssi":"viu_repositories_3_resources_1396","parent_ssim":["Watts family papers-addition, 1786/1950"],"parent_ids_ssim":["viu_repositories_3_resources_1396"],"title_filing_ssi":"Series 4. Financial and Legal papers","title_ssm":["Series 4. Financial and Legal papers"],"title_tesim":["Series 4. Financial and Legal papers"],"normalized_title_ssm":["Series 4. Financial and Legal papers, 1794/1910"],"text":["Series 4. Financial and Legal papers, 1794/1910","Watts family papers-addition, 1786/1950","English","A. Indentures, deeds, plats, receipts, tax statements,petitions, and wills. B. Letters about debt collection. C.Stocks D. 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Indentures, deeds, plats, receipts, tax statements,petitions, and wills. B. Letters about debt collection. C.Stocks D. Receipt for goods and services for Watts family\u003c/p\u003e"],"scopecontent_heading_ssm":["Scope and Contents"],"scopecontent_tesim":["A. Indentures, deeds, plats, receipts, tax statements,petitions, and wills. B. Letters about debt collection. C.Stocks D. Receipt for goods and services for Watts family"],"_nest_path_":"/components#3","timestamp":"2026-08-14T22:53:38.700Z","collection":{"numFound":1,"start":0,"numFoundExact":true,"docs":[{"id":"viu_repositories_3_resources_1396","ead_ssi":"viu_repositories_3_resources_1396","_root_":"viu_repositories_3_resources_1396","_nest_parent_":"viu_repositories_3_resources_1396","ead_source_url_ssi":"data/oai/UVA/repositories_3_resources_1396.xml","aspace_url_ssi":"https://archives.lib.virginia.edu/ark:/59853/151360","title_filing_ssi":"Watts family papers","title_ssm":["Watts family papers-addition"],"title_tesim":["Watts family papers-addition"],"unitdate_ssm":["1786-1950"],"unitdate_inclusive_ssm":["1786-1950"],"normalized_date_ssm":["1786/1950"],"normalized_title_ssm":["Watts family papers-addition, 1786/1950"],"text":["Watts family papers-addition, 1786/1950","MSS 12170","Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","/repositories/3/resources/1396","United States --  History  -- Civil War, 1861-1865","Slavery--United States -- Virginia","lawyers -- Virginia","The collection is open for research use.","The Watts family papers are arranged into 9 series. Series 1. Family Correspondence, Series 2. Genealogy, History and letters of James and Dolley Madison, Series 3. Documents related to enslavement, Series 4. Legal and Financial papers, Subseries A. Indentures, Subseries B. Marriage agreements, petitions, statements, and wills, Subseries C. Letters about collecting debts, Subseries D. Receipts for goods and services of the Watts family, Series 5. Newspaper clippings and miscellaneous family papers and oversize photographs, Series 6. Family Bibles, Series 7. Roanoke Gun Club Inc. land, Series 8. Showalter transcriptions on digital materials and a flash drive. Box 1 contains folders with some transcription of the letters in the collection and a folder with biographical information. Box 12 contains folders with an index and a folder of miscellaneous information about the collection.","Added existing collection MSS 12170 (3 folders) of Breckinridge, Gamble and Watts families into this addition of Watts family papers MSS 12170.","The Watts family has been part of the Roanoke Valley (also called \"Big Lick\") in Virginia for six generations. General Edward Watts was born on 7 April 1779, in Prince Edward, Virginia. He was the son of William Watts (1742-1797), and Mary Scott (1758-1836). He married Elizabeth Breckinridge, the daughter of James Breckinridge on 6 May 1811 and they had 10 children, including William Watts (1817-1877), Mary Scott Gamble (1814-1840), Ann Selden Watts Holcombe (1820-1888), Alice Watts Robertson (1832-1914), Emma Gilmer Watts Carr (1834-1872) and Letitia Watts Sorrell (1829-1900). Edward Watts purchased 400 acres of land from his father-in-law, James Breckinridge (called The Barrens) where he built his home \"Oaklands\" in 1817. General Edward Watts died in 1859 at age 59. The Watts and Breckinridge families were well-known families in southwest Virginia who enslaved people during the American Revolution and the American Civil War. They were admired by their peers as influential attorneys, politicians, and land owners who often opened their house to the community.","General Edward Watts was educated at Liberty Hall Academy (Washington \u0026 Lee), and Princeton. He was an officer in the War of 1812 and was the Commonwealth attorney for Roanoke County from 1839 to 1845. His son, William Watts (1817-1877) was a Colonel in the 28th Infantry of the Confederate Army (Roanoke Greys). He was educated in medicine and law at the University of Virginia.","After the war, he followed in his father's path as the Commonwealth attorney from 1845 to 1854. He was in the State Constitutional Convention (1850-1851), and was president of the Exchange Bank of Virginia. He also ran for governor in 1834 and 1842. He served in the legislature for one term in 1875. He married Mary Allen in 1850 and they had one living son, John Allen Watts (1855-1904). Mary Allen died following his birth in 1855. Colonel William Watts was also a farmer who enslaved over 100 people. He was said to have one enslaved person as his \"body servant\" through the war and gave him a home for life. Research of the collection has not yet provided his name.","John Allen Watts (1855-1904) nicknamed \"Squat\" was also a student at the University of Virginia and became an attorney. He married Gertrude Lee and they had a son named William. John Allen Watts sold Oaklands to a develpment company and it burned down in 1897. Descendants Jean Staples Showalter, English Showalter, and Katherine Watts donated this collection of their family's papers.","Sources:\n\"Roanoke and Western Virginia: Glimpses of the Pst: Oaklands\" http://showalter.blogspot.com/2010/12/oaklands.html","Barnes, Raymond. \"Confederates of Roanoke-V: General Edward Watts and Colonel William Watts Founded Clan\" Roanoke World News. 5 April 1961. The Historical Society of Western Virginia. O. Winston Link Museum. History Museum of Western Virginia\nhttps://hswv.pastperfectonline.com/archive/94647C8F-8806-4D18-8A04-445143233613#gallery","Barnes, Raymond. 'Oaklands' Was Hospitable Seat of Watts Family for Generations: Needed Big Staff\" Roanoke World News. 21 May 1958. The Historical Society of Western Virginia. O. Winston Link Museum. History Museum of Western Virginia\nhttps://hswv.pastperfectonline.com/archive/53DC8EB0-DBE3-4B95-B4AF-027946626463#gallery","Watts, Katherine. \"The Roanoke Valley and the Watts Family\" June 1984.","There is a website at the O. Winston Link Museum (History Museum of West Virginia) that has many of the Watts family letters online","https://hswv.pastperfectonline.com/byperson?page=3\u0026keyword=Watts%2C%20William\u0026searchType=person\u0026showsearch=True","Related collections include MSS 4111-a,-b,-c,-d,-e,-f; MSS 8914, and MSS 653.","MSS 38-33 Irvine, Saunders, Davis, and Watts families (William Watts daybooks 1768-1786); MSS 259; MSS 653; MSS 9715 Abram Penn Staples.","The Watts family papers of Roanoke County, Virginia at \"Oaklands\" in Flat Creek, Campbell County) consist of correspondence and documents related to the American Revolution, the War of 1812, the United States Civil War, war with Osceola and Seminole tribes in Florida, Virginia politics, economic and social history (including enslavement),land ownership, farming, court cases and debt from 1786 to 1950 in southwest Virginia. The Watts are related to many other Virginia families including James and Dolley Madison. This collection represents a great view into historical and social events of the eighteenth and nineteenth century in Virginia.","The papers of this family of landowners, farmers, politicians, and attorneys portray the rich southern antebellum life on the Oaklands plantation. Despite the told and true characteristics of the kindness of the Watts family, they were nineteenth century southern plantation owners who owned hundreds of enslaved persons. The letters and receipts in the collection include many first names and some last names. One enslaved person, Henry Langhorne, a lifetime attendant of Colonel William Watts was bequeathed $1,000 and a home for life.","Some letters mention the Watt's efforts to keep enslaved families from being separated by intervening in the sales of enslaved persons. There are many references to enslaved people among their households and farm, including descriptions of providing their clothing, housing, and nurturing them when they were sick, like family members. It is important to note that the collection also contains receipts for their purchase and loan.","The issue of enslavement is discussed in local meetings that Watts attended. There are also letters from former enslaved persons such as [Malinda] Langhorne and William Langhorne to Watts family members and photographs of enslaved persons, Aunt Sally and Aunt Phoebe standing together, and a photograph of Uncle Lou with the Watts children.","There is also correspondence about financial and legal matters as Colonel William Watts (1817-1877) and his father, General Edward Watts (1779-1859), were attorneys. Much of their correspondence relates to collecting debts, indentures, land surveys, receipts, and politics (Whig party, Commonwealth Attorney, Constitutional Convention, Virginia Delegates, and candidacy for Governor), and religion. The papers contain discussions about the popular faith of Presbyterians and Episcopalians). The University of Virginia, Washington \u0026 Lee, and William \u0026 Mary College are also mentioned.","The collection spans six generations of the Watts family including General Edward Watts and his wife Elizabeth Breckinridge (1794-1862), their son Colonel William Watts (1817-1877) and his wife Mary Jane Allen (1825-1855). Also included is their son, John Allen Watts and his wife Gertrude Lee.","Other related families include Madison, Breckenridge, Allen, Jackson, Watson, Morris, Gamble, Payne, Washington, Meigs, and Saunders. (MSS 653) Other related collections include MSS 4111-a,-b,-c,-d,-e,-f; MSS 38-33 Irvine, Saunders, Davis, and Watts families (William Watts daybooks 1768-1786); MSS 259; MSS 9715 Abram Penn Staples..(see related materials note)","The papers of Mary Scott Watts Gamble have been combined into this collection. These letters contain her accounts of attacks by Osceola and Seminole people in Florida. She mentions that Robert [Watts?] and Robert Gamble joined the local militia to remove the Seminoles from the swamps and send them out West. (1835)","Albert and Shirley Small Special Collections Library","English"],"collection_title_tesim":["Watts family papers-addition, 1786/1950"],"collection_ssim":["Watts family papers-addition, 1786/1950"],"level_ssm":["collection"],"level_ssim":["Collection"],"unitid_ssm":["MSS 12170","Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource 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Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","/repositories/3/resources/1396"],"repository_ssm":["University of Virginia, Special Collections Dept."],"repository_ssim":["University of Virginia, Special Collections Dept."],"geogname_ssm":["United States --  History  -- Civil War, 1861-1865"],"geogname_ssim":["United States --  History  -- Civil War, 1861-1865"],"places_ssim":["United States --  History  -- Civil War, 1861-1865"],"creator_corpname_ssim":["Albert and Shirley Small Special Collections Library"],"creators_ssim":["Albert and Shirley Small Special Collections Library"],"acqinfo_ssim":["This collection was a gift from Katherine Watts to the Small Special Collections Library at the University of Virginia Library on 9 April 2022."],"access_subjects_ssim":["Slavery--United States -- Virginia","lawyers -- Virginia"],"access_subjects_ssm":["Slavery--United States -- Virginia","lawyers -- Virginia"],"has_online_content_ssim":["true"],"extent_ssm":["9 Cubic Feet 12 legal size document boxes, 1 half-size legal document box, 2 cubics of bibles, and 2 oversize boxes",".107 Gigabytes","0.25 Cubic Feet"],"extent_tesim":["9 Cubic Feet 12 legal size document boxes, 1 half-size legal document box, 2 cubics of bibles, and 2 oversize boxes",".107 Gigabytes","0.25 Cubic Feet"],"physfacet_tesim":["2,588 files, 2, 371 MS Word files, 176 Open office documents, 23 jpegs, 13 Apple/Double files, 3 tiffs, 1 pdf.","Oversize box: Photographs and certificates of Watts family members (deframed)"],"date_range_isim":[1786,1787,1788,1789,1790,1791,1792,1793,1794,1795,1796,1797,1798,1799,1800,1801,1802,1803,1804,1805,1806,1807,1808,1809,1810,1811,1812,1813,1814,1815,1816,1817,1818,1819,1820,1821,1822,1823,1824,1825,1826,1827,1828,1829,1830,1831,1832,1833,1834,1835,1836,1837,1838,1839,1840,1841,1842,1843,1844,1845,1846,1847,1848,1849,1850,1851,1852,1853,1854,1855,1856,1857,1858,1859,1860,1861,1862,1863,1864,1865,1866,1867,1868,1869,1870,1871,1872,1873,1874,1875,1876,1877,1878,1879,1880,1881,1882,1883,1884,1885,1886,1887,1888,1889,1890,1891,1892,1893,1894,1895,1896,1897,1898,1899,1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935,1936,1937,1938,1939,1940,1941,1942,1943,1944,1945,1946,1947,1948,1949,1950],"accessrestrict_html_tesm":["\u003cp\u003eThe collection is open for research use.\u003c/p\u003e  "],"accessrestrict_heading_ssm":["Conditions Governing Access"],"accessrestrict_tesim":["The collection is open for research use."],"arrangement_html_tesm":["\u003cp\u003eThe Watts family papers are arranged into 9 series. Series 1. Family Correspondence, Series 2. Genealogy, History and letters of James and Dolley Madison, Series 3. Documents related to enslavement, Series 4. Legal and Financial papers, Subseries A. Indentures, Subseries B. Marriage agreements, petitions, statements, and wills, Subseries C. Letters about collecting debts, Subseries D. Receipts for goods and services of the Watts family, Series 5. Newspaper clippings and miscellaneous family papers and oversize photographs, Series 6. Family Bibles, Series 7. Roanoke Gun Club Inc. land, Series 8. Showalter transcriptions on digital materials and a flash drive. Box 1 contains folders with some transcription of the letters in the collection and a folder with biographical information. Box 12 contains folders with an index and a folder of miscellaneous information about the collection. \u003c/p\u003e","\u003cp\u003eAdded existing collection MSS 12170 (3 folders) of Breckinridge, Gamble and Watts families into this addition of Watts family papers MSS 12170. \u003c/p\u003e  "],"arrangement_heading_ssm":["Arrangement"],"arrangement_tesim":["The Watts family papers are arranged into 9 series. Series 1. Family Correspondence, Series 2. Genealogy, History and letters of James and Dolley Madison, Series 3. Documents related to enslavement, Series 4. Legal and Financial papers, Subseries A. Indentures, Subseries B. Marriage agreements, petitions, statements, and wills, Subseries C. Letters about collecting debts, Subseries D. Receipts for goods and services of the Watts family, Series 5. Newspaper clippings and miscellaneous family papers and oversize photographs, Series 6. Family Bibles, Series 7. Roanoke Gun Club Inc. land, Series 8. Showalter transcriptions on digital materials and a flash drive. Box 1 contains folders with some transcription of the letters in the collection and a folder with biographical information. Box 12 contains folders with an index and a folder of miscellaneous information about the collection.","Added existing collection MSS 12170 (3 folders) of Breckinridge, Gamble and Watts families into this addition of Watts family papers MSS 12170."],"bioghist_html_tesm":["\u003cp\u003eThe Watts family has been part of the Roanoke Valley (also called \"Big Lick\") in Virginia for six generations. General Edward Watts was born on 7 April 1779, in Prince Edward, Virginia. He was the son of William Watts (1742-1797), and Mary Scott (1758-1836). He married Elizabeth Breckinridge, the daughter of James Breckinridge on 6 May 1811 and they had 10 children, including William Watts (1817-1877), Mary Scott Gamble (1814-1840), Ann Selden Watts Holcombe (1820-1888), Alice Watts Robertson (1832-1914), Emma Gilmer Watts Carr (1834-1872) and Letitia Watts Sorrell (1829-1900). Edward Watts purchased 400 acres of land from his father-in-law, James Breckinridge (called The Barrens) where he built his home \"Oaklands\" in 1817. General Edward Watts died in 1859 at age 59. The Watts and Breckinridge families were well-known families in southwest Virginia who enslaved people during the American Revolution and the American Civil War. They were admired by their peers as influential attorneys, politicians, and land owners who often opened their house to the community.\u003c/p\u003e","\u003cp\u003eGeneral Edward Watts was educated at Liberty Hall Academy (Washington \u0026amp; Lee), and Princeton. He was an officer in the War of 1812 and was the Commonwealth attorney for Roanoke County from 1839 to 1845. His son, William Watts (1817-1877) was a Colonel in the 28th Infantry of the Confederate Army (Roanoke Greys). He was educated in medicine and law at the University of Virginia. \u003c/p\u003e","\u003cp\u003eAfter the war, he followed in his father's path as the Commonwealth attorney from 1845 to 1854. He was in the State Constitutional Convention (1850-1851), and was president of the Exchange Bank of Virginia. He also ran for governor in 1834 and 1842. He served in the legislature for one term in 1875. He married Mary Allen in 1850 and they had one living son, John Allen Watts (1855-1904). Mary Allen died following his birth in 1855. Colonel William Watts was also a farmer who enslaved over 100 people. He was said to have one enslaved person as his \"body servant\" through the war and gave him a home for life. Research of the collection has not yet provided his name.\u003c/p\u003e","\u003cp\u003eJohn Allen Watts (1855-1904) nicknamed \"Squat\" was also a student at the University of Virginia and became an attorney. He married Gertrude Lee and they had a son named William. John Allen Watts sold Oaklands to a develpment company and it burned down in 1897. Descendants Jean Staples Showalter, English Showalter, and Katherine Watts donated this collection of their family's papers. \u003c/p\u003e","\u003cp\u003eSources:\n\"Roanoke and Western Virginia: Glimpses of the Pst: Oaklands\" http://showalter.blogspot.com/2010/12/oaklands.html\u003c/p\u003e","\u003cp\u003eBarnes, Raymond. \"Confederates of Roanoke-V: General Edward Watts and Colonel William Watts Founded Clan\" Roanoke World News. 5 April 1961. The Historical Society of Western Virginia. O. Winston Link Museum. History Museum of Western Virginia\nhttps://hswv.pastperfectonline.com/archive/94647C8F-8806-4D18-8A04-445143233613#gallery\u003c/p\u003e","\u003cp\u003e\nBarnes, Raymond. 'Oaklands' Was Hospitable Seat of Watts Family for Generations: Needed Big Staff\" Roanoke World News. 21 May 1958. The Historical Society of Western Virginia. O. Winston Link Museum. History Museum of Western Virginia\nhttps://hswv.pastperfectonline.com/archive/53DC8EB0-DBE3-4B95-B4AF-027946626463#gallery\u003c/p\u003e","\u003cp\u003e\nWatts, Katherine. \"The Roanoke Valley and the Watts Family\" June 1984.\u003c/p\u003e  "],"bioghist_heading_ssm":["Biographical / Historical"],"bioghist_tesim":["The Watts family has been part of the Roanoke Valley (also called \"Big Lick\") in Virginia for six generations. General Edward Watts was born on 7 April 1779, in Prince Edward, Virginia. He was the son of William Watts (1742-1797), and Mary Scott (1758-1836). He married Elizabeth Breckinridge, the daughter of James Breckinridge on 6 May 1811 and they had 10 children, including William Watts (1817-1877), Mary Scott Gamble (1814-1840), Ann Selden Watts Holcombe (1820-1888), Alice Watts Robertson (1832-1914), Emma Gilmer Watts Carr (1834-1872) and Letitia Watts Sorrell (1829-1900). Edward Watts purchased 400 acres of land from his father-in-law, James Breckinridge (called The Barrens) where he built his home \"Oaklands\" in 1817. General Edward Watts died in 1859 at age 59. The Watts and Breckinridge families were well-known families in southwest Virginia who enslaved people during the American Revolution and the American Civil War. They were admired by their peers as influential attorneys, politicians, and land owners who often opened their house to the community.","General Edward Watts was educated at Liberty Hall Academy (Washington \u0026 Lee), and Princeton. He was an officer in the War of 1812 and was the Commonwealth attorney for Roanoke County from 1839 to 1845. His son, William Watts (1817-1877) was a Colonel in the 28th Infantry of the Confederate Army (Roanoke Greys). He was educated in medicine and law at the University of Virginia.","After the war, he followed in his father's path as the Commonwealth attorney from 1845 to 1854. He was in the State Constitutional Convention (1850-1851), and was president of the Exchange Bank of Virginia. He also ran for governor in 1834 and 1842. He served in the legislature for one term in 1875. He married Mary Allen in 1850 and they had one living son, John Allen Watts (1855-1904). Mary Allen died following his birth in 1855. Colonel William Watts was also a farmer who enslaved over 100 people. He was said to have one enslaved person as his \"body servant\" through the war and gave him a home for life. Research of the collection has not yet provided his name.","John Allen Watts (1855-1904) nicknamed \"Squat\" was also a student at the University of Virginia and became an attorney. He married Gertrude Lee and they had a son named William. John Allen Watts sold Oaklands to a develpment company and it burned down in 1897. Descendants Jean Staples Showalter, English Showalter, and Katherine Watts donated this collection of their family's papers.","Sources:\n\"Roanoke and Western Virginia: Glimpses of the Pst: Oaklands\" http://showalter.blogspot.com/2010/12/oaklands.html","Barnes, Raymond. \"Confederates of Roanoke-V: General Edward Watts and Colonel William Watts Founded Clan\" Roanoke World News. 5 April 1961. The Historical Society of Western Virginia. O. Winston Link Museum. History Museum of Western Virginia\nhttps://hswv.pastperfectonline.com/archive/94647C8F-8806-4D18-8A04-445143233613#gallery","Barnes, Raymond. 'Oaklands' Was Hospitable Seat of Watts Family for Generations: Needed Big Staff\" Roanoke World News. 21 May 1958. The Historical Society of Western Virginia. O. Winston Link Museum. History Museum of Western Virginia\nhttps://hswv.pastperfectonline.com/archive/53DC8EB0-DBE3-4B95-B4AF-027946626463#gallery","Watts, Katherine. \"The Roanoke Valley and the Watts Family\" June 1984."],"prefercite_html_tesm":["\u003cp\u003eMSS 12170, Watts family papers, Albert and Shirley Small Special Collections Library, University of Virginia Library.\u003c/p\u003e  "],"prefercite_tesim":["MSS 12170, Watts family papers, Albert and Shirley Small Special Collections Library, University of Virginia Library."],"relatedmaterial_html_tesm":["\u003cp\u003eThere is a website at the O. Winston Link Museum (History Museum of West Virginia) that has many of the Watts family letters online \u003c/p\u003e","\u003cp\u003ehttps://hswv.pastperfectonline.com/byperson?page=3\u0026amp;keyword=Watts%2C%20William\u0026amp;searchType=person\u0026amp;showsearch=True\u003c/p\u003e","\u003cp\u003eRelated collections include MSS 4111-a,-b,-c,-d,-e,-f; MSS 8914, and MSS 653.\u003c/p\u003e  ","\u003cp\u003eMSS 38-33 Irvine, Saunders, Davis, and Watts families (William Watts daybooks 1768-1786); MSS 259; MSS 653; MSS 9715 Abram Penn Staples.\u003c/p\u003e  "],"relatedmaterial_heading_ssm":["Related Materials","Related Materials"],"relatedmaterial_tesim":["There is a website at the O. Winston Link Museum (History Museum of West Virginia) that has many of the Watts family letters online","https://hswv.pastperfectonline.com/byperson?page=3\u0026keyword=Watts%2C%20William\u0026searchType=person\u0026showsearch=True","Related collections include MSS 4111-a,-b,-c,-d,-e,-f; MSS 8914, and MSS 653.","MSS 38-33 Irvine, Saunders, Davis, and Watts families (William Watts daybooks 1768-1786); MSS 259; MSS 653; MSS 9715 Abram Penn Staples."],"scopecontent_html_tesm":["\u003cp\u003eThe Watts family papers of Roanoke County, Virginia at \"Oaklands\" in Flat Creek, Campbell County) consist of correspondence and documents related to the American Revolution, the War of 1812, the United States Civil War, war with Osceola and Seminole tribes in Florida, Virginia politics, economic and social history (including enslavement),land ownership, farming, court cases and debt from 1786 to 1950 in southwest Virginia. The Watts are related to many other Virginia families including James and Dolley Madison. This collection represents a great view into historical and social events of the eighteenth and nineteenth century in Virginia.\u003c/p\u003e","\u003cp\u003eThe papers of this family of landowners, farmers, politicians, and attorneys portray the rich southern antebellum life on the Oaklands plantation. Despite the told and true characteristics of the kindness of the Watts family, they were nineteenth century southern plantation owners who owned hundreds of enslaved persons. The letters and receipts in the collection include many first names and some last names. One enslaved person, Henry Langhorne, a lifetime attendant of Colonel William Watts was bequeathed $1,000 and a home for life. \u003c/p\u003e","\u003cp\u003eSome letters mention the Watt's efforts to keep enslaved families from being separated by intervening in the sales of enslaved persons. There are many references to enslaved people among their households and farm, including descriptions of providing their clothing, housing, and nurturing them when they were sick, like family members. It is important to note that the collection also contains receipts for their purchase and loan. \u003c/p\u003e","\u003cp\u003eThe issue of enslavement is discussed in local meetings that Watts attended. There are also letters from former enslaved persons such as [Malinda] Langhorne and William Langhorne to Watts family members and photographs of enslaved persons, Aunt Sally and Aunt Phoebe standing together, and a photograph of Uncle Lou with the Watts children. \u003c/p\u003e","\u003cp\u003eThere is also correspondence about financial and legal matters as Colonel William Watts (1817-1877) and his father, General Edward Watts (1779-1859), were attorneys. Much of their correspondence relates to collecting debts, indentures, land surveys, receipts, and politics (Whig party, Commonwealth Attorney, Constitutional Convention, Virginia Delegates, and candidacy for Governor), and religion. The papers contain discussions about the popular faith of Presbyterians and Episcopalians). The University of Virginia, Washington \u0026amp; Lee, and William \u0026amp; Mary College are also mentioned.\u003c/p\u003e","\u003cp\u003eThe collection spans six generations of the Watts family including General Edward Watts and his wife Elizabeth Breckinridge (1794-1862), their son Colonel William Watts (1817-1877) and his wife Mary Jane Allen (1825-1855). Also included is their son, John Allen Watts and his wife Gertrude Lee. \u003c/p\u003e","\u003cp\u003eOther related families include Madison, Breckenridge, Allen, Jackson, Watson, Morris, Gamble, Payne, Washington, Meigs, and Saunders. (MSS 653) Other related collections include MSS 4111-a,-b,-c,-d,-e,-f; MSS 38-33 Irvine, Saunders, Davis, and Watts families (William Watts daybooks 1768-1786); MSS 259; MSS 9715 Abram Penn Staples..(see related materials note)\u003c/p\u003e","\u003cp\u003eThe papers of Mary Scott Watts Gamble have been combined into this collection. These letters contain her accounts of attacks by Osceola and Seminole people in Florida. She mentions that Robert [Watts?] and Robert Gamble joined the local militia to remove the Seminoles from the swamps and send them out West. (1835) \u003c/p\u003e  "],"scopecontent_heading_ssm":["Content Description"],"scopecontent_tesim":["The Watts family papers of Roanoke County, Virginia at \"Oaklands\" in Flat Creek, Campbell County) consist of correspondence and documents related to the American Revolution, the War of 1812, the United States Civil War, war with Osceola and Seminole tribes in Florida, Virginia politics, economic and social history (including enslavement),land ownership, farming, court cases and debt from 1786 to 1950 in southwest Virginia. The Watts are related to many other Virginia families including James and Dolley Madison. This collection represents a great view into historical and social events of the eighteenth and nineteenth century in Virginia.","The papers of this family of landowners, farmers, politicians, and attorneys portray the rich southern antebellum life on the Oaklands plantation. Despite the told and true characteristics of the kindness of the Watts family, they were nineteenth century southern plantation owners who owned hundreds of enslaved persons. The letters and receipts in the collection include many first names and some last names. One enslaved person, Henry Langhorne, a lifetime attendant of Colonel William Watts was bequeathed $1,000 and a home for life.","Some letters mention the Watt's efforts to keep enslaved families from being separated by intervening in the sales of enslaved persons. There are many references to enslaved people among their households and farm, including descriptions of providing their clothing, housing, and nurturing them when they were sick, like family members. It is important to note that the collection also contains receipts for their purchase and loan.","The issue of enslavement is discussed in local meetings that Watts attended. There are also letters from former enslaved persons such as [Malinda] Langhorne and William Langhorne to Watts family members and photographs of enslaved persons, Aunt Sally and Aunt Phoebe standing together, and a photograph of Uncle Lou with the Watts children.","There is also correspondence about financial and legal matters as Colonel William Watts (1817-1877) and his father, General Edward Watts (1779-1859), were attorneys. Much of their correspondence relates to collecting debts, indentures, land surveys, receipts, and politics (Whig party, Commonwealth Attorney, Constitutional Convention, Virginia Delegates, and candidacy for Governor), and religion. The papers contain discussions about the popular faith of Presbyterians and Episcopalians). The University of Virginia, Washington \u0026 Lee, and William \u0026 Mary College are also mentioned.","The collection spans six generations of the Watts family including General Edward Watts and his wife Elizabeth Breckinridge (1794-1862), their son Colonel William Watts (1817-1877) and his wife Mary Jane Allen (1825-1855). Also included is their son, John Allen Watts and his wife Gertrude Lee.","Other related families include Madison, Breckenridge, Allen, Jackson, Watson, Morris, Gamble, Payne, Washington, Meigs, and Saunders. (MSS 653) Other related collections include MSS 4111-a,-b,-c,-d,-e,-f; MSS 38-33 Irvine, Saunders, Davis, and Watts families (William Watts daybooks 1768-1786); MSS 259; MSS 9715 Abram Penn Staples..(see related materials note)","The papers of Mary Scott Watts Gamble have been combined into this collection. These letters contain her accounts of attacks by Osceola and Seminole people in Florida. She mentions that Robert [Watts?] and Robert Gamble joined the local militia to remove the Seminoles from the swamps and send them out West. (1835)"],"corpname_ssim":["Albert and Shirley Small Special Collections Library"],"names_ssim":["Albert and Shirley Small Special Collections Library"],"language_ssim":["English"],"descrules_ssm":["Describing Archives: A Content Standard"],"total_component_count_is":281,"online_item_count_is":1,"component_level_isim":[0],"sort_isi":0,"timestamp":"2026-08-14T22:53:38.700Z"}]}},"label":"Breadcrumbs"}}},"links":{"self":"https://arvasarchive.org/catalog/viu_repositories_3_resources_1396_c04"}},{"id":"viu_repositories_3_resources_1396_c08","type":"Series","attributes":{"title":"Series 9. Existing Collection: Watts family papers (original name: Correspondence of the Breckinridge, Gamble and Watts families particularly Mary Watts Gamble), 1794/1850","abstract_or_scope":{"id":"https://arvasarchive.org/catalog/viu_repositories_3_resources_1396_c08#abstract_or_scope","type":"document_value","attributes":{"value":"\u003cp\u003eThis series consists of the correspondence of the Breckinridge, Gamble, and Watts families, ca.1794-1850, but chiefly that of Mary Scott Watts Gamble (1814-1840)daughter of General Edward Watts. The name has been changed to Watts family papers as of March 2023. There are many related collections of the Watts family papers. MSS 38-33 Irvine, Saunders, Davis, and Watts families (William Watts daybooks 1768-1786); MSS 259; MSS 653; and MSS 9715 Abram Penn Staples.\u003c/p\u003e","label":"Abstract Or Scope"}},"breadcrumbs":{"id":"https://arvasarchive.org/catalog/viu_repositories_3_resources_1396_c08#breadcrumbs","type":"document_value","attributes":{"value":{"ref_ssi":"viu_repositories_3_resources_1396_c08","ref_ssm":["viu_repositories_3_resources_1396_c08"],"id":"viu_repositories_3_resources_1396_c08","ead_ssi":"viu_repositories_3_resources_1396","_root_":"viu_repositories_3_resources_1396","_nest_parent_":"viu_repositories_3_resources_1396","parent_ssi":"viu_repositories_3_resources_1396","parent_ssim":["Watts family papers-addition, 1786/1950"],"parent_ids_ssim":["viu_repositories_3_resources_1396"],"title_filing_ssi":"Series 9. Existing Collection: Watts family papers (original name: Correspondence of the Breckinridge, Gamble and Watts families particularly Mary Watts Gamble)","title_ssm":["Series 9. Existing Collection: Watts family papers (original name: Correspondence of the Breckinridge, Gamble and Watts families particularly Mary Watts Gamble)"],"title_tesim":["Series 9. Existing Collection: Watts family papers (original name: Correspondence of the Breckinridge, Gamble and Watts families particularly Mary Watts Gamble)"],"normalized_title_ssm":["Series 9. Existing Collection: Watts family papers (original name: Correspondence of the Breckinridge, Gamble and Watts families particularly Mary Watts Gamble), 1794/1850"],"text":["Series 9. Existing Collection: Watts family papers (original name: Correspondence of the Breckinridge, Gamble and Watts families particularly Mary Watts Gamble), 1794/1850","Watts family papers-addition, 1786/1950","English","This series consists of the correspondence of the Breckinridge, Gamble, and Watts families, ca.1794-1850, but chiefly that of Mary Scott Watts Gamble (1814-1840)daughter of General Edward Watts. The name has been changed to Watts family papers as of March 2023. There are many related collections of the Watts family papers. MSS 38-33 Irvine, Saunders, Davis, and Watts families (William Watts daybooks 1768-1786); MSS 259; MSS 653; and MSS 9715 Abram Penn Staples.","Mary Gamble wrote to her aunt, Emma W. Breckinridge, Grove Hill, Fincastle, Botetourt County, Virginia; her mother, Elizabeth Breckinridge Watts and her father, General Edward Watts, Oakland, near Big Lick, Botetourt County, Virginia; her brothers, William and James B. Watts; and her sisters, Ann S. Watts and Letitia G. Watts.","Most of the letters to her immediate family were written after her marriage and move to Welaunee, Florida, located near Tallahassee, except for several to her brother William Watts while he was away at the New London Academy, Campbell County, Virginia. Many of Mary Watts Gamble's letters are to her aunt, Mrs. Cary Breckinridge (Emma W. Gilmer), 1831-1838, and most of them were written prior to her marriage in 1834. All of her undated letters to her aunt appear to have been written before her marriage and are filed at the beginning of the year 1834 as [ante 1834].","Mary Watts Gamble at Flat Creek writes about the purchase of 34 enslaved persons by Uncle Gamble to prepare the ground for cotton. Her letters also describe her experiences of the conflicts with the Osceola and Seminole warriors in Florida (causing her to learn how to load and shoot a gun). She mentions the Second Seminole War in Florida. Robert [Watts?] and Robert Gamble joined the local militia to remove the Seminoles from the swamps and send them out West. (1835)","There are details of her accounts of the interactions of the Seminoles  on women, children, and enslaved persons including one on the property of Judge Randall, including the burning of buildings in Magnolia and Hickstown and upon the home, family, and enslaved persons of Mrs. Purifoy, wife of a Methodist minister and daughter of Captain Byrd, just four miles away from Welaunee (April 13, 1838). She mentions the removal of the Apalachicola tribe to the West; the actions of Territorial Governor Richard Keith Call (1792-1862), and the Gambles forced evacuation from Welaunee to Tallahassee for safety. (May 9, 1836) They planned to sail on the Brig Orion from St. Marks to New Orleans, taking a steamboat to Louisville, and then proceeding by mail [coach?] to White Sulphur Springs, [West] Virginia (May 21, 1836).","She also mentions her disapproval of the plans of General [Winfield?] Scott for delaying the pursuit of the Seminole War to a later time. She writes about the recent Texas disasters at [the Alamo?] and the loss of [James Walker] Fannin's detachment at the Massacre at La Bahia (Goliad), including concern about the fate of her acquaintances Burr and John Duval. A website on the history of Texas records that Burr and Duval were captured and executed (April 24, 1836).","Her letters also include the health and news of famly members; her marriage to her cousin James Gamble; her attendance at three days of preaching at the Academy (May 19, 1832); the unpopularity of the Reverend [Gyng?] in Tallahasseethe family's concern for William and Robert over an outbreak of scarlet fever near New London Academy(January 12, 1833); and the illness and death of her grandfather, General James Breckinridge.   (May 15, 1833).","Additional subjects include  attempts to persuade her her attempts to convince her brother James to begin his law practice in Tallahassee and comments about the presidential election.She describes the romantic affairs of her brother James; her illness and plans to recover in Virginia (May 15, 1837); her stay in St. Joseph [Bay?] for the summer because of her health, reading the works of Hannah More (1745-1833) while staying in St. Joseph, especially The History of Hester Wilmot and description of the area (July 30, 1838); her return to Tallahassee, and her husband's new store (October 22, 1838); and her stay in a boarding house near the store (December 15, 1838).","Correspondents in the folder of general correspondence of the Breckinridge, Gamble, and Watts families include: Robert Breckinridge to James Breckinridge concerning business matters (March 20 and July 23, 1794; n.d.); John Breckinridge to James Breckinridge concerning business matters, his lawsuit with Isaac Robinson, and a reference to the Whisky Rebellion at Pittsburg, Pennsylvania (August 19, 1794); William Breckinridge to James Breckinridge (September 1794); James Breckinridge to Ann Breckinridge discussing the sickness of Lewis and news about others of their acquaintance (January 24, 1819); James Breckinridge to Edward Watts mentions the James River bill and the death of Judge Fleming which left a vacancy on the court (February 22, 1824).","Mary Page Randolph discusses her unexpected trip to Montpelier, Orange County, and Edgehill, Albemarle County, Virginia, with Thomas Jefferson Randolph, and sympathy for Mary S. Watts' \"late bereavement\" (July 22, 1833); Robert Gamble to Colonel Edward Watts discusses the visit of Mary Scott Watts and the death of his niece Laura (January 13, 1834); Edward Watts to his daughter, Elizabeth B. Watts, announcing the death of Mary Watts Gamble on May 22, 1840 (1840); Emma W. Breckinridge to her niece Letty [Letitia G. Watts?] (December 21, 1850); and John Wickham to James Breckinridge, notifying them of a death which has greatly distressed Betsy (August 14, n.y.).","There are several letters from Nannie Gamble to her cousin, Letitia G. Watts, in which she describes her return visit from New York to Savannah, Georgia by ship (November 13, 1843) furnishes news of the family while in the mountains, near Abingdon, Virginia (January 20, 1845); expresses her sorrow at the news of the death of their friend, Lizzie Peyton, and describes the difficult journey home from Abingdon to Tallahassee which took five weeks (March 4, 1845); mentions the death of Lucy Gilmer (May 31, 1845); and a final letter from Nannie Gamble with a note written by Letitia on the bottom, \"The last letter ever received from my darling cousin N.S.G. who is now numbered with the dead\" (September 9, 1845)."],"parent_unittitles_ssm":["Watts family papers-addition, 1786/1950"],"parent_unittitles_tesim":["Watts family papers-addition, 1786/1950"],"normalized_date_ssm":["1794/1850"],"unitdate_inclusive_ssm":["1794-1850"],"level_ssm":["Series"],"level_ssim":["Series"],"component_level_isim":[1],"sort_isi":278,"repository_ssim":["University of Virginia, Special Collections Dept."],"collection_ssim":["Watts family papers-addition, 1786/1950"],"extent_ssm":["0.012 Cubic Feet"],"extent_tesim":["0.012 Cubic Feet"],"has_online_content_ssim":["false"],"child_component_count_isi":3,"parent_access_restrict_tesm":["The collection is open for research use."],"language_ssim":["English"],"date_range_isim":[1794,1795,1796,1797,1798,1799,1800,1801,1802,1803,1804,1805,1806,1807,1808,1809,1810,1811,1812,1813,1814,1815,1816,1817,1818,1819,1820,1821,1822,1823,1824,1825,1826,1827,1828,1829,1830,1831,1832,1833,1834,1835,1836,1837,1838,1839,1840,1841,1842,1843,1844,1845,1846,1847,1848,1849,1850],"scopecontent_html_tesm":["\u003cp\u003eThis series consists of the correspondence of the Breckinridge, Gamble, and Watts families, ca.1794-1850, but chiefly that of Mary Scott Watts Gamble (1814-1840)daughter of General Edward Watts. The name has been changed to Watts family papers as of March 2023. There are many related collections of the Watts family papers. MSS 38-33 Irvine, Saunders, Davis, and Watts families (William Watts daybooks 1768-1786); MSS 259; MSS 653; and MSS 9715 Abram Penn Staples.\u003c/p\u003e","\u003cp\u003eMary Gamble wrote to her aunt, Emma W. Breckinridge, Grove Hill, Fincastle, Botetourt County, Virginia; her mother, Elizabeth Breckinridge Watts and her father, General Edward Watts, Oakland, near Big Lick, Botetourt County, Virginia; her brothers, William and James B. Watts; and her sisters, Ann S. Watts and Letitia G. Watts. \u003c/p\u003e","\u003cp\u003eMost of the letters to her immediate family were written after her marriage and move to Welaunee, Florida, located near Tallahassee, except for several to her brother William Watts while he was away at the New London Academy, Campbell County, Virginia. Many of Mary Watts Gamble's letters are to her aunt, Mrs. Cary Breckinridge (Emma W. Gilmer), 1831-1838, and most of them were written prior to her marriage in 1834. All of her undated letters to her aunt appear to have been written before her marriage and are filed at the beginning of the year 1834 as [ante 1834]. \u003c/p\u003e","\u003cp\u003eMary Watts Gamble at Flat Creek writes about the purchase of 34 enslaved persons by Uncle Gamble to prepare the ground for cotton. Her letters also describe her experiences of the conflicts with the Osceola and Seminole warriors in Florida (causing her to learn how to load and shoot a gun). She mentions the Second Seminole War in Florida. Robert [Watts?] and Robert Gamble joined the local militia to remove the Seminoles from the swamps and send them out West. (1835) \u003c/p\u003e","\u003cp\u003eThere are details of her accounts of the interactions of the Seminoles  on women, children, and enslaved persons including one on the property of Judge Randall, including the burning of buildings in Magnolia and Hickstown and upon the home, family, and enslaved persons of Mrs. Purifoy, wife of a Methodist minister and daughter of Captain Byrd, just four miles away from Welaunee (April 13, 1838). She mentions the removal of the Apalachicola tribe to the West; the actions of Territorial Governor Richard Keith Call (1792-1862), and the Gambles forced evacuation from Welaunee to Tallahassee for safety. (May 9, 1836) They planned to sail on the Brig Orion from St. Marks to New Orleans, taking a steamboat to Louisville, and then proceeding by mail [coach?] to White Sulphur Springs, [West] Virginia (May 21, 1836). \u003c/p\u003e","\u003cp\u003eShe also mentions her disapproval of the plans of General [Winfield?] Scott for delaying the pursuit of the Seminole War to a later time. She writes about the recent Texas disasters at [the Alamo?] and the loss of [James Walker] Fannin's detachment at the Massacre at La Bahia (Goliad), including concern about the fate of her acquaintances Burr and John Duval. A website on the history of Texas records that Burr and Duval were captured and executed (April 24, 1836). \u003c/p\u003e","\u003cp\u003eHer letters also include the health and news of famly members; her marriage to her cousin James Gamble; her attendance at three days of preaching at the Academy (May 19, 1832); the unpopularity of the Reverend [Gyng?] in Tallahasseethe family's concern for William and Robert over an outbreak of scarlet fever near New London Academy(January 12, 1833); and the illness and death of her grandfather, General James Breckinridge.   (May 15, 1833).\u003c/p\u003e","\u003cp\u003e\nAdditional subjects include  attempts to persuade her her attempts to convince her brother James to begin his law practice in Tallahassee and comments about the presidential election.She describes the romantic affairs of her brother James; her illness and plans to recover in Virginia (May 15, 1837); her stay in St. Joseph [Bay?] for the summer because of her health, reading the works of Hannah More (1745-1833) while staying in St. Joseph, especially The History of Hester Wilmot and description of the area (July 30, 1838); her return to Tallahassee, and her husband's new store (October 22, 1838); and her stay in a boarding house near the store (December 15, 1838). \u003c/p\u003e","\u003cp\u003eCorrespondents in the folder of general correspondence of the Breckinridge, Gamble, and Watts families include: Robert Breckinridge to James Breckinridge concerning business matters (March 20 and July 23, 1794; n.d.); John Breckinridge to James Breckinridge concerning business matters, his lawsuit with Isaac Robinson, and a reference to the Whisky Rebellion at Pittsburg, Pennsylvania (August 19, 1794); William Breckinridge to James Breckinridge (September 1794); James Breckinridge to Ann Breckinridge discussing the sickness of Lewis and news about others of their acquaintance (January 24, 1819); James Breckinridge to Edward Watts mentions the James River bill and the death of Judge Fleming which left a vacancy on the court (February 22, 1824). \u003c/p\u003e","\u003cp\u003eMary Page Randolph discusses her unexpected trip to Montpelier, Orange County, and Edgehill, Albemarle County, Virginia, with Thomas Jefferson Randolph, and sympathy for Mary S. Watts' \"late bereavement\" (July 22, 1833); Robert Gamble to Colonel Edward Watts discusses the visit of Mary Scott Watts and the death of his niece Laura (January 13, 1834); Edward Watts to his daughter, Elizabeth B. Watts, announcing the death of Mary Watts Gamble on May 22, 1840 (1840); Emma W. Breckinridge to her niece Letty [Letitia G. Watts?] (December 21, 1850); and John Wickham to James Breckinridge, notifying them of a death which has greatly distressed Betsy (August 14, n.y.). \u003c/p\u003e","\u003cp\u003eThere are several letters from Nannie Gamble to her cousin, Letitia G. Watts, in which she describes her return visit from New York to Savannah, Georgia by ship (November 13, 1843) furnishes news of the family while in the mountains, near Abingdon, Virginia (January 20, 1845); expresses her sorrow at the news of the death of their friend, Lizzie Peyton, and describes the difficult journey home from Abingdon to Tallahassee which took five weeks (March 4, 1845); mentions the death of Lucy Gilmer (May 31, 1845); and a final letter from Nannie Gamble with a note written by Letitia on the bottom, \"The last letter ever received from my darling cousin N.S.G. who is now numbered with the dead\" (September 9, 1845). \u003c/p\u003e"],"scopecontent_heading_ssm":["Scope and Contents"],"scopecontent_tesim":["This series consists of the correspondence of the Breckinridge, Gamble, and Watts families, ca.1794-1850, but chiefly that of Mary Scott Watts Gamble (1814-1840)daughter of General Edward Watts. The name has been changed to Watts family papers as of March 2023. There are many related collections of the Watts family papers. MSS 38-33 Irvine, Saunders, Davis, and Watts families (William Watts daybooks 1768-1786); MSS 259; MSS 653; and MSS 9715 Abram Penn Staples.","Mary Gamble wrote to her aunt, Emma W. Breckinridge, Grove Hill, Fincastle, Botetourt County, Virginia; her mother, Elizabeth Breckinridge Watts and her father, General Edward Watts, Oakland, near Big Lick, Botetourt County, Virginia; her brothers, William and James B. Watts; and her sisters, Ann S. Watts and Letitia G. Watts.","Most of the letters to her immediate family were written after her marriage and move to Welaunee, Florida, located near Tallahassee, except for several to her brother William Watts while he was away at the New London Academy, Campbell County, Virginia. Many of Mary Watts Gamble's letters are to her aunt, Mrs. Cary Breckinridge (Emma W. Gilmer), 1831-1838, and most of them were written prior to her marriage in 1834. All of her undated letters to her aunt appear to have been written before her marriage and are filed at the beginning of the year 1834 as [ante 1834].","Mary Watts Gamble at Flat Creek writes about the purchase of 34 enslaved persons by Uncle Gamble to prepare the ground for cotton. Her letters also describe her experiences of the conflicts with the Osceola and Seminole warriors in Florida (causing her to learn how to load and shoot a gun). She mentions the Second Seminole War in Florida. Robert [Watts?] and Robert Gamble joined the local militia to remove the Seminoles from the swamps and send them out West. (1835)","There are details of her accounts of the interactions of the Seminoles  on women, children, and enslaved persons including one on the property of Judge Randall, including the burning of buildings in Magnolia and Hickstown and upon the home, family, and enslaved persons of Mrs. Purifoy, wife of a Methodist minister and daughter of Captain Byrd, just four miles away from Welaunee (April 13, 1838). She mentions the removal of the Apalachicola tribe to the West; the actions of Territorial Governor Richard Keith Call (1792-1862), and the Gambles forced evacuation from Welaunee to Tallahassee for safety. (May 9, 1836) They planned to sail on the Brig Orion from St. Marks to New Orleans, taking a steamboat to Louisville, and then proceeding by mail [coach?] to White Sulphur Springs, [West] Virginia (May 21, 1836).","She also mentions her disapproval of the plans of General [Winfield?] Scott for delaying the pursuit of the Seminole War to a later time. She writes about the recent Texas disasters at [the Alamo?] and the loss of [James Walker] Fannin's detachment at the Massacre at La Bahia (Goliad), including concern about the fate of her acquaintances Burr and John Duval. A website on the history of Texas records that Burr and Duval were captured and executed (April 24, 1836).","Her letters also include the health and news of famly members; her marriage to her cousin James Gamble; her attendance at three days of preaching at the Academy (May 19, 1832); the unpopularity of the Reverend [Gyng?] in Tallahasseethe family's concern for William and Robert over an outbreak of scarlet fever near New London Academy(January 12, 1833); and the illness and death of her grandfather, General James Breckinridge.   (May 15, 1833).","Additional subjects include  attempts to persuade her her attempts to convince her brother James to begin his law practice in Tallahassee and comments about the presidential election.She describes the romantic affairs of her brother James; her illness and plans to recover in Virginia (May 15, 1837); her stay in St. Joseph [Bay?] for the summer because of her health, reading the works of Hannah More (1745-1833) while staying in St. Joseph, especially The History of Hester Wilmot and description of the area (July 30, 1838); her return to Tallahassee, and her husband's new store (October 22, 1838); and her stay in a boarding house near the store (December 15, 1838).","Correspondents in the folder of general correspondence of the Breckinridge, Gamble, and Watts families include: Robert Breckinridge to James Breckinridge concerning business matters (March 20 and July 23, 1794; n.d.); John Breckinridge to James Breckinridge concerning business matters, his lawsuit with Isaac Robinson, and a reference to the Whisky Rebellion at Pittsburg, Pennsylvania (August 19, 1794); William Breckinridge to James Breckinridge (September 1794); James Breckinridge to Ann Breckinridge discussing the sickness of Lewis and news about others of their acquaintance (January 24, 1819); James Breckinridge to Edward Watts mentions the James River bill and the death of Judge Fleming which left a vacancy on the court (February 22, 1824).","Mary Page Randolph discusses her unexpected trip to Montpelier, Orange County, and Edgehill, Albemarle County, Virginia, with Thomas Jefferson Randolph, and sympathy for Mary S. Watts' \"late bereavement\" (July 22, 1833); Robert Gamble to Colonel Edward Watts discusses the visit of Mary Scott Watts and the death of his niece Laura (January 13, 1834); Edward Watts to his daughter, Elizabeth B. Watts, announcing the death of Mary Watts Gamble on May 22, 1840 (1840); Emma W. Breckinridge to her niece Letty [Letitia G. Watts?] (December 21, 1850); and John Wickham to James Breckinridge, notifying them of a death which has greatly distressed Betsy (August 14, n.y.).","There are several letters from Nannie Gamble to her cousin, Letitia G. Watts, in which she describes her return visit from New York to Savannah, Georgia by ship (November 13, 1843) furnishes news of the family while in the mountains, near Abingdon, Virginia (January 20, 1845); expresses her sorrow at the news of the death of their friend, Lizzie Peyton, and describes the difficult journey home from Abingdon to Tallahassee which took five weeks (March 4, 1845); mentions the death of Lucy Gilmer (May 31, 1845); and a final letter from Nannie Gamble with a note written by Letitia on the bottom, \"The last letter ever received from my darling cousin N.S.G. who is now numbered with the dead\" (September 9, 1845)."],"_nest_path_":"/components#7","timestamp":"2026-08-14T22:53:38.700Z","collection":{"numFound":1,"start":0,"numFoundExact":true,"docs":[{"id":"viu_repositories_3_resources_1396","ead_ssi":"viu_repositories_3_resources_1396","_root_":"viu_repositories_3_resources_1396","_nest_parent_":"viu_repositories_3_resources_1396","ead_source_url_ssi":"data/oai/UVA/repositories_3_resources_1396.xml","aspace_url_ssi":"https://archives.lib.virginia.edu/ark:/59853/151360","title_filing_ssi":"Watts family papers","title_ssm":["Watts family papers-addition"],"title_tesim":["Watts family papers-addition"],"unitdate_ssm":["1786-1950"],"unitdate_inclusive_ssm":["1786-1950"],"normalized_date_ssm":["1786/1950"],"normalized_title_ssm":["Watts family papers-addition, 1786/1950"],"text":["Watts family papers-addition, 1786/1950","MSS 12170","Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","/repositories/3/resources/1396","United States --  History  -- Civil War, 1861-1865","Slavery--United States -- Virginia","lawyers -- Virginia","The collection is open for research use.","The Watts family papers are arranged into 9 series. Series 1. Family Correspondence, Series 2. Genealogy, History and letters of James and Dolley Madison, Series 3. Documents related to enslavement, Series 4. Legal and Financial papers, Subseries A. Indentures, Subseries B. Marriage agreements, petitions, statements, and wills, Subseries C. Letters about collecting debts, Subseries D. Receipts for goods and services of the Watts family, Series 5. Newspaper clippings and miscellaneous family papers and oversize photographs, Series 6. Family Bibles, Series 7. Roanoke Gun Club Inc. land, Series 8. Showalter transcriptions on digital materials and a flash drive. Box 1 contains folders with some transcription of the letters in the collection and a folder with biographical information. Box 12 contains folders with an index and a folder of miscellaneous information about the collection.","Added existing collection MSS 12170 (3 folders) of Breckinridge, Gamble and Watts families into this addition of Watts family papers MSS 12170.","The Watts family has been part of the Roanoke Valley (also called \"Big Lick\") in Virginia for six generations. General Edward Watts was born on 7 April 1779, in Prince Edward, Virginia. He was the son of William Watts (1742-1797), and Mary Scott (1758-1836). He married Elizabeth Breckinridge, the daughter of James Breckinridge on 6 May 1811 and they had 10 children, including William Watts (1817-1877), Mary Scott Gamble (1814-1840), Ann Selden Watts Holcombe (1820-1888), Alice Watts Robertson (1832-1914), Emma Gilmer Watts Carr (1834-1872) and Letitia Watts Sorrell (1829-1900). Edward Watts purchased 400 acres of land from his father-in-law, James Breckinridge (called The Barrens) where he built his home \"Oaklands\" in 1817. General Edward Watts died in 1859 at age 59. The Watts and Breckinridge families were well-known families in southwest Virginia who enslaved people during the American Revolution and the American Civil War. They were admired by their peers as influential attorneys, politicians, and land owners who often opened their house to the community.","General Edward Watts was educated at Liberty Hall Academy (Washington \u0026 Lee), and Princeton. He was an officer in the War of 1812 and was the Commonwealth attorney for Roanoke County from 1839 to 1845. His son, William Watts (1817-1877) was a Colonel in the 28th Infantry of the Confederate Army (Roanoke Greys). He was educated in medicine and law at the University of Virginia.","After the war, he followed in his father's path as the Commonwealth attorney from 1845 to 1854. He was in the State Constitutional Convention (1850-1851), and was president of the Exchange Bank of Virginia. He also ran for governor in 1834 and 1842. He served in the legislature for one term in 1875. He married Mary Allen in 1850 and they had one living son, John Allen Watts (1855-1904). Mary Allen died following his birth in 1855. Colonel William Watts was also a farmer who enslaved over 100 people. He was said to have one enslaved person as his \"body servant\" through the war and gave him a home for life. Research of the collection has not yet provided his name.","John Allen Watts (1855-1904) nicknamed \"Squat\" was also a student at the University of Virginia and became an attorney. He married Gertrude Lee and they had a son named William. John Allen Watts sold Oaklands to a develpment company and it burned down in 1897. Descendants Jean Staples Showalter, English Showalter, and Katherine Watts donated this collection of their family's papers.","Sources:\n\"Roanoke and Western Virginia: Glimpses of the Pst: Oaklands\" http://showalter.blogspot.com/2010/12/oaklands.html","Barnes, Raymond. \"Confederates of Roanoke-V: General Edward Watts and Colonel William Watts Founded Clan\" Roanoke World News. 5 April 1961. The Historical Society of Western Virginia. O. Winston Link Museum. History Museum of Western Virginia\nhttps://hswv.pastperfectonline.com/archive/94647C8F-8806-4D18-8A04-445143233613#gallery","Barnes, Raymond. 'Oaklands' Was Hospitable Seat of Watts Family for Generations: Needed Big Staff\" Roanoke World News. 21 May 1958. The Historical Society of Western Virginia. O. Winston Link Museum. History Museum of Western Virginia\nhttps://hswv.pastperfectonline.com/archive/53DC8EB0-DBE3-4B95-B4AF-027946626463#gallery","Watts, Katherine. \"The Roanoke Valley and the Watts Family\" June 1984.","There is a website at the O. Winston Link Museum (History Museum of West Virginia) that has many of the Watts family letters online","https://hswv.pastperfectonline.com/byperson?page=3\u0026keyword=Watts%2C%20William\u0026searchType=person\u0026showsearch=True","Related collections include MSS 4111-a,-b,-c,-d,-e,-f; MSS 8914, and MSS 653.","MSS 38-33 Irvine, Saunders, Davis, and Watts families (William Watts daybooks 1768-1786); MSS 259; MSS 653; MSS 9715 Abram Penn Staples.","The Watts family papers of Roanoke County, Virginia at \"Oaklands\" in Flat Creek, Campbell County) consist of correspondence and documents related to the American Revolution, the War of 1812, the United States Civil War, war with Osceola and Seminole tribes in Florida, Virginia politics, economic and social history (including enslavement),land ownership, farming, court cases and debt from 1786 to 1950 in southwest Virginia. The Watts are related to many other Virginia families including James and Dolley Madison. This collection represents a great view into historical and social events of the eighteenth and nineteenth century in Virginia.","The papers of this family of landowners, farmers, politicians, and attorneys portray the rich southern antebellum life on the Oaklands plantation. Despite the told and true characteristics of the kindness of the Watts family, they were nineteenth century southern plantation owners who owned hundreds of enslaved persons. The letters and receipts in the collection include many first names and some last names. One enslaved person, Henry Langhorne, a lifetime attendant of Colonel William Watts was bequeathed $1,000 and a home for life.","Some letters mention the Watt's efforts to keep enslaved families from being separated by intervening in the sales of enslaved persons. There are many references to enslaved people among their households and farm, including descriptions of providing their clothing, housing, and nurturing them when they were sick, like family members. It is important to note that the collection also contains receipts for their purchase and loan.","The issue of enslavement is discussed in local meetings that Watts attended. There are also letters from former enslaved persons such as [Malinda] Langhorne and William Langhorne to Watts family members and photographs of enslaved persons, Aunt Sally and Aunt Phoebe standing together, and a photograph of Uncle Lou with the Watts children.","There is also correspondence about financial and legal matters as Colonel William Watts (1817-1877) and his father, General Edward Watts (1779-1859), were attorneys. Much of their correspondence relates to collecting debts, indentures, land surveys, receipts, and politics (Whig party, Commonwealth Attorney, Constitutional Convention, Virginia Delegates, and candidacy for Governor), and religion. The papers contain discussions about the popular faith of Presbyterians and Episcopalians). The University of Virginia, Washington \u0026 Lee, and William \u0026 Mary College are also mentioned.","The collection spans six generations of the Watts family including General Edward Watts and his wife Elizabeth Breckinridge (1794-1862), their son Colonel William Watts (1817-1877) and his wife Mary Jane Allen (1825-1855). Also included is their son, John Allen Watts and his wife Gertrude Lee.","Other related families include Madison, Breckenridge, Allen, Jackson, Watson, Morris, Gamble, Payne, Washington, Meigs, and Saunders. (MSS 653) Other related collections include MSS 4111-a,-b,-c,-d,-e,-f; MSS 38-33 Irvine, Saunders, Davis, and Watts families (William Watts daybooks 1768-1786); MSS 259; MSS 9715 Abram Penn Staples..(see related materials note)","The papers of Mary Scott Watts Gamble have been combined into this collection. These letters contain her accounts of attacks by Osceola and Seminole people in Florida. She mentions that Robert [Watts?] and Robert Gamble joined the local militia to remove the Seminoles from the swamps and send them out West. (1835)","Albert and Shirley Small Special Collections Library","English"],"collection_title_tesim":["Watts family papers-addition, 1786/1950"],"collection_ssim":["Watts family papers-addition, 1786/1950"],"level_ssm":["collection"],"level_ssim":["Collection"],"unitid_ssm":["MSS 12170","Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource 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Key","Previous Archival Resource Key","Previous Archival Resource Key","Previous Archival Resource Key","/repositories/3/resources/1396"],"repository_ssm":["University of Virginia, Special Collections Dept."],"repository_ssim":["University of Virginia, Special Collections Dept."],"geogname_ssm":["United States --  History  -- Civil War, 1861-1865"],"geogname_ssim":["United States --  History  -- Civil War, 1861-1865"],"places_ssim":["United States --  History  -- Civil War, 1861-1865"],"creator_corpname_ssim":["Albert and Shirley Small Special Collections Library"],"creators_ssim":["Albert and Shirley Small Special Collections Library"],"acqinfo_ssim":["This collection was a gift from Katherine Watts to the Small Special Collections Library at the University of Virginia Library on 9 April 2022."],"access_subjects_ssim":["Slavery--United States -- Virginia","lawyers -- Virginia"],"access_subjects_ssm":["Slavery--United States -- Virginia","lawyers -- Virginia"],"has_online_content_ssim":["true"],"extent_ssm":["9 Cubic Feet 12 legal size document boxes, 1 half-size legal document box, 2 cubics of bibles, and 2 oversize boxes",".107 Gigabytes","0.25 Cubic Feet"],"extent_tesim":["9 Cubic Feet 12 legal size document boxes, 1 half-size legal document box, 2 cubics of bibles, and 2 oversize boxes",".107 Gigabytes","0.25 Cubic Feet"],"physfacet_tesim":["2,588 files, 2, 371 MS Word files, 176 Open office documents, 23 jpegs, 13 Apple/Double files, 3 tiffs, 1 pdf.","Oversize box: Photographs and certificates of Watts family members (deframed)"],"date_range_isim":[1786,1787,1788,1789,1790,1791,1792,1793,1794,1795,1796,1797,1798,1799,1800,1801,1802,1803,1804,1805,1806,1807,1808,1809,1810,1811,1812,1813,1814,1815,1816,1817,1818,1819,1820,1821,1822,1823,1824,1825,1826,1827,1828,1829,1830,1831,1832,1833,1834,1835,1836,1837,1838,1839,1840,1841,1842,1843,1844,1845,1846,1847,1848,1849,1850,1851,1852,1853,1854,1855,1856,1857,1858,1859,1860,1861,1862,1863,1864,1865,1866,1867,1868,1869,1870,1871,1872,1873,1874,1875,1876,1877,1878,1879,1880,1881,1882,1883,1884,1885,1886,1887,1888,1889,1890,1891,1892,1893,1894,1895,1896,1897,1898,1899,1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935,1936,1937,1938,1939,1940,1941,1942,1943,1944,1945,1946,1947,1948,1949,1950],"accessrestrict_html_tesm":["\u003cp\u003eThe collection is open for research use.\u003c/p\u003e  "],"accessrestrict_heading_ssm":["Conditions Governing Access"],"accessrestrict_tesim":["The collection is open for research use."],"arrangement_html_tesm":["\u003cp\u003eThe Watts family papers are arranged into 9 series. Series 1. Family Correspondence, Series 2. Genealogy, History and letters of James and Dolley Madison, Series 3. Documents related to enslavement, Series 4. Legal and Financial papers, Subseries A. Indentures, Subseries B. Marriage agreements, petitions, statements, and wills, Subseries C. Letters about collecting debts, Subseries D. Receipts for goods and services of the Watts family, Series 5. Newspaper clippings and miscellaneous family papers and oversize photographs, Series 6. Family Bibles, Series 7. Roanoke Gun Club Inc. land, Series 8. Showalter transcriptions on digital materials and a flash drive. Box 1 contains folders with some transcription of the letters in the collection and a folder with biographical information. Box 12 contains folders with an index and a folder of miscellaneous information about the collection. \u003c/p\u003e","\u003cp\u003eAdded existing collection MSS 12170 (3 folders) of Breckinridge, Gamble and Watts families into this addition of Watts family papers MSS 12170. \u003c/p\u003e  "],"arrangement_heading_ssm":["Arrangement"],"arrangement_tesim":["The Watts family papers are arranged into 9 series. Series 1. Family Correspondence, Series 2. Genealogy, History and letters of James and Dolley Madison, Series 3. Documents related to enslavement, Series 4. Legal and Financial papers, Subseries A. Indentures, Subseries B. Marriage agreements, petitions, statements, and wills, Subseries C. Letters about collecting debts, Subseries D. Receipts for goods and services of the Watts family, Series 5. Newspaper clippings and miscellaneous family papers and oversize photographs, Series 6. Family Bibles, Series 7. Roanoke Gun Club Inc. land, Series 8. Showalter transcriptions on digital materials and a flash drive. Box 1 contains folders with some transcription of the letters in the collection and a folder with biographical information. Box 12 contains folders with an index and a folder of miscellaneous information about the collection.","Added existing collection MSS 12170 (3 folders) of Breckinridge, Gamble and Watts families into this addition of Watts family papers MSS 12170."],"bioghist_html_tesm":["\u003cp\u003eThe Watts family has been part of the Roanoke Valley (also called \"Big Lick\") in Virginia for six generations. General Edward Watts was born on 7 April 1779, in Prince Edward, Virginia. He was the son of William Watts (1742-1797), and Mary Scott (1758-1836). He married Elizabeth Breckinridge, the daughter of James Breckinridge on 6 May 1811 and they had 10 children, including William Watts (1817-1877), Mary Scott Gamble (1814-1840), Ann Selden Watts Holcombe (1820-1888), Alice Watts Robertson (1832-1914), Emma Gilmer Watts Carr (1834-1872) and Letitia Watts Sorrell (1829-1900). Edward Watts purchased 400 acres of land from his father-in-law, James Breckinridge (called The Barrens) where he built his home \"Oaklands\" in 1817. General Edward Watts died in 1859 at age 59. The Watts and Breckinridge families were well-known families in southwest Virginia who enslaved people during the American Revolution and the American Civil War. They were admired by their peers as influential attorneys, politicians, and land owners who often opened their house to the community.\u003c/p\u003e","\u003cp\u003eGeneral Edward Watts was educated at Liberty Hall Academy (Washington \u0026amp; Lee), and Princeton. He was an officer in the War of 1812 and was the Commonwealth attorney for Roanoke County from 1839 to 1845. His son, William Watts (1817-1877) was a Colonel in the 28th Infantry of the Confederate Army (Roanoke Greys). He was educated in medicine and law at the University of Virginia. \u003c/p\u003e","\u003cp\u003eAfter the war, he followed in his father's path as the Commonwealth attorney from 1845 to 1854. He was in the State Constitutional Convention (1850-1851), and was president of the Exchange Bank of Virginia. He also ran for governor in 1834 and 1842. He served in the legislature for one term in 1875. He married Mary Allen in 1850 and they had one living son, John Allen Watts (1855-1904). Mary Allen died following his birth in 1855. Colonel William Watts was also a farmer who enslaved over 100 people. He was said to have one enslaved person as his \"body servant\" through the war and gave him a home for life. Research of the collection has not yet provided his name.\u003c/p\u003e","\u003cp\u003eJohn Allen Watts (1855-1904) nicknamed \"Squat\" was also a student at the University of Virginia and became an attorney. He married Gertrude Lee and they had a son named William. John Allen Watts sold Oaklands to a develpment company and it burned down in 1897. Descendants Jean Staples Showalter, English Showalter, and Katherine Watts donated this collection of their family's papers. \u003c/p\u003e","\u003cp\u003eSources:\n\"Roanoke and Western Virginia: Glimpses of the Pst: Oaklands\" http://showalter.blogspot.com/2010/12/oaklands.html\u003c/p\u003e","\u003cp\u003eBarnes, Raymond. \"Confederates of Roanoke-V: General Edward Watts and Colonel William Watts Founded Clan\" Roanoke World News. 5 April 1961. The Historical Society of Western Virginia. O. Winston Link Museum. History Museum of Western Virginia\nhttps://hswv.pastperfectonline.com/archive/94647C8F-8806-4D18-8A04-445143233613#gallery\u003c/p\u003e","\u003cp\u003e\nBarnes, Raymond. 'Oaklands' Was Hospitable Seat of Watts Family for Generations: Needed Big Staff\" Roanoke World News. 21 May 1958. The Historical Society of Western Virginia. O. Winston Link Museum. History Museum of Western Virginia\nhttps://hswv.pastperfectonline.com/archive/53DC8EB0-DBE3-4B95-B4AF-027946626463#gallery\u003c/p\u003e","\u003cp\u003e\nWatts, Katherine. \"The Roanoke Valley and the Watts Family\" June 1984.\u003c/p\u003e  "],"bioghist_heading_ssm":["Biographical / Historical"],"bioghist_tesim":["The Watts family has been part of the Roanoke Valley (also called \"Big Lick\") in Virginia for six generations. General Edward Watts was born on 7 April 1779, in Prince Edward, Virginia. He was the son of William Watts (1742-1797), and Mary Scott (1758-1836). He married Elizabeth Breckinridge, the daughter of James Breckinridge on 6 May 1811 and they had 10 children, including William Watts (1817-1877), Mary Scott Gamble (1814-1840), Ann Selden Watts Holcombe (1820-1888), Alice Watts Robertson (1832-1914), Emma Gilmer Watts Carr (1834-1872) and Letitia Watts Sorrell (1829-1900). Edward Watts purchased 400 acres of land from his father-in-law, James Breckinridge (called The Barrens) where he built his home \"Oaklands\" in 1817. General Edward Watts died in 1859 at age 59. The Watts and Breckinridge families were well-known families in southwest Virginia who enslaved people during the American Revolution and the American Civil War. They were admired by their peers as influential attorneys, politicians, and land owners who often opened their house to the community.","General Edward Watts was educated at Liberty Hall Academy (Washington \u0026 Lee), and Princeton. He was an officer in the War of 1812 and was the Commonwealth attorney for Roanoke County from 1839 to 1845. His son, William Watts (1817-1877) was a Colonel in the 28th Infantry of the Confederate Army (Roanoke Greys). He was educated in medicine and law at the University of Virginia.","After the war, he followed in his father's path as the Commonwealth attorney from 1845 to 1854. He was in the State Constitutional Convention (1850-1851), and was president of the Exchange Bank of Virginia. He also ran for governor in 1834 and 1842. He served in the legislature for one term in 1875. He married Mary Allen in 1850 and they had one living son, John Allen Watts (1855-1904). Mary Allen died following his birth in 1855. Colonel William Watts was also a farmer who enslaved over 100 people. He was said to have one enslaved person as his \"body servant\" through the war and gave him a home for life. Research of the collection has not yet provided his name.","John Allen Watts (1855-1904) nicknamed \"Squat\" was also a student at the University of Virginia and became an attorney. He married Gertrude Lee and they had a son named William. John Allen Watts sold Oaklands to a develpment company and it burned down in 1897. Descendants Jean Staples Showalter, English Showalter, and Katherine Watts donated this collection of their family's papers.","Sources:\n\"Roanoke and Western Virginia: Glimpses of the Pst: Oaklands\" http://showalter.blogspot.com/2010/12/oaklands.html","Barnes, Raymond. \"Confederates of Roanoke-V: General Edward Watts and Colonel William Watts Founded Clan\" Roanoke World News. 5 April 1961. The Historical Society of Western Virginia. O. Winston Link Museum. History Museum of Western Virginia\nhttps://hswv.pastperfectonline.com/archive/94647C8F-8806-4D18-8A04-445143233613#gallery","Barnes, Raymond. 'Oaklands' Was Hospitable Seat of Watts Family for Generations: Needed Big Staff\" Roanoke World News. 21 May 1958. The Historical Society of Western Virginia. O. Winston Link Museum. History Museum of Western Virginia\nhttps://hswv.pastperfectonline.com/archive/53DC8EB0-DBE3-4B95-B4AF-027946626463#gallery","Watts, Katherine. \"The Roanoke Valley and the Watts Family\" June 1984."],"prefercite_html_tesm":["\u003cp\u003eMSS 12170, Watts family papers, Albert and Shirley Small Special Collections Library, University of Virginia Library.\u003c/p\u003e  "],"prefercite_tesim":["MSS 12170, Watts family papers, Albert and Shirley Small Special Collections Library, University of Virginia Library."],"relatedmaterial_html_tesm":["\u003cp\u003eThere is a website at the O. Winston Link Museum (History Museum of West Virginia) that has many of the Watts family letters online \u003c/p\u003e","\u003cp\u003ehttps://hswv.pastperfectonline.com/byperson?page=3\u0026amp;keyword=Watts%2C%20William\u0026amp;searchType=person\u0026amp;showsearch=True\u003c/p\u003e","\u003cp\u003eRelated collections include MSS 4111-a,-b,-c,-d,-e,-f; MSS 8914, and MSS 653.\u003c/p\u003e  ","\u003cp\u003eMSS 38-33 Irvine, Saunders, Davis, and Watts families (William Watts daybooks 1768-1786); MSS 259; MSS 653; MSS 9715 Abram Penn Staples.\u003c/p\u003e  "],"relatedmaterial_heading_ssm":["Related Materials","Related Materials"],"relatedmaterial_tesim":["There is a website at the O. Winston Link Museum (History Museum of West Virginia) that has many of the Watts family letters online","https://hswv.pastperfectonline.com/byperson?page=3\u0026keyword=Watts%2C%20William\u0026searchType=person\u0026showsearch=True","Related collections include MSS 4111-a,-b,-c,-d,-e,-f; MSS 8914, and MSS 653.","MSS 38-33 Irvine, Saunders, Davis, and Watts families (William Watts daybooks 1768-1786); MSS 259; MSS 653; MSS 9715 Abram Penn Staples."],"scopecontent_html_tesm":["\u003cp\u003eThe Watts family papers of Roanoke County, Virginia at \"Oaklands\" in Flat Creek, Campbell County) consist of correspondence and documents related to the American Revolution, the War of 1812, the United States Civil War, war with Osceola and Seminole tribes in Florida, Virginia politics, economic and social history (including enslavement),land ownership, farming, court cases and debt from 1786 to 1950 in southwest Virginia. The Watts are related to many other Virginia families including James and Dolley Madison. This collection represents a great view into historical and social events of the eighteenth and nineteenth century in Virginia.\u003c/p\u003e","\u003cp\u003eThe papers of this family of landowners, farmers, politicians, and attorneys portray the rich southern antebellum life on the Oaklands plantation. Despite the told and true characteristics of the kindness of the Watts family, they were nineteenth century southern plantation owners who owned hundreds of enslaved persons. The letters and receipts in the collection include many first names and some last names. One enslaved person, Henry Langhorne, a lifetime attendant of Colonel William Watts was bequeathed $1,000 and a home for life. \u003c/p\u003e","\u003cp\u003eSome letters mention the Watt's efforts to keep enslaved families from being separated by intervening in the sales of enslaved persons. There are many references to enslaved people among their households and farm, including descriptions of providing their clothing, housing, and nurturing them when they were sick, like family members. It is important to note that the collection also contains receipts for their purchase and loan. \u003c/p\u003e","\u003cp\u003eThe issue of enslavement is discussed in local meetings that Watts attended. There are also letters from former enslaved persons such as [Malinda] Langhorne and William Langhorne to Watts family members and photographs of enslaved persons, Aunt Sally and Aunt Phoebe standing together, and a photograph of Uncle Lou with the Watts children. \u003c/p\u003e","\u003cp\u003eThere is also correspondence about financial and legal matters as Colonel William Watts (1817-1877) and his father, General Edward Watts (1779-1859), were attorneys. Much of their correspondence relates to collecting debts, indentures, land surveys, receipts, and politics (Whig party, Commonwealth Attorney, Constitutional Convention, Virginia Delegates, and candidacy for Governor), and religion. The papers contain discussions about the popular faith of Presbyterians and Episcopalians). The University of Virginia, Washington \u0026amp; Lee, and William \u0026amp; Mary College are also mentioned.\u003c/p\u003e","\u003cp\u003eThe collection spans six generations of the Watts family including General Edward Watts and his wife Elizabeth Breckinridge (1794-1862), their son Colonel William Watts (1817-1877) and his wife Mary Jane Allen (1825-1855). Also included is their son, John Allen Watts and his wife Gertrude Lee. \u003c/p\u003e","\u003cp\u003eOther related families include Madison, Breckenridge, Allen, Jackson, Watson, Morris, Gamble, Payne, Washington, Meigs, and Saunders. (MSS 653) Other related collections include MSS 4111-a,-b,-c,-d,-e,-f; MSS 38-33 Irvine, Saunders, Davis, and Watts families (William Watts daybooks 1768-1786); MSS 259; MSS 9715 Abram Penn Staples..(see related materials note)\u003c/p\u003e","\u003cp\u003eThe papers of Mary Scott Watts Gamble have been combined into this collection. These letters contain her accounts of attacks by Osceola and Seminole people in Florida. She mentions that Robert [Watts?] and Robert Gamble joined the local militia to remove the Seminoles from the swamps and send them out West. (1835) \u003c/p\u003e  "],"scopecontent_heading_ssm":["Content Description"],"scopecontent_tesim":["The Watts family papers of Roanoke County, Virginia at \"Oaklands\" in Flat Creek, Campbell County) consist of correspondence and documents related to the American Revolution, the War of 1812, the United States Civil War, war with Osceola and Seminole tribes in Florida, Virginia politics, economic and social history (including enslavement),land ownership, farming, court cases and debt from 1786 to 1950 in southwest Virginia. The Watts are related to many other Virginia families including James and Dolley Madison. This collection represents a great view into historical and social events of the eighteenth and nineteenth century in Virginia.","The papers of this family of landowners, farmers, politicians, and attorneys portray the rich southern antebellum life on the Oaklands plantation. Despite the told and true characteristics of the kindness of the Watts family, they were nineteenth century southern plantation owners who owned hundreds of enslaved persons. The letters and receipts in the collection include many first names and some last names. One enslaved person, Henry Langhorne, a lifetime attendant of Colonel William Watts was bequeathed $1,000 and a home for life.","Some letters mention the Watt's efforts to keep enslaved families from being separated by intervening in the sales of enslaved persons. There are many references to enslaved people among their households and farm, including descriptions of providing their clothing, housing, and nurturing them when they were sick, like family members. It is important to note that the collection also contains receipts for their purchase and loan.","The issue of enslavement is discussed in local meetings that Watts attended. There are also letters from former enslaved persons such as [Malinda] Langhorne and William Langhorne to Watts family members and photographs of enslaved persons, Aunt Sally and Aunt Phoebe standing together, and a photograph of Uncle Lou with the Watts children.","There is also correspondence about financial and legal matters as Colonel William Watts (1817-1877) and his father, General Edward Watts (1779-1859), were attorneys. Much of their correspondence relates to collecting debts, indentures, land surveys, receipts, and politics (Whig party, Commonwealth Attorney, Constitutional Convention, Virginia Delegates, and candidacy for Governor), and religion. The papers contain discussions about the popular faith of Presbyterians and Episcopalians). The University of Virginia, Washington \u0026 Lee, and William \u0026 Mary College are also mentioned.","The collection spans six generations of the Watts family including General Edward Watts and his wife Elizabeth Breckinridge (1794-1862), their son Colonel William Watts (1817-1877) and his wife Mary Jane Allen (1825-1855). Also included is their son, John Allen Watts and his wife Gertrude Lee.","Other related families include Madison, Breckenridge, Allen, Jackson, Watson, Morris, Gamble, Payne, Washington, Meigs, and Saunders. (MSS 653) Other related collections include MSS 4111-a,-b,-c,-d,-e,-f; MSS 38-33 Irvine, Saunders, Davis, and Watts families (William Watts daybooks 1768-1786); MSS 259; MSS 9715 Abram Penn Staples..(see related materials note)","The papers of Mary Scott Watts Gamble have been combined into this collection. These letters contain her accounts of attacks by Osceola and Seminole people in Florida. She mentions that Robert [Watts?] and Robert Gamble joined the local militia to remove the Seminoles from the swamps and send them out West. (1835)"],"corpname_ssim":["Albert and Shirley Small Special Collections Library"],"names_ssim":["Albert and Shirley Small Special Collections Library"],"language_ssim":["English"],"descrules_ssm":["Describing Archives: A Content Standard"],"total_component_count_is":281,"online_item_count_is":1,"component_level_isim":[0],"sort_isi":0,"timestamp":"2026-08-14T22:53:38.700Z"}]}},"label":"Breadcrumbs"}}},"links":{"self":"https://arvasarchive.org/catalog/viu_repositories_3_resources_1396_c08"}},{"id":"viu_repositories_3_resources_1675_c03","type":"Series","attributes":{"title":"Series III: Personal Papers, Files, and Realia, 1824/2003","abstract_or_scope":{"id":"https://arvasarchive.org/catalog/viu_repositories_3_resources_1675_c03#abstract_or_scope","type":"document_value","attributes":{"value":"\u003cp\u003eSeries III of the William Faulkner Collection contains the personal papers, files, belongings, and related realia of William Faulkner. Materials in the collection range in date from 1824 to 2003 and are divided into eight subseries: William Faulkner's working papers related to his literary works, drawings made by Faulkner, his childhood ephemera and student records, military and flight records, family papers, honors and awards, belongings and related realia, and reminiscences or accounts of William Faulkner. \u003c/p\u003e","label":"Abstract Or Scope"}},"breadcrumbs":{"id":"https://arvasarchive.org/catalog/viu_repositories_3_resources_1675_c03#breadcrumbs","type":"document_value","attributes":{"value":{"ref_ssi":"viu_repositories_3_resources_1675_c03","ref_ssm":["viu_repositories_3_resources_1675_c03"],"id":"viu_repositories_3_resources_1675_c03","ead_ssi":"viu_repositories_3_resources_1675","_root_":"viu_repositories_3_resources_1675","_nest_parent_":"viu_repositories_3_resources_1675","parent_ssi":"viu_repositories_3_resources_1675","parent_ssim":["William Faulkner Collection, 1824/2006"],"parent_ids_ssim":["viu_repositories_3_resources_1675"],"title_filing_ssi":"Series III: Personal Papers, Files, and Realia","title_ssm":["Series III: Personal Papers, Files, and Realia"],"title_tesim":["Series III: Personal Papers, Files, and Realia"],"normalized_title_ssm":["Series III: Personal Papers, Files, and Realia, 1824/2003"],"text":["Series III: Personal Papers, Files, and Realia, 1824/2003","William Faulkner Collection, 1824/2006","Material pertaining to individual student records is restricted in accordance with the Family Education Rights and Privacy Act (FERPA). Please contact the Archives with specific questions regarding access to such records.","This material contains offensive and harmful language and imagery, including references to outdated terminology for Black individuals, references or imagery involving racism, and references or imagery involving sexual assault, domestic violence, or crimes based on gender or sexual orientation.","Series III of the William Faulkner Collection contains the personal papers, files, belongings, and related realia of William Faulkner. Materials in the collection range in date from 1824 to 2003 and are divided into eight subseries: William Faulkner's working papers related to his literary works, drawings made by Faulkner, his childhood ephemera and student records, military and flight records, family papers, honors and awards, belongings and related realia, and reminiscences or accounts of William Faulkner.","Many of William Faulkner's student and family records differ in the spelling of his last name due to changes made over time by family members and by Faulkner himself. For this reason, Faulkner's student and childhood records will often refer to him as \"William Falkner.\" William Faulkner's family papers are also listed as \"Faulkner/Falkner Family Papers\" for this reason.","Photocopies of correspondence between Andrew Brown and T.F. Hickerson regarding \"William Faulkner: Man of Legends\" came from original copies housed at the University of North Carolina at Chapel Hill and are not to be quoted in print without their permission."],"parent_unittitles_ssm":["William Faulkner Collection, 1824/2006"],"parent_unittitles_tesim":["William Faulkner Collection, 1824/2006"],"normalized_date_ssm":["1824/2003"],"unitdate_inclusive_ssm":["1824-2003"],"level_ssm":["Series"],"level_ssim":["Series"],"component_level_isim":[1],"sort_isi":1185,"repository_ssim":["University of Virginia, Special Collections Dept."],"collection_ssim":["William Faulkner Collection, 1824/2006"],"has_online_content_ssim":["false"],"child_component_count_isi":8,"parent_access_restrict_tesm":["This collection is open for research use with the following exceptions: Material pertaining to individual student records may be restricted in accordance with the Family Educational Rights and Privacy Act (FERPA). Please contact the Archives with specific questions regarding access to such records."],"parent_access_terms_tesm":["Photocopies of correspondence between Andrew Brown and T.F. Hickerson regarding \"William Faulkner: Man of Legends\" came from original copies housed at the University of North Carolina at Chapel Hill and are not to be quoted in print without their permission."],"date_range_isim":[1824,1825,1826,1827,1828,1829,1830,1831,1832,1833,1834,1835,1836,1837,1838,1839,1840,1841,1842,1843,1844,1845,1846,1847,1848,1849,1850,1851,1852,1853,1854,1855,1856,1857,1858,1859,1860,1861,1862,1863,1864,1865,1866,1867,1868,1869,1870,1871,1872,1873,1874,1875,1876,1877,1878,1879,1880,1881,1882,1883,1884,1885,1886,1887,1888,1889,1890,1891,1892,1893,1894,1895,1896,1897,1898,1899,1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935,1936,1937,1938,1939,1940,1941,1942,1943,1944,1945,1946,1947,1948,1949,1950,1951,1952,1953,1954,1955,1956,1957,1958,1959,1960,1961,1962,1963,1964,1965,1966,1967,1968,1969,1970,1971,1972,1973,1974,1975,1976,1977,1978,1979,1980,1981,1982,1983,1984,1985,1986,1987,1988,1989,1990,1991,1992,1993,1994,1995,1996,1997,1998,1999,2000,2001,2002,2003],"accessrestrict_html_tesm":["\u003cp\u003eMaterial pertaining to individual student records is restricted in accordance with the Family Education Rights and Privacy Act (FERPA). Please contact the Archives with specific questions regarding access to such records.\u003c/p\u003e"],"accessrestrict_heading_ssm":["Conditions Governing Access"],"accessrestrict_tesim":["Material pertaining to individual student records is restricted in accordance with the Family Education Rights and Privacy Act (FERPA). Please contact the Archives with specific questions regarding access to such records."],"odd_html_tesm":["\u003cp\u003eThis material contains offensive and harmful language and imagery, including references to outdated terminology for Black individuals, references or imagery involving racism, and references or imagery involving sexual assault, domestic violence, or crimes based on gender or sexual orientation.\u003c/p\u003e"],"odd_heading_ssm":["Content Warning"],"odd_tesim":["This material contains offensive and harmful language and imagery, including references to outdated terminology for Black individuals, references or imagery involving racism, and references or imagery involving sexual assault, domestic violence, or crimes based on gender or sexual orientation."],"scopecontent_html_tesm":["\u003cp\u003eSeries III of the William Faulkner Collection contains the personal papers, files, belongings, and related realia of William Faulkner. Materials in the collection range in date from 1824 to 2003 and are divided into eight subseries: William Faulkner's working papers related to his literary works, drawings made by Faulkner, his childhood ephemera and student records, military and flight records, family papers, honors and awards, belongings and related realia, and reminiscences or accounts of William Faulkner.  \u003c/p\u003e","\u003cp\u003eMany of William Faulkner's student and family records differ in the spelling of his last name due to changes made over time by family members and by Faulkner himself. For this reason, Faulkner's student and childhood records will often refer to him as \"William Falkner.\" William Faulkner's family papers are also listed as \"Faulkner/Falkner Family Papers\" for this reason.  \u003c/p\u003e"],"scopecontent_heading_ssm":["Scope and Contents"],"scopecontent_tesim":["Series III of the William Faulkner Collection contains the personal papers, files, belongings, and related realia of William Faulkner. Materials in the collection range in date from 1824 to 2003 and are divided into eight subseries: William Faulkner's working papers related to his literary works, drawings made by Faulkner, his childhood ephemera and student records, military and flight records, family papers, honors and awards, belongings and related realia, and reminiscences or accounts of William Faulkner.","Many of William Faulkner's student and family records differ in the spelling of his last name due to changes made over time by family members and by Faulkner himself. For this reason, Faulkner's student and childhood records will often refer to him as \"William Falkner.\" William Faulkner's family papers are also listed as \"Faulkner/Falkner Family Papers\" for this reason."],"userestrict_html_tesm":["\u003cp\u003ePhotocopies of correspondence between Andrew Brown and T.F. Hickerson regarding \"William Faulkner: Man of Legends\" came from original copies housed at the University of North Carolina at Chapel Hill and are not to be quoted in print without their permission.\u003c/p\u003e"],"userestrict_heading_ssm":["Conditions Governing Use"],"userestrict_tesim":["Photocopies of correspondence between Andrew Brown and T.F. Hickerson regarding \"William Faulkner: Man of Legends\" came from original copies housed at the University of North Carolina at Chapel Hill and are not to be quoted in print without their permission."],"_nest_path_":"/components#2","timestamp":"2026-08-14T22:53:44.527Z","collection":{"numFound":1,"start":0,"numFoundExact":true,"docs":[{"id":"viu_repositories_3_resources_1675","ead_ssi":"viu_repositories_3_resources_1675","_root_":"viu_repositories_3_resources_1675","_nest_parent_":"viu_repositories_3_resources_1675","ead_source_url_ssi":"data/oai/UVA/repositories_3_resources_1675.xml","aspace_url_ssi":"https://archives.lib.virginia.edu/ark:/59853/196837","title_filing_ssi":"Faulkner, William, Collection","title_ssm":["William Faulkner Collection"],"title_tesim":["William Faulkner Collection"],"unitdate_ssm":["1824-2006"],"unitdate_inclusive_ssm":["1824-2006"],"normalized_date_ssm":["1824/2006"],"normalized_title_ssm":["William Faulkner Collection, 1824/2006"],"text":["William Faulkner Collection, 1824/2006","MSS 16807","Archival Resource Key","/repositories/3/resources/1675","Faulkner, William, 1897-1962","American literature--Southern States","American fiction--20th Century","This collection is open for research use with the following exceptions: Material pertaining to individual student records may be restricted in accordance with the Family Educational Rights and Privacy Act (FERPA). Please contact the Archives with specific questions regarding access to such records.","The William Faulkner Collection, MSS 16807, also known as \"The William Faulkner Papers,\" centers on the life and work of William Faulkner, a renowned American author and a foundational voice in Southern Gothic Literature.  William Faulkner was born on September 15, 1897, in New Albany, Mississippi, to Murry Falkner and Maud Butler Falkner. Faulkner was primarily raised in Oxford, Mississippi. He left high school shortly after the eleventh grade in 1915 to work at his grandfather's bank. William Faulkner would go on to briefly join the Canadian Royal Air Force from 1918-1919 before coming back to Oxford, Mississippi and holding various jobs throughout Mississippi and New York until he published his first book, Soldier's Pay, in 1926. He married Lida Estelle Oldham in 1929, and together they had one daughter to survive past infancy, Jill Faulkner, in 1933. Faulkner grew in popularity as an author after the publication of The Sound and the Fury in 1929. Though a Mississippi native, William Faulkner moved to Charlottesville, VA, in 1957 to be closer to Jill, her husband, Paul Summers, and their children. It was during this time that Faulkner began work as the University of Virginia's first ever writer-in-residence. Faulkner continued to teach at the University of Virginia in several different positions until his death on July 6, 1962.","Source: Materials within the collection.","This material may contain offensive or harmful language or imagery. The purpose of this note is to give users the opportunity to decide whether they need or want to view these materials, or at least, to mentally or emotionally prepare themselves to view the materials.","This collection was reprocessed during 2024-2026 by archivists Elizabeth Nosari and Kaylin Preslar. The collection was originally described in 180 different catalog records and housed in non-consecutive boxes.\nArchivists worked to bring these disparate parts together to create a single William Faulkner Collection (MSS 16807) and finding aid to improve access and discoverability.","The William Faulkner collection has historically been represented by numerous different manuscript numbers (collection identifiers). MSS 16807 is a new manuscript number which serves to identify the collection as a whole. Original manuscript numbers have been retained in this guide and are noted in the title of each item.","In this example, the original manuscript number is 6074, and \"Series IA, Item 9b\" refers to the item's original location within MSS 6074, prior to reprocessing.","Absalom, Absalom! - Typescript (17 Leaves) - 6074, Series IA, Item 9b, 1936","This collection contains some in-copyright material. Visit our Permissions and Publishing page for more information about use of Special Collections materials. The library can provide copyright information upon request, but users are responsible for making their own determination about lawful use of collections materials.","Permissions and Publishing Page:\nhttps://www.library.virginia.edu/special-collections/services/publishing","Please note that W.W. Norton holds copyright to all of Faulkner's published works.","If you would like to publish images in print or online of original manuscript materials from our collection that pertain to these published works, including holograph drafts and typescripts, please contact: \nPenguin Random House LLC\nRandom House Publishing Group\n1745 Broadway\nNew York, NY 10019\nAttention: Permissions Department\nPhone: 212-782-9000","For permission to quote from or publish images in print or online of any of Faulkner's unpublished works or correspondence, please contact:\nW.W. Norton \u0026 Company, Inc.\nAttention: Permissions Department\n500 5th Avenue\nNew York, NY 10110\nPhone: 212-354-5500\nEmail: permissions@wwnorton.com","For permission to use copyrighted Faulkner materials in any way than listed above, please contact:\nFaulkner Literary Rights, LLC\nP.O. Box 1408\nCharlottesville, VA 22902\nPhone: 434-296-2156","Photocopies of correspondence between Andrew Brown and T.F. Hickerson regarding \"William Faulkner: Man of Legends\" came from original copies housed at the University of North Carolina at Chapel Hill and are not to be quoted in print without their permission.","Albert and Shirley Small Special Collections Library","Faulkner, William, 1897-1962","Materials primarily in English, with some publications in French and German."],"collection_title_tesim":["William Faulkner Collection, 1824/2006"],"collection_ssim":["William Faulkner Collection, 1824/2006"],"level_ssm":["collection"],"level_ssim":["Collection"],"unitid_ssm":["MSS 16807","Archival Resource Key","/repositories/3/resources/1675"],"unitid_tesim":["MSS 16807","Archival Resource Key","/repositories/3/resources/1675"],"repository_ssm":["University of Virginia, Special Collections Dept."],"repository_ssim":["University of Virginia, Special Collections Dept."],"creator_ssm":["Faulkner, William, 1897-1962"],"creator_ssim":["Faulkner, William, 1897-1962"],"creator_persname_ssim":["Faulkner, William, 1897-1962"],"creator_corpname_ssim":["Albert and Shirley Small Special Collections Library"],"creators_ssim":["Faulkner, William, 1897-1962","Albert and Shirley Small Special Collections Library"],"access_terms_ssm":["This collection contains some in-copyright material. Visit our Permissions and Publishing page for more information about use of Special Collections materials. The library can provide copyright information upon request, but users are responsible for making their own determination about lawful use of collections materials.","Permissions and Publishing Page:\nhttps://www.library.virginia.edu/special-collections/services/publishing","Please note that W.W. Norton holds copyright to all of Faulkner's published works.","If you would like to publish images in print or online of original manuscript materials from our collection that pertain to these published works, including holograph drafts and typescripts, please contact: \nPenguin Random House LLC\nRandom House Publishing Group\n1745 Broadway\nNew York, NY 10019\nAttention: Permissions Department\nPhone: 212-782-9000","For permission to quote from or publish images in print or online of any of Faulkner's unpublished works or correspondence, please contact:\nW.W. Norton \u0026 Company, Inc.\nAttention: Permissions Department\n500 5th Avenue\nNew York, NY 10110\nPhone: 212-354-5500\nEmail: permissions@wwnorton.com","For permission to use copyrighted Faulkner materials in any way than listed above, please contact:\nFaulkner Literary Rights, LLC\nP.O. Box 1408\nCharlottesville, VA 22902\nPhone: 434-296-2156","Photocopies of correspondence between Andrew Brown and T.F. Hickerson regarding \"William Faulkner: Man of Legends\" came from original copies housed at the University of North Carolina at Chapel Hill and are not to be quoted in print without their permission."],"access_subjects_ssim":["Faulkner, William, 1897-1962","American literature--Southern States","American fiction--20th Century"],"access_subjects_ssm":["Faulkner, William, 1897-1962","American literature--Southern States","American fiction--20th Century"],"has_online_content_ssim":["false"],"extent_ssm":["150 Cubic Feet"],"extent_tesim":["150 Cubic Feet"],"genreform_ssim":["American literature--Southern States","American fiction--20th Century"],"date_range_isim":[1824,1825,1826,1827,1828,1829,1830,1831,1832,1833,1834,1835,1836,1837,1838,1839,1840,1841,1842,1843,1844,1845,1846,1847,1848,1849,1850,1851,1852,1853,1854,1855,1856,1857,1858,1859,1860,1861,1862,1863,1864,1865,1866,1867,1868,1869,1870,1871,1872,1873,1874,1875,1876,1877,1878,1879,1880,1881,1882,1883,1884,1885,1886,1887,1888,1889,1890,1891,1892,1893,1894,1895,1896,1897,1898,1899,1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935,1936,1937,1938,1939,1940,1941,1942,1943,1944,1945,1946,1947,1948,1949,1950,1951,1952,1953,1954,1955,1956,1957,1958,1959,1960,1961,1962,1963,1964,1965,1966,1967,1968,1969,1970,1971,1972,1973,1974,1975,1976,1977,1978,1979,1980,1981,1982,1983,1984,1985,1986,1987,1988,1989,1990,1991,1992,1993,1994,1995,1996,1997,1998,1999,2000,2001,2002,2003,2004,2005,2006],"accessrestrict_html_tesm":["\u003cp\u003eThis collection is open for research use with the following exceptions: Material pertaining to individual student records may be restricted in accordance with the Family Educational Rights and Privacy Act (FERPA). Please contact the Archives with specific questions regarding access to such records.\u003c/p\u003e  "],"accessrestrict_heading_ssm":["Conditions Governing Access"],"accessrestrict_tesim":["This collection is open for research use with the following exceptions: Material pertaining to individual student records may be restricted in accordance with the Family Educational Rights and Privacy Act (FERPA). Please contact the Archives with specific questions regarding access to such records."],"bioghist_html_tesm":["\u003cp\u003eThe William Faulkner Collection, MSS 16807, also known as \"The William Faulkner Papers,\" centers on the life and work of William Faulkner, a renowned American author and a foundational voice in Southern Gothic Literature.  William Faulkner was born on September 15, 1897, in New Albany, Mississippi, to Murry Falkner and Maud Butler Falkner. Faulkner was primarily raised in Oxford, Mississippi. He left high school shortly after the eleventh grade in 1915 to work at his grandfather's bank. William Faulkner would go on to briefly join the Canadian Royal Air Force from 1918-1919 before coming back to Oxford, Mississippi and holding various jobs throughout Mississippi and New York until he published his first book, \u003cemph render=\"italic\"\u003e\u003ctitle\u003eSoldier's Pay\u003c/title\u003e\u003c/emph\u003e, in 1926. He married Lida Estelle Oldham in 1929, and together they had one daughter to survive past infancy, Jill Faulkner, in 1933. Faulkner grew in popularity as an author after the publication of \u003ctitle\u003e\u003cemph render=\"italic\"\u003eThe Sound and the Fury\u003c/emph\u003e\u003c/title\u003e in 1929. Though a Mississippi native, William Faulkner moved to Charlottesville, VA, in 1957 to be closer to Jill, her husband, Paul Summers, and their children. It was during this time that Faulkner began work as the University of Virginia's first ever writer-in-residence. Faulkner continued to teach at the University of Virginia in several different positions until his death on July 6, 1962.  \u003c/p\u003e","\u003cp\u003eSource: Materials within the collection.   \u003c/p\u003e  "],"bioghist_heading_ssm":["Biographical / Historical"],"bioghist_tesim":["The William Faulkner Collection, MSS 16807, also known as \"The William Faulkner Papers,\" centers on the life and work of William Faulkner, a renowned American author and a foundational voice in Southern Gothic Literature.  William Faulkner was born on September 15, 1897, in New Albany, Mississippi, to Murry Falkner and Maud Butler Falkner. Faulkner was primarily raised in Oxford, Mississippi. He left high school shortly after the eleventh grade in 1915 to work at his grandfather's bank. William Faulkner would go on to briefly join the Canadian Royal Air Force from 1918-1919 before coming back to Oxford, Mississippi and holding various jobs throughout Mississippi and New York until he published his first book, Soldier's Pay, in 1926. He married Lida Estelle Oldham in 1929, and together they had one daughter to survive past infancy, Jill Faulkner, in 1933. Faulkner grew in popularity as an author after the publication of The Sound and the Fury in 1929. Though a Mississippi native, William Faulkner moved to Charlottesville, VA, in 1957 to be closer to Jill, her husband, Paul Summers, and their children. It was during this time that Faulkner began work as the University of Virginia's first ever writer-in-residence. Faulkner continued to teach at the University of Virginia in several different positions until his death on July 6, 1962.","Source: Materials within the collection."],"odd_html_tesm":["\u003cp\u003eThis material may contain offensive or harmful language or imagery. The purpose of this note is to give users the opportunity to decide whether they need or want to view these materials, or at least, to mentally or emotionally prepare themselves to view the materials.\u003c/p\u003e  "],"odd_heading_ssm":["Content Warning"],"odd_tesim":["This material may contain offensive or harmful language or imagery. The purpose of this note is to give users the opportunity to decide whether they need or want to view these materials, or at least, to mentally or emotionally prepare themselves to view the materials."],"prefercite_html_tesm":["\u003cp\u003eMSS 16807 William Faulkner collection, Albert and Shirley Small Special Collections Library, University of Virginia.\u003c/p\u003e  "],"prefercite_tesim":["MSS 16807 William Faulkner collection, Albert and Shirley Small Special Collections Library, University of Virginia."],"processinfo_html_tesm":["\u003cp\u003eThis collection was reprocessed during 2024-2026 by archivists Elizabeth Nosari and Kaylin Preslar. The collection was originally described in 180 different catalog records and housed in non-consecutive boxes.\nArchivists worked to bring these disparate parts together to create a single William Faulkner Collection (MSS 16807) and finding aid to improve access and discoverability.\u003c/p\u003e","\u003cp\u003eThe William Faulkner collection has historically been represented by numerous different manuscript numbers (collection identifiers). MSS 16807 is a new manuscript number which serves to identify the collection as a whole. Original manuscript numbers have been retained in this guide and are noted in the title of each item.\u003c/p\u003e","\u003cp\u003eIn this example, the original manuscript number is 6074, and \"Series IA, Item 9b\" refers to the item's original location within MSS 6074, prior to reprocessing.\u003c/p\u003e","\u003cp\u003eAbsalom, Absalom! - Typescript (17 Leaves) - 6074, Series IA, Item 9b, 1936\u003c/p\u003e  "],"processinfo_heading_ssm":["Processing Information"],"processinfo_tesim":["This collection was reprocessed during 2024-2026 by archivists Elizabeth Nosari and Kaylin Preslar. The collection was originally described in 180 different catalog records and housed in non-consecutive boxes.\nArchivists worked to bring these disparate parts together to create a single William Faulkner Collection (MSS 16807) and finding aid to improve access and discoverability.","The William Faulkner collection has historically been represented by numerous different manuscript numbers (collection identifiers). MSS 16807 is a new manuscript number which serves to identify the collection as a whole. Original manuscript numbers have been retained in this guide and are noted in the title of each item.","In this example, the original manuscript number is 6074, and \"Series IA, Item 9b\" refers to the item's original location within MSS 6074, prior to reprocessing.","Absalom, Absalom! - Typescript (17 Leaves) - 6074, Series IA, Item 9b, 1936"],"userestrict_html_tesm":["\u003cp\u003eThis collection contains some in-copyright material. Visit our Permissions and Publishing page for more information about use of Special Collections materials. The library can provide copyright information upon request, but users are responsible for making their own determination about lawful use of collections materials.  \u003c/p\u003e","\u003cp\u003ePermissions and Publishing Page:\nhttps://www.library.virginia.edu/special-collections/services/publishing\u003c/p\u003e","\u003cp\u003ePlease note that W.W. Norton holds copyright to all of Faulkner's published works.\u003c/p\u003e","\u003cp\u003eIf you would like to publish images in print or online of original manuscript materials from our collection that pertain to these published works, including holograph drafts and typescripts, please contact: \nPenguin Random House LLC\nRandom House Publishing Group\n1745 Broadway\nNew York, NY 10019\nAttention: Permissions Department\nPhone: 212-782-9000\u003c/p\u003e","\u003cp\u003eFor permission to quote from or publish images in print or online of any of Faulkner's unpublished works or correspondence, please contact:\nW.W. Norton \u0026amp; Company, Inc.\nAttention: Permissions Department\n500 5th Avenue\nNew York, NY 10110\nPhone: 212-354-5500\nEmail: permissions@wwnorton.com\u003c/p\u003e","\u003cp\u003eFor permission to use copyrighted Faulkner materials in any way than listed above, please contact:\nFaulkner Literary Rights, LLC\nP.O. Box 1408\nCharlottesville, VA 22902\nPhone: 434-296-2156\u003c/p\u003e","\u003cp\u003ePhotocopies of correspondence between Andrew Brown and T.F. Hickerson regarding \"William Faulkner: Man of Legends\" came from original copies housed at the University of North Carolina at Chapel Hill and are not to be quoted in print without their permission. \u003c/p\u003e  "],"userestrict_heading_ssm":["Conditions Governing Use"],"userestrict_tesim":["This collection contains some in-copyright material. Visit our Permissions and Publishing page for more information about use of Special Collections materials. The library can provide copyright information upon request, but users are responsible for making their own determination about lawful use of collections materials.","Permissions and Publishing Page:\nhttps://www.library.virginia.edu/special-collections/services/publishing","Please note that W.W. Norton holds copyright to all of Faulkner's published works.","If you would like to publish images in print or online of original manuscript materials from our collection that pertain to these published works, including holograph drafts and typescripts, please contact: \nPenguin Random House LLC\nRandom House Publishing Group\n1745 Broadway\nNew York, NY 10019\nAttention: Permissions Department\nPhone: 212-782-9000","For permission to quote from or publish images in print or online of any of Faulkner's unpublished works or correspondence, please contact:\nW.W. Norton \u0026 Company, Inc.\nAttention: Permissions Department\n500 5th Avenue\nNew York, NY 10110\nPhone: 212-354-5500\nEmail: permissions@wwnorton.com","For permission to use copyrighted Faulkner materials in any way than listed above, please contact:\nFaulkner Literary Rights, LLC\nP.O. Box 1408\nCharlottesville, VA 22902\nPhone: 434-296-2156","Photocopies of correspondence between Andrew Brown and T.F. Hickerson regarding \"William Faulkner: Man of Legends\" came from original copies housed at the University of North Carolina at Chapel Hill and are not to be quoted in print without their permission."],"corpname_ssim":["Albert and Shirley Small Special Collections Library"],"persname_ssim":["Faulkner, William, 1897-1962"],"names_ssim":["Albert and Shirley Small Special Collections Library","Faulkner, William, 1897-1962"],"language_ssim":["Materials primarily in English, with some publications in French and German."],"descrules_ssm":["Describing Archives: A Content Standard"],"total_component_count_is":3370,"online_item_count_is":0,"component_level_isim":[0],"sort_isi":0,"timestamp":"2026-08-14T22:53:44.527Z"}]}},"label":"Breadcrumbs"}}},"links":{"self":"https://arvasarchive.org/catalog/viu_repositories_3_resources_1675_c03"}},{"id":"viu_repositories_7_resources_1710_c03","type":"Series","attributes":{"title":"Series III. Walter Reed, 1806/1955, bulk 1874/1936","abstract_or_scope":{"id":"https://arvasarchive.org/catalog/viu_repositories_7_resources_1710_c03#abstract_or_scope","type":"document_value","attributes":{"value":"\u003cp\u003eSeries III. Walter Reed consists of materials that document the life of Walter Reed as well as the work and legacy of the U.S. Army Yellow Fever Commission. Items in the series date from 1806 to around 1955 with the bulk of the items dating from 1874 to 1936. The series is particularly rich in materials that document the professional and personal life of Walter Reed from 1874 to his death in 1902. These materials include, but are not limited to the following:\u003c/p\u003e","label":"Abstract Or Scope"}},"breadcrumbs":{"id":"https://arvasarchive.org/catalog/viu_repositories_7_resources_1710_c03#breadcrumbs","type":"document_value","attributes":{"value":{"ref_ssi":"viu_repositories_7_resources_1710_c03","ref_ssm":["viu_repositories_7_resources_1710_c03"],"id":"viu_repositories_7_resources_1710_c03","ead_ssi":"viu_repositories_7_resources_1710","_root_":"viu_repositories_7_resources_1710","_nest_parent_":"viu_repositories_7_resources_1710","parent_ssi":"viu_repositories_7_resources_1710","parent_ssim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"parent_ids_ssim":["viu_repositories_7_resources_1710"],"title_filing_ssi":"Series III. Walter Reed","title_ssm":["Series III. Walter Reed"],"title_tesim":["Series III. Walter Reed"],"normalized_title_ssm":["Series III. Walter Reed, 1806/1955, bulk 1874/1936"],"text":["Series III. Walter Reed, 1806/1955, bulk 1874/1936","Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974","box 16-33","accounts","advertisements","articles","bills (legislative records)","bills of sale","biographies (documents)","black-and-white prints (prints on paper)","booklets","books","budgets","business cards","calendars","certificates","charts (graphic documents)","chronologies (lists)","clippings (information artifacts)","contracts","Daybooks","death records","decrees","diaries","drawings (visual works)","editorial cartoons","editorials","envelopes","essays","examinations (documents)","excerpts","extracts","financial records","greeting cards","interviews","inventories","invitations","journals (periodicals)","Lectures","letters (correspondence)","letters to the editor","lists (document genres)","magazines (periodicals)","manuscripts (document genre)","medals","medical records","Memorandums","military records","minutes (administrative records)","mortgages","newspapers","Notebooks","notes","oaths","obituaries","pamphlets","photographs","postcards","press releases","proceedings","proclamations","programs (documents)","questionnaires","receipts (financial records)","registers (lists)","reports","requisitions","Resolutions (administrative records)","Reviews","rosters","Short stories","shoulder boards","sketches","speeches","tables (documents)","telegrams","testimonials","Series III. Walter Reed consists of materials that document the life of Walter Reed as well as the work and legacy of the U.S. Army Yellow Fever Commission. Items in the series date from 1806 to around 1955 with the bulk of the items dating from 1874 to 1936. The series is particularly rich in materials that document the professional and personal life of Walter Reed from 1874 to his death in 1902. These materials include, but are not limited to the following:","correspondence between Walter Reed and members of his immediate family that cover a wide range of topics including Reed's courtship of Emilie Lawrence Reed, family life, Walter Reed's work in the Western United States, and Walter Reed's work in Cuba;military records relating to Walter Reed including military orders for Reed, Reed's performance reviews, and reports of Reed's work for army officials;Walter Reed's correspondence with professional colleagues including members of the U.S. Army Yellow Fever Commission, military doctors, and medical researchers interested in the study of yellow fever;medical records (e.g. fever charts of experiment participants), military orders, administrative records, reports, and publications documenting the results of the U.S. Army Yellow Fever Commission's experiments in Cuba;articles announcing the death of Walter Reed;and the shoulder boards from Walter Reed's U.S. Army uniform.","In addition to the above items, Series III. contains materials that document campaigns, spanning from 1902 to 1937, to publicly honor members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments. These materials include, but are not limited to the following:","articles and editorials relating to efforts to memorialize and provide pensions for members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments;biographical sketches of members of the U.S. Army Yellow Fever Commission and experiment participants;records relating to the Walter Reed Memorial Association (e.g. correspondence, donor lists);copies of Congressional bills and resolutions to honor members of the U.S. Army Yellow Fever Commission and experiment participants;and letters, reviews, and other materials relating to the production of Sidney Coe Howard's play,Yellow Jack.","Finally, Series III. also consists of materials that document the history of yellow fever during the nineteenth and early twentieth century. These materials include, but are not limited to the following:","items (e.g. correspondence, reports, reviews, and articles) relating to U.S. efforts to eradicate yellow fever in the Panama Canal Zone;materials (e.g. correspondence, reports, and articles) documenting early twentieth century efforts to eradicate yellow fever in Peru;scientific reports and publications related to the study and eradication of yellow fever and malaria;and newspaper articles describing various outbreaks of yellow fever epidemics.","Materials in Series III. are largely arranged in chronological order according to their date of creation."],"parent_unittitles_ssm":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"parent_unittitles_tesim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"normalized_date_ssm":["1806/1955, bulk 1874/1936"],"unitdate_inclusive_ssm":["1806-circa 1955"],"unitdate_bulk_ssim":["bulk 1874-1936"],"level_ssm":["Series"],"level_ssim":["Series"],"component_level_isim":[1],"sort_isi":1919,"repository_ssim":["University of Virginia, Special Collections Dept."],"collection_ssim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"extent_ssm":["17 boxes"],"extent_tesim":["17 boxes"],"containers_ssim":["box 16-33"],"has_online_content_ssim":["false"],"child_component_count_isi":1262,"parent_access_restrict_tesm":["There are no restrictions on user access to any of the materials in the collection except where noted in the container list."],"parent_access_terms_tesm":["Copyright restrictions may apply for some materials in the collection."],"access_subjects_ssim":["accounts","advertisements","articles","bills (legislative records)","bills of sale","biographies (documents)","black-and-white prints (prints on paper)","booklets","books","budgets","business cards","calendars","certificates","charts (graphic documents)","chronologies (lists)","clippings (information artifacts)","contracts","Daybooks","death records","decrees","diaries","drawings (visual works)","editorial cartoons","editorials","envelopes","essays","examinations (documents)","excerpts","extracts","financial records","greeting cards","interviews","inventories","invitations","journals (periodicals)","Lectures","letters (correspondence)","letters to the editor","lists (document genres)","magazines (periodicals)","manuscripts (document genre)","medals","medical records","Memorandums","military records","minutes (administrative records)","mortgages","newspapers","Notebooks","notes","oaths","obituaries","pamphlets","photographs","postcards","press releases","proceedings","proclamations","programs (documents)","questionnaires","receipts (financial records)","registers (lists)","reports","requisitions","Resolutions (administrative records)","Reviews","rosters","Short stories","shoulder boards","sketches","speeches","tables (documents)","telegrams","testimonials"],"access_subjects_ssm":["accounts","advertisements","articles","bills (legislative records)","bills of sale","biographies (documents)","black-and-white prints (prints on paper)","booklets","books","budgets","business cards","calendars","certificates","charts (graphic documents)","chronologies (lists)","clippings (information artifacts)","contracts","Daybooks","death records","decrees","diaries","drawings (visual works)","editorial cartoons","editorials","envelopes","essays","examinations (documents)","excerpts","extracts","financial records","greeting cards","interviews","inventories","invitations","journals (periodicals)","Lectures","letters (correspondence)","letters to the editor","lists (document genres)","magazines (periodicals)","manuscripts (document genre)","medals","medical records","Memorandums","military records","minutes (administrative records)","mortgages","newspapers","Notebooks","notes","oaths","obituaries","pamphlets","photographs","postcards","press releases","proceedings","proclamations","programs (documents)","questionnaires","receipts (financial records)","registers (lists)","reports","requisitions","Resolutions (administrative records)","Reviews","rosters","Short stories","shoulder boards","sketches","speeches","tables (documents)","telegrams","testimonials"],"date_range_isim":[1806,1807,1808,1809,1810,1811,1812,1813,1814,1815,1816,1817,1818,1819,1820,1821,1822,1823,1824,1825,1826,1827,1828,1829,1830,1831,1832,1833,1834,1835,1836,1837,1838,1839,1840,1841,1842,1843,1844,1845,1846,1847,1848,1849,1850,1851,1852,1853,1854,1855,1856,1857,1858,1859,1860,1861,1862,1863,1864,1865,1866,1867,1868,1869,1870,1871,1872,1873,1874,1875,1876,1877,1878,1879,1880,1881,1882,1883,1884,1885,1886,1887,1888,1889,1890,1891,1892,1893,1894,1895,1896,1897,1898,1899,1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935,1936,1937,1938,1939,1940,1941,1942,1943,1944,1945,1946,1947,1948,1949,1950,1951,1952,1953,1954,1955],"scopecontent_html_tesm":["\u003cp\u003eSeries III. Walter Reed consists of materials that document the life of Walter Reed as well as the work and legacy of the U.S. Army Yellow Fever Commission. Items in the series date from 1806 to around 1955 with the bulk of the items dating from 1874 to 1936. The series is particularly rich in materials that document the professional and personal life of Walter Reed from 1874 to his death in 1902. These materials include, but are not limited to the following:\u003c/p\u003e","\u003clist type=\"ordered\"\u003e\u003citem\u003ecorrespondence between Walter Reed and members of his immediate family that cover a wide range of topics including Reed's courtship of Emilie Lawrence Reed, family life, Walter Reed's work in the Western United States, and Walter Reed's work in Cuba;\u003c/item\u003e\u003citem\u003emilitary records relating to Walter Reed including military orders for Reed, Reed's performance reviews, and reports of Reed's work for army officials;\u003c/item\u003e\u003citem\u003eWalter Reed's correspondence with professional colleagues including members of the U.S. Army Yellow Fever Commission, military doctors, and medical researchers interested in the study of yellow fever;\u003c/item\u003e\u003citem\u003emedical records (e.g. fever charts of experiment participants), military orders, administrative records, reports, and publications documenting the results of the U.S. Army Yellow Fever Commission's experiments in Cuba;\u003c/item\u003e\u003citem\u003earticles announcing the death of Walter Reed;\u003c/item\u003e\u003citem\u003eand the shoulder boards from Walter Reed's U.S. Army uniform.\u003c/item\u003e\u003c/list\u003e","\u003cp\u003eIn addition to the above items, Series III. contains materials that document campaigns, spanning from 1902 to 1937, to publicly honor members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments. These materials include, but are not limited to the following:\u003c/p\u003e","\u003clist type=\"ordered\"\u003e\u003citem\u003earticles and editorials relating to efforts to memorialize and provide pensions for members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments;\u003c/item\u003e\u003citem\u003ebiographical sketches of members of the U.S. Army Yellow Fever Commission and experiment participants;\u003c/item\u003e\u003citem\u003erecords relating to the Walter Reed Memorial Association (e.g. correspondence, donor lists);\u003c/item\u003e\u003citem\u003ecopies of Congressional bills and resolutions to honor members of the U.S. Army Yellow Fever Commission and experiment participants;\u003c/item\u003e\u003citem\u003eand letters, reviews, and other materials relating to the production of Sidney Coe Howard's play,\u003ctitle render=\"italic\"\u003eYellow Jack\u003c/title\u003e.\u003c/item\u003e\u003c/list\u003e","\u003cp\u003eFinally, Series III. also consists of materials that document the history of yellow fever during the nineteenth and early twentieth century. These materials include, but are not limited to the following:\u003c/p\u003e","\u003clist type=\"ordered\"\u003e\u003citem\u003eitems (e.g. correspondence, reports, reviews, and articles) relating to U.S. efforts to eradicate yellow fever in the Panama Canal Zone;\u003c/item\u003e\u003citem\u003ematerials (e.g. correspondence, reports, and articles) documenting early twentieth century efforts to eradicate yellow fever in Peru;\u003c/item\u003e\u003citem\u003escientific reports and publications related to the study and eradication of yellow fever and malaria;\u003c/item\u003e\u003citem\u003eand newspaper articles describing various outbreaks of yellow fever epidemics.\u003c/item\u003e\u003c/list\u003e","\u003cp\u003eMaterials in Series III. are largely arranged in chronological order according to their date of creation.\u003c/p\u003e"],"scopecontent_heading_ssm":["Scope and Contents"],"scopecontent_tesim":["Series III. Walter Reed consists of materials that document the life of Walter Reed as well as the work and legacy of the U.S. Army Yellow Fever Commission. Items in the series date from 1806 to around 1955 with the bulk of the items dating from 1874 to 1936. The series is particularly rich in materials that document the professional and personal life of Walter Reed from 1874 to his death in 1902. These materials include, but are not limited to the following:","correspondence between Walter Reed and members of his immediate family that cover a wide range of topics including Reed's courtship of Emilie Lawrence Reed, family life, Walter Reed's work in the Western United States, and Walter Reed's work in Cuba;military records relating to Walter Reed including military orders for Reed, Reed's performance reviews, and reports of Reed's work for army officials;Walter Reed's correspondence with professional colleagues including members of the U.S. Army Yellow Fever Commission, military doctors, and medical researchers interested in the study of yellow fever;medical records (e.g. fever charts of experiment participants), military orders, administrative records, reports, and publications documenting the results of the U.S. Army Yellow Fever Commission's experiments in Cuba;articles announcing the death of Walter Reed;and the shoulder boards from Walter Reed's U.S. Army uniform.","In addition to the above items, Series III. contains materials that document campaigns, spanning from 1902 to 1937, to publicly honor members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments. These materials include, but are not limited to the following:","articles and editorials relating to efforts to memorialize and provide pensions for members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments;biographical sketches of members of the U.S. Army Yellow Fever Commission and experiment participants;records relating to the Walter Reed Memorial Association (e.g. correspondence, donor lists);copies of Congressional bills and resolutions to honor members of the U.S. Army Yellow Fever Commission and experiment participants;and letters, reviews, and other materials relating to the production of Sidney Coe Howard's play,Yellow Jack.","Finally, Series III. also consists of materials that document the history of yellow fever during the nineteenth and early twentieth century. These materials include, but are not limited to the following:","items (e.g. correspondence, reports, reviews, and articles) relating to U.S. efforts to eradicate yellow fever in the Panama Canal Zone;materials (e.g. correspondence, reports, and articles) documenting early twentieth century efforts to eradicate yellow fever in Peru;scientific reports and publications related to the study and eradication of yellow fever and malaria;and newspaper articles describing various outbreaks of yellow fever epidemics.","Materials in Series III. are largely arranged in chronological order according to their date of creation."],"_nest_path_":"/components#2","timestamp":"2026-08-14T22:54:59.526Z","collection":{"numFound":1,"start":0,"numFoundExact":true,"docs":[{"id":"viu_repositories_7_resources_1710","ead_ssi":"viu_repositories_7_resources_1710","_root_":"viu_repositories_7_resources_1710","_nest_parent_":"viu_repositories_7_resources_1710","ead_source_url_ssi":"data/oai/UVA/repositories_7_resources_1710.xml","aspace_url_ssi":"https://archives.lib.virginia.edu/ark:/59853/202324","title_ssm":["Philip S. Hench Walter Reed Yellow Fever collection"],"title_tesim":["Philip S. Hench Walter Reed Yellow Fever collection"],"unitdate_ssm":["circa 1800-circa 1998","bulk 1863-1974"],"unitdate_inclusive_ssm":["circa 1800-circa 1998"],"unitdate_bulk_ssim":["bulk 1863-1974"],"normalized_date_ssm":["1800/1998, bulk 1863/1974"],"normalized_title_ssm":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"text":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974","MS.1","Archival Resource Key","/repositories/7/resources/1710","Human Experimentation","Military Medicine","Physicians","Public health","Tropical medicine","Yellow Fever","There are no restrictions on user access to any of the materials in the collection except where noted in the container list.","The Philip S. Hench Walter Reed Yellow Fever Collection is organized in 16 series:","I. Jesse W. Lazear\n      II. Henry Rose Carter\n      III. Walter Reed\n      IV. Philip Showalter Hench\n      V. Maps\n      VI. Alphabetical files\n      VII. Truby-Kean-Hench\n      VIII. Miscellany\n      IX. Photographs\n      X. Photographic negatives\n      XI. Reprints\n      XII. Houston Academy of Medicine/Texas Medical Center additions\n      XIII. Reed family additions\n      XIV. P. Kahler Hench additions\n      XV. Laura Wood\n      XVI. Edward Hook additions","The U.S. Army Yellow Fever Commission (1900-1901) was a board of physicians that the U.S. government formed in order to determine how yellow fever was transmitted between hosts. Ultimately, the commission's experiments in Cuba proved that mosquitoes transmit yellow fever--a discovery that would spur successful campaigns to control and eradicate yellow fever throughout much of the globe.","When Major Walter Reed and Acting Assistant Surgeons James Carroll, Aristides Agramonte, and Jesse Lazear gathered on the porch of the Columbia Barracks Hospital in June of 1900, they became the fourth successive board of U.S. medical officers to grapple with the appalling plague that was yellow fever.","The persistence of this disease across the Cuban archipelago and its periodic re-emergence along the coastlines and great river drainages of the Americas was taking countless thousands of lives. Lack of precise knowledge as to its cause and transmission had augmented yellow fever's extraordinarily high mortality rate and had given rise to quarantine regulations which constituted substantial impediments to efficient regional trade. Endemic in the tropics, yellow fever imposed high humanitarian and economic costs upon the entire region. Specialists regarded Cuba as one of the principal foci of the disease, and the island consequently attracted considerable attention from the medical sciences.","In 1879, one year after a devastating epidemic swept up the Mississippi valley from New Orleans, Tulane University Professor Stanford E. Chaille led the first investigatory commission to Havana, Rio de Janeiro, and the West Indies. The Chaille Commission remained in Havana three months, and its members -- including George Miller Sternberg, who became Surgeon General of the Army, and Juan Guiteras, later Director of Public Health for Havana -- consulted with Cuban scientist Carlos J. Finlay. They concluded that the causal agent for yellow fever was possibly a living entity in the atmosphere, an assertion which set Finlay on the path to the mosquito theory he developed in 1881.","Louis Pasteur's foundational and highly successful work in modern immunology in 1880 and 1881 gave a renewed impetus to investigations aimed at discovering the \"yellow fever germ.\" Over the middle years of the 1880s several scientists advanced different theories, all readily refuted by bacteriological work Sternberg undertook in Brazil and Mexico in 1887 and again in Havana in 1888 and 1889. In 1897, Italian scientist Giuseppe Sanarelli argued thatBacillus icteroideswas the culprit, and the following year a third scientific team sailed to Cuba for additional tests. Eugene Wasdin and Henry D. Geddings appeared to confirm Sanarelli's assertion, though Sternberg, by then Surgeon General, remained skeptical.","Despite Wasdin and Geddings' insistence, theB. icteroidestheory garnered significant opposition. In fact, a few months before the third commission's report reached the public, Walter Reed and James Carroll -- Reed's assistant at the Columbian University (later George Washington University) bacteriology laboratories in Washington, D.C. -- published a thorough refutation of theicteroidesproposal: the bacteria was not a unique cause of yellow fever, but a variety of the hog cholera bacillus, \"a secondary invader in yellow fever,\" Reed determined, unrelated to its etiology. [1] Dispute continued, however, and when Sternberg organized the fourth investigatory board, he charged Reed and his associates to settle theB. icteroidesquestion once and for all, then to proceed with analysis of other blood cultures and intestinal flora from yellow fever cases.","Reed and Carroll had considerable experience in bacteriological analysis, and, Sternberg reasoned, might well be able to find the specific agent of the disease. Aristides Agramonte, a Cuban scientist who had worked in Reed's lab at the Columbian University in 1898, was also an accomplished bacteriologist; he had identifiedB. icteroidesin tissue samples from cases other than yellow fever, providing further evidence opposed to Sanarelli's thesis. Jesse Lazear, a scientist from Johns Hopkins University in Baltimore, Maryland, had joined the Army Medical Corps to study tropical diseases at their point of origin; he received orders for Cuba in February 1900. Lazear impressed Reed with his abilities when the two men became acquainted in March. No doubt with Reed's advice, Sternberg assembled a crack team -- all experienced in scientific research, but each with interests as diverse as their temperaments. The mix of talent and personalities generated spectacular results.","What causes yellow fever? This simple, even obvious question had dictated yellow fever research for over two decades, and so it guided Reed in organizing the work of the commission.Bacillus icteroidesand other bacteriological sampling dominated their work for the first months. \"Reed and Carroll have been at that for a long time,\" Lazear wrote with some impatience to his wife on August 23, \". . . I would rather try to find the germ without bothering about Sanarelli.\" [2] Again and again, tests for the bacteria proved negative, and at the same time, perplexing cases of yellow fever were developing in the region. Agramonte and Reed investigated an epidemic at Pinar del Rio, 110 miles southwest of Havana; Lazear followed later to collect more specimens, and he also assessed the situation at Guanjay thirty miles southwest. To \"my very great surprise,\" Reed admitted, the specific circumstances of the appearance and development of these cases gave strong evidence against the widely-accepted notion that the excreta of patients spread the disease. The theory of fomites -- infection from contaminated clothing and bedding -- and indeed even infection from airborne particles seemed altogether untrue. \"At this stage of our investigation,\" Reed concluded, \". . . the time had arrived when the plan of our work should be radically changed.\" [3] The fundamental question underwent a subtle but critical transformation: from what causes yellow fever to what transmits it. A clear and accurate understanding of how the disease was spread would open a new avenue to its specific cause.","\"Personally, I feel that only can experimentation on human beings serve to clear the field for further effective work,\" Reed stated to Surgeon General Sternberg, who concurred. [4] Evidence gathering around them pointed strongly to an intermediate host, and the Commission resolved to test Carlos Finlay's mosquito theory -- then not generally accepted -- on human volunteers. Nine times from August 11 to August 25, 1900, mosquitoes landed on the arms of volunteers and proceeded to feed. Nine times the results were negative. On August 27, Lazear placed a mosquito on the doubting Dr. Carroll, and four days later on William J. Dean, a soldier designated XY in the \"Preliminary Note.\" [5] Both promptly developed yellow fever. Significantly, their mosquitoes had fed on cases within the initial three days of an attack and had been allowed to ripen for at least twelve days before the inoculations. Carroll vitiated the results of his experimental sickness by traveling off the post to Havana, a contaminated zone, even as Reed, ecstatic, wrote from Washington in a confidential letter: \"Did the Mosquito do it?\" [6] Dean's case seemed to prove it, since he claimed not to have left the garrison before becoming ill. Lazear also developed a case of yellow fever, almost certainly experimental in origin, though he never revealed the actual circumstances of his inoculation. His severe bout of fever took a fatal turn on September 25, 1900.","Nevertheless, these results could not have been more dramatic or convincing for the Commission. Reed quickly assembled a \"Preliminary Note,\" which he presented to the annual meeting of the American Public Health Association in Indianapolis, Indiana, October 23, 1900. After initial consultations in Cuba with General Leonard Wood, military governor of the island, and with Surgeon General Sternberg in Washington, he returned to Cuba with authorization and funding to design and carry forward a fully defensible series of experiments. His aim was confirmation of the mosquito theory and invalidation of the long-held belief in fomites.","On open terrain beyond the precincts of Columbia Barracks -- the American military base just west of Havana near the adjacent suburban towns of Quemados and Marianao (also called Quemados de Marianao) -- Reed established the quarantined experimental station. Camp Lazear, as the Commission dedicated it, took form in the rolling fields of the Finca San Jose, on the farm of Dr. Ignacio Rojas, who leased the land to the Americans. Here Reed designed two small wood-frame buildings, each 14 by 20 feet, for the experimental work, and nearby raised a group of seven tents for the accommodation and support of the volunteers. The buildings faced each other across a small swale, about 80 yards apart, and stood 75 yards from the tent encampment. Building Number One, called the Infected Clothing Building, was a single room tightly constructed to contain as much foul air as possible. A small stove kept the temperature and humidity at tropical levels, and carefully attached screening secured the pair of doorways in a vestibule against intrusion by mosquitoes. Wooden blinds on two small sealed windows shielded the room from direct sun. Building Number Two, the Infected Mosquito Building, contained a principal room, divided into two sections by a floor-to-ceiling wire mesh screen. A door direct to the exterior let into one section, while a vestibule with a solid exterior door and pair of successive screened doors opened to the other, so configured to keep infected mosquitoes inside that section alone. The spare furnishings in both sections -- cots with bedding -- were steam sterilized. Windows exposed the entire room to the clean, steady ocean breezes and to sunlight. Like the doorways, they were carefully screened. A secondary room attached to the building but not communicating with the experimental spaces sheltered the small, heated laboratory where the Commission members raised and stored the mosquitoes to be used.","These two experimental buildings presented alternate environments -- one conspicuously clean and well ventilated, the other filthy and fetid. Contemporary theories of disease held that yellow fever developed in unclean conditions, and consequently much time and money had been devoted to sanitation projects. Workers steamed clothing, burned sulphur in ships' holds, and thoroughly scrubbed surfaces with disinfectant. In cases of severe epidemic, entire buildings presumed to be infected were set afire along with their contents. Thus the extraordinary -- and intentional -- paradox of the Commission's experimental regime: Reed expected yellow fever to develop not in the unsanitary environment, but in the one thought to be most healthful.","Camp Lazear went into quarantine the day of its completion, November 20, 1900, with a command of four immune and nine non-immune individuals, all save one U.S. Army personnel. Soon a group of recent Spanish immigrants to Cuba augmented the non-immune numbers, bringing the resident total to about twenty. Reed strictly controlled access to the camp and ordered regular temperature recording for each volunteer to eliminate any unanticipated source of infection and to identify the onset of any case of yellow fever as early as possible. As a result, non-immunes were barred from returning should they leave the precinct, and two of the Spaniards who developed intermittent fevers shortly after arrival were immediately transferred with their baggage to Columbia Barracks Hospital. The immune members of the detachment oversaw medical treatments and drove the teams of mules that pulled supply wagons and the ambulance. Experimentation did not begin until each volunteer had passed the incubation period for yellow fever in perfect health.","Reed took as much care with the design of the experimental protocol as he had with the configuration of the camp and its buildings. Each evening, the occupants of the infected clothing building unpacked trunks and boxes of bed linens and blankets, nightshirts and other clothing recently worn and soiled by cases from the wards of Columbia Barracks Hospital and Las Animas Hospital in Havana. These they shook out and spread around the room to permeate the atmosphere. The stench was overpowering. Yellow fever causes severe internal hemorrhaging, and its unfortunate victims often suffer from black vomit and other bloody discharges. One routine delivery proved so putrid the volunteers \"retreated from the house,\" Reed stated. \"They pluckily returned, however, within a short time, and spent the night as usual.\" [7] In two succeeding trials the protocol became progressively more daring , as the volunteers then wore the clothing and slept on the mattresses used by yellow fever patients, and finally put towels on their bedding smeared with blood drawn from cases in the early stages of an attack. Each morning, the volunteers carefully repacked the rank, encrusted materials into boxes and emerged to an adjacent tent where they spent the day quarantined from the rest of the company. Three trials of twenty days each involved seven men altogether, lead by Robert P. Cooke, a physician in the Army Medical Corps. None developed yellow fever.","The Commission's mosquito experiments proceeded in four series. First, Reed sought to demonstrate that mosquitoes of the varietyCulex fasciata(later calledStegomyia fasciata, and later stillAedes aegypti) could in fact transmit yellow fever, as Carlos J. Finlay had argued and the initial experiments at Camp Columbia strongly suggested. Here the Commission members simply applied infected mosquitoes contained in test tubes or jars to the skin of the initial volunteers. Success in these tests raised a number of questions, each one addressed in the subsequent series:","How could a building become infected?\n      When does a mosquito develop the ability to transmit the disease?\n      Over what length of time can a mosquito retain this capacity to infect?","The second series consequently employed the specialized \"Infected Mosquito Building\" to indicate how a structure could be considered infected with yellow fever. This experiment required two groups of volunteers, one to be inoculated and another to serve as controls. \"Loaded\" mosquitoes, as the men called them, were released into the screened section of Building Two -- on the side with the protected vestibule entry. One or more non-immune men then entered the opposite section of the room through the direct exterior door, and lay down on bunks adjacent to the wire mesh screen in the center of the room. Now the young man to be inoculated walked through the vestibule into the mosquito side of the room and proceeded to lie on a bunk adjacent to the wire screen separating him from the controls. The inoculation volunteer remained in the building for about twenty minutes -- enough time to suffer several mosquito bites -- he then exited to a quarantine tent outside. The controls spent the remainder of the evening and night in the uninfected side of the room, and indeed returned to sleep in the room for as many as eighteen more nights. As Reed stated, absence of yellow fever in the controls showed \"that the essential factor in the infection of a building with yellow fever is the presence therein of [infected] mosquitoes,\" and nothing more. [8] The degree of sanitation, so long considered critical, was utterly irrelevant.","The third series of mosquito experiments confirmed what Henry Rose Carter, of the U.S. Public Health Service, called the \"period of extrinsic incubation,\" [9] the length of time required for secondary cases of yellow fever to develop after an initial intrusion of the disease into a locality. In this series, a single volunteer underwent three successive inoculations by the same mosquitoes, each group of inoculations interrupted by a period of time equal in length to the typical incubation period of the disease in humans, about five days. In this manner, the volunteer's illness could be specifically attributed to a single inoculation group. The use of the same mosquitoes and the same volunteer concurrently demonstrated that no peculiar personal immunity was at play, since logic dictates that a person susceptible to yellow fever on day 17 of a mosquito's contamination -- as happened in the experiment -- could not have been immune to yellow fever on day 11 or day 4. It was thus only the mosquito's capacity to infect which changed, and that occurred no less than 11 days after contamination.","The duration of time over which these \"fully ripened\" mosquitoes remained infective comprised the fourth series of experiments. For this series the Commission kept alive a group of infected mosquitoes for as long as possible, and proceeded to inoculate three volunteers -- on the 39th, 51st, and 57th day after contamination. Each developed yellow fever. A fourth volunteer declined to be bitten on day 65, and the last two mosquitoes of the group, \"deprived of further opportunity to feed on human blood\" [10] expired on day 69 and day 71, clear evidence that even a sparsely populated region may retain the potential for new infections more than two months after the first appearance of the disease.","Although it went unrecorded in the published papers, Reed organized a supplemental experiment to test another species of mosquito.Culex pungensfailed to transmit yellow fever to at least one volunteer and probably to a second. Reed's preliminary conclusions indicated thatCulex fasciatawas the only species capable of transmitting yellow fever. [11]","A last experimental regime involved subcutaneous injections of blood from positive cases of yellow fever to presumed non-immunes. Reed devised these tests to confirm the presence of the yellow fever agent in the blood of a victim during the first days of an attack, and, more importantly, to settle theBacillus icteroidesquestion. The same blood cultures which produced yellow fever in four volunteers also failed to grow anyB. icteroides, conclusively invalidating Sanarelli's claim.","Altogether, the mosquito inoculations and the blood injections produced fourteen cases of yellow fever. All made a full recovery.","Notwithstanding the decisive medical victory -- as Reed declared, \"aside from the antitoxin of Diptheria and Koch's discovery of the tubercle bacillus, it will be regarded as the most important piece of work, scientifically, during the 19th century\" [12] -- success at Camp Lazear unfolded in its own time. Initially, Reed observed, \"the results obtained at this station were not encouraging.\" [13] The first inoculations of four volunteers over a period of two weeks proved disconcertingly negative each time. Then, on December 5, 1900, private John R. Kissinger presented his arm to the mosquitoes, and late in the evening on December 8, suffered the first chills of \"a well-marked attack of yellow fever.\" [14] Three more men in rapid succession fell victim to the insects -- Spanish volunteers Antonio Benigno, Nicanor Fernandez, and Vicente Presedo. The force of the conclusions was evident to everyone:","\"It can readily be imagined,\" Reed empathetically and wryly described in his first presentation of the experiments, \"that the concurrence of 4 cases of yellow fever in our small command of 12 non-immunes within the space of 1 week, while giving rise to feelings of exultation in the hearts of the experimenters, in view of the vast importance attaching to these results, might inspire quite other sentiments in the bosoms of those who had previously consented to submit themselves to the mosquito's bite. In fact, several of our good-natured Spanish friends who had jokingly compared our mosquitoes to 'the little flies that buzzed harmlessly about their tables,' suddenly appeared to lose all interest in the progress of science, and, forgetting for the moment even their own personal aggrandizement, incontinently severed their connection with Camp Lazear. Personally, while lamenting to some extent their departure, I could not but feel that in placing themselves beyond our control they were exercising the soundest judgment.\"","\"In striking contrast,\" Reed continued, the anxiety of the fomites volunteers began to melt into relief. \"[T]he countenances of these men, which had before borne the serious aspect of those who were bravely facing an unseen foe, suddenly took on the glad expression of 'schoolboys let out for a holiday,' and from this time their contempt for 'fomites' could not find sufficient expression. Thus illustrating once more, gentlemen, the old adage that familiarity, even with fomites, may breed contempt.\" [15]","The question of human experimentation was indeed a serious one -- unavoidable, in actuality, as Reed had stated the previous summer to Surgeon General Sternberg. When the Commission first considered a trial of Finlay's mosquito theory, Reed, Carroll, and Lazear agreed to experiment on themselves. Agramonte, a native Cuban, had acquired immunity as a child. Doubtless Finlay's experience of many unsuccessful inoculations communicated that positive results would not be forthcoming rapidly, so before the first series of inoculations began under Lazear's direction at Columbia Barracks, Reed left Cuba for Washington, where he completed a monumental report on typhoid fever among the army corps -- left unfinished by the sudden death of co-author Edward O. Shakespeare. Carroll and Lazear both sickened while Reed was in Washington, and Lazear, young and strong, had no reason to anticipate that his case would be fatal. Reed was shocked at Lazear's death, and because of his own age -- 49, a decade and a half older than Lazear and a dozen years older than Carroll -- he resolved not to inoculate himself when he returned to Cuba on October 4, 1900. The point had already been amply demonstrated, and only a rigidly controlled experimental regime would establish the necessary proof. Carroll, however, remained embittered about this for the remainder of his life, though he evidently never communicated his objections directly to Reed.","That initial series of mosquito inoculations was probably accomplished without formal documentation of informed consent. Indeed, the experiments may also have been carried forward without the full knowledge of the commanding officer of Camp Columbia, and Reed consequently shielded the identity of Private William J. Dean, the second positive experimental case, behind the pseudonym \"XY\" in the \"Preliminary Note.\" No such potentially troublesome problems arose for the experimental series at Camp Lazear; Reed obtained prior support from all of the appropriate authorities in the military and the administration, even including the Spanish Consul to Cuba. With the advice of the Commission and others, he drafted what is now one of the oldest series of extant informed consent documents. The surviving examples are in Spanish with English translations, and were signed by volunteers Antonio Benigno and Vicente Presedo, and a third with the mark of Nicanor Fernandez, who was illiterate.","The documents take the form of a contract between individual volunteers and the Commission, represented by Reed. At least 25 years old, each volunteer explicitly consented to participate, and balanced the certainty of contracting yellow fever in the general population against the risks of developing an experimental case, followed by expert and timely medical care. The volunteers agreed to remain at Camp Lazear for the duration of the experiments, and as a reward for participation would receive $100 \"in American gold,\" with an additional hundred-dollar supplement for contracting yellow fever. These payments could be assigned to a survivor, and the volunteers agreed to forfeit any remuneration in cases of desertion.","For the American participants no consent documents appear to survive, though in contemporary letters Reed assured his correspondents that the Commission obtained written consent from all the volunteers. The record of expenses for Camp Lazear -- maintained by Reed's friend and colleague in the medical corps, Jefferson Randolph Kean -- indicates that the same schedule of payments for participation and sickness applied to the Americans as well. Volunteers who participated in the fomites tests and in addition the later series of blood injections and the single trial of an alternative species of mosquito also earned $100 each plus the $100 supplement if yellow fever developed. Two Americans declined these gratuities, as Kean termed them, Dr. Robert P. Cooke, of the fomites tests, and John J. Moran, who had recently received an honorable discharge from the service, and was the only American civilian to participate. His was the fourth case of yellow fever to develop from mosquito inoculation. Moran eventually settled in Cuba, where he managed the Havana offices of the Sun Oil Company, and late in life became a close friend of Philip S. Hench. Together the two men rediscovered the site of Camp Lazear in 1940 -- Building Number One still intact -- and successfully lobbied the Cuban government to memorialize there the work of Finlay and the American Commission in the conquest of yellow fever.","Reed informally commemorated his own experiences at Camp Lazear by commissioning a group photograph, evidently taken there shortly before he left Cuba in February 1901. A more important event occurred on the sixth of that month when Reed presented the results of the Camp Lazear yellow fever experiments to a great ovation at the Pan-American Medical Congress in Havana. Three days later he set sail for the United States, and once landed, drafted the Congress paper asThe Etiology of Yellow Fever -- An Additional Note, published immediately in theJournal of the American Medical Association. [16]","Though his correspondence intimates a great appreciation for Cuba, Reed never returned to the warm, sunny shores of the island freed of a dreadful plague. Carroll stayed behind at Camp Lazear through February to complete the last experimental series officially bearing the imprimatur of the Yellow Fever Commission, and returned to Washington soon after March first. [17] The Medical Corps retained the lease on Camp Lazear against the possibility of continuing experiments another season, and Carroll, in fact, returned to Havana in August 1901 for a final experimental series, though he did not make use of Camp Lazear. This work involved at least three volunteers at Las Animas Hospital, Havana, who submitted to blood injections. Carroll's assignment aimed at a greater understanding of the yellow fever agent, and he proved that blood drawn from active cases of yellow fever remained virulent even after passing through fine bacteria filters. In addition, by heating contaminated blood which had previously caused cases of yellow fever, Carroll rendered it non-infective -- thereby establishing that this filterable entity, though sub-microscopic, was demonstrably present in the bloodstream. Carroll wrapped up the series in October and returned home to stay. [18] In Cuba, J. Randolph Kean made the last rental payments to Signore Rojas on October 9, 1901, and Camp Lazear, for more than a generation, slipped out of the realm of memory.","Sources:","[1] Walter Reed and James Carroll,Bacillus Icteroides and Bacillus Cholerae Suis -- A Preliminary Note,Medical News(29 April 1899), reprinted in: United States Senate Document No. 822,Yellow Fever, A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 55.\n      [2] Letter from Jesse W. Lazear to Mabel Houston Lazear, 23 August 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00341001.\n      [3] Walter Reed, \"The Propagation of Yellow Fever -- Observations Based on Recent Researches,\" in United States Senate Document No. 822,Yellow Fever A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 94.\n      [4] Letter from Walter Reed to George M. Sternberg, 24 July 1900, Hench Reed Yellow Fever Collection, accession number: 02064001.\n      [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note,Proceedings of the Twenty-eighth Annual Meeting of the American Public Health AssociationIndianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n      [6] Letter from Walter Reed to James Carroll, 7 September 1900, Edward Hook Additions to the Philip S. Hench Walter Reed Yellow Fever Collection: James Carroll Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 15312004. The originals of these letters remain in a private collection.\n      [7] Walter Reed, James Carroll, Aristides Agramonte,The Etiology of Yellow Fever -- An Additional Note,Journal of the American Medical Association36 (16 February 1901): 431-440, reprinted in: Senate Document No. 822, p. 84.\n      [8] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n      [9] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n      [10] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 101.\n      [11]Culex fasciatawas reclassified shortly after the experiments asStegomyiaand later becameAedes aegypti.\n      [12] Letter to from Walter Reed to Emilie Lawrence Reed, 9 December 1900, Hench Reed Collection, accession number: 02231001.\n      [13] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 97.\n      [14] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 98.\n      [15] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n      [16] Please see note [7].\n      [17] The Commission reported these concluding experiments in: Walter Reed, James Carroll, Aristides Agramonte,Experimental Yellow Fever,American MedicineII (6 July 1901) 1: 15-23.\n      [18] Walter Reed, James Carroll,The Etiology of Yellow Fever (A Supplemental Note),American MedicineIII (22 February 1902) 8: 301-305.","Walter Reed (September 13, 1851 - November 22, 1902) was a U.S. Army physician who led the army's Yellow Fever Commission 1900 and 1901. Experiments conducted by the commission confirmed a theory that yellow fever is transmitted by mosquitoes--a discovery that led to the control and eradication of this disease across much of the globe. Reed would receive much of the credit for the work of the commission because of his role as its leader, and, long after his death in 1902, he would be widely celebrated as a heroic figure in the fields of public health and medical research.","Reed spent his first days in a small house which served as the parsonage for a Methodist congregation in Gloucester County, Virginia, where his father was minister.  Lemuel Sutton Reed and Pharaba White Reed welcomed young Walter into the family on September 13, 1851;  he was the youngest of their five children.  The Reeds moved to other Virginia parishes during Walter's childhood, and just after the close of the Civil War, transferred to the town of Charlottesville.  That move in 1866 placed Walter in the orbit of the University of Virginia, which he entered a year later at age sixteen under the care of his older brother Christopher, also a student at the University.  Reed attended two year-long sessions, the second devoted entirely to the medical curriculum, and he completed an M.D. degree on July 1, 1869, as one of the youngest students to graduate in the history of the medical school.","At that time the School of Medicine at the University offered little opportunity for direct clinical experience, so Reed subsequently enrolled at the Bellevue Hospital Medical College, in Manhattan, New York.  There he obtained a second M.D. degree in 1870.  Reed interned at a number of hospitals in the New York metropolitan area, including the Infants' Hospital on Randall's Island and the Brooklyn City Hospital.  In 1873, he assumed the position of assistant sanitary officer for the Brooklyn Board of Health.  The large and diverse population of New York, with its many immigrant communities and dense, tenement housing, provided countless medical cases to treat and study;  these served to expose Reed to the vital importance of public health, and developed in him a lifelong interest in the field.  Yet the frenetic life of the great cities began to pall after a few years: \"Here the ever bustling day is crowded into the busy night; nor can we draw the line of separation between the two,\"[1] he wrote to Emilie Lawrence, of Murfreesboro, North Carolina, later to become Mrs. Walter Reed.  Their courtship letters reveal much of his maturing character, interests, and philosophy of life.  Increasing responsibilities with the Board of Health precluded opening a private practice, and Reed's youth proved a barrier in a culture given to offering respect more to the appearance of maturity than to its actual demonstration. Reed consequently resolved to join the Army Medical Corps, both for the professional opportunities it offered immediately and for the modest financial security it could provide to a young man without independent means.  He passed the qualifying examinations in January 1875 and proceeded to his first assignment at the military base on Willet's Point, New York Harbor.","Reed remained in the Medical Corps for the rest of his life, spending many years of the '70s, '80s, and early '90s at difficult postings in the American West.  The first of these -- to the Arizona Territory -- began in the late spring of 1876, and indeed hurried along his wedding to Emilie Lawrence, on April 25, shortly before his departure.  She joined him the following November, and bore two children at frontier posts, a son Walter Lawrence and a daughter Emilie, called Blossom.","Reed's other western assignments included forts in Nebraska, Dakota Territory, and Minnesota, with two eastern interludes at Baltimore, Maryland and another at Mount Vernon Barracks, Alabama.  During the second of these tours in Baltimore -- over the 1890-1891 academic year -- Reed completed advanced coursework in pathology and bacteriology in the Johns Hopkins University Hospital Pathology Laboratory.  When he returned from his last western appointment in 1893, Reed joined the faculty of the Army Medical School in Washington, D.C., where he held the professorship of Bacteriology and Clinical Microscopy.  He also became curator of the Army Medical Museum and joined the faculty of the Columbian University in Washington (later the George Washington University).  In addition, Reed maintained close ties with professor William Welch and other leading lights in the scientific community he had come to know at Hopkins a few years earlier.","Beyond his teaching responsibilities for the Army and the Columbian University programs, Reed actively pursued medical research projects.  A bibliography of his publications finds entries from 1892 to the year of his untimely death a decade later, and the subjects he investigated range from erysipelas to cholera, typhoid, malaria, and yellow fever, among others.[2]   In 1896, a research trip to investigate an outbreak of smallpox took him to Key West, and there he developed a close friendship with Jefferson Randolph Kean, a fellow Virginian and colleague in the Medical Corps ten years his junior.  When Reed traveled to Cuba in 1899 to study typhoid in the army encampments of the U.S. forces, Kean was already there, and Kean was still in Cuba when Reed returned as the head of the Army board charged by Surgeon General George Miller Sternberg to examine tropical diseases including yellow fever.  Kean and his first wife Louise were great supporters of the U.S. Army Yellow Fever Commission's work, and Kean in fact served as quartermaster for the famous series of experiments at Camp Lazear.  After the dramatic and conclusive success of those experiments, Kean actively -- though unsuccessfully -- promoted Reed's candidacy for Surgeon General.","Reed continued to speak and publish on yellow fever after his return from Cuba in 1901, receiving honorary degrees from Harvard and the University of Michigan in recognition of his seminal work.  In November 1902, Reed developed what had been for him recurring gastro-intestinal trouble.  This time, however, his appendix ruptured, and surgery came too late to save him from the peritonitis which developed.  He died on November 23, 1902, almost two years to the day from the opening of Camp Lazear and the stunning experimental victory there.  Kean remained a champion of his deceased friend's role in the conquest of yellow fever.  He organized the Walter Reed Memorial Association, to provide support for Reed's family and to build a suitable memorial, and was instrumental in lobbying the United States Congress to establish the Yellow Fever Roll of Honor.  In 1929, Congress mandated the annual publication of the Roll in theArmy Register, and struck a series Congressional Gold Medals saluting the Commission members and the young Americans who bravely suffered experimental yellow fever a generation before.","Sources:","[1] Letter from Walter Reed to Emilie Lawrence, 18 July 1874, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 01605001.\n      [2] The bibliography of Reed's scientific papers may be found in: Howard Atwood Kelly,Walter Reed and Yellow Fever(New York: McClure, Phillips and Co., 1906), pp. 281-283. Kelly's complete biography of Reed is contained on this Web site.","Jesse William Lazear (May 2, 1866 - September 26, 1900) was a physician who was a member of the U.S. Army Yellow Fever Commission in 1900. Lazear's death from yellow fever at the outset of the commission's work in Cuba would lead to his elevation as a martyr for medical science in the eyes of many during the twentieth century.","\"I rather think I am on the track of the real germ,\" Jesse W. Lazear wrote his wife from Cuba on September 8, 1900.[1] Seventeen days later, the fulminating case of yellow fever Lazear had contracted just over a week after writing Mabel H. Lazear suddenly ended the young scientist's life. He was 34 years old. Unlike so many other yellow fever fatalities, however, this one would lead to a direct and highly successful assault on the disease itself. Yellow fever's ascendancy, endemic in Cuba, was about to be undermined.","Lazear had reported to Camp Columbia, Cuba in February 1900 for duty as an acting assistant surgeon with the U. S. Army Corps stationed on the island. Here he undertook bacteriological study of tropical diseases, particularly malaria and yellow fever, and in May he was named to the Army board charged with \"pursuing scientific investigations with reference to the infectious diseases prevalent on the island of Cuba.\"[2]","These orders placed him officially in the company of Walter Reed, James Carroll, and Aristides Agramonte -- the U.S. Army Yellow Fever Commission -- though Lazear had already met Reed the preceding March on a project to evaluate the efficacy of electrozone, a disinfectant made from seawater collected off the Cuban coast. While Reed was in Cuba that March, Lazear discussed with him the recent discovery of British scientist Sir Ronald Ross concerning the mosquito vector for malaria. At Johns Hopkins Hospital in Baltimore, where he was first a medical resident and later in charge of the clinical laboratory, Lazear had followed Ross's accomplishments with great interest, and pursued field work and experimentation on theAnophelesmosquito with fellow Hopkins scientist William S. Thayer. Lazear was thus the only member of the Commission who had experience with mosquito work, and was consequently the most open to the possible verity of Cuban scientist Carlos Juan Finlay's theory of mosquito transmission for yellow fever.","The record is apparently silent as to when Lazear first visited Finlay. Certainly by late June Lazear was beginning to grow mosquito larvae acquired from Finlay's laboratory, the first specimens brought to him by Henry Rose Carter, of the United States Public Health Service.[3] Not long after arriving in Cuba Lazear met Carter, whose own observations on yellow fever strongly suggested an intermediate host in the spread of the disease. However, Army Surgeon General George Miller Sternberg, who organized the Yellow Fever Commission, first charged the board members to investigate the relationship ofBacillus icteroidesto yellow fever -- proposed by the Italian Scientist Giuseppe Sanarelli as the actual cause of the disease. \"Dr. Reed had been in the old discussion over Sanarelli's bacillus and he still works on that subject,\" Lazear wrote his wife in July, \"I am not all interested in it but want to do work which may lead to the discovery of the real organism.\"[4] Soon he would have the opportunity. The relatively quick failure of the Bacillus icteroides inquiry opened the door to what became the ground-breaking mosquito work, and Lazear was well placed to begin.","The project started in earnest on August 1, 1900. In a small pocket notebook Lazear noted the preparatory work of raising and infecting mosquitoes, and subsequently recorded the series of eleven experimental inoculations made from the 11th to the 31st of August, the last two producing cases of full-blown yellow fever. These two positive cases developed from mosquitoes allowed to ripen over a period of 12 days, and this was Lazear's crucial discovery. The epidemiological pattern was thus entirely consistent with Carter's observations of a delay between the primary and secondary outbreaks of yellow fever in an epidemic, and, in addition, explained why Finlay's experiments had been largely unsuccessful -- he had not waited long enough before inoculating his subjects.","Although Lazear never directly admitted to experimenting on himself, when Reed reviewed Lazear's sketchy notations he evidently found entries strongly suggesting Lazear's case was not accidental, as officially reported. Unfortunately, the little notebook so crucial to the preparation of the Commission's famous initial paper,The Etiology of Yellow Fever -- A Preliminary Note[5], vanished from Reed's Washington office after his own untimely death in 1902. Still, Lazear's invaluable contribution to the Commission's victory was widely recognized and elicited tributes from many quarters: \"He was a splendid, brave fellow,\" Reed said of his young colleague, \" and I lament his loss more than words can tell; but his death was not in vain- His name will live in the history of those who have benefited humanity.\" [6] \"His death was a sacrifice to scientific research of the highest character,\" stated General Leonard Wood, military Governor of Cuba.[7] \"Your husband was a martyr in the noblest of causes,\" Dr. L. O. Howard wrote to Mabel Lazear, \"and I am proud to have known him. . . . His work contributed towards one of the greatest discoveries of the century, the results of which will be of invaluable benefit to mankind.\"[8] And so they were. Though Lazear's one-year-old son and newborn daughter never knew their father, they grew up in a world liberated -- almost in its entirety -- from the disease that killed him.","[1] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 8 September 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00344001.","Sources:","[2] Military Orders for Walter Reed, James Carroll, Aristides Agramonte, and Jesse W. Lazear, 24 May 1900, Hench Reed Collection, accession number 02019001.\n      [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n      [4] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 15 July 1900, Hench Reed Collection, accession number: 00334001.\n      [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note, Proceedings of the Twenty-eighth Annual Meeting of the American Public Health Association Indianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n      [6] Letter from Walter Reed to Emilie Lawrence Reed, 6 October 1900, Hench Reed Collection, accession number: 02135001.\n      [7] Letter from Leonard Wood to the Adjutant-General, United States Army, November 1900, Hench Reed Collection, accession number: 00375002.\n      [8] Letter from Leland Ossian Howard to Mabel Houston Lazear, 7 February 1901, Hench Reed Collection, accession number: 00388001.","Henry Rose Carter (August 25, 1852 - September 14, 1925) was a prominent physician in the U.S. Public Health Service who was a leading authority in the transmission and control of tropical diseases, particularly yellow fever and malaria. During his long career as a sanitarian, Carter undertook campaigns to investigate and control the spread of tropical diseases in Cuba, the Panama Canal Zone, the Southeastern United States, and Peru.","Like Walter Reed and Jefferson Randolph Kean, Henry Rose Carter was a native Virginian and a graduate of the University of Virginia. Carter obtained a civil engineering degree from Virginia in 1873 and also undertook post-graduate work in mathematics and applied chemistry the next year. Subsequently, however, Carter's interests turned towards medicine, and he completed a medical degree at the University of Maryland in 1879. The same year Assistant Surgeon Carter joined the Marine Hospital Service -- later the United States Public Health Service -- and the young surgeon rose steadily through the ranks, ultimately attaining the position of Assistant Surgeon General in 1915.","Carter's initial assignments with the Hospital Service placed him at the center of the yellow fever maelstrom. In 1879 he was detailed to Memphis and other Southern cities, then in the throes of a second year of devastating epidemics. Here began, as his colleague T. H. D. Griffitts observed, Carter's \"lifelong interest in the epidemiology and control of yellow fever.\"[1] After several years of clinical practice in various Marine hospitals, Carter resumed a direct confrontation with yellow fever when his orders for duty with the Gulf Coast Maritime Quarantine assigned him to Ship Island, Mississippi, in 1888. Here and at subsequent quarantine station postings around the Gulf, he quietly championed a thorough review and rationalization of quarantine policies, with a view toward establishing uniform regulation, more thorough disinfection of vessels, and minimized interference with naval commerce. Crucial to the success of these activities was Carter's attention to the incubation period of yellow fever, which his on-site observations indicated to vary between 5 and 7 days. At the time the official literature stated with far less precision a variance of between 1 and 14 days; Carter's work consequently greatly increased the efficiency and effectiveness of quarantine operations.","Nevertheless, yellow fever continued to menace the temperate coastline of the United States, and Carter ably directed the Health Service's epidemiological control efforts in numerous threatened regions. In conjunction with this sanitary work for the 1898 season, Carter made detailed notes on the development of yellow fever at Orwood and Taylor, Mississippi. The isolation of these communities enabled him to identify more reliably the phenomenon of a delay between the initial cases of yellow fever in a locality and the subsequent appearance of secondary infection -- a delay two to four times longer than the incubation period of the disease in an infected person. Carter called this interval between the primary and secondary cases \"the period of extrinsic incubation,\" and he defined its \"usual limits . . . [as ranging] from ten to seventeen days.\"[2]","Before he was able to publish his conclusions, Carter took the helm of the quarantine service in war-time Cuba. There, in 1900, he met U. S. Army Yellow Fever Commission member Jesse Lazear. Carter had finally arranged for his paper's publication that year in theNew Orleans Medical and Surgical Journal, and gave a draft to Lazear. \"If these dates are correct,\" Carter later recalled Lazear saying, \"it spells a living host.\"[3] The theory of mosquito transmission long advanced by Cuban scientist Carlos J. Finlay began to seem more likely. And indeed it was. The Commission's experiments in 1900-1901 irrefutably proved the mosquito vector and established the extrinsic incubation period at twelve days. Shortly after these successes Reed saluted Carter, \"I know of no one more competent to pass judgment on all that pertains to the subject of yellow fever. You must not forget that your own work in Mississippi did more to impress me with the importance of an intermediate host than everything else put to-gether.\"[4]","Carter's long and distinguished sanitary career took him to the Panama Canal Zone in 1904, where he served as Chief Quarantine Officer and Chief of Hospitals for five years. He undertook detailed investigations and control measures of malaria in North Carolina and elsewhere in the South, and became a founder of the National Malaria Committee. With the support of the Rockefeller Foundation International Health Board, he undertook additional investigation and control measures for yellow fever in Central and South America. His expertise recommended him to the Peruvian government, which named Carter Sanitary Advisor in 1920-1921. Health problems at the end of his life compelled Carter to withdraw from active fieldwork, though he remained a highly valued consultant to the Health Board and a much-beloved and respected teacher for a new generation of sanitarians. Carter closed his career researching and writing the manuscript that his daughter Laura Armistead Carter edited and published posthumously in 1931:Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.[5]","Sources:","[1] T. H. D. Griffitts,Henry Rose Carter: The Scientist and the Man,Southern Medical Journal32 (August 1939) 8: 842.\n      [2] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n      [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n      [4] Letter from Walter Reed to Henry Rose Carter, 26 February 1901, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 02447001.\n      [5] Carter, Henry Rose.Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.Baltimore: The Williams and Wilkins Company, 1931.","Jefferson Randolph Kean (June 27, 1860 - September 4, 1950) was a U.S. Army physician who was a leading authority in sanitation, public health, and tropical diseases. Later in his career, Kean would become widely recognized for his role in organizing and administering medical services for the U.S. armed forces during World War I.","\"He possessed one of the keenest, most scholarly minds I've ever encountered,\" recalled Nobel Prize winner Philip S. Hench of Jefferson Randolph Kean. [1] Kean and Hench shared an abiding interest in the work of the United States Army Yellow Fever Commission -- Kean, as a contemporary and supporter, and Hench, as a scholar and scientist intent on accurate historical documentation. On the advice of yellow fever experiment volunteer John J. Moran, Hench first wrote Kean in 1939. From that initial contact developed a close friendship which would last for the remainder of their lives. Kean entrusted Hench not only with numerous period documents, including original letters, accounts, fever charts, and other items, but also with the freely-given counsel and insight of a trusted friend.","Like Walter Reed and Henry Rose Carter before him, Jefferson Randolph Kean was an alumnus of the University of Virginia, completing the medical program there in 1883. Kean joined the U.S. Army Medical Corps in 1884, and after forty years in the service, retired with the rank of Colonel. Congress awarded him a promotion to Brigadier General, retired, in 1930. The early years of Kean's career passed in medical postings in the American West, and no doubt offered him experiences similar to those of Walter Reed, whom he met not on the frontier, but in Florida in 1896. Kean became an expert in tropical diseases and sanitation during his five-year assignment in the Florida tropics, an expertise which served him well over two terms of service later in Cuba. During the Spanish-American War and subsequent U. S. occupation of Cuba, Kean was Chief Surgeon for the Department of Havana, then Superintendent of the Department of Charities -- from 1898 to 1902. After a four-year interlude as an assistant to the Surgeon General in Washington, D.C., Kean again returned to Cuba as an advisor to the Department of Sanitation from 1906-1909.","Kean himself stated: \"Reed and I were good friends before the Yellow Fever Board came to Cuba in June 1900, and [Reed] located himself at Marianao, 8 miles S. W. of Havana,\" to be within the medical and administrative jurisdiction overseen by Kean. [2] The Chief Surgeon did indeed offer significant assistance, and was an early convert to Carlos Finlay's mosquito theory of transmission, which the Yellow Fever Board's experiments ultimately proved true in the late autumn and winter of 1900-1901. As early as October 13, 1900 -- after the Board's preliminary work, but before the final convincing demonstrations -- Kean issued \"Circular No. 8,\" concerning the latest scholarship on the mosquito vector for disease. [3] The circular contained a set of instructions for the entire command on mosquito eradication. Kean subsequently served as quartermaster and financial administrator for the famous series of yellow fever experiments at Camp Lazear and, for the rest of his life, Kean remained a strong proponent of the Commission's conclusions. He worked tirelessly not only to apply them in the field, but also to accord proper public recognition to the Commission's work.","In addition to his career as a sanitarian, Kean organized the department of military relief of the American Red Cross, and during World War One served as Chief of the U. S. Ambulance Service with the French Army and Deputy Chief Surgeon of the American forces. France named him an Officier de la Légion d'Honneur in recognition for these services. Cuban authorities as well offered Kean recognition with the grand cross of the Order of Merit Carlos J. Finlay, and he received both a Distinguished Service Medal from the United States government and the Gorgas Medal from the Association of Military Surgeons. For a decade after his retirement from active duty, Kean edited this last organization's medical journal,The Military Surgeon, and served on the Surgeon General's editorial board for the multi-volume history of the medical department in World War One. A great-grandson of Thomas Jefferson, Kean also took a seat with the government commission established to build the Jefferson Memorial in Washington, D.C. He held charter membership in the Walter Reed Memorial Association, and remained active in its affairs until his death in 1950.","Sources:","[1] Telegram from Philip Showalter Hench and Mary Hench to Cornelia Knox Kean, September 5, 1950, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 06501173.\n      [2] Letter from Jefferson Randolph Kean to Philip Showalter Hench, October 31, 1939, Hench Reed Yellow Fever Collection, accession number: 06282022.\n      [3] Military Orders to Commanding Officers, October 15, 1900, Hench Reed Yellow Fever Collection, accession number: 02140001.","Philip Showalter Hench (February 28, 1896 - March 30, 1965) was a U.S. physician who in 1950 was awarded the Nobel Prize for Physiology and Medicine for his role in the discovery of the hormone cortisone. In addition to his medical research, Hench spent almost three decades of his life studying the history of the U.S. Army Yellow Fever Commission and became a leading authority in the subject.","Philip Showalter Hench was born in Pittsburgh, Pennsylvania, the son of Jacob Bixler Hench and Clara Showalter. After attending local schools, Hench entered Lafayette College and graduated from the school 1916 with a Bachelor of Arts. Hench completed his medical degree at the University of Pittsburgh in 1920, and subsequently entered a residency program at St. Francis Hospital, Pittsburgh. His association with the Mayo Clinic began in 1921 as a fellow at the institution. Two years later he would become an assistant at the clinic, and then, in 1926, he would be made the head of its Department of Rheumatic Diseases After pursuing post-graduate study in Germany in 1928-1929, Hench obtained a Masters of Science in Internal Medicine at the University of Minnesota in 1931, and a Doctor of Science degree from Lafayette College in 1940. Hench remained for the duration of his career at the Mayo Clinic, where his life-long passion for meticulous research and analysis brought him the Nobel Prize for Physiology and Medicine in 1950, which he shared with Edward C. Kendall and Tadeus Reichstein, for the discovery of cortisone.","The same persistence and determination present in his professional life is also evident in Hench's research on the U. S. Army Yellow Fever Commission's famous experiments. \"As a physician particularly interested in medical history,\" he stated to experiment volunteer John J. Moran in 1937, \"I have been long interested in the story of the yellow fever work in John J. Moran, Ralph C. Hutchison, Havana.\" [1] So began a remarkable odyssey. At the request of his friend Ralph Cooper Hutchison, then president of Washington and Jefferson College, Hench had written Moran to gather information for the dedication of the College's new chemistry building, named for Commission member and former Washington and Jefferson student Jesse W. Lazear. Hench also began a correspondence with another of the yellow fever experiment's original volunteers, John R. Kissinger. Moran's and Kissinger's recollections proved so intriguing that Hench initially offered to edit and publish them. However, in the course of his research Hench discovered that much general information on the topic was inaccurate. Conflicting assertions concerning the participants and unverified claims by medical and governmental authorities in the United States and Cuba -- often politically motivated -- clouded interpretation of the facts. \"May I suggest,\" Moran consequently urged in 1938, \"that a clearing up of the REED-FINLAY-CONQUEST-OF-YELLOW-FEVER, or an effort to do so, on your part, is a task far more pressing than publishing the Kissinger-Moran stories or memoirs.\" [2] Hench resolved to document every aspect of the \"Conquest of Yellow-Fever\" and to write a much needed accurate and comprehensive history.","For the next two decades, Hench tirelessly combed through public archive collections and personal papers in the United States and Cuba. He met and interviewed surviving participants of the experiments and others associated with the project, as well as family members of the Yellow Fever Commission. He sought out physicians and scientists who had worked with the principal players or who had applied the results in the campaign to eradicate yellow fever. He identified and photographed sites associated with the yellow fever story, and he successfully petitioned politicians in the United States and Cuba to commemorate the work. In the process, Hench became the trusted friend and advisor of many of these same individuals, and they, in turn, presented him with much of the surviving original material for safekeeping.","In short, Hench came to be the world's expert on the yellow fever story and the steward of thousands of original letters and documents. His premature death at age 69 found him still hoping to uncover important missing evidence, his book unwritten. Hench's widow Mary Kahler Hench gave his yellow fever collection to the University of Virginia, Walter Reed's alma mater, and this extensive personal archive forms the most detailed and accurate record available on the Conquest of Yellow Fever.","Sources:","[1] Letter from Philip S. Hench to John J. Moran, 6 July 1937, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 03419001.\n      [2] Letter from John J. Moran to Philip S. Hench, 30 October 1938, Hench Reed Yellow Fever Collection, accession number: 03476001.","Materials from the following series were initially deposited at the University of Virginia's Alderman Library. In 1982, they were moved to the Claude Moore Health Sciences Library under the terms of a gift agreement that required the transferral of Mary K. Hench's donation to the library when adequate storage space for the collection could be found there.","Series I. Jesse W. Lazear\n      Series II. Henry Rose Carter\n      Series III. Walter Reed\n      Series IV. Philip Showalter Hench\n      Series V. Maps\n      Series VI. Alphabetical files\n      Series VII. Truby-Kean-Hench\n      Series VIII. Miscellany\n      Series IX. Photographs\n      Series X. Negatives\n      Series XI. Reprints\n      Series XIII. Reed family additions\n      Series XV. Laura Wood","Materials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were initially deposited in the HAM/TMC and were a part of the Philip S. Hench papers. In 1991, the materials were transferred from HAM/TMC to the Claude Moore Health Sciences Library after both repositories agreed that it would be more appropriate to include them in the Philip S. Hench Walter Reed Yellow Fever Collection.","Materials from Series XVI. Edward Hook additions were transferred from the Papers of Dr. Edward Watson Hook, Jr. to the Philip S. Hench Walter Reed Yellow Fever Collection around the late 1990s and early 2000s.","Processed by:\n        Historical Collections Staff","Mary K. Hench's donation arrived in Charlottesville in a number of large crates which were packed much as the collection had been found in Philip Showalter Hench's home in Rochester, Minnesota. Some confusion about Dr. Hench's filing order had been created while the collection was packed for shipping, and thus the Manuscripts Department of the University of Virginia Library found it necessary to perform some sorting and arrangement to make the collection more accessible.","Around 1968, William Bennett Bean was hired by the University of Virginia as a visiting scholar in residence to begin work on a new biography of Walter Reed. Dr. Bean found that the order of the collection was not such that he could readily use it for biographical purposes. He employed a former assistant in the Manuscripts Department, sought and received permission to refile the collection, and had his assistant perform this task. The refiling of the collection had been finished by the fall of 1969, but Bean and his assistant had no time to prepare a finding aid.","In the fall of 1969 Donna L. Purvis of the Manuscripts Department staff began writing the first edition of the collection's finding aid. During this project, Mrs. Purvis found some problems with Dr. Bean's description and arrangement of the collection and felt that it was necessary to reprocess parts of it.","Around 1990 staff members in the Claude Moore Health Sciences Library processed additions to the collection donated by Philip Showalter Hench's son, P. Kahler Hench.","Between 1999 and 2004, the Claude Moore Health Sciences Library digitized a significant portion of the collection and made the digitized files available to users in an online exhibit. During this project, over 8,000 items from the collection were scanned, transcribed, and described at the item level. Metadata for the digitized items was recorded in XML files using the TEI 2 standard.","In 2001, the Claude Moore Health Sciences Library processed additions that had been made to the collection since 1982, excepting the materials donated by P. Kahler Hench. Staff members also processed significant portions of Mary K. Hench's original donation that had not been described in the first edition of the collection finding aid. This work led to the development of a second edition finding aid that was coded in EAD and ingested into the Virginia Heritage database. This finding aid contained both new metadata and metadata that had been migrated from a Microsoft Access file.","In the 2000s the Claude Moore Health Sciences Library processed the materials in Series XV. Edward Hook additions.","In 2009, staff members in the Claude Moore Health Sciences Library processed Box 154 of the collection.","In 2013, staff members in the Claude Moore Health Sciences Library produced a third edition of the finding aid using EAD that merged collection description from four sources (the first edition finding aid, the second edition finding aid, the online exhibit, and the physical collection). When possible, metadata from the existing online exhibit's TEI files and metadata from the second edition finding aid were transformed with XSL and included in the EAD file. However, staff members sometimes found it necessary to create new metadata for the collection. The new finding aid was structured in such a way to facilitate the migration of the collection's digital files and metadata into the University of Virginia's digital repository and make it available to users via the library's online catalog.","The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audio cassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). All of these materials are arranged in 16 series: I. Jesse W. Lazear, II. Henry Rose Carter, III. Walter Reed, IV. Philip Showalter Hench, V. Maps, VI. Alphabetical files, VII. Truby-Kean-Hench, VIII. Miscellany, IX. Photographs, X. Photographic negatives, XI. Reprints, XII. Houston Academy of Medicine/Texas Medical Center additions, XIII. Reed family additions, XIV. P. Kahler Hench additions, XV. Laura Wood, and XVI. Edward Hook additions.","Series I. Jesse W. Lazear consists of materials relating to Lazear that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1800 to 1956 with the bulk of the items dating from 1863 to 1943. Much of the series consists of the correspondence of Jesse W. Lazear and his wife Mabel H. Lazear. Jesse's correspondence dates from his time as a student at Johns Hopkins University to his death in 1900. Researchers can learn a great deal about Jesse from these letters, including his relationships with friends and family, his educational background, and his professional life. Mabel's correspondence dates from the time she met Jesse to her death in 1946. This correspondence primarily concern her husband's historical legacy and a campaign to secure a pension from the U.S. government for herself and her family.","In addition to Jesse and Mabel's correspondence, the series contains other materials relating to them and their families including, but not limited to the following:","the diaries documenting the travels of Jesse and Mabel's mothers in Europe;\n      correspondence of other Lazear family members (e.g. Jesse's parents);\n      genealogical summaries and tables relating to the Lazear family;\n      legal documents (e.g. wills, certificates, deeds);\n      military records relating to Jesse;\n      certificates, reports, and other materials documenting Jesse's educational background and achievements;\n      obituaries;\n      copies of congressional bills and reports concerning the provision of a federal pension for Mabel H. Lazear;\n      newspaper articles;\n      a microscope and sets of microscope slides owned by Jesse;\n      and a medical chart that shows the progression of the yellow fever infection that killed Jesse.","Series II. Henry Rose Carter consists of materials relating to Henry Rose Carter that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1880 to 1932 with the bulk of the materials dating from 1883 to 1932. The series is particularly rich in materials that document Henry Rose Carter's professional activities in the last eleven years of his life (1914-1925). These materials include, but are not limited to the following:","correspondence with colleagues in the medical and scientific community including Rupert E. Blue, Hideyo Noguchi, Henry Hanson, Joseph A. LePrince, Frederick F. Russell, T.H.D. Griffitts, and Lunsford D. Fricks;\n      scientific, medical, and government reports relating to the study and eradication of yellow fever and malaria in North America, South America, and Africa;\n      journal articles concerning the study and eradication of yellow fever and malaria;\n      research notes written by Henry Rose Carter;\n      and photographs of Henry Rose Carter at work and with professional colleagues.","Series II. also contains correspondence between Henry Rose Carter and members of his family that date from 1880 to 1925. The family members with whom Henry corresponds most frequently in this series are his mother, Emma Coleman Carter; his wife, Laura Eugenia Hook Carter; his daughter, Laura Armistead Carter; and his son, Henry Rose Carter, Jr. These letters are not only a rich source of information about Carter's personal views and family life, they also provide valuable insights into his professional activities such as his experiences aboard vessels and in ports while working for the U.S. Marine Hospital Service and his public health work in Cuba, Panama, and Peru.","In addition to the materials that were produced during Henry Rose Carter's lifetime, the Series II. contains materials that were produced between 1925 and 1940 (after Henry Rose Carter's death) including, but not limited to the following:","copies of obituaries for Henry Rose Carter;\n      condolence letters for Henry Rose Carter's family after Henry's death;\n      and the correspondence of Laura Armistead Carter relating to her father and other members of the Carter family.","Series III. Walter Reed consists of materials that document the life of Walter Reed as well as the work and legacy of the U.S. Army Yellow Fever Commission. Items in the series date from 1806 to around 1955 with the bulk of the items dating from 1874 to 1936. The series is particularly rich in materials that document the professional and personal life of Walter Reed from 1874 to his death in 1902. These materials include, but are not limited to the following:","correspondence between Walter Reed and members of his immediate family that cover a wide range of topics including Reed's courtship of Emilie Lawrence Reed, family life, Walter Reed's work in the Western United States, and Walter Reed's work in Cuba;\n      military records relating to Walter Reed including military orders for Reed, Reed's performance reviews, and reports of Reed's work for army officials;\n      Walter Reed's correspondence with professional colleagues including members of the U.S. Army Yellow Fever Commission, military doctors, and medical researchers interested in the study of yellow fever;\n      medical records (e.g. fever charts of experiment participants), military orders, administrative records, reports, and publications documenting the results of the U.S. Army Yellow Fever Commission's experiments in Cuba;\n      articles announcing the death of Walter Reed;\n      and the shoulder boards from Walter Reed's U.S. Army uniform.","In addition to the above items, Series III. contains materials that document campaigns, spanning from 1902 to 1937, to publicly honor members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments. These materials include, but are not limited to the following:","articles and editorials relating to efforts to memorialize and provide pensions for members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments;\n      biographical sketches of members of the U.S. Army Yellow Fever Commission and experiment participants;\n      records relating to the Walter Reed Memorial Association (e.g. correspondence, donor lists);\n      copies of Congressional bills and resolutions to honor members of the U.S. Army Yellow Fever Commission and experiment participants;\n      and letters, reviews, and other materials relating to the production of Sidney Coe Howard's play,Yellow Jack.","Finally, Series III. also consists of materials that document the history of yellow fever during the nineteenth and early twentieth century. These materials include, but are not limited to the following:","items (e.g. correspondence, reports, reviews, and articles) relating to U.S. efforts to eradicate yellow fever in the Panama Canal Zone;\n      materials (e.g. correspondence, reports, and articles) documenting early twentieth century efforts to eradicate yellow fever in Peru;\n      scientific reports and publications related to the study and eradication of yellow fever and malaria;\n      and newspaper articles describing various outbreaks of yellow fever epidemics.","Series IV. Philip Showalter Hench primarily consists of materials that Hench created or collected while researching the U.S. Army Yellow Fever Commission. Items in this series date from around 1850 to around 1865 with the bulk of the items dating from 1937 to 1960. Researchers who are studying the yellow fever experiments will be particularly interested in the materials (e.g. interviews, autobiographies) that document first-hand accounts of the events surrounding the experiments. Other researchers may be interested in items that document Hench's role in shaping public memory of the commission and its experiments. The materials in this series include, but are not limited to the following:","Hench's correspondence and interviews with participants in the yellow fever experiments and their families including: Emilie Lawrence Reed, Emilie M. (Blossom) Reed, Walter Lawrence Reed, John J. Moran, Albert E. Truby, Jefferson Randolph Kean, John H. Andrus, and John R. Kissinger;\n      autobiographical accounts of the experiment's participants and their families;\n      notes, reports, correspondence and other materials relating to Hench's search for the original site of Camp Lazear in Cuba;\n      correspondence with Cuban government officials and members of the scientific community relating to Hench's campaign to build a Camp Lazear memorial;\n      correspondence and other materials relating to ceremonies honoring Jesse W. Lazear at Washington and Jefferson College;\n      newspaper articles, magazine articles, and other printed matter concerning the yellow fever experiments and its participants;\n      drafts of speeches and presentations Hench gave on the history of the yellow fever experiments to various audiences;\n      meeting minutes and other materials that document Hench's relationship with and participation in the Walter Reed Memorial Association;\n      scripts for radio programs relating to the yellow fever experiments;\n      notes, outlines, lists, correspondence, and other materials that document Hench's research about the yellow fever experiments and a book he had planned to write on the subject;\n      and the gold medal that Congress posthumously awarded to Walter Reed for his work with yellow fever.","Series V. Maps primarily consists of maps and floor plans that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1960 with the bulk of the items dating from 1899 to 1951. The maps and floor plans often include annotations and illustrate a wide range of locations including, but not limited to the following:","Havana and its environs;\n      Cuba;\n      sites associated with the yellow fever experiments;\n      and military installations in the United States.","In addition to the maps and floor plans, Series V. also consists of a few newspaper and magazine clippings that contain information relating to the yellow fever experiments.","Series VI. Alphabetical files primarily consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1860 to around 1966 with the bulk of the items dating from 1940 to 1956. All of these items have been arranged thematically into biographical files. Each file contains materials created by or relating to people who were either involved with the yellow fever experiments or aided Philip Showalter Hench in his research of the subject. These people include, but are not limited to: John J. Moran, Carlos E. Finlay, Laura Wood Roper, Mabel Lazear, Clara Maas, John R. Kissinger, Roger Post Ames, James C. Carroll, and Carlos J. Finlay. The files are arranged alphabetically by the last names of the individuals listed on the files and it is unclear whether the overall arrangement was made by Hench or by staff members at the University of Virginia. The biographical files contain a wide range of different materials that pertain to the individuals listed on the files. These materials include, but are not limited to the following:","correspondence between Philip Showalter Hench and the individuals;\n      other correspondence;\n      newspaper and magazine clippings;\n      unpublished manuscripts;\n      biographical and autobiographical accounts;\n      transcripts of oral history interviews that were conducted by Philip Showalter Hench;\n      and copies of medical charts for volunteers in the yellow fever experiments that shows the progression of the disease.","In addition to the materials that Hench created or collected during his lifetime, the biographical files in Series VI. also contain items that were added by staff at the University of Virginia Library during the late 1960s and early 1970s.","Series VII. Truby-Kean-Hench primarily consists of materials relating to Albert E. Truby and Jefferson Randolph Kean that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1879 to around 1960 with the bulk of the items dating from 1900 to 1954. These items include, but are not limited to the following:","correspondence of Jefferson Randolph Kean dating from 1900 to 1950 that relates to his personal life, the yellow fever experiments, public health initiatives, his publications, the legacy of the yellow fever experiments, Kean's work in World War I, and other topics;\n      Philip Showalter Hench's correspondence with people related to the yellow fever experiments, particularly Albert E. Truby and Jefferson Randolph Kean primarily from between 1940 and 1955;\n      a scrapbook and other materials that relate to Truby's book,Memoir of Walter Reed: the Yellow Fever Episode;\n      and Philip Showalter Hench's interviews and questionnaires for Kean and Truby from the 1940s.","In addition to the materials relating to Kean and Truby, Series VII. also includes the following:","notes from Philip Showalter Hench's research of the yellow fever experiments;\n      the recollections, autobiographies, and reports of other people involved with the yellow fever experiments including John Andrus and A.S. Pinto;\n      articles and clippings related to the yellow fever experiments;\n      a short biography of Lemuel S. Reed;\n      and a sketch Philip Showalter Hench made of a proposed museum at the Camp Lazear site.","Series VIII. Miscellany consists of oversize and miscellaneous materials in the Philip S. Hench Walter Reed yellow fever collection that were, for various reasons, not included in any of the other series in the collection. Items in this series date from around 1849 to 1982 with the bulk of the materials dating from 1885 to 1974. These materials include, but are not limited to the following:","informed consent agreements for volunteers in the yellow fever experiments;\n      diplomas and certificates for Walter Reed and Jesse W. Lazear;\n      copies and sketches of Dean Cornwell's painting,Conquerors of Yellow Fever;\n      artifacts, including a wooden board from Camp Lazear and a U.S. flag;\n      copies of correspondence, reports, medical records, and military orders from the U.S. National Archives relating to the yellow fever experiments;\n      manuscripts and related notes for published works and research relating to Walter Reed and the yellow fever experiments;\n      correspondence of Philip Showalter Hench from circa 1940 to 1966;\n      articles and clippings relating to the yellow fever experiments, the experiments' participants, and the Philip S. Hench Walter Reed yellow fever collection;\n      correspondence of Atcheson Laughlin Hench and members of the University of Virginia community relating to the Philip S. Hench Walter Reed yellow fever collection;\n      items that document the provenance and custodial history of some materials in the Philip S. Hench Walter Reed yellow fever collection;\n      photographs relating to Cuba and the yellow fever experiments;\n      notes for photographs and photographic negatives housed in Series IX. and Series X. of this collection.","Series IX. Photographs consists primarily of photographs that Philip Showalter Hench created and collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1966 with the bulk of the items dating from around 1870 to around 1960. The subjects shown in the photographs include, but are not limited to the following:","physicians, military personnel, nurses, and volunteers associated with the experiments including Walter Reed, Jesse W. Lazear, Jefferson Randolph Kean, and Aristides Agramonte;\n      family members of people associated with the yellow fever experiments including their spouses, children, and grandchildren.\n      Camp Lazear, Camp Columbia, and other locations in Cuba related to the yellow fever experiments between 1900 and 1960;\n      the U.S.S.Maineand the Spanish-American War;\n      aerial views of Havana, Cuba and its environs from the 1940s and 1950s;\n      scenes of daily life in Cuba generally from between 1898 and 1960;\n      the 1952 dedication of the Camp Lazear National Monument in Cuba;\n      the creation and unveiling of Dean Cornwell's painting,Conquerors of Yellow Fever;\n      still scenes from the movies,Yellow JackandJezebel;\n      other events and works of art commemorating the work of the participants in the yellow fever experiments;\n      documents and maps that Philip Showalter Hench copied for his research;\n      and Philip Showalter Hench and his family.","Series IX. also includes a watercolor that was painted by Emilie Lawrence Reed.","Series X. Photographic negatives consists of a mix of original and copy negatives that Philip Showalter Hench collected while researching the yellow fever experiments. Although the original images recorded on the negatives date from between the 1860s and the 1960s, it appears that the negatives themselves were produced during a narrower time frame, most likely between 1930 and 1966.","The negatives in Series X. record images associated with the yellow fever experiments and many of them are related to photographic prints found in Series VIII. Where a match between a negative and a print from these series has been made, the negative number has been written on the folder of the print in the physical collection. Finally, the negatives are generally arranged in numerical order by identification numbers that were most likely assigned by Philip Showalter Hench.","Series XI. Reprints consists of reprints and photocopies of journal articles, book extracts, book reviews and other published works that were primarily collected by Philip Showalter Hench while researching the yellow fever experiments. Items in this series date from 1856 to 1971 and cover a wide range of topics related to the study and eradication of yellow fever, including, but not limited to the following:","the results of the U.S. Army Yellow Fever Commission's work in Cuba;\n      biographical accounts of various people who had an association with the yellow fever experiments;\n      the research of people associated with the experiments including Walter Reed, Jesse W. Lazear, Aristides Agramonte, and James Carroll;\n      scientific and medical research related to yellow fever and malaria;\n      and events honoring the work of those involved with the yellow fever experiments.","Series XII. Houston Academy of Medicine/Texas Medical Center additions consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1901 to around 1966. These materials were originally a part of the Philip S. Hench papers in the John P. McGovern Historical Collections and Research Center at the Texas Medical Center Library, but they were transferred to the University of Virginia in 1991. These items include, but are not limited to the following:","correspondence between Philip Showalter Hench and people connected with the yellow fever experiments including John J. Moran and Walter Reed's children;\n      newspaper clippings relating to the death or commemoration of individuals associated with the yellow fever experiments;\n      photographs of the Camp Lazear Memorial, everyday scenes in Cuba, and John J. Moran;\n      and journal articles, booklets, and other printed matter relating to the yellow fever experiments and its participants.","Series XIII. Reed family additions consists of materials relating to the yellow fever experiments that several different donors gave to the University of Virginia. Items in the series date from around 1850 to 1967 with the bulk of the items dating from 1868 to 1949. The largest portion of the series is comprised of correspondence written by Walter Reed and his family between 1877 and 1902 that provide insights into their relationships and personal lives.","In addition to the Reed family's correspondence, the series also contains other materials relating to the Reed family and the yellow fever experiments including, but not limited to the following:","a flag that was flown over Camp Lazear;\n      newspaper clippings and articles relating to the yellow fever experiments;\n      a chemistry notebook that was owned by Walter Reed;\n      correspondence of and works by Philip Showalter Hench;\n      an inventory of materials in Series XIII. and information about their accession into the Claude Moore Health Sciences Library;\n      and materials from an exhibit on the yellow fever experiments that was hosted in Alderman Library at the University of Virginia.","Series XIV. P. Kahler Hench additions consists of original and photocopied materials that Philip Showalter Hench's son, P. Kahler Hench, donated to the University of Virginia in 1988 and 1989. Items in the series date from around 1860 to 1965 with the bulk of the materials dating from 1898 to 1965. Most of these items were collected or created by Philip Showalter Hench while researching the yellow fever experiments. These items include the following:","the correspondence of experiment participants;\n      correspondence between Philip Showalter Hench and the experiment participants;\n      correspondence between Philip Showalter Hench and families of the experiment participants;\n      press clippings relating to the experiments and the experiment participants;\n      oral history interviews conducted by Philip Showalter Hench;\n      scientific articles related to the study of yellow fever;\n      photographs of Havana, Camp Columbia, and Camp Lazear;\n      genealogical tables and summaries for the family of Jesse W. Lazear;\n      autobiographical accounts written by experiment participants;\n      unpublished manuscripts;\n      artifacts (e.g. a wooden board) from Camp Lazear;\n      Philip Showalter Hench's research notes.","Series XIV. also contains correspondence and financial records that record the transfer of collection items from the Reed family to Philip Showalter Hench and later from the Hench family to the University of Virginia.","Series XV. Laura Wood primarily consists of Laura Wood's correspondence relating to her research for a Walter Reed biography that she wrote. The series also includes, but is not limited to the following materials:","photocopies of two letters written by Walter Reed;\n      a journal article by George Sternberg;\n      and a short work that Laura Wood wrote about Walter Reed entitled,Walter Reed and yellow Fever.","Items in Series XV. date from 1875 to 1946 with the bulk of the items dating from 1941 to 1946.","Series XVI. Edward Hook additions consists of copies of letters, articles, and photographs relating to the yellow fever experiments that had been collected by Edward W. Hook, Jr, a professor of medicine at the University of Virginia. The bulk of this series is comprised of copies of a small collection of James Carroll's correspondence. The original versions of Carroll's correspondence are not housed at the University of Virginia. In addition to the Carroll letters, this series also includes, but is not limited to the following:","photographs of Walter Reed and others related to the yellow fever experiments;\n      copies of some of Theodore E. Woodward's works relating to James Carroll and yellow fever;\n      and exhibition materials.","Items in Series XVI. date from around 1880 to around 1998 with the bulk of the items dating from 1898 to 1901.","Copyright restrictions may apply for some materials in the collection.","The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audiocassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). Most of the materials in the collection were collected or created by Nobel laureate Philip Showalter Hench while researching the history of the U.S. Army Yellow Fever Commission.","Claude Moore Health Sciences Library","Collection is predominantly in English; other materials in the collection are in Spanish, French, and Portuguese."],"collection_title_tesim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"collection_ssim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"level_ssm":["collection"],"level_ssim":["Collection"],"unitid_ssm":["MS.1","Archival Resource Key","/repositories/7/resources/1710"],"unitid_tesim":["MS.1","Archival Resource Key","/repositories/7/resources/1710"],"repository_ssm":["University of Virginia, Special Collections Dept."],"repository_ssim":["University of Virginia, Special Collections Dept."],"creator_corpname_ssim":["Claude Moore Health Sciences Library"],"creators_ssim":["Claude Moore Health Sciences Library"],"access_terms_ssm":["Copyright restrictions may apply for some materials in the collection."],"acqinfo_ssim":["Materials from the following series were donated to the University of Virginia's Alderman Library in the fall of 1966 and the summer of 1970 by Philip Showalter Hench's widow, Mary Kahler Hench, with the approval of his estate:","Series I. Jesse W. Lazear\n      Series II. Henry Rose Carter\n      Series III. Walter Reed\n      Series IV. Philip Showalter Hench\n      Series V. Maps\n      Series VI. Alphabetical files\n      Series VII. Truby-Kean-Hench\n      Series VIII. Miscellany\n      Series IX. Photographs\n      Series X. Negatives\n      Series XI. Reprints","Materials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were donated to the HAM/TMC by Philip Showalter Hench as a small part of a larger collection of materials.","Materials from Series XIII. Reed family additions were donated by various individuals to Alderman Library between 1947 and 1972. Box 139, Folder 1 contains a list that describes each of these donations in detail.","Materials from Series XIV. P. Kahler Hench were donated to the Claude Moore Health Sciences Library by Philip Showalter Hench's son, P. Kahler Hench, in 1988 and 1989.","Materials from Series XV. Laura Wood were most likely donated to Alderman Library between 1972 and 1982.","Materials from Series XVI. Edward Hook additions were donated to the Claude Moore Health Sciences Library as a part of the Papers of Dr. Edward Watson Hook, Jr."],"access_subjects_ssim":["Human Experimentation","Military Medicine","Physicians","Public health","Tropical medicine","Yellow Fever"],"access_subjects_ssm":["Human Experimentation","Military Medicine","Physicians","Public health","Tropical medicine","Yellow Fever"],"has_online_content_ssim":["false"],"extent_ssm":["67 Linear Feet 154 boxes"],"extent_tesim":["67 Linear Feet 154 boxes"],"date_range_isim":[1800,1801,1802,1803,1804,1805,1806,1807,1808,1809,1810,1811,1812,1813,1814,1815,1816,1817,1818,1819,1820,1821,1822,1823,1824,1825,1826,1827,1828,1829,1830,1831,1832,1833,1834,1835,1836,1837,1838,1839,1840,1841,1842,1843,1844,1845,1846,1847,1848,1849,1850,1851,1852,1853,1854,1855,1856,1857,1858,1859,1860,1861,1862,1863,1864,1865,1866,1867,1868,1869,1870,1871,1872,1873,1874,1875,1876,1877,1878,1879,1880,1881,1882,1883,1884,1885,1886,1887,1888,1889,1890,1891,1892,1893,1894,1895,1896,1897,1898,1899,1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935,1936,1937,1938,1939,1940,1941,1942,1943,1944,1945,1946,1947,1948,1949,1950,1951,1952,1953,1954,1955,1956,1957,1958,1959,1960,1961,1962,1963,1964,1965,1966,1967,1968,1969,1970,1971,1972,1973,1974,1975,1976,1977,1978,1979,1980,1981,1982,1983,1984,1985,1986,1987,1988,1989,1990,1991,1992,1993,1994,1995,1996,1997,1998],"accessrestrict_html_tesm":["\u003cp\u003eThere are no restrictions on user access to any of the materials in the collection except where noted in the container list.\u003c/p\u003e  "],"accessrestrict_heading_ssm":["Access"],"accessrestrict_tesim":["There are no restrictions on user access to any of the materials in the collection except where noted in the container list."],"arrangement_html_tesm":["\u003cp\u003eThe Philip S. Hench Walter Reed Yellow Fever Collection is organized in 16 series:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003eI. Jesse W. Lazear\u003c/item\u003e\n      \u003citem\u003eII. Henry Rose Carter\u003c/item\u003e\n      \u003citem\u003eIII. Walter Reed\u003c/item\u003e\n      \u003citem\u003eIV. Philip Showalter Hench\u003c/item\u003e\n      \u003citem\u003eV. Maps\u003c/item\u003e\n      \u003citem\u003eVI. Alphabetical files\u003c/item\u003e\n      \u003citem\u003eVII. Truby-Kean-Hench\u003c/item\u003e\n      \u003citem\u003eVIII. Miscellany\u003c/item\u003e\n      \u003citem\u003eIX. Photographs\u003c/item\u003e\n      \u003citem\u003eX. Photographic negatives\u003c/item\u003e\n      \u003citem\u003eXI. Reprints\u003c/item\u003e\n      \u003citem\u003eXII. Houston Academy of Medicine/Texas Medical Center additions\u003c/item\u003e\n      \u003citem\u003eXIII. Reed family additions\u003c/item\u003e\n      \u003citem\u003eXIV. P. Kahler Hench additions\u003c/item\u003e\n      \u003citem\u003eXV. Laura Wood\u003c/item\u003e\n      \u003citem\u003eXVI. Edward Hook additions\u003c/item\u003e\n    \u003c/list\u003e\n  "],"arrangement_heading_ssm":["Organization of the Collection"],"arrangement_tesim":["The Philip S. Hench Walter Reed Yellow Fever Collection is organized in 16 series:","I. Jesse W. Lazear\n      II. Henry Rose Carter\n      III. Walter Reed\n      IV. Philip Showalter Hench\n      V. Maps\n      VI. Alphabetical files\n      VII. Truby-Kean-Hench\n      VIII. Miscellany\n      IX. Photographs\n      X. Photographic negatives\n      XI. Reprints\n      XII. Houston Academy of Medicine/Texas Medical Center additions\n      XIII. Reed family additions\n      XIV. P. Kahler Hench additions\n      XV. Laura Wood\n      XVI. Edward Hook additions"],"bioghist_heading_ssm":["Historical Information for the U.S. Army Yellow Fever Commission","Biographical Information for Walter Reed","Biographical Information for Jesse W. Lazear","Biographical Information for Henry Rose Carter","Biographical Information for Jefferson Randolph Kean","Biographical Information for Philip Showalter Hench"],"bioghist_tesim":["The U.S. Army Yellow Fever Commission (1900-1901) was a board of physicians that the U.S. government formed in order to determine how yellow fever was transmitted between hosts. Ultimately, the commission's experiments in Cuba proved that mosquitoes transmit yellow fever--a discovery that would spur successful campaigns to control and eradicate yellow fever throughout much of the globe.","When Major Walter Reed and Acting Assistant Surgeons James Carroll, Aristides Agramonte, and Jesse Lazear gathered on the porch of the Columbia Barracks Hospital in June of 1900, they became the fourth successive board of U.S. medical officers to grapple with the appalling plague that was yellow fever.","The persistence of this disease across the Cuban archipelago and its periodic re-emergence along the coastlines and great river drainages of the Americas was taking countless thousands of lives. Lack of precise knowledge as to its cause and transmission had augmented yellow fever's extraordinarily high mortality rate and had given rise to quarantine regulations which constituted substantial impediments to efficient regional trade. Endemic in the tropics, yellow fever imposed high humanitarian and economic costs upon the entire region. Specialists regarded Cuba as one of the principal foci of the disease, and the island consequently attracted considerable attention from the medical sciences.","In 1879, one year after a devastating epidemic swept up the Mississippi valley from New Orleans, Tulane University Professor Stanford E. Chaille led the first investigatory commission to Havana, Rio de Janeiro, and the West Indies. The Chaille Commission remained in Havana three months, and its members -- including George Miller Sternberg, who became Surgeon General of the Army, and Juan Guiteras, later Director of Public Health for Havana -- consulted with Cuban scientist Carlos J. Finlay. They concluded that the causal agent for yellow fever was possibly a living entity in the atmosphere, an assertion which set Finlay on the path to the mosquito theory he developed in 1881.","Louis Pasteur's foundational and highly successful work in modern immunology in 1880 and 1881 gave a renewed impetus to investigations aimed at discovering the \"yellow fever germ.\" Over the middle years of the 1880s several scientists advanced different theories, all readily refuted by bacteriological work Sternberg undertook in Brazil and Mexico in 1887 and again in Havana in 1888 and 1889. In 1897, Italian scientist Giuseppe Sanarelli argued thatBacillus icteroideswas the culprit, and the following year a third scientific team sailed to Cuba for additional tests. Eugene Wasdin and Henry D. Geddings appeared to confirm Sanarelli's assertion, though Sternberg, by then Surgeon General, remained skeptical.","Despite Wasdin and Geddings' insistence, theB. icteroidestheory garnered significant opposition. In fact, a few months before the third commission's report reached the public, Walter Reed and James Carroll -- Reed's assistant at the Columbian University (later George Washington University) bacteriology laboratories in Washington, D.C. -- published a thorough refutation of theicteroidesproposal: the bacteria was not a unique cause of yellow fever, but a variety of the hog cholera bacillus, \"a secondary invader in yellow fever,\" Reed determined, unrelated to its etiology. [1] Dispute continued, however, and when Sternberg organized the fourth investigatory board, he charged Reed and his associates to settle theB. icteroidesquestion once and for all, then to proceed with analysis of other blood cultures and intestinal flora from yellow fever cases.","Reed and Carroll had considerable experience in bacteriological analysis, and, Sternberg reasoned, might well be able to find the specific agent of the disease. Aristides Agramonte, a Cuban scientist who had worked in Reed's lab at the Columbian University in 1898, was also an accomplished bacteriologist; he had identifiedB. icteroidesin tissue samples from cases other than yellow fever, providing further evidence opposed to Sanarelli's thesis. Jesse Lazear, a scientist from Johns Hopkins University in Baltimore, Maryland, had joined the Army Medical Corps to study tropical diseases at their point of origin; he received orders for Cuba in February 1900. Lazear impressed Reed with his abilities when the two men became acquainted in March. No doubt with Reed's advice, Sternberg assembled a crack team -- all experienced in scientific research, but each with interests as diverse as their temperaments. The mix of talent and personalities generated spectacular results.","What causes yellow fever? This simple, even obvious question had dictated yellow fever research for over two decades, and so it guided Reed in organizing the work of the commission.Bacillus icteroidesand other bacteriological sampling dominated their work for the first months. \"Reed and Carroll have been at that for a long time,\" Lazear wrote with some impatience to his wife on August 23, \". . . I would rather try to find the germ without bothering about Sanarelli.\" [2] Again and again, tests for the bacteria proved negative, and at the same time, perplexing cases of yellow fever were developing in the region. Agramonte and Reed investigated an epidemic at Pinar del Rio, 110 miles southwest of Havana; Lazear followed later to collect more specimens, and he also assessed the situation at Guanjay thirty miles southwest. To \"my very great surprise,\" Reed admitted, the specific circumstances of the appearance and development of these cases gave strong evidence against the widely-accepted notion that the excreta of patients spread the disease. The theory of fomites -- infection from contaminated clothing and bedding -- and indeed even infection from airborne particles seemed altogether untrue. \"At this stage of our investigation,\" Reed concluded, \". . . the time had arrived when the plan of our work should be radically changed.\" [3] The fundamental question underwent a subtle but critical transformation: from what causes yellow fever to what transmits it. A clear and accurate understanding of how the disease was spread would open a new avenue to its specific cause.","\"Personally, I feel that only can experimentation on human beings serve to clear the field for further effective work,\" Reed stated to Surgeon General Sternberg, who concurred. [4] Evidence gathering around them pointed strongly to an intermediate host, and the Commission resolved to test Carlos Finlay's mosquito theory -- then not generally accepted -- on human volunteers. Nine times from August 11 to August 25, 1900, mosquitoes landed on the arms of volunteers and proceeded to feed. Nine times the results were negative. On August 27, Lazear placed a mosquito on the doubting Dr. Carroll, and four days later on William J. Dean, a soldier designated XY in the \"Preliminary Note.\" [5] Both promptly developed yellow fever. Significantly, their mosquitoes had fed on cases within the initial three days of an attack and had been allowed to ripen for at least twelve days before the inoculations. Carroll vitiated the results of his experimental sickness by traveling off the post to Havana, a contaminated zone, even as Reed, ecstatic, wrote from Washington in a confidential letter: \"Did the Mosquito do it?\" [6] Dean's case seemed to prove it, since he claimed not to have left the garrison before becoming ill. Lazear also developed a case of yellow fever, almost certainly experimental in origin, though he never revealed the actual circumstances of his inoculation. His severe bout of fever took a fatal turn on September 25, 1900.","Nevertheless, these results could not have been more dramatic or convincing for the Commission. Reed quickly assembled a \"Preliminary Note,\" which he presented to the annual meeting of the American Public Health Association in Indianapolis, Indiana, October 23, 1900. After initial consultations in Cuba with General Leonard Wood, military governor of the island, and with Surgeon General Sternberg in Washington, he returned to Cuba with authorization and funding to design and carry forward a fully defensible series of experiments. His aim was confirmation of the mosquito theory and invalidation of the long-held belief in fomites.","On open terrain beyond the precincts of Columbia Barracks -- the American military base just west of Havana near the adjacent suburban towns of Quemados and Marianao (also called Quemados de Marianao) -- Reed established the quarantined experimental station. Camp Lazear, as the Commission dedicated it, took form in the rolling fields of the Finca San Jose, on the farm of Dr. Ignacio Rojas, who leased the land to the Americans. Here Reed designed two small wood-frame buildings, each 14 by 20 feet, for the experimental work, and nearby raised a group of seven tents for the accommodation and support of the volunteers. The buildings faced each other across a small swale, about 80 yards apart, and stood 75 yards from the tent encampment. Building Number One, called the Infected Clothing Building, was a single room tightly constructed to contain as much foul air as possible. A small stove kept the temperature and humidity at tropical levels, and carefully attached screening secured the pair of doorways in a vestibule against intrusion by mosquitoes. Wooden blinds on two small sealed windows shielded the room from direct sun. Building Number Two, the Infected Mosquito Building, contained a principal room, divided into two sections by a floor-to-ceiling wire mesh screen. A door direct to the exterior let into one section, while a vestibule with a solid exterior door and pair of successive screened doors opened to the other, so configured to keep infected mosquitoes inside that section alone. The spare furnishings in both sections -- cots with bedding -- were steam sterilized. Windows exposed the entire room to the clean, steady ocean breezes and to sunlight. Like the doorways, they were carefully screened. A secondary room attached to the building but not communicating with the experimental spaces sheltered the small, heated laboratory where the Commission members raised and stored the mosquitoes to be used.","These two experimental buildings presented alternate environments -- one conspicuously clean and well ventilated, the other filthy and fetid. Contemporary theories of disease held that yellow fever developed in unclean conditions, and consequently much time and money had been devoted to sanitation projects. Workers steamed clothing, burned sulphur in ships' holds, and thoroughly scrubbed surfaces with disinfectant. In cases of severe epidemic, entire buildings presumed to be infected were set afire along with their contents. Thus the extraordinary -- and intentional -- paradox of the Commission's experimental regime: Reed expected yellow fever to develop not in the unsanitary environment, but in the one thought to be most healthful.","Camp Lazear went into quarantine the day of its completion, November 20, 1900, with a command of four immune and nine non-immune individuals, all save one U.S. Army personnel. Soon a group of recent Spanish immigrants to Cuba augmented the non-immune numbers, bringing the resident total to about twenty. Reed strictly controlled access to the camp and ordered regular temperature recording for each volunteer to eliminate any unanticipated source of infection and to identify the onset of any case of yellow fever as early as possible. As a result, non-immunes were barred from returning should they leave the precinct, and two of the Spaniards who developed intermittent fevers shortly after arrival were immediately transferred with their baggage to Columbia Barracks Hospital. The immune members of the detachment oversaw medical treatments and drove the teams of mules that pulled supply wagons and the ambulance. Experimentation did not begin until each volunteer had passed the incubation period for yellow fever in perfect health.","Reed took as much care with the design of the experimental protocol as he had with the configuration of the camp and its buildings. Each evening, the occupants of the infected clothing building unpacked trunks and boxes of bed linens and blankets, nightshirts and other clothing recently worn and soiled by cases from the wards of Columbia Barracks Hospital and Las Animas Hospital in Havana. These they shook out and spread around the room to permeate the atmosphere. The stench was overpowering. Yellow fever causes severe internal hemorrhaging, and its unfortunate victims often suffer from black vomit and other bloody discharges. One routine delivery proved so putrid the volunteers \"retreated from the house,\" Reed stated. \"They pluckily returned, however, within a short time, and spent the night as usual.\" [7] In two succeeding trials the protocol became progressively more daring , as the volunteers then wore the clothing and slept on the mattresses used by yellow fever patients, and finally put towels on their bedding smeared with blood drawn from cases in the early stages of an attack. Each morning, the volunteers carefully repacked the rank, encrusted materials into boxes and emerged to an adjacent tent where they spent the day quarantined from the rest of the company. Three trials of twenty days each involved seven men altogether, lead by Robert P. Cooke, a physician in the Army Medical Corps. None developed yellow fever.","The Commission's mosquito experiments proceeded in four series. First, Reed sought to demonstrate that mosquitoes of the varietyCulex fasciata(later calledStegomyia fasciata, and later stillAedes aegypti) could in fact transmit yellow fever, as Carlos J. Finlay had argued and the initial experiments at Camp Columbia strongly suggested. Here the Commission members simply applied infected mosquitoes contained in test tubes or jars to the skin of the initial volunteers. Success in these tests raised a number of questions, each one addressed in the subsequent series:","How could a building become infected?\n      When does a mosquito develop the ability to transmit the disease?\n      Over what length of time can a mosquito retain this capacity to infect?","The second series consequently employed the specialized \"Infected Mosquito Building\" to indicate how a structure could be considered infected with yellow fever. This experiment required two groups of volunteers, one to be inoculated and another to serve as controls. \"Loaded\" mosquitoes, as the men called them, were released into the screened section of Building Two -- on the side with the protected vestibule entry. One or more non-immune men then entered the opposite section of the room through the direct exterior door, and lay down on bunks adjacent to the wire mesh screen in the center of the room. Now the young man to be inoculated walked through the vestibule into the mosquito side of the room and proceeded to lie on a bunk adjacent to the wire screen separating him from the controls. The inoculation volunteer remained in the building for about twenty minutes -- enough time to suffer several mosquito bites -- he then exited to a quarantine tent outside. The controls spent the remainder of the evening and night in the uninfected side of the room, and indeed returned to sleep in the room for as many as eighteen more nights. As Reed stated, absence of yellow fever in the controls showed \"that the essential factor in the infection of a building with yellow fever is the presence therein of [infected] mosquitoes,\" and nothing more. [8] The degree of sanitation, so long considered critical, was utterly irrelevant.","The third series of mosquito experiments confirmed what Henry Rose Carter, of the U.S. Public Health Service, called the \"period of extrinsic incubation,\" [9] the length of time required for secondary cases of yellow fever to develop after an initial intrusion of the disease into a locality. In this series, a single volunteer underwent three successive inoculations by the same mosquitoes, each group of inoculations interrupted by a period of time equal in length to the typical incubation period of the disease in humans, about five days. In this manner, the volunteer's illness could be specifically attributed to a single inoculation group. The use of the same mosquitoes and the same volunteer concurrently demonstrated that no peculiar personal immunity was at play, since logic dictates that a person susceptible to yellow fever on day 17 of a mosquito's contamination -- as happened in the experiment -- could not have been immune to yellow fever on day 11 or day 4. It was thus only the mosquito's capacity to infect which changed, and that occurred no less than 11 days after contamination.","The duration of time over which these \"fully ripened\" mosquitoes remained infective comprised the fourth series of experiments. For this series the Commission kept alive a group of infected mosquitoes for as long as possible, and proceeded to inoculate three volunteers -- on the 39th, 51st, and 57th day after contamination. Each developed yellow fever. A fourth volunteer declined to be bitten on day 65, and the last two mosquitoes of the group, \"deprived of further opportunity to feed on human blood\" [10] expired on day 69 and day 71, clear evidence that even a sparsely populated region may retain the potential for new infections more than two months after the first appearance of the disease.","Although it went unrecorded in the published papers, Reed organized a supplemental experiment to test another species of mosquito.Culex pungensfailed to transmit yellow fever to at least one volunteer and probably to a second. Reed's preliminary conclusions indicated thatCulex fasciatawas the only species capable of transmitting yellow fever. [11]","A last experimental regime involved subcutaneous injections of blood from positive cases of yellow fever to presumed non-immunes. Reed devised these tests to confirm the presence of the yellow fever agent in the blood of a victim during the first days of an attack, and, more importantly, to settle theBacillus icteroidesquestion. The same blood cultures which produced yellow fever in four volunteers also failed to grow anyB. icteroides, conclusively invalidating Sanarelli's claim.","Altogether, the mosquito inoculations and the blood injections produced fourteen cases of yellow fever. All made a full recovery.","Notwithstanding the decisive medical victory -- as Reed declared, \"aside from the antitoxin of Diptheria and Koch's discovery of the tubercle bacillus, it will be regarded as the most important piece of work, scientifically, during the 19th century\" [12] -- success at Camp Lazear unfolded in its own time. Initially, Reed observed, \"the results obtained at this station were not encouraging.\" [13] The first inoculations of four volunteers over a period of two weeks proved disconcertingly negative each time. Then, on December 5, 1900, private John R. Kissinger presented his arm to the mosquitoes, and late in the evening on December 8, suffered the first chills of \"a well-marked attack of yellow fever.\" [14] Three more men in rapid succession fell victim to the insects -- Spanish volunteers Antonio Benigno, Nicanor Fernandez, and Vicente Presedo. The force of the conclusions was evident to everyone:","\"It can readily be imagined,\" Reed empathetically and wryly described in his first presentation of the experiments, \"that the concurrence of 4 cases of yellow fever in our small command of 12 non-immunes within the space of 1 week, while giving rise to feelings of exultation in the hearts of the experimenters, in view of the vast importance attaching to these results, might inspire quite other sentiments in the bosoms of those who had previously consented to submit themselves to the mosquito's bite. In fact, several of our good-natured Spanish friends who had jokingly compared our mosquitoes to 'the little flies that buzzed harmlessly about their tables,' suddenly appeared to lose all interest in the progress of science, and, forgetting for the moment even their own personal aggrandizement, incontinently severed their connection with Camp Lazear. Personally, while lamenting to some extent their departure, I could not but feel that in placing themselves beyond our control they were exercising the soundest judgment.\"","\"In striking contrast,\" Reed continued, the anxiety of the fomites volunteers began to melt into relief. \"[T]he countenances of these men, which had before borne the serious aspect of those who were bravely facing an unseen foe, suddenly took on the glad expression of 'schoolboys let out for a holiday,' and from this time their contempt for 'fomites' could not find sufficient expression. Thus illustrating once more, gentlemen, the old adage that familiarity, even with fomites, may breed contempt.\" [15]","The question of human experimentation was indeed a serious one -- unavoidable, in actuality, as Reed had stated the previous summer to Surgeon General Sternberg. When the Commission first considered a trial of Finlay's mosquito theory, Reed, Carroll, and Lazear agreed to experiment on themselves. Agramonte, a native Cuban, had acquired immunity as a child. Doubtless Finlay's experience of many unsuccessful inoculations communicated that positive results would not be forthcoming rapidly, so before the first series of inoculations began under Lazear's direction at Columbia Barracks, Reed left Cuba for Washington, where he completed a monumental report on typhoid fever among the army corps -- left unfinished by the sudden death of co-author Edward O. Shakespeare. Carroll and Lazear both sickened while Reed was in Washington, and Lazear, young and strong, had no reason to anticipate that his case would be fatal. Reed was shocked at Lazear's death, and because of his own age -- 49, a decade and a half older than Lazear and a dozen years older than Carroll -- he resolved not to inoculate himself when he returned to Cuba on October 4, 1900. The point had already been amply demonstrated, and only a rigidly controlled experimental regime would establish the necessary proof. Carroll, however, remained embittered about this for the remainder of his life, though he evidently never communicated his objections directly to Reed.","That initial series of mosquito inoculations was probably accomplished without formal documentation of informed consent. Indeed, the experiments may also have been carried forward without the full knowledge of the commanding officer of Camp Columbia, and Reed consequently shielded the identity of Private William J. Dean, the second positive experimental case, behind the pseudonym \"XY\" in the \"Preliminary Note.\" No such potentially troublesome problems arose for the experimental series at Camp Lazear; Reed obtained prior support from all of the appropriate authorities in the military and the administration, even including the Spanish Consul to Cuba. With the advice of the Commission and others, he drafted what is now one of the oldest series of extant informed consent documents. The surviving examples are in Spanish with English translations, and were signed by volunteers Antonio Benigno and Vicente Presedo, and a third with the mark of Nicanor Fernandez, who was illiterate.","The documents take the form of a contract between individual volunteers and the Commission, represented by Reed. At least 25 years old, each volunteer explicitly consented to participate, and balanced the certainty of contracting yellow fever in the general population against the risks of developing an experimental case, followed by expert and timely medical care. The volunteers agreed to remain at Camp Lazear for the duration of the experiments, and as a reward for participation would receive $100 \"in American gold,\" with an additional hundred-dollar supplement for contracting yellow fever. These payments could be assigned to a survivor, and the volunteers agreed to forfeit any remuneration in cases of desertion.","For the American participants no consent documents appear to survive, though in contemporary letters Reed assured his correspondents that the Commission obtained written consent from all the volunteers. The record of expenses for Camp Lazear -- maintained by Reed's friend and colleague in the medical corps, Jefferson Randolph Kean -- indicates that the same schedule of payments for participation and sickness applied to the Americans as well. Volunteers who participated in the fomites tests and in addition the later series of blood injections and the single trial of an alternative species of mosquito also earned $100 each plus the $100 supplement if yellow fever developed. Two Americans declined these gratuities, as Kean termed them, Dr. Robert P. Cooke, of the fomites tests, and John J. Moran, who had recently received an honorable discharge from the service, and was the only American civilian to participate. His was the fourth case of yellow fever to develop from mosquito inoculation. Moran eventually settled in Cuba, where he managed the Havana offices of the Sun Oil Company, and late in life became a close friend of Philip S. Hench. Together the two men rediscovered the site of Camp Lazear in 1940 -- Building Number One still intact -- and successfully lobbied the Cuban government to memorialize there the work of Finlay and the American Commission in the conquest of yellow fever.","Reed informally commemorated his own experiences at Camp Lazear by commissioning a group photograph, evidently taken there shortly before he left Cuba in February 1901. A more important event occurred on the sixth of that month when Reed presented the results of the Camp Lazear yellow fever experiments to a great ovation at the Pan-American Medical Congress in Havana. Three days later he set sail for the United States, and once landed, drafted the Congress paper asThe Etiology of Yellow Fever -- An Additional Note, published immediately in theJournal of the American Medical Association. [16]","Though his correspondence intimates a great appreciation for Cuba, Reed never returned to the warm, sunny shores of the island freed of a dreadful plague. Carroll stayed behind at Camp Lazear through February to complete the last experimental series officially bearing the imprimatur of the Yellow Fever Commission, and returned to Washington soon after March first. [17] The Medical Corps retained the lease on Camp Lazear against the possibility of continuing experiments another season, and Carroll, in fact, returned to Havana in August 1901 for a final experimental series, though he did not make use of Camp Lazear. This work involved at least three volunteers at Las Animas Hospital, Havana, who submitted to blood injections. Carroll's assignment aimed at a greater understanding of the yellow fever agent, and he proved that blood drawn from active cases of yellow fever remained virulent even after passing through fine bacteria filters. In addition, by heating contaminated blood which had previously caused cases of yellow fever, Carroll rendered it non-infective -- thereby establishing that this filterable entity, though sub-microscopic, was demonstrably present in the bloodstream. Carroll wrapped up the series in October and returned home to stay. [18] In Cuba, J. Randolph Kean made the last rental payments to Signore Rojas on October 9, 1901, and Camp Lazear, for more than a generation, slipped out of the realm of memory.","Sources:","[1] Walter Reed and James Carroll,Bacillus Icteroides and Bacillus Cholerae Suis -- A Preliminary Note,Medical News(29 April 1899), reprinted in: United States Senate Document No. 822,Yellow Fever, A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 55.\n      [2] Letter from Jesse W. Lazear to Mabel Houston Lazear, 23 August 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00341001.\n      [3] Walter Reed, \"The Propagation of Yellow Fever -- Observations Based on Recent Researches,\" in United States Senate Document No. 822,Yellow Fever A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 94.\n      [4] Letter from Walter Reed to George M. Sternberg, 24 July 1900, Hench Reed Yellow Fever Collection, accession number: 02064001.\n      [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note,Proceedings of the Twenty-eighth Annual Meeting of the American Public Health AssociationIndianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n      [6] Letter from Walter Reed to James Carroll, 7 September 1900, Edward Hook Additions to the Philip S. Hench Walter Reed Yellow Fever Collection: James Carroll Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 15312004. The originals of these letters remain in a private collection.\n      [7] Walter Reed, James Carroll, Aristides Agramonte,The Etiology of Yellow Fever -- An Additional Note,Journal of the American Medical Association36 (16 February 1901): 431-440, reprinted in: Senate Document No. 822, p. 84.\n      [8] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n      [9] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n      [10] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 101.\n      [11]Culex fasciatawas reclassified shortly after the experiments asStegomyiaand later becameAedes aegypti.\n      [12] Letter to from Walter Reed to Emilie Lawrence Reed, 9 December 1900, Hench Reed Collection, accession number: 02231001.\n      [13] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 97.\n      [14] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 98.\n      [15] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n      [16] Please see note [7].\n      [17] The Commission reported these concluding experiments in: Walter Reed, James Carroll, Aristides Agramonte,Experimental Yellow Fever,American MedicineII (6 July 1901) 1: 15-23.\n      [18] Walter Reed, James Carroll,The Etiology of Yellow Fever (A Supplemental Note),American MedicineIII (22 February 1902) 8: 301-305.","Walter Reed (September 13, 1851 - November 22, 1902) was a U.S. Army physician who led the army's Yellow Fever Commission 1900 and 1901. Experiments conducted by the commission confirmed a theory that yellow fever is transmitted by mosquitoes--a discovery that led to the control and eradication of this disease across much of the globe. Reed would receive much of the credit for the work of the commission because of his role as its leader, and, long after his death in 1902, he would be widely celebrated as a heroic figure in the fields of public health and medical research.","Reed spent his first days in a small house which served as the parsonage for a Methodist congregation in Gloucester County, Virginia, where his father was minister.  Lemuel Sutton Reed and Pharaba White Reed welcomed young Walter into the family on September 13, 1851;  he was the youngest of their five children.  The Reeds moved to other Virginia parishes during Walter's childhood, and just after the close of the Civil War, transferred to the town of Charlottesville.  That move in 1866 placed Walter in the orbit of the University of Virginia, which he entered a year later at age sixteen under the care of his older brother Christopher, also a student at the University.  Reed attended two year-long sessions, the second devoted entirely to the medical curriculum, and he completed an M.D. degree on July 1, 1869, as one of the youngest students to graduate in the history of the medical school.","At that time the School of Medicine at the University offered little opportunity for direct clinical experience, so Reed subsequently enrolled at the Bellevue Hospital Medical College, in Manhattan, New York.  There he obtained a second M.D. degree in 1870.  Reed interned at a number of hospitals in the New York metropolitan area, including the Infants' Hospital on Randall's Island and the Brooklyn City Hospital.  In 1873, he assumed the position of assistant sanitary officer for the Brooklyn Board of Health.  The large and diverse population of New York, with its many immigrant communities and dense, tenement housing, provided countless medical cases to treat and study;  these served to expose Reed to the vital importance of public health, and developed in him a lifelong interest in the field.  Yet the frenetic life of the great cities began to pall after a few years: \"Here the ever bustling day is crowded into the busy night; nor can we draw the line of separation between the two,\"[1] he wrote to Emilie Lawrence, of Murfreesboro, North Carolina, later to become Mrs. Walter Reed.  Their courtship letters reveal much of his maturing character, interests, and philosophy of life.  Increasing responsibilities with the Board of Health precluded opening a private practice, and Reed's youth proved a barrier in a culture given to offering respect more to the appearance of maturity than to its actual demonstration. Reed consequently resolved to join the Army Medical Corps, both for the professional opportunities it offered immediately and for the modest financial security it could provide to a young man without independent means.  He passed the qualifying examinations in January 1875 and proceeded to his first assignment at the military base on Willet's Point, New York Harbor.","Reed remained in the Medical Corps for the rest of his life, spending many years of the '70s, '80s, and early '90s at difficult postings in the American West.  The first of these -- to the Arizona Territory -- began in the late spring of 1876, and indeed hurried along his wedding to Emilie Lawrence, on April 25, shortly before his departure.  She joined him the following November, and bore two children at frontier posts, a son Walter Lawrence and a daughter Emilie, called Blossom.","Reed's other western assignments included forts in Nebraska, Dakota Territory, and Minnesota, with two eastern interludes at Baltimore, Maryland and another at Mount Vernon Barracks, Alabama.  During the second of these tours in Baltimore -- over the 1890-1891 academic year -- Reed completed advanced coursework in pathology and bacteriology in the Johns Hopkins University Hospital Pathology Laboratory.  When he returned from his last western appointment in 1893, Reed joined the faculty of the Army Medical School in Washington, D.C., where he held the professorship of Bacteriology and Clinical Microscopy.  He also became curator of the Army Medical Museum and joined the faculty of the Columbian University in Washington (later the George Washington University).  In addition, Reed maintained close ties with professor William Welch and other leading lights in the scientific community he had come to know at Hopkins a few years earlier.","Beyond his teaching responsibilities for the Army and the Columbian University programs, Reed actively pursued medical research projects.  A bibliography of his publications finds entries from 1892 to the year of his untimely death a decade later, and the subjects he investigated range from erysipelas to cholera, typhoid, malaria, and yellow fever, among others.[2]   In 1896, a research trip to investigate an outbreak of smallpox took him to Key West, and there he developed a close friendship with Jefferson Randolph Kean, a fellow Virginian and colleague in the Medical Corps ten years his junior.  When Reed traveled to Cuba in 1899 to study typhoid in the army encampments of the U.S. forces, Kean was already there, and Kean was still in Cuba when Reed returned as the head of the Army board charged by Surgeon General George Miller Sternberg to examine tropical diseases including yellow fever.  Kean and his first wife Louise were great supporters of the U.S. Army Yellow Fever Commission's work, and Kean in fact served as quartermaster for the famous series of experiments at Camp Lazear.  After the dramatic and conclusive success of those experiments, Kean actively -- though unsuccessfully -- promoted Reed's candidacy for Surgeon General.","Reed continued to speak and publish on yellow fever after his return from Cuba in 1901, receiving honorary degrees from Harvard and the University of Michigan in recognition of his seminal work.  In November 1902, Reed developed what had been for him recurring gastro-intestinal trouble.  This time, however, his appendix ruptured, and surgery came too late to save him from the peritonitis which developed.  He died on November 23, 1902, almost two years to the day from the opening of Camp Lazear and the stunning experimental victory there.  Kean remained a champion of his deceased friend's role in the conquest of yellow fever.  He organized the Walter Reed Memorial Association, to provide support for Reed's family and to build a suitable memorial, and was instrumental in lobbying the United States Congress to establish the Yellow Fever Roll of Honor.  In 1929, Congress mandated the annual publication of the Roll in theArmy Register, and struck a series Congressional Gold Medals saluting the Commission members and the young Americans who bravely suffered experimental yellow fever a generation before.","Sources:","[1] Letter from Walter Reed to Emilie Lawrence, 18 July 1874, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 01605001.\n      [2] The bibliography of Reed's scientific papers may be found in: Howard Atwood Kelly,Walter Reed and Yellow Fever(New York: McClure, Phillips and Co., 1906), pp. 281-283. Kelly's complete biography of Reed is contained on this Web site.","Jesse William Lazear (May 2, 1866 - September 26, 1900) was a physician who was a member of the U.S. Army Yellow Fever Commission in 1900. Lazear's death from yellow fever at the outset of the commission's work in Cuba would lead to his elevation as a martyr for medical science in the eyes of many during the twentieth century.","\"I rather think I am on the track of the real germ,\" Jesse W. Lazear wrote his wife from Cuba on September 8, 1900.[1] Seventeen days later, the fulminating case of yellow fever Lazear had contracted just over a week after writing Mabel H. Lazear suddenly ended the young scientist's life. He was 34 years old. Unlike so many other yellow fever fatalities, however, this one would lead to a direct and highly successful assault on the disease itself. Yellow fever's ascendancy, endemic in Cuba, was about to be undermined.","Lazear had reported to Camp Columbia, Cuba in February 1900 for duty as an acting assistant surgeon with the U. S. Army Corps stationed on the island. Here he undertook bacteriological study of tropical diseases, particularly malaria and yellow fever, and in May he was named to the Army board charged with \"pursuing scientific investigations with reference to the infectious diseases prevalent on the island of Cuba.\"[2]","These orders placed him officially in the company of Walter Reed, James Carroll, and Aristides Agramonte -- the U.S. Army Yellow Fever Commission -- though Lazear had already met Reed the preceding March on a project to evaluate the efficacy of electrozone, a disinfectant made from seawater collected off the Cuban coast. While Reed was in Cuba that March, Lazear discussed with him the recent discovery of British scientist Sir Ronald Ross concerning the mosquito vector for malaria. At Johns Hopkins Hospital in Baltimore, where he was first a medical resident and later in charge of the clinical laboratory, Lazear had followed Ross's accomplishments with great interest, and pursued field work and experimentation on theAnophelesmosquito with fellow Hopkins scientist William S. Thayer. Lazear was thus the only member of the Commission who had experience with mosquito work, and was consequently the most open to the possible verity of Cuban scientist Carlos Juan Finlay's theory of mosquito transmission for yellow fever.","The record is apparently silent as to when Lazear first visited Finlay. Certainly by late June Lazear was beginning to grow mosquito larvae acquired from Finlay's laboratory, the first specimens brought to him by Henry Rose Carter, of the United States Public Health Service.[3] Not long after arriving in Cuba Lazear met Carter, whose own observations on yellow fever strongly suggested an intermediate host in the spread of the disease. However, Army Surgeon General George Miller Sternberg, who organized the Yellow Fever Commission, first charged the board members to investigate the relationship ofBacillus icteroidesto yellow fever -- proposed by the Italian Scientist Giuseppe Sanarelli as the actual cause of the disease. \"Dr. Reed had been in the old discussion over Sanarelli's bacillus and he still works on that subject,\" Lazear wrote his wife in July, \"I am not all interested in it but want to do work which may lead to the discovery of the real organism.\"[4] Soon he would have the opportunity. The relatively quick failure of the Bacillus icteroides inquiry opened the door to what became the ground-breaking mosquito work, and Lazear was well placed to begin.","The project started in earnest on August 1, 1900. In a small pocket notebook Lazear noted the preparatory work of raising and infecting mosquitoes, and subsequently recorded the series of eleven experimental inoculations made from the 11th to the 31st of August, the last two producing cases of full-blown yellow fever. These two positive cases developed from mosquitoes allowed to ripen over a period of 12 days, and this was Lazear's crucial discovery. The epidemiological pattern was thus entirely consistent with Carter's observations of a delay between the primary and secondary outbreaks of yellow fever in an epidemic, and, in addition, explained why Finlay's experiments had been largely unsuccessful -- he had not waited long enough before inoculating his subjects.","Although Lazear never directly admitted to experimenting on himself, when Reed reviewed Lazear's sketchy notations he evidently found entries strongly suggesting Lazear's case was not accidental, as officially reported. Unfortunately, the little notebook so crucial to the preparation of the Commission's famous initial paper,The Etiology of Yellow Fever -- A Preliminary Note[5], vanished from Reed's Washington office after his own untimely death in 1902. Still, Lazear's invaluable contribution to the Commission's victory was widely recognized and elicited tributes from many quarters: \"He was a splendid, brave fellow,\" Reed said of his young colleague, \" and I lament his loss more than words can tell; but his death was not in vain- His name will live in the history of those who have benefited humanity.\" [6] \"His death was a sacrifice to scientific research of the highest character,\" stated General Leonard Wood, military Governor of Cuba.[7] \"Your husband was a martyr in the noblest of causes,\" Dr. L. O. Howard wrote to Mabel Lazear, \"and I am proud to have known him. . . . His work contributed towards one of the greatest discoveries of the century, the results of which will be of invaluable benefit to mankind.\"[8] And so they were. Though Lazear's one-year-old son and newborn daughter never knew their father, they grew up in a world liberated -- almost in its entirety -- from the disease that killed him.","[1] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 8 September 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00344001.","Sources:","[2] Military Orders for Walter Reed, James Carroll, Aristides Agramonte, and Jesse W. Lazear, 24 May 1900, Hench Reed Collection, accession number 02019001.\n      [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n      [4] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 15 July 1900, Hench Reed Collection, accession number: 00334001.\n      [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note, Proceedings of the Twenty-eighth Annual Meeting of the American Public Health Association Indianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n      [6] Letter from Walter Reed to Emilie Lawrence Reed, 6 October 1900, Hench Reed Collection, accession number: 02135001.\n      [7] Letter from Leonard Wood to the Adjutant-General, United States Army, November 1900, Hench Reed Collection, accession number: 00375002.\n      [8] Letter from Leland Ossian Howard to Mabel Houston Lazear, 7 February 1901, Hench Reed Collection, accession number: 00388001.","Henry Rose Carter (August 25, 1852 - September 14, 1925) was a prominent physician in the U.S. Public Health Service who was a leading authority in the transmission and control of tropical diseases, particularly yellow fever and malaria. During his long career as a sanitarian, Carter undertook campaigns to investigate and control the spread of tropical diseases in Cuba, the Panama Canal Zone, the Southeastern United States, and Peru.","Like Walter Reed and Jefferson Randolph Kean, Henry Rose Carter was a native Virginian and a graduate of the University of Virginia. Carter obtained a civil engineering degree from Virginia in 1873 and also undertook post-graduate work in mathematics and applied chemistry the next year. Subsequently, however, Carter's interests turned towards medicine, and he completed a medical degree at the University of Maryland in 1879. The same year Assistant Surgeon Carter joined the Marine Hospital Service -- later the United States Public Health Service -- and the young surgeon rose steadily through the ranks, ultimately attaining the position of Assistant Surgeon General in 1915.","Carter's initial assignments with the Hospital Service placed him at the center of the yellow fever maelstrom. In 1879 he was detailed to Memphis and other Southern cities, then in the throes of a second year of devastating epidemics. Here began, as his colleague T. H. D. Griffitts observed, Carter's \"lifelong interest in the epidemiology and control of yellow fever.\"[1] After several years of clinical practice in various Marine hospitals, Carter resumed a direct confrontation with yellow fever when his orders for duty with the Gulf Coast Maritime Quarantine assigned him to Ship Island, Mississippi, in 1888. Here and at subsequent quarantine station postings around the Gulf, he quietly championed a thorough review and rationalization of quarantine policies, with a view toward establishing uniform regulation, more thorough disinfection of vessels, and minimized interference with naval commerce. Crucial to the success of these activities was Carter's attention to the incubation period of yellow fever, which his on-site observations indicated to vary between 5 and 7 days. At the time the official literature stated with far less precision a variance of between 1 and 14 days; Carter's work consequently greatly increased the efficiency and effectiveness of quarantine operations.","Nevertheless, yellow fever continued to menace the temperate coastline of the United States, and Carter ably directed the Health Service's epidemiological control efforts in numerous threatened regions. In conjunction with this sanitary work for the 1898 season, Carter made detailed notes on the development of yellow fever at Orwood and Taylor, Mississippi. The isolation of these communities enabled him to identify more reliably the phenomenon of a delay between the initial cases of yellow fever in a locality and the subsequent appearance of secondary infection -- a delay two to four times longer than the incubation period of the disease in an infected person. Carter called this interval between the primary and secondary cases \"the period of extrinsic incubation,\" and he defined its \"usual limits . . . [as ranging] from ten to seventeen days.\"[2]","Before he was able to publish his conclusions, Carter took the helm of the quarantine service in war-time Cuba. There, in 1900, he met U. S. Army Yellow Fever Commission member Jesse Lazear. Carter had finally arranged for his paper's publication that year in theNew Orleans Medical and Surgical Journal, and gave a draft to Lazear. \"If these dates are correct,\" Carter later recalled Lazear saying, \"it spells a living host.\"[3] The theory of mosquito transmission long advanced by Cuban scientist Carlos J. Finlay began to seem more likely. And indeed it was. The Commission's experiments in 1900-1901 irrefutably proved the mosquito vector and established the extrinsic incubation period at twelve days. Shortly after these successes Reed saluted Carter, \"I know of no one more competent to pass judgment on all that pertains to the subject of yellow fever. You must not forget that your own work in Mississippi did more to impress me with the importance of an intermediate host than everything else put to-gether.\"[4]","Carter's long and distinguished sanitary career took him to the Panama Canal Zone in 1904, where he served as Chief Quarantine Officer and Chief of Hospitals for five years. He undertook detailed investigations and control measures of malaria in North Carolina and elsewhere in the South, and became a founder of the National Malaria Committee. With the support of the Rockefeller Foundation International Health Board, he undertook additional investigation and control measures for yellow fever in Central and South America. His expertise recommended him to the Peruvian government, which named Carter Sanitary Advisor in 1920-1921. Health problems at the end of his life compelled Carter to withdraw from active fieldwork, though he remained a highly valued consultant to the Health Board and a much-beloved and respected teacher for a new generation of sanitarians. Carter closed his career researching and writing the manuscript that his daughter Laura Armistead Carter edited and published posthumously in 1931:Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.[5]","Sources:","[1] T. H. D. Griffitts,Henry Rose Carter: The Scientist and the Man,Southern Medical Journal32 (August 1939) 8: 842.\n      [2] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n      [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n      [4] Letter from Walter Reed to Henry Rose Carter, 26 February 1901, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 02447001.\n      [5] Carter, Henry Rose.Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.Baltimore: The Williams and Wilkins Company, 1931.","Jefferson Randolph Kean (June 27, 1860 - September 4, 1950) was a U.S. Army physician who was a leading authority in sanitation, public health, and tropical diseases. Later in his career, Kean would become widely recognized for his role in organizing and administering medical services for the U.S. armed forces during World War I.","\"He possessed one of the keenest, most scholarly minds I've ever encountered,\" recalled Nobel Prize winner Philip S. Hench of Jefferson Randolph Kean. [1] Kean and Hench shared an abiding interest in the work of the United States Army Yellow Fever Commission -- Kean, as a contemporary and supporter, and Hench, as a scholar and scientist intent on accurate historical documentation. On the advice of yellow fever experiment volunteer John J. Moran, Hench first wrote Kean in 1939. From that initial contact developed a close friendship which would last for the remainder of their lives. Kean entrusted Hench not only with numerous period documents, including original letters, accounts, fever charts, and other items, but also with the freely-given counsel and insight of a trusted friend.","Like Walter Reed and Henry Rose Carter before him, Jefferson Randolph Kean was an alumnus of the University of Virginia, completing the medical program there in 1883. Kean joined the U.S. Army Medical Corps in 1884, and after forty years in the service, retired with the rank of Colonel. Congress awarded him a promotion to Brigadier General, retired, in 1930. The early years of Kean's career passed in medical postings in the American West, and no doubt offered him experiences similar to those of Walter Reed, whom he met not on the frontier, but in Florida in 1896. Kean became an expert in tropical diseases and sanitation during his five-year assignment in the Florida tropics, an expertise which served him well over two terms of service later in Cuba. During the Spanish-American War and subsequent U. S. occupation of Cuba, Kean was Chief Surgeon for the Department of Havana, then Superintendent of the Department of Charities -- from 1898 to 1902. After a four-year interlude as an assistant to the Surgeon General in Washington, D.C., Kean again returned to Cuba as an advisor to the Department of Sanitation from 1906-1909.","Kean himself stated: \"Reed and I were good friends before the Yellow Fever Board came to Cuba in June 1900, and [Reed] located himself at Marianao, 8 miles S. W. of Havana,\" to be within the medical and administrative jurisdiction overseen by Kean. [2] The Chief Surgeon did indeed offer significant assistance, and was an early convert to Carlos Finlay's mosquito theory of transmission, which the Yellow Fever Board's experiments ultimately proved true in the late autumn and winter of 1900-1901. As early as October 13, 1900 -- after the Board's preliminary work, but before the final convincing demonstrations -- Kean issued \"Circular No. 8,\" concerning the latest scholarship on the mosquito vector for disease. [3] The circular contained a set of instructions for the entire command on mosquito eradication. Kean subsequently served as quartermaster and financial administrator for the famous series of yellow fever experiments at Camp Lazear and, for the rest of his life, Kean remained a strong proponent of the Commission's conclusions. He worked tirelessly not only to apply them in the field, but also to accord proper public recognition to the Commission's work.","In addition to his career as a sanitarian, Kean organized the department of military relief of the American Red Cross, and during World War One served as Chief of the U. S. Ambulance Service with the French Army and Deputy Chief Surgeon of the American forces. France named him an Officier de la Légion d'Honneur in recognition for these services. Cuban authorities as well offered Kean recognition with the grand cross of the Order of Merit Carlos J. Finlay, and he received both a Distinguished Service Medal from the United States government and the Gorgas Medal from the Association of Military Surgeons. For a decade after his retirement from active duty, Kean edited this last organization's medical journal,The Military Surgeon, and served on the Surgeon General's editorial board for the multi-volume history of the medical department in World War One. A great-grandson of Thomas Jefferson, Kean also took a seat with the government commission established to build the Jefferson Memorial in Washington, D.C. He held charter membership in the Walter Reed Memorial Association, and remained active in its affairs until his death in 1950.","Sources:","[1] Telegram from Philip Showalter Hench and Mary Hench to Cornelia Knox Kean, September 5, 1950, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 06501173.\n      [2] Letter from Jefferson Randolph Kean to Philip Showalter Hench, October 31, 1939, Hench Reed Yellow Fever Collection, accession number: 06282022.\n      [3] Military Orders to Commanding Officers, October 15, 1900, Hench Reed Yellow Fever Collection, accession number: 02140001.","Philip Showalter Hench (February 28, 1896 - March 30, 1965) was a U.S. physician who in 1950 was awarded the Nobel Prize for Physiology and Medicine for his role in the discovery of the hormone cortisone. In addition to his medical research, Hench spent almost three decades of his life studying the history of the U.S. Army Yellow Fever Commission and became a leading authority in the subject.","Philip Showalter Hench was born in Pittsburgh, Pennsylvania, the son of Jacob Bixler Hench and Clara Showalter. After attending local schools, Hench entered Lafayette College and graduated from the school 1916 with a Bachelor of Arts. Hench completed his medical degree at the University of Pittsburgh in 1920, and subsequently entered a residency program at St. Francis Hospital, Pittsburgh. His association with the Mayo Clinic began in 1921 as a fellow at the institution. Two years later he would become an assistant at the clinic, and then, in 1926, he would be made the head of its Department of Rheumatic Diseases After pursuing post-graduate study in Germany in 1928-1929, Hench obtained a Masters of Science in Internal Medicine at the University of Minnesota in 1931, and a Doctor of Science degree from Lafayette College in 1940. Hench remained for the duration of his career at the Mayo Clinic, where his life-long passion for meticulous research and analysis brought him the Nobel Prize for Physiology and Medicine in 1950, which he shared with Edward C. Kendall and Tadeus Reichstein, for the discovery of cortisone.","The same persistence and determination present in his professional life is also evident in Hench's research on the U. S. Army Yellow Fever Commission's famous experiments. \"As a physician particularly interested in medical history,\" he stated to experiment volunteer John J. Moran in 1937, \"I have been long interested in the story of the yellow fever work in John J. Moran, Ralph C. Hutchison, Havana.\" [1] So began a remarkable odyssey. At the request of his friend Ralph Cooper Hutchison, then president of Washington and Jefferson College, Hench had written Moran to gather information for the dedication of the College's new chemistry building, named for Commission member and former Washington and Jefferson student Jesse W. Lazear. Hench also began a correspondence with another of the yellow fever experiment's original volunteers, John R. Kissinger. Moran's and Kissinger's recollections proved so intriguing that Hench initially offered to edit and publish them. However, in the course of his research Hench discovered that much general information on the topic was inaccurate. Conflicting assertions concerning the participants and unverified claims by medical and governmental authorities in the United States and Cuba -- often politically motivated -- clouded interpretation of the facts. \"May I suggest,\" Moran consequently urged in 1938, \"that a clearing up of the REED-FINLAY-CONQUEST-OF-YELLOW-FEVER, or an effort to do so, on your part, is a task far more pressing than publishing the Kissinger-Moran stories or memoirs.\" [2] Hench resolved to document every aspect of the \"Conquest of Yellow-Fever\" and to write a much needed accurate and comprehensive history.","For the next two decades, Hench tirelessly combed through public archive collections and personal papers in the United States and Cuba. He met and interviewed surviving participants of the experiments and others associated with the project, as well as family members of the Yellow Fever Commission. He sought out physicians and scientists who had worked with the principal players or who had applied the results in the campaign to eradicate yellow fever. He identified and photographed sites associated with the yellow fever story, and he successfully petitioned politicians in the United States and Cuba to commemorate the work. In the process, Hench became the trusted friend and advisor of many of these same individuals, and they, in turn, presented him with much of the surviving original material for safekeeping.","In short, Hench came to be the world's expert on the yellow fever story and the steward of thousands of original letters and documents. His premature death at age 69 found him still hoping to uncover important missing evidence, his book unwritten. Hench's widow Mary Kahler Hench gave his yellow fever collection to the University of Virginia, Walter Reed's alma mater, and this extensive personal archive forms the most detailed and accurate record available on the Conquest of Yellow Fever.","Sources:","[1] Letter from Philip S. Hench to John J. Moran, 6 July 1937, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 03419001.\n      [2] Letter from John J. Moran to Philip S. Hench, 30 October 1938, Hench Reed Yellow Fever Collection, accession number: 03476001."],"custodhist_html_tesm":["\u003cp\u003eMaterials from the following series were initially deposited at the University of Virginia's Alderman Library. In 1982, they were moved to the Claude Moore Health Sciences Library under the terms of a gift agreement that required the transferral of Mary K. Hench's donation to the library when adequate storage space for the collection could be found there.\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003eSeries I. Jesse W. Lazear\u003c/item\u003e\n      \u003citem\u003eSeries II. Henry Rose Carter\u003c/item\u003e\n      \u003citem\u003eSeries III. Walter Reed\u003c/item\u003e\n      \u003citem\u003eSeries IV. Philip Showalter Hench\u003c/item\u003e\n      \u003citem\u003eSeries V. Maps\u003c/item\u003e\n      \u003citem\u003eSeries VI. Alphabetical files\u003c/item\u003e\n      \u003citem\u003eSeries VII. Truby-Kean-Hench\u003c/item\u003e\n      \u003citem\u003eSeries VIII. Miscellany\u003c/item\u003e\n      \u003citem\u003eSeries IX. Photographs\u003c/item\u003e\n      \u003citem\u003eSeries X. Negatives\u003c/item\u003e\n      \u003citem\u003eSeries XI. Reprints\u003c/item\u003e\n      \u003citem\u003eSeries XIII. Reed family additions\u003c/item\u003e\n      \u003citem\u003eSeries XV. Laura Wood\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eMaterials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were initially deposited in the HAM/TMC and were a part of the Philip S. Hench papers. In 1991, the materials were transferred from HAM/TMC to the Claude Moore Health Sciences Library after both repositories agreed that it would be more appropriate to include them in the Philip S. Hench Walter Reed Yellow Fever Collection.\u003c/p\u003e","\u003cp\u003e Materials from Series XVI. Edward Hook additions were transferred from the Papers of Dr. Edward Watson Hook, Jr. to the Philip S. Hench Walter Reed Yellow Fever Collection around the late 1990s and early 2000s.\u003c/p\u003e  "],"custodhist_heading_ssm":["Custodial History"],"custodhist_tesim":["Materials from the following series were initially deposited at the University of Virginia's Alderman Library. In 1982, they were moved to the Claude Moore Health Sciences Library under the terms of a gift agreement that required the transferral of Mary K. Hench's donation to the library when adequate storage space for the collection could be found there.","Series I. Jesse W. Lazear\n      Series II. Henry Rose Carter\n      Series III. Walter Reed\n      Series IV. Philip Showalter Hench\n      Series V. Maps\n      Series VI. Alphabetical files\n      Series VII. Truby-Kean-Hench\n      Series VIII. Miscellany\n      Series IX. Photographs\n      Series X. Negatives\n      Series XI. Reprints\n      Series XIII. Reed family additions\n      Series XV. Laura Wood","Materials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were initially deposited in the HAM/TMC and were a part of the Philip S. Hench papers. In 1991, the materials were transferred from HAM/TMC to the Claude Moore Health Sciences Library after both repositories agreed that it would be more appropriate to include them in the Philip S. Hench Walter Reed Yellow Fever Collection.","Materials from Series XVI. Edward Hook additions were transferred from the Papers of Dr. Edward Watson Hook, Jr. to the Philip S. Hench Walter Reed Yellow Fever Collection around the late 1990s and early 2000s."],"odd_html_tesm":["\u003clist type=\"deflist\"\u003e\n      \u003cdefitem\u003e\n        \u003clabel\u003eProcessed by:\u003c/label\u003e\n        \u003citem\u003eHistorical Collections Staff\u003c/item\u003e\n      \u003c/defitem\u003e\n    \u003c/list\u003e\n  "],"odd_heading_ssm":["General"],"odd_tesim":["Processed by:\n        Historical Collections Staff"],"prefercite_html_tesm":["\u003cp\u003ePhilip S. Hench Walter Reed Yellow Fever Collection, 1800-1998, MS-1, Claude Moore Health Sciences Library, Historical Collections and Services, University of Virginia\u003c/p\u003e  "],"prefercite_tesim":["Philip S. Hench Walter Reed Yellow Fever Collection, 1800-1998, MS-1, Claude Moore Health Sciences Library, Historical Collections and Services, University of Virginia"],"processinfo_html_tesm":["\u003cp\u003eMary K. Hench's donation arrived in Charlottesville in a number of large crates which were packed much as the collection had been found in Philip Showalter Hench's home in Rochester, Minnesota. Some confusion about Dr. Hench's filing order had been created while the collection was packed for shipping, and thus the Manuscripts Department of the University of Virginia Library found it necessary to perform some sorting and arrangement to make the collection more accessible.\u003c/p\u003e","\u003cp\u003e Around 1968, William Bennett Bean was hired by the University of Virginia as a visiting scholar in residence to begin work on a new biography of Walter Reed. Dr. Bean found that the order of the collection was not such that he could readily use it for biographical purposes. He employed a former assistant in the Manuscripts Department, sought and received permission to refile the collection, and had his assistant perform this task. The refiling of the collection had been finished by the fall of 1969, but Bean and his assistant had no time to prepare a finding aid.\u003c/p\u003e","\u003cp\u003e In the fall of 1969 Donna L. Purvis of the Manuscripts Department staff began writing the first edition of the collection's finding aid. During this project, Mrs. Purvis found some problems with Dr. Bean's description and arrangement of the collection and felt that it was necessary to reprocess parts of it.\u003c/p\u003e","\u003cp\u003e Around 1990 staff members in the Claude Moore Health Sciences Library processed additions to the collection donated by Philip Showalter Hench's son, P. Kahler Hench.\u003c/p\u003e","\u003cp\u003e Between 1999 and 2004, the Claude Moore Health Sciences Library digitized a significant portion of the collection and made the digitized files available to users in an online exhibit. During this project, over 8,000 items from the collection were scanned, transcribed, and described at the item level. Metadata for the digitized items was recorded in XML files using the TEI 2 standard.\u003c/p\u003e","\u003cp\u003e In 2001, the Claude Moore Health Sciences Library processed additions that had been made to the collection since 1982, excepting the materials donated by P. Kahler Hench. Staff members also processed significant portions of Mary K. Hench's original donation that had not been described in the first edition of the collection finding aid. This work led to the development of a second edition finding aid that was coded in EAD and ingested into the Virginia Heritage database. This finding aid contained both new metadata and metadata that had been migrated from a Microsoft Access file.\u003c/p\u003e","\u003cp\u003e In the 2000s the Claude Moore Health Sciences Library processed the materials in Series XV. Edward Hook additions.\u003c/p\u003e","\u003cp\u003e In 2009, staff members in the Claude Moore Health Sciences Library processed Box 154 of the collection.\u003c/p\u003e","\u003cp\u003e In 2013, staff members in the Claude Moore Health Sciences Library produced a third edition of the finding aid using EAD that merged collection description from four sources (the first edition finding aid, the second edition finding aid, the online exhibit, and the physical collection). When possible, metadata from the existing online exhibit's TEI files and metadata from the second edition finding aid were transformed with XSL and included in the EAD file. However, staff members sometimes found it necessary to create new metadata for the collection. The new finding aid was structured in such a way to facilitate the migration of the collection's digital files and metadata into the University of Virginia's digital repository and make it available to users via the library's online catalog.\u003c/p\u003e  "],"processinfo_heading_ssm":["Processing History"],"processinfo_tesim":["Mary K. Hench's donation arrived in Charlottesville in a number of large crates which were packed much as the collection had been found in Philip Showalter Hench's home in Rochester, Minnesota. Some confusion about Dr. Hench's filing order had been created while the collection was packed for shipping, and thus the Manuscripts Department of the University of Virginia Library found it necessary to perform some sorting and arrangement to make the collection more accessible.","Around 1968, William Bennett Bean was hired by the University of Virginia as a visiting scholar in residence to begin work on a new biography of Walter Reed. Dr. Bean found that the order of the collection was not such that he could readily use it for biographical purposes. He employed a former assistant in the Manuscripts Department, sought and received permission to refile the collection, and had his assistant perform this task. The refiling of the collection had been finished by the fall of 1969, but Bean and his assistant had no time to prepare a finding aid.","In the fall of 1969 Donna L. Purvis of the Manuscripts Department staff began writing the first edition of the collection's finding aid. During this project, Mrs. Purvis found some problems with Dr. Bean's description and arrangement of the collection and felt that it was necessary to reprocess parts of it.","Around 1990 staff members in the Claude Moore Health Sciences Library processed additions to the collection donated by Philip Showalter Hench's son, P. Kahler Hench.","Between 1999 and 2004, the Claude Moore Health Sciences Library digitized a significant portion of the collection and made the digitized files available to users in an online exhibit. During this project, over 8,000 items from the collection were scanned, transcribed, and described at the item level. Metadata for the digitized items was recorded in XML files using the TEI 2 standard.","In 2001, the Claude Moore Health Sciences Library processed additions that had been made to the collection since 1982, excepting the materials donated by P. Kahler Hench. Staff members also processed significant portions of Mary K. Hench's original donation that had not been described in the first edition of the collection finding aid. This work led to the development of a second edition finding aid that was coded in EAD and ingested into the Virginia Heritage database. This finding aid contained both new metadata and metadata that had been migrated from a Microsoft Access file.","In the 2000s the Claude Moore Health Sciences Library processed the materials in Series XV. Edward Hook additions.","In 2009, staff members in the Claude Moore Health Sciences Library processed Box 154 of the collection.","In 2013, staff members in the Claude Moore Health Sciences Library produced a third edition of the finding aid using EAD that merged collection description from four sources (the first edition finding aid, the second edition finding aid, the online exhibit, and the physical collection). When possible, metadata from the existing online exhibit's TEI files and metadata from the second edition finding aid were transformed with XSL and included in the EAD file. However, staff members sometimes found it necessary to create new metadata for the collection. The new finding aid was structured in such a way to facilitate the migration of the collection's digital files and metadata into the University of Virginia's digital repository and make it available to users via the library's online catalog."],"scopecontent_html_tesm":["\u003cp\u003eThe Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audio cassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). All of these materials are arranged in 16 series: I. Jesse W. Lazear, II. Henry Rose Carter, III. Walter Reed, IV. Philip Showalter Hench, V. Maps, VI. Alphabetical files, VII. Truby-Kean-Hench, VIII. Miscellany, IX. Photographs, X. Photographic negatives, XI. Reprints, XII. Houston Academy of Medicine/Texas Medical Center additions, XIII. Reed family additions, XIV. P. Kahler Hench additions, XV. Laura Wood, and XVI. Edward Hook additions.\u003c/p\u003e","\u003cp\u003e Series I. Jesse W. Lazear consists of materials relating to Lazear that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1800 to 1956 with the bulk of the items dating from 1863 to 1943. Much of the series consists of the correspondence of Jesse W. Lazear and his wife Mabel H. Lazear. Jesse's correspondence dates from his time as a student at Johns Hopkins University to his death in 1900. Researchers can learn a great deal about Jesse from these letters, including his relationships with friends and family, his educational background, and his professional life. Mabel's correspondence dates from the time she met Jesse to her death in 1946. This correspondence primarily concern her husband's historical legacy and a campaign to secure a pension from the U.S. government for herself and her family.\u003c/p\u003e","\u003cp\u003e In addition to Jesse and Mabel's correspondence, the series contains other materials relating to them and their families including, but not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ethe diaries documenting the travels of Jesse and Mabel's mothers in Europe;\u003c/item\u003e\n      \u003citem\u003ecorrespondence of other Lazear family members (e.g. Jesse's parents);\u003c/item\u003e\n      \u003citem\u003egenealogical summaries and tables relating to the Lazear family;\u003c/item\u003e\n      \u003citem\u003elegal documents (e.g. wills, certificates, deeds);\u003c/item\u003e\n      \u003citem\u003emilitary records relating to Jesse;\u003c/item\u003e\n      \u003citem\u003ecertificates, reports, and other materials documenting Jesse's educational background and achievements;\u003c/item\u003e\n      \u003citem\u003eobituaries;\u003c/item\u003e\n      \u003citem\u003ecopies of congressional bills and reports concerning the provision of a federal pension for Mabel H. Lazear;\u003c/item\u003e\n      \u003citem\u003enewspaper articles;\u003c/item\u003e\n      \u003citem\u003ea microscope and sets of microscope slides owned by Jesse;\u003c/item\u003e\n      \u003citem\u003eand a medical chart that shows the progression of the yellow fever infection that killed Jesse.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries II. Henry Rose Carter consists of materials relating to Henry Rose Carter that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1880 to 1932 with the bulk of the materials dating from 1883 to 1932. The series is particularly rich in materials that document Henry Rose Carter's professional activities in the last eleven years of his life (1914-1925). These materials include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ecorrespondence with colleagues in the medical and scientific community including Rupert E. Blue, Hideyo Noguchi, Henry Hanson, Joseph A. LePrince, Frederick F. Russell, T.H.D. Griffitts, and Lunsford D. Fricks;\u003c/item\u003e\n      \u003citem\u003escientific, medical, and government reports relating to the study and eradication of yellow fever and malaria in North America, South America, and Africa;\u003c/item\u003e\n      \u003citem\u003ejournal articles concerning the study and eradication of yellow fever and malaria;\u003c/item\u003e\n      \u003citem\u003eresearch notes written by Henry Rose Carter;\u003c/item\u003e\n      \u003citem\u003eand photographs of Henry Rose Carter at work and with professional colleagues.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries II. also contains correspondence between Henry Rose Carter and members of his family that date from 1880 to 1925. The family members with whom Henry corresponds most frequently in this series are his mother, Emma Coleman Carter; his wife, Laura Eugenia Hook Carter; his daughter, Laura Armistead Carter; and his son, Henry Rose Carter, Jr. These letters are not only a rich source of information about Carter's personal views and family life, they also provide valuable insights into his professional activities such as his experiences aboard vessels and in ports while working for the U.S. Marine Hospital Service and his public health work in Cuba, Panama, and Peru.\u003c/p\u003e","\u003cp\u003e In addition to the materials that were produced during Henry Rose Carter's lifetime, the Series II. contains materials that were produced between 1925 and 1940 (after Henry Rose Carter's death) including, but not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ecopies of obituaries for Henry Rose Carter;\u003c/item\u003e\n      \u003citem\u003econdolence letters for Henry Rose Carter's family after Henry's death;\u003c/item\u003e\n      \u003citem\u003eand the correspondence of Laura Armistead Carter relating to her father and other members of the Carter family.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries III. Walter Reed consists of materials that document the life of Walter Reed as well as the work and legacy of the U.S. Army Yellow Fever Commission. Items in the series date from 1806 to around 1955 with the bulk of the items dating from 1874 to 1936. The series is particularly rich in materials that document the professional and personal life of Walter Reed from 1874 to his death in 1902. These materials include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ecorrespondence between Walter Reed and members of his immediate family that cover a wide range of topics including Reed's courtship of Emilie Lawrence Reed, family life, Walter Reed's work in the Western United States, and Walter Reed's work in Cuba;\u003c/item\u003e\n      \u003citem\u003emilitary records relating to Walter Reed including military orders for Reed, Reed's performance reviews, and reports of Reed's work for army officials;\u003c/item\u003e\n      \u003citem\u003eWalter Reed's correspondence with professional colleagues including members of the U.S. Army Yellow Fever Commission, military doctors, and medical researchers interested in the study of yellow fever;\u003c/item\u003e\n      \u003citem\u003emedical records (e.g. fever charts of experiment participants), military orders, administrative records, reports, and publications documenting the results of the U.S. Army Yellow Fever Commission's experiments in Cuba;\u003c/item\u003e\n      \u003citem\u003earticles announcing the death of Walter Reed;\u003c/item\u003e\n      \u003citem\u003eand the shoulder boards from Walter Reed's U.S. Army uniform.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eIn addition to the above items, Series III. contains materials that document campaigns, spanning from 1902 to 1937, to publicly honor members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments. These materials include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003earticles and editorials relating to efforts to memorialize and provide pensions for members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments;\u003c/item\u003e\n      \u003citem\u003ebiographical sketches of members of the U.S. Army Yellow Fever Commission and experiment participants;\u003c/item\u003e\n      \u003citem\u003erecords relating to the Walter Reed Memorial Association (e.g. correspondence, donor lists);\u003c/item\u003e\n      \u003citem\u003ecopies of Congressional bills and resolutions to honor members of the U.S. Army Yellow Fever Commission and experiment participants;\u003c/item\u003e\n      \u003citem\u003eand letters, reviews, and other materials relating to the production of Sidney Coe Howard's play,\u003ctitle render=\"italic\"\u003eYellow Jack\u003c/title\u003e.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eFinally, Series III. also consists of materials that document the history of yellow fever during the nineteenth and early twentieth century. These materials include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003eitems (e.g. correspondence, reports, reviews, and articles) relating to U.S. efforts to eradicate yellow fever in the Panama Canal Zone;\u003c/item\u003e\n      \u003citem\u003ematerials (e.g. correspondence, reports, and articles) documenting early twentieth century efforts to eradicate yellow fever in Peru;\u003c/item\u003e\n      \u003citem\u003escientific reports and publications related to the study and eradication of yellow fever and malaria;\u003c/item\u003e\n      \u003citem\u003eand newspaper articles describing various outbreaks of yellow fever epidemics.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries IV. Philip Showalter Hench primarily consists of materials that Hench created or collected while researching the U.S. Army Yellow Fever Commission. Items in this series date from around 1850 to around 1865 with the bulk of the items dating from 1937 to 1960. Researchers who are studying the yellow fever experiments will be particularly interested in the materials (e.g. interviews, autobiographies) that document first-hand accounts of the events surrounding the experiments. Other researchers may be interested in items that document Hench's role in shaping public memory of the commission and its experiments. The materials in this series include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003eHench's correspondence and interviews with participants in the yellow fever experiments and their families including: Emilie Lawrence Reed, Emilie M. (Blossom) Reed, Walter Lawrence Reed, John J. Moran, Albert E. Truby, Jefferson Randolph Kean, John H. Andrus, and John R. Kissinger;\u003c/item\u003e\n      \u003citem\u003eautobiographical accounts of the experiment's participants and their families;\u003c/item\u003e\n      \u003citem\u003enotes, reports, correspondence and other materials relating to Hench's search for the original site of Camp Lazear in Cuba;\u003c/item\u003e\n      \u003citem\u003ecorrespondence with Cuban government officials and members of the scientific community relating to Hench's campaign to build a Camp Lazear memorial;\u003c/item\u003e\n      \u003citem\u003ecorrespondence and other materials relating to ceremonies honoring Jesse W. Lazear at Washington and Jefferson College;\u003c/item\u003e\n      \u003citem\u003enewspaper articles, magazine articles, and other printed matter concerning the yellow fever experiments and its participants;\u003c/item\u003e\n      \u003citem\u003edrafts of speeches and presentations Hench gave on the history of the yellow fever experiments to various audiences;\u003c/item\u003e\n      \u003citem\u003emeeting minutes and other materials that document Hench's relationship with and participation in the Walter Reed Memorial Association;\u003c/item\u003e\n      \u003citem\u003escripts for radio programs relating to the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003enotes, outlines, lists, correspondence, and other materials that document Hench's research about the yellow fever experiments and a book he had planned to write on the subject;\u003c/item\u003e\n      \u003citem\u003eand the gold medal that Congress posthumously awarded to Walter Reed for his work with yellow fever.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries V. Maps primarily consists of maps and floor plans that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1960 with the bulk of the items dating from 1899 to 1951. The maps and floor plans often include annotations and illustrate a wide range of locations including, but not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003eHavana and its environs;\u003c/item\u003e\n      \u003citem\u003eCuba;\u003c/item\u003e\n      \u003citem\u003esites associated with the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003eand military installations in the United States.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eIn addition to the maps and floor plans, Series V. also consists of a few newspaper and magazine clippings that contain information relating to the yellow fever experiments.\u003c/p\u003e","\u003cp\u003e Series VI. Alphabetical files primarily consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1860 to around 1966 with the bulk of the items dating from 1940 to 1956. All of these items have been arranged thematically into biographical files. Each file contains materials created by or relating to people who were either involved with the yellow fever experiments or aided Philip Showalter Hench in his research of the subject. These people include, but are not limited to: John J. Moran, Carlos E. Finlay, Laura Wood Roper, Mabel Lazear, Clara Maas, John R. Kissinger, Roger Post Ames, James C. Carroll, and Carlos J. Finlay. The files are arranged alphabetically by the last names of the individuals listed on the files and it is unclear whether the overall arrangement was made by Hench or by staff members at the University of Virginia. The biographical files contain a wide range of different materials that pertain to the individuals listed on the files. These materials include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ecorrespondence between Philip Showalter Hench and the individuals;\u003c/item\u003e\n      \u003citem\u003eother correspondence;\u003c/item\u003e\n      \u003citem\u003enewspaper and magazine clippings;\u003c/item\u003e\n      \u003citem\u003eunpublished manuscripts;\u003c/item\u003e\n      \u003citem\u003ebiographical and autobiographical accounts;\u003c/item\u003e\n      \u003citem\u003etranscripts of oral history interviews that were conducted by Philip Showalter Hench;\u003c/item\u003e\n      \u003citem\u003eand copies of medical charts for volunteers in the yellow fever experiments that shows the progression of the disease.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eIn addition to the materials that Hench created or collected during his lifetime, the biographical files in Series VI. also contain items that were added by staff at the University of Virginia Library during the late 1960s and early 1970s.\u003c/p\u003e","\u003cp\u003e Series VII. Truby-Kean-Hench primarily consists of materials relating to Albert E. Truby and Jefferson Randolph Kean that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1879 to around 1960 with the bulk of the items dating from 1900 to 1954. These items include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ecorrespondence of Jefferson Randolph Kean dating from 1900 to 1950 that relates to his personal life, the yellow fever experiments, public health initiatives, his publications, the legacy of the yellow fever experiments, Kean's work in World War I, and other topics;\u003c/item\u003e\n      \u003citem\u003ePhilip Showalter Hench's correspondence with people related to the yellow fever experiments, particularly Albert E. Truby and Jefferson Randolph Kean primarily from between 1940 and 1955;\u003c/item\u003e\n      \u003citem\u003ea scrapbook and other materials that relate to Truby's book,\u003ctitle render=\"italic\"\u003eMemoir of Walter Reed: the Yellow Fever Episode\u003c/title\u003e;\u003c/item\u003e\n      \u003citem\u003eand Philip Showalter Hench's interviews and questionnaires for Kean and Truby from the 1940s.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eIn addition to the materials relating to Kean and Truby, Series VII. also includes the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003enotes from Philip Showalter Hench's research of the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ethe recollections, autobiographies, and reports of other people involved with the yellow fever experiments including John Andrus and A.S. Pinto;\u003c/item\u003e\n      \u003citem\u003earticles and clippings related to the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ea short biography of Lemuel S. Reed;\u003c/item\u003e\n      \u003citem\u003eand a sketch Philip Showalter Hench made of a proposed museum at the Camp Lazear site.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries VIII. Miscellany consists of oversize and miscellaneous materials in the Philip S. Hench Walter Reed yellow fever collection that were, for various reasons, not included in any of the other series in the collection. Items in this series date from around 1849 to 1982 with the bulk of the materials dating from 1885 to 1974. These materials include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003einformed consent agreements for volunteers in the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ediplomas and certificates for Walter Reed and Jesse W. Lazear;\u003c/item\u003e\n      \u003citem\u003ecopies and sketches of Dean Cornwell's painting,\u003ctitle render=\"italic\"\u003eConquerors of Yellow Fever\u003c/title\u003e;\u003c/item\u003e\n      \u003citem\u003eartifacts, including a wooden board from Camp Lazear and a U.S. flag;\u003c/item\u003e\n      \u003citem\u003ecopies of correspondence, reports, medical records, and military orders from the U.S. National Archives relating to the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003emanuscripts and related notes for published works and research relating to Walter Reed and the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ecorrespondence of Philip Showalter Hench from circa 1940 to 1966;\u003c/item\u003e\n      \u003citem\u003earticles and clippings relating to the yellow fever experiments, the experiments' participants, and the Philip S. Hench Walter Reed yellow fever collection;\u003c/item\u003e\n      \u003citem\u003ecorrespondence of Atcheson Laughlin Hench and members of the University of Virginia community relating to the Philip S. Hench Walter Reed yellow fever collection;\u003c/item\u003e\n      \u003citem\u003eitems that document the provenance and custodial history of some materials in the Philip S. Hench Walter Reed yellow fever collection;\u003c/item\u003e\n      \u003citem\u003ephotographs relating to Cuba and the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003enotes for photographs and photographic negatives housed in Series IX. and Series X. of this collection.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries IX. Photographs consists primarily of photographs that Philip Showalter Hench created and collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1966 with the bulk of the items dating from around 1870 to around 1960. The subjects shown in the photographs include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ephysicians, military personnel, nurses, and volunteers associated with the experiments including Walter Reed, Jesse W. Lazear, Jefferson Randolph Kean, and Aristides Agramonte;\u003c/item\u003e\n      \u003citem\u003efamily members of people associated with the yellow fever experiments including their spouses, children, and grandchildren.\u003c/item\u003e\n      \u003citem\u003eCamp Lazear, Camp Columbia, and other locations in Cuba related to the yellow fever experiments between 1900 and 1960;\u003c/item\u003e\n      \u003citem\u003ethe U.S.S.\u003cemph render=\"italic\"\u003eMaine\u003c/emph\u003eand the Spanish-American War;\u003c/item\u003e\n      \u003citem\u003eaerial views of Havana, Cuba and its environs from the 1940s and 1950s;\u003c/item\u003e\n      \u003citem\u003escenes of daily life in Cuba generally from between 1898 and 1960;\u003c/item\u003e\n      \u003citem\u003ethe 1952 dedication of the Camp Lazear National Monument in Cuba;\u003c/item\u003e\n      \u003citem\u003ethe creation and unveiling of Dean Cornwell's painting,\u003ctitle render=\"italic\"\u003eConquerors of Yellow Fever\u003c/title\u003e;\u003c/item\u003e\n      \u003citem\u003estill scenes from the movies,\u003ctitle render=\"italic\"\u003eYellow Jack\u003c/title\u003eand\u003ctitle render=\"italic\"\u003eJezebel\u003c/title\u003e;\u003c/item\u003e\n      \u003citem\u003eother events and works of art commemorating the work of the participants in the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003edocuments and maps that Philip Showalter Hench copied for his research;\u003c/item\u003e\n      \u003citem\u003eand Philip Showalter Hench and his family.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries IX. also includes a watercolor that was painted by Emilie Lawrence Reed.\u003c/p\u003e","\u003cp\u003e Series X. Photographic negatives consists of a mix of original and copy negatives that Philip Showalter Hench collected while researching the yellow fever experiments. Although the original images recorded on the negatives date from between the 1860s and the 1960s, it appears that the negatives themselves were produced during a narrower time frame, most likely between 1930 and 1966.\u003c/p\u003e","\u003cp\u003e The negatives in Series X. record images associated with the yellow fever experiments and many of them are related to photographic prints found in Series VIII. Where a match between a negative and a print from these series has been made, the negative number has been written on the folder of the print in the physical collection. Finally, the negatives are generally arranged in numerical order by identification numbers that were most likely assigned by Philip Showalter Hench.\u003c/p\u003e","\u003cp\u003e Series XI. Reprints consists of reprints and photocopies of journal articles, book extracts, book reviews and other published works that were primarily collected by Philip Showalter Hench while researching the yellow fever experiments. Items in this series date from 1856 to 1971 and cover a wide range of topics related to the study and eradication of yellow fever, including, but not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ethe results of the U.S. Army Yellow Fever Commission's work in Cuba;\u003c/item\u003e\n      \u003citem\u003ebiographical accounts of various people who had an association with the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ethe research of people associated with the experiments including Walter Reed, Jesse W. Lazear, Aristides Agramonte, and James Carroll;\u003c/item\u003e\n      \u003citem\u003escientific and medical research related to yellow fever and malaria;\u003c/item\u003e\n      \u003citem\u003eand events honoring the work of those involved with the yellow fever experiments.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries XII. Houston Academy of Medicine/Texas Medical Center additions consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1901 to around 1966. These materials were originally a part of the Philip S. Hench papers in the John P. McGovern Historical Collections and Research Center at the Texas Medical Center Library, but they were transferred to the University of Virginia in 1991. These items include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ecorrespondence between Philip Showalter Hench and people connected with the yellow fever experiments including John J. Moran and Walter Reed's children;\u003c/item\u003e\n      \u003citem\u003enewspaper clippings relating to the death or commemoration of individuals associated with the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ephotographs of the Camp Lazear Memorial, everyday scenes in Cuba, and John J. Moran;\u003c/item\u003e\n      \u003citem\u003eand journal articles, booklets, and other printed matter relating to the yellow fever experiments and its participants.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries XIII. Reed family additions consists of materials relating to the yellow fever experiments that several different donors gave to the University of Virginia. Items in the series date from around 1850 to 1967 with the bulk of the items dating from 1868 to 1949. The largest portion of the series is comprised of correspondence written by Walter Reed and his family between 1877 and 1902 that provide insights into their relationships and personal lives.\u003c/p\u003e","\u003cp\u003e In addition to the Reed family's correspondence, the series also contains other materials relating to the Reed family and the yellow fever experiments including, but not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ea flag that was flown over Camp Lazear;\u003c/item\u003e\n      \u003citem\u003enewspaper clippings and articles relating to the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ea chemistry notebook that was owned by Walter Reed;\u003c/item\u003e\n      \u003citem\u003ecorrespondence of and works by Philip Showalter Hench;\u003c/item\u003e\n      \u003citem\u003ean inventory of materials in Series XIII. and information about their accession into the Claude Moore Health Sciences Library;\u003c/item\u003e\n      \u003citem\u003eand materials from an exhibit on the yellow fever experiments that was hosted in Alderman Library at the University of Virginia.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries XIV. P. Kahler Hench additions consists of original and photocopied materials that Philip Showalter Hench's son, P. Kahler Hench, donated to the University of Virginia in 1988 and 1989. Items in the series date from around 1860 to 1965 with the bulk of the materials dating from 1898 to 1965. Most of these items were collected or created by Philip Showalter Hench while researching the yellow fever experiments. These items include the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ethe correspondence of experiment participants;\u003c/item\u003e\n      \u003citem\u003ecorrespondence between Philip Showalter Hench and the experiment participants;\u003c/item\u003e\n      \u003citem\u003ecorrespondence between Philip Showalter Hench and families of the experiment participants;\u003c/item\u003e\n      \u003citem\u003epress clippings relating to the experiments and the experiment participants;\u003c/item\u003e\n      \u003citem\u003eoral history interviews conducted by Philip Showalter Hench;\u003c/item\u003e\n      \u003citem\u003escientific articles related to the study of yellow fever;\u003c/item\u003e\n      \u003citem\u003ephotographs of Havana, Camp Columbia, and Camp Lazear;\u003c/item\u003e\n      \u003citem\u003egenealogical tables and summaries for the family of Jesse W. Lazear;\u003c/item\u003e\n      \u003citem\u003eautobiographical accounts written by experiment participants;\u003c/item\u003e\n      \u003citem\u003eunpublished manuscripts;\u003c/item\u003e\n      \u003citem\u003eartifacts (e.g. a wooden board) from Camp Lazear;\u003c/item\u003e\n      \u003citem\u003ePhilip Showalter Hench's research notes.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries XIV. also contains correspondence and financial records that record the transfer of collection items from the Reed family to Philip Showalter Hench and later from the Hench family to the University of Virginia.\u003c/p\u003e","\u003cp\u003e Series XV. Laura Wood primarily consists of Laura Wood's correspondence relating to her research for a Walter Reed biography that she wrote. The series also includes, but is not limited to the following materials:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ephotocopies of two letters written by Walter Reed;\u003c/item\u003e\n      \u003citem\u003ea journal article by George Sternberg;\u003c/item\u003e\n      \u003citem\u003eand a short work that Laura Wood wrote about Walter Reed entitled,\u003ctitle render=\"italic\"\u003eWalter Reed and yellow Fever\u003c/title\u003e.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eItems in Series XV. date from 1875 to 1946 with the bulk of the items dating from 1941 to 1946.\u003c/p\u003e","\u003cp\u003e Series XVI. Edward Hook additions consists of copies of letters, articles, and photographs relating to the yellow fever experiments that had been collected by Edward W. Hook, Jr, a professor of medicine at the University of Virginia. The bulk of this series is comprised of copies of a small collection of James Carroll's correspondence. The original versions of Carroll's correspondence are not housed at the University of Virginia. In addition to the Carroll letters, this series also includes, but is not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ephotographs of Walter Reed and others related to the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ecopies of some of Theodore E. Woodward's works relating to James Carroll and yellow fever;\u003c/item\u003e\n      \u003citem\u003eand exhibition materials.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eItems in Series XVI. date from around 1880 to around 1998 with the bulk of the items dating from 1898 to 1901.\u003c/p\u003e  "],"scopecontent_heading_ssm":["Scope and Content Information"],"scopecontent_tesim":["The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audio cassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). All of these materials are arranged in 16 series: I. Jesse W. Lazear, II. Henry Rose Carter, III. Walter Reed, IV. Philip Showalter Hench, V. Maps, VI. Alphabetical files, VII. Truby-Kean-Hench, VIII. Miscellany, IX. Photographs, X. Photographic negatives, XI. Reprints, XII. Houston Academy of Medicine/Texas Medical Center additions, XIII. Reed family additions, XIV. P. Kahler Hench additions, XV. Laura Wood, and XVI. Edward Hook additions.","Series I. Jesse W. Lazear consists of materials relating to Lazear that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1800 to 1956 with the bulk of the items dating from 1863 to 1943. Much of the series consists of the correspondence of Jesse W. Lazear and his wife Mabel H. Lazear. Jesse's correspondence dates from his time as a student at Johns Hopkins University to his death in 1900. Researchers can learn a great deal about Jesse from these letters, including his relationships with friends and family, his educational background, and his professional life. Mabel's correspondence dates from the time she met Jesse to her death in 1946. This correspondence primarily concern her husband's historical legacy and a campaign to secure a pension from the U.S. government for herself and her family.","In addition to Jesse and Mabel's correspondence, the series contains other materials relating to them and their families including, but not limited to the following:","the diaries documenting the travels of Jesse and Mabel's mothers in Europe;\n      correspondence of other Lazear family members (e.g. Jesse's parents);\n      genealogical summaries and tables relating to the Lazear family;\n      legal documents (e.g. wills, certificates, deeds);\n      military records relating to Jesse;\n      certificates, reports, and other materials documenting Jesse's educational background and achievements;\n      obituaries;\n      copies of congressional bills and reports concerning the provision of a federal pension for Mabel H. Lazear;\n      newspaper articles;\n      a microscope and sets of microscope slides owned by Jesse;\n      and a medical chart that shows the progression of the yellow fever infection that killed Jesse.","Series II. Henry Rose Carter consists of materials relating to Henry Rose Carter that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1880 to 1932 with the bulk of the materials dating from 1883 to 1932. The series is particularly rich in materials that document Henry Rose Carter's professional activities in the last eleven years of his life (1914-1925). These materials include, but are not limited to the following:","correspondence with colleagues in the medical and scientific community including Rupert E. Blue, Hideyo Noguchi, Henry Hanson, Joseph A. LePrince, Frederick F. Russell, T.H.D. Griffitts, and Lunsford D. Fricks;\n      scientific, medical, and government reports relating to the study and eradication of yellow fever and malaria in North America, South America, and Africa;\n      journal articles concerning the study and eradication of yellow fever and malaria;\n      research notes written by Henry Rose Carter;\n      and photographs of Henry Rose Carter at work and with professional colleagues.","Series II. also contains correspondence between Henry Rose Carter and members of his family that date from 1880 to 1925. The family members with whom Henry corresponds most frequently in this series are his mother, Emma Coleman Carter; his wife, Laura Eugenia Hook Carter; his daughter, Laura Armistead Carter; and his son, Henry Rose Carter, Jr. These letters are not only a rich source of information about Carter's personal views and family life, they also provide valuable insights into his professional activities such as his experiences aboard vessels and in ports while working for the U.S. Marine Hospital Service and his public health work in Cuba, Panama, and Peru.","In addition to the materials that were produced during Henry Rose Carter's lifetime, the Series II. contains materials that were produced between 1925 and 1940 (after Henry Rose Carter's death) including, but not limited to the following:","copies of obituaries for Henry Rose Carter;\n      condolence letters for Henry Rose Carter's family after Henry's death;\n      and the correspondence of Laura Armistead Carter relating to her father and other members of the Carter family.","Series III. Walter Reed consists of materials that document the life of Walter Reed as well as the work and legacy of the U.S. Army Yellow Fever Commission. Items in the series date from 1806 to around 1955 with the bulk of the items dating from 1874 to 1936. The series is particularly rich in materials that document the professional and personal life of Walter Reed from 1874 to his death in 1902. These materials include, but are not limited to the following:","correspondence between Walter Reed and members of his immediate family that cover a wide range of topics including Reed's courtship of Emilie Lawrence Reed, family life, Walter Reed's work in the Western United States, and Walter Reed's work in Cuba;\n      military records relating to Walter Reed including military orders for Reed, Reed's performance reviews, and reports of Reed's work for army officials;\n      Walter Reed's correspondence with professional colleagues including members of the U.S. Army Yellow Fever Commission, military doctors, and medical researchers interested in the study of yellow fever;\n      medical records (e.g. fever charts of experiment participants), military orders, administrative records, reports, and publications documenting the results of the U.S. Army Yellow Fever Commission's experiments in Cuba;\n      articles announcing the death of Walter Reed;\n      and the shoulder boards from Walter Reed's U.S. Army uniform.","In addition to the above items, Series III. contains materials that document campaigns, spanning from 1902 to 1937, to publicly honor members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments. These materials include, but are not limited to the following:","articles and editorials relating to efforts to memorialize and provide pensions for members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments;\n      biographical sketches of members of the U.S. Army Yellow Fever Commission and experiment participants;\n      records relating to the Walter Reed Memorial Association (e.g. correspondence, donor lists);\n      copies of Congressional bills and resolutions to honor members of the U.S. Army Yellow Fever Commission and experiment participants;\n      and letters, reviews, and other materials relating to the production of Sidney Coe Howard's play,Yellow Jack.","Finally, Series III. also consists of materials that document the history of yellow fever during the nineteenth and early twentieth century. These materials include, but are not limited to the following:","items (e.g. correspondence, reports, reviews, and articles) relating to U.S. efforts to eradicate yellow fever in the Panama Canal Zone;\n      materials (e.g. correspondence, reports, and articles) documenting early twentieth century efforts to eradicate yellow fever in Peru;\n      scientific reports and publications related to the study and eradication of yellow fever and malaria;\n      and newspaper articles describing various outbreaks of yellow fever epidemics.","Series IV. Philip Showalter Hench primarily consists of materials that Hench created or collected while researching the U.S. Army Yellow Fever Commission. Items in this series date from around 1850 to around 1865 with the bulk of the items dating from 1937 to 1960. Researchers who are studying the yellow fever experiments will be particularly interested in the materials (e.g. interviews, autobiographies) that document first-hand accounts of the events surrounding the experiments. Other researchers may be interested in items that document Hench's role in shaping public memory of the commission and its experiments. The materials in this series include, but are not limited to the following:","Hench's correspondence and interviews with participants in the yellow fever experiments and their families including: Emilie Lawrence Reed, Emilie M. (Blossom) Reed, Walter Lawrence Reed, John J. Moran, Albert E. Truby, Jefferson Randolph Kean, John H. Andrus, and John R. Kissinger;\n      autobiographical accounts of the experiment's participants and their families;\n      notes, reports, correspondence and other materials relating to Hench's search for the original site of Camp Lazear in Cuba;\n      correspondence with Cuban government officials and members of the scientific community relating to Hench's campaign to build a Camp Lazear memorial;\n      correspondence and other materials relating to ceremonies honoring Jesse W. Lazear at Washington and Jefferson College;\n      newspaper articles, magazine articles, and other printed matter concerning the yellow fever experiments and its participants;\n      drafts of speeches and presentations Hench gave on the history of the yellow fever experiments to various audiences;\n      meeting minutes and other materials that document Hench's relationship with and participation in the Walter Reed Memorial Association;\n      scripts for radio programs relating to the yellow fever experiments;\n      notes, outlines, lists, correspondence, and other materials that document Hench's research about the yellow fever experiments and a book he had planned to write on the subject;\n      and the gold medal that Congress posthumously awarded to Walter Reed for his work with yellow fever.","Series V. Maps primarily consists of maps and floor plans that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1960 with the bulk of the items dating from 1899 to 1951. The maps and floor plans often include annotations and illustrate a wide range of locations including, but not limited to the following:","Havana and its environs;\n      Cuba;\n      sites associated with the yellow fever experiments;\n      and military installations in the United States.","In addition to the maps and floor plans, Series V. also consists of a few newspaper and magazine clippings that contain information relating to the yellow fever experiments.","Series VI. Alphabetical files primarily consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1860 to around 1966 with the bulk of the items dating from 1940 to 1956. All of these items have been arranged thematically into biographical files. Each file contains materials created by or relating to people who were either involved with the yellow fever experiments or aided Philip Showalter Hench in his research of the subject. These people include, but are not limited to: John J. Moran, Carlos E. Finlay, Laura Wood Roper, Mabel Lazear, Clara Maas, John R. Kissinger, Roger Post Ames, James C. Carroll, and Carlos J. Finlay. The files are arranged alphabetically by the last names of the individuals listed on the files and it is unclear whether the overall arrangement was made by Hench or by staff members at the University of Virginia. The biographical files contain a wide range of different materials that pertain to the individuals listed on the files. These materials include, but are not limited to the following:","correspondence between Philip Showalter Hench and the individuals;\n      other correspondence;\n      newspaper and magazine clippings;\n      unpublished manuscripts;\n      biographical and autobiographical accounts;\n      transcripts of oral history interviews that were conducted by Philip Showalter Hench;\n      and copies of medical charts for volunteers in the yellow fever experiments that shows the progression of the disease.","In addition to the materials that Hench created or collected during his lifetime, the biographical files in Series VI. also contain items that were added by staff at the University of Virginia Library during the late 1960s and early 1970s.","Series VII. Truby-Kean-Hench primarily consists of materials relating to Albert E. Truby and Jefferson Randolph Kean that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1879 to around 1960 with the bulk of the items dating from 1900 to 1954. These items include, but are not limited to the following:","correspondence of Jefferson Randolph Kean dating from 1900 to 1950 that relates to his personal life, the yellow fever experiments, public health initiatives, his publications, the legacy of the yellow fever experiments, Kean's work in World War I, and other topics;\n      Philip Showalter Hench's correspondence with people related to the yellow fever experiments, particularly Albert E. Truby and Jefferson Randolph Kean primarily from between 1940 and 1955;\n      a scrapbook and other materials that relate to Truby's book,Memoir of Walter Reed: the Yellow Fever Episode;\n      and Philip Showalter Hench's interviews and questionnaires for Kean and Truby from the 1940s.","In addition to the materials relating to Kean and Truby, Series VII. also includes the following:","notes from Philip Showalter Hench's research of the yellow fever experiments;\n      the recollections, autobiographies, and reports of other people involved with the yellow fever experiments including John Andrus and A.S. Pinto;\n      articles and clippings related to the yellow fever experiments;\n      a short biography of Lemuel S. Reed;\n      and a sketch Philip Showalter Hench made of a proposed museum at the Camp Lazear site.","Series VIII. Miscellany consists of oversize and miscellaneous materials in the Philip S. Hench Walter Reed yellow fever collection that were, for various reasons, not included in any of the other series in the collection. Items in this series date from around 1849 to 1982 with the bulk of the materials dating from 1885 to 1974. These materials include, but are not limited to the following:","informed consent agreements for volunteers in the yellow fever experiments;\n      diplomas and certificates for Walter Reed and Jesse W. Lazear;\n      copies and sketches of Dean Cornwell's painting,Conquerors of Yellow Fever;\n      artifacts, including a wooden board from Camp Lazear and a U.S. flag;\n      copies of correspondence, reports, medical records, and military orders from the U.S. National Archives relating to the yellow fever experiments;\n      manuscripts and related notes for published works and research relating to Walter Reed and the yellow fever experiments;\n      correspondence of Philip Showalter Hench from circa 1940 to 1966;\n      articles and clippings relating to the yellow fever experiments, the experiments' participants, and the Philip S. Hench Walter Reed yellow fever collection;\n      correspondence of Atcheson Laughlin Hench and members of the University of Virginia community relating to the Philip S. Hench Walter Reed yellow fever collection;\n      items that document the provenance and custodial history of some materials in the Philip S. Hench Walter Reed yellow fever collection;\n      photographs relating to Cuba and the yellow fever experiments;\n      notes for photographs and photographic negatives housed in Series IX. and Series X. of this collection.","Series IX. Photographs consists primarily of photographs that Philip Showalter Hench created and collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1966 with the bulk of the items dating from around 1870 to around 1960. The subjects shown in the photographs include, but are not limited to the following:","physicians, military personnel, nurses, and volunteers associated with the experiments including Walter Reed, Jesse W. Lazear, Jefferson Randolph Kean, and Aristides Agramonte;\n      family members of people associated with the yellow fever experiments including their spouses, children, and grandchildren.\n      Camp Lazear, Camp Columbia, and other locations in Cuba related to the yellow fever experiments between 1900 and 1960;\n      the U.S.S.Maineand the Spanish-American War;\n      aerial views of Havana, Cuba and its environs from the 1940s and 1950s;\n      scenes of daily life in Cuba generally from between 1898 and 1960;\n      the 1952 dedication of the Camp Lazear National Monument in Cuba;\n      the creation and unveiling of Dean Cornwell's painting,Conquerors of Yellow Fever;\n      still scenes from the movies,Yellow JackandJezebel;\n      other events and works of art commemorating the work of the participants in the yellow fever experiments;\n      documents and maps that Philip Showalter Hench copied for his research;\n      and Philip Showalter Hench and his family.","Series IX. also includes a watercolor that was painted by Emilie Lawrence Reed.","Series X. Photographic negatives consists of a mix of original and copy negatives that Philip Showalter Hench collected while researching the yellow fever experiments. Although the original images recorded on the negatives date from between the 1860s and the 1960s, it appears that the negatives themselves were produced during a narrower time frame, most likely between 1930 and 1966.","The negatives in Series X. record images associated with the yellow fever experiments and many of them are related to photographic prints found in Series VIII. Where a match between a negative and a print from these series has been made, the negative number has been written on the folder of the print in the physical collection. Finally, the negatives are generally arranged in numerical order by identification numbers that were most likely assigned by Philip Showalter Hench.","Series XI. Reprints consists of reprints and photocopies of journal articles, book extracts, book reviews and other published works that were primarily collected by Philip Showalter Hench while researching the yellow fever experiments. Items in this series date from 1856 to 1971 and cover a wide range of topics related to the study and eradication of yellow fever, including, but not limited to the following:","the results of the U.S. Army Yellow Fever Commission's work in Cuba;\n      biographical accounts of various people who had an association with the yellow fever experiments;\n      the research of people associated with the experiments including Walter Reed, Jesse W. Lazear, Aristides Agramonte, and James Carroll;\n      scientific and medical research related to yellow fever and malaria;\n      and events honoring the work of those involved with the yellow fever experiments.","Series XII. Houston Academy of Medicine/Texas Medical Center additions consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1901 to around 1966. These materials were originally a part of the Philip S. Hench papers in the John P. McGovern Historical Collections and Research Center at the Texas Medical Center Library, but they were transferred to the University of Virginia in 1991. These items include, but are not limited to the following:","correspondence between Philip Showalter Hench and people connected with the yellow fever experiments including John J. Moran and Walter Reed's children;\n      newspaper clippings relating to the death or commemoration of individuals associated with the yellow fever experiments;\n      photographs of the Camp Lazear Memorial, everyday scenes in Cuba, and John J. Moran;\n      and journal articles, booklets, and other printed matter relating to the yellow fever experiments and its participants.","Series XIII. Reed family additions consists of materials relating to the yellow fever experiments that several different donors gave to the University of Virginia. Items in the series date from around 1850 to 1967 with the bulk of the items dating from 1868 to 1949. The largest portion of the series is comprised of correspondence written by Walter Reed and his family between 1877 and 1902 that provide insights into their relationships and personal lives.","In addition to the Reed family's correspondence, the series also contains other materials relating to the Reed family and the yellow fever experiments including, but not limited to the following:","a flag that was flown over Camp Lazear;\n      newspaper clippings and articles relating to the yellow fever experiments;\n      a chemistry notebook that was owned by Walter Reed;\n      correspondence of and works by Philip Showalter Hench;\n      an inventory of materials in Series XIII. and information about their accession into the Claude Moore Health Sciences Library;\n      and materials from an exhibit on the yellow fever experiments that was hosted in Alderman Library at the University of Virginia.","Series XIV. P. Kahler Hench additions consists of original and photocopied materials that Philip Showalter Hench's son, P. Kahler Hench, donated to the University of Virginia in 1988 and 1989. Items in the series date from around 1860 to 1965 with the bulk of the materials dating from 1898 to 1965. Most of these items were collected or created by Philip Showalter Hench while researching the yellow fever experiments. These items include the following:","the correspondence of experiment participants;\n      correspondence between Philip Showalter Hench and the experiment participants;\n      correspondence between Philip Showalter Hench and families of the experiment participants;\n      press clippings relating to the experiments and the experiment participants;\n      oral history interviews conducted by Philip Showalter Hench;\n      scientific articles related to the study of yellow fever;\n      photographs of Havana, Camp Columbia, and Camp Lazear;\n      genealogical tables and summaries for the family of Jesse W. Lazear;\n      autobiographical accounts written by experiment participants;\n      unpublished manuscripts;\n      artifacts (e.g. a wooden board) from Camp Lazear;\n      Philip Showalter Hench's research notes.","Series XIV. also contains correspondence and financial records that record the transfer of collection items from the Reed family to Philip Showalter Hench and later from the Hench family to the University of Virginia.","Series XV. Laura Wood primarily consists of Laura Wood's correspondence relating to her research for a Walter Reed biography that she wrote. The series also includes, but is not limited to the following materials:","photocopies of two letters written by Walter Reed;\n      a journal article by George Sternberg;\n      and a short work that Laura Wood wrote about Walter Reed entitled,Walter Reed and yellow Fever.","Items in Series XV. date from 1875 to 1946 with the bulk of the items dating from 1941 to 1946.","Series XVI. Edward Hook additions consists of copies of letters, articles, and photographs relating to the yellow fever experiments that had been collected by Edward W. Hook, Jr, a professor of medicine at the University of Virginia. The bulk of this series is comprised of copies of a small collection of James Carroll's correspondence. The original versions of Carroll's correspondence are not housed at the University of Virginia. In addition to the Carroll letters, this series also includes, but is not limited to the following:","photographs of Walter Reed and others related to the yellow fever experiments;\n      copies of some of Theodore E. Woodward's works relating to James Carroll and yellow fever;\n      and exhibition materials.","Items in Series XVI. date from around 1880 to around 1998 with the bulk of the items dating from 1898 to 1901."],"userestrict_html_tesm":["\u003cp\u003eCopyright restrictions may apply for some materials in the collection.\u003c/p\u003e  "],"userestrict_heading_ssm":["Copyright Status"],"userestrict_tesim":["Copyright restrictions may apply for some materials in the collection."],"abstract_html_tesm":["\u003cabstract id=\"aspace_98fe81a152b4be0b7388b1814ffaf4bd\"\u003eThe Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audiocassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). Most of the materials in the collection were collected or created by Nobel laureate Philip Showalter Hench while researching the history of the U.S. Army Yellow Fever Commission.\u003c/abstract\u003e\n    "],"abstract_tesim":["The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audiocassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). Most of the materials in the collection were collected or created by Nobel laureate Philip Showalter Hench while researching the history of the U.S. Army Yellow Fever Commission."],"corpname_ssim":["Claude Moore Health Sciences Library"],"names_ssim":["Claude Moore Health Sciences Library"],"language_ssim":["Collection is predominantly in English; other materials in the collection are in Spanish, French, and Portuguese."],"descrules_ssm":["Describing Archives: A Content Standard"],"total_component_count_is":10452,"online_item_count_is":0,"component_level_isim":[0],"sort_isi":0,"timestamp":"2026-08-14T22:54:59.526Z","bioghist_html_tesm":["\u003cp\u003eThe U.S. Army Yellow Fever Commission (1900-1901) was a board of physicians that the U.S. government formed in order to determine how yellow fever was transmitted between hosts. Ultimately, the commission's experiments in Cuba proved that mosquitoes transmit yellow fever--a discovery that would spur successful campaigns to control and eradicate yellow fever throughout much of the globe.\u003c/p\u003e","\u003cp\u003e When Major Walter Reed and Acting Assistant Surgeons James Carroll, Aristides Agramonte, and Jesse Lazear gathered on the porch of the Columbia Barracks Hospital in June of 1900, they became the fourth successive board of U.S. medical officers to grapple with the appalling plague that was yellow fever.\u003c/p\u003e","\u003cp\u003e The persistence of this disease across the Cuban archipelago and its periodic re-emergence along the coastlines and great river drainages of the Americas was taking countless thousands of lives. Lack of precise knowledge as to its cause and transmission had augmented yellow fever's extraordinarily high mortality rate and had given rise to quarantine regulations which constituted substantial impediments to efficient regional trade. Endemic in the tropics, yellow fever imposed high humanitarian and economic costs upon the entire region. Specialists regarded Cuba as one of the principal foci of the disease, and the island consequently attracted considerable attention from the medical sciences.\u003c/p\u003e","\u003cp\u003e In 1879, one year after a devastating epidemic swept up the Mississippi valley from New Orleans, Tulane University Professor Stanford E. Chaille led the first investigatory commission to Havana, Rio de Janeiro, and the West Indies. The Chaille Commission remained in Havana three months, and its members -- including George Miller Sternberg, who became Surgeon General of the Army, and Juan Guiteras, later Director of Public Health for Havana -- consulted with Cuban scientist Carlos J. Finlay. They concluded that the causal agent for yellow fever was possibly a living entity in the atmosphere, an assertion which set Finlay on the path to the mosquito theory he developed in 1881.\u003c/p\u003e","\u003cp\u003e Louis Pasteur's foundational and highly successful work in modern immunology in 1880 and 1881 gave a renewed impetus to investigations aimed at discovering the \"yellow fever germ.\" Over the middle years of the 1880s several scientists advanced different theories, all readily refuted by bacteriological work Sternberg undertook in Brazil and Mexico in 1887 and again in Havana in 1888 and 1889. In 1897, Italian scientist Giuseppe Sanarelli argued that\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003ewas the culprit, and the following year a third scientific team sailed to Cuba for additional tests. Eugene Wasdin and Henry D. Geddings appeared to confirm Sanarelli's assertion, though Sternberg, by then Surgeon General, remained skeptical.\u003c/p\u003e","\u003cp\u003e Despite Wasdin and Geddings' insistence, the\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003etheory garnered significant opposition. In fact, a few months before the third commission's report reached the public, Walter Reed and James Carroll -- Reed's assistant at the Columbian University (later George Washington University) bacteriology laboratories in Washington, D.C. -- published a thorough refutation of the\u003cemph render=\"italic\"\u003eicteroides\u003c/emph\u003eproposal: the bacteria was not a unique cause of yellow fever, but a variety of the hog cholera bacillus, \"a secondary invader in yellow fever,\" Reed determined, unrelated to its etiology. [1] Dispute continued, however, and when Sternberg organized the fourth investigatory board, he charged Reed and his associates to settle the\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003equestion once and for all, then to proceed with analysis of other blood cultures and intestinal flora from yellow fever cases.\u003c/p\u003e","\u003cp\u003e Reed and Carroll had considerable experience in bacteriological analysis, and, Sternberg reasoned, might well be able to find the specific agent of the disease. Aristides Agramonte, a Cuban scientist who had worked in Reed's lab at the Columbian University in 1898, was also an accomplished bacteriologist; he had identified\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003ein tissue samples from cases other than yellow fever, providing further evidence opposed to Sanarelli's thesis. Jesse Lazear, a scientist from Johns Hopkins University in Baltimore, Maryland, had joined the Army Medical Corps to study tropical diseases at their point of origin; he received orders for Cuba in February 1900. Lazear impressed Reed with his abilities when the two men became acquainted in March. No doubt with Reed's advice, Sternberg assembled a crack team -- all experienced in scientific research, but each with interests as diverse as their temperaments. The mix of talent and personalities generated spectacular results.\u003c/p\u003e","\u003cp\u003e What causes yellow fever? This simple, even obvious question had dictated yellow fever research for over two decades, and so it guided Reed in organizing the work of the commission.\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003eand other bacteriological sampling dominated their work for the first months. \"Reed and Carroll have been at that for a long time,\" Lazear wrote with some impatience to his wife on August 23, \". . . I would rather try to find the germ without bothering about Sanarelli.\" [2] Again and again, tests for the bacteria proved negative, and at the same time, perplexing cases of yellow fever were developing in the region. Agramonte and Reed investigated an epidemic at Pinar del Rio, 110 miles southwest of Havana; Lazear followed later to collect more specimens, and he also assessed the situation at Guanjay thirty miles southwest. To \"my very great surprise,\" Reed admitted, the specific circumstances of the appearance and development of these cases gave strong evidence against the widely-accepted notion that the excreta of patients spread the disease. The theory of fomites -- infection from contaminated clothing and bedding -- and indeed even infection from airborne particles seemed altogether untrue. \"At this stage of our investigation,\" Reed concluded, \". . . the time had arrived when the plan of our work should be radically changed.\" [3] The fundamental question underwent a subtle but critical transformation: from what causes yellow fever to what transmits it. A clear and accurate understanding of how the disease was spread would open a new avenue to its specific cause.\u003c/p\u003e","\u003cp\u003e \"Personally, I feel that only can experimentation on human beings serve to clear the field for further effective work,\" Reed stated to Surgeon General Sternberg, who concurred. [4] Evidence gathering around them pointed strongly to an intermediate host, and the Commission resolved to test Carlos Finlay's mosquito theory -- then not generally accepted -- on human volunteers. Nine times from August 11 to August 25, 1900, mosquitoes landed on the arms of volunteers and proceeded to feed. Nine times the results were negative. On August 27, Lazear placed a mosquito on the doubting Dr. Carroll, and four days later on William J. Dean, a soldier designated XY in the \"Preliminary Note.\" [5] Both promptly developed yellow fever. Significantly, their mosquitoes had fed on cases within the initial three days of an attack and had been allowed to ripen for at least twelve days before the inoculations. Carroll vitiated the results of his experimental sickness by traveling off the post to Havana, a contaminated zone, even as Reed, ecstatic, wrote from Washington in a confidential letter: \"Did the Mosquito do it?\" [6] Dean's case seemed to prove it, since he claimed not to have left the garrison before becoming ill. Lazear also developed a case of yellow fever, almost certainly experimental in origin, though he never revealed the actual circumstances of his inoculation. His severe bout of fever took a fatal turn on September 25, 1900.\u003c/p\u003e","\u003cp\u003e Nevertheless, these results could not have been more dramatic or convincing for the Commission. Reed quickly assembled a \"Preliminary Note,\" which he presented to the annual meeting of the American Public Health Association in Indianapolis, Indiana, October 23, 1900. After initial consultations in Cuba with General Leonard Wood, military governor of the island, and with Surgeon General Sternberg in Washington, he returned to Cuba with authorization and funding to design and carry forward a fully defensible series of experiments. His aim was confirmation of the mosquito theory and invalidation of the long-held belief in fomites.\u003c/p\u003e","\u003cp\u003e On open terrain beyond the precincts of Columbia Barracks -- the American military base just west of Havana near the adjacent suburban towns of Quemados and Marianao (also called Quemados de Marianao) -- Reed established the quarantined experimental station. Camp Lazear, as the Commission dedicated it, took form in the rolling fields of the Finca San Jose, on the farm of Dr. Ignacio Rojas, who leased the land to the Americans. Here Reed designed two small wood-frame buildings, each 14 by 20 feet, for the experimental work, and nearby raised a group of seven tents for the accommodation and support of the volunteers. The buildings faced each other across a small swale, about 80 yards apart, and stood 75 yards from the tent encampment. Building Number One, called the Infected Clothing Building, was a single room tightly constructed to contain as much foul air as possible. A small stove kept the temperature and humidity at tropical levels, and carefully attached screening secured the pair of doorways in a vestibule against intrusion by mosquitoes. Wooden blinds on two small sealed windows shielded the room from direct sun. Building Number Two, the Infected Mosquito Building, contained a principal room, divided into two sections by a floor-to-ceiling wire mesh screen. A door direct to the exterior let into one section, while a vestibule with a solid exterior door and pair of successive screened doors opened to the other, so configured to keep infected mosquitoes inside that section alone. The spare furnishings in both sections -- cots with bedding -- were steam sterilized. Windows exposed the entire room to the clean, steady ocean breezes and to sunlight. Like the doorways, they were carefully screened. A secondary room attached to the building but not communicating with the experimental spaces sheltered the small, heated laboratory where the Commission members raised and stored the mosquitoes to be used.\u003c/p\u003e","\u003cp\u003e These two experimental buildings presented alternate environments -- one conspicuously clean and well ventilated, the other filthy and fetid. Contemporary theories of disease held that yellow fever developed in unclean conditions, and consequently much time and money had been devoted to sanitation projects. Workers steamed clothing, burned sulphur in ships' holds, and thoroughly scrubbed surfaces with disinfectant. In cases of severe epidemic, entire buildings presumed to be infected were set afire along with their contents. Thus the extraordinary -- and intentional -- paradox of the Commission's experimental regime: Reed expected yellow fever to develop not in the unsanitary environment, but in the one thought to be most healthful.\u003c/p\u003e","\u003cp\u003e Camp Lazear went into quarantine the day of its completion, November 20, 1900, with a command of four immune and nine non-immune individuals, all save one U.S. Army personnel. Soon a group of recent Spanish immigrants to Cuba augmented the non-immune numbers, bringing the resident total to about twenty. Reed strictly controlled access to the camp and ordered regular temperature recording for each volunteer to eliminate any unanticipated source of infection and to identify the onset of any case of yellow fever as early as possible. As a result, non-immunes were barred from returning should they leave the precinct, and two of the Spaniards who developed intermittent fevers shortly after arrival were immediately transferred with their baggage to Columbia Barracks Hospital. The immune members of the detachment oversaw medical treatments and drove the teams of mules that pulled supply wagons and the ambulance. Experimentation did not begin until each volunteer had passed the incubation period for yellow fever in perfect health.\u003c/p\u003e","\u003cp\u003e Reed took as much care with the design of the experimental protocol as he had with the configuration of the camp and its buildings. Each evening, the occupants of the infected clothing building unpacked trunks and boxes of bed linens and blankets, nightshirts and other clothing recently worn and soiled by cases from the wards of Columbia Barracks Hospital and Las Animas Hospital in Havana. These they shook out and spread around the room to permeate the atmosphere. The stench was overpowering. Yellow fever causes severe internal hemorrhaging, and its unfortunate victims often suffer from black vomit and other bloody discharges. One routine delivery proved so putrid the volunteers \"retreated from the house,\" Reed stated. \"They pluckily returned, however, within a short time, and spent the night as usual.\" [7] In two succeeding trials the protocol became progressively more daring , as the volunteers then wore the clothing and slept on the mattresses used by yellow fever patients, and finally put towels on their bedding smeared with blood drawn from cases in the early stages of an attack. Each morning, the volunteers carefully repacked the rank, encrusted materials into boxes and emerged to an adjacent tent where they spent the day quarantined from the rest of the company. Three trials of twenty days each involved seven men altogether, lead by Robert P. Cooke, a physician in the Army Medical Corps. None developed yellow fever.\u003c/p\u003e","\u003cp\u003e The Commission's mosquito experiments proceeded in four series. First, Reed sought to demonstrate that mosquitoes of the variety\u003cemph render=\"italic\"\u003eCulex fasciata\u003c/emph\u003e(later called\u003cemph render=\"italic\"\u003eStegomyia fasciata\u003c/emph\u003e, and later still\u003cemph render=\"italic\"\u003eAedes aegypti\u003c/emph\u003e) could in fact transmit yellow fever, as Carlos J. Finlay had argued and the initial experiments at Camp Columbia strongly suggested. Here the Commission members simply applied infected mosquitoes contained in test tubes or jars to the skin of the initial volunteers. Success in these tests raised a number of questions, each one addressed in the subsequent series:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003eHow could a building become infected?\u003c/item\u003e\n      \u003citem\u003eWhen does a mosquito develop the ability to transmit the disease?\u003c/item\u003e\n      \u003citem\u003eOver what length of time can a mosquito retain this capacity to infect?\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eThe second series consequently employed the specialized \"Infected Mosquito Building\" to indicate how a structure could be considered infected with yellow fever. This experiment required two groups of volunteers, one to be inoculated and another to serve as controls. \"Loaded\" mosquitoes, as the men called them, were released into the screened section of Building Two -- on the side with the protected vestibule entry. One or more non-immune men then entered the opposite section of the room through the direct exterior door, and lay down on bunks adjacent to the wire mesh screen in the center of the room. Now the young man to be inoculated walked through the vestibule into the mosquito side of the room and proceeded to lie on a bunk adjacent to the wire screen separating him from the controls. The inoculation volunteer remained in the building for about twenty minutes -- enough time to suffer several mosquito bites -- he then exited to a quarantine tent outside. The controls spent the remainder of the evening and night in the uninfected side of the room, and indeed returned to sleep in the room for as many as eighteen more nights. As Reed stated, absence of yellow fever in the controls showed \"that the essential factor in the infection of a building with yellow fever is the presence therein of [infected] mosquitoes,\" and nothing more. [8] The degree of sanitation, so long considered critical, was utterly irrelevant.\u003c/p\u003e","\u003cp\u003e The third series of mosquito experiments confirmed what Henry Rose Carter, of the U.S. Public Health Service, called the \"period of extrinsic incubation,\" [9] the length of time required for secondary cases of yellow fever to develop after an initial intrusion of the disease into a locality. In this series, a single volunteer underwent three successive inoculations by the same mosquitoes, each group of inoculations interrupted by a period of time equal in length to the typical incubation period of the disease in humans, about five days. In this manner, the volunteer's illness could be specifically attributed to a single inoculation group. The use of the same mosquitoes and the same volunteer concurrently demonstrated that no peculiar personal immunity was at play, since logic dictates that a person susceptible to yellow fever on day 17 of a mosquito's contamination -- as happened in the experiment -- could not have been immune to yellow fever on day 11 or day 4. It was thus only the mosquito's capacity to infect which changed, and that occurred no less than 11 days after contamination.\u003c/p\u003e","\u003cp\u003e The duration of time over which these \"fully ripened\" mosquitoes remained infective comprised the fourth series of experiments. For this series the Commission kept alive a group of infected mosquitoes for as long as possible, and proceeded to inoculate three volunteers -- on the 39th, 51st, and 57th day after contamination. Each developed yellow fever. A fourth volunteer declined to be bitten on day 65, and the last two mosquitoes of the group, \"deprived of further opportunity to feed on human blood\" [10] expired on day 69 and day 71, clear evidence that even a sparsely populated region may retain the potential for new infections more than two months after the first appearance of the disease.\u003c/p\u003e","\u003cp\u003e Although it went unrecorded in the published papers, Reed organized a supplemental experiment to test another species of mosquito.\u003cemph render=\"italic\"\u003eCulex pungens\u003c/emph\u003efailed to transmit yellow fever to at least one volunteer and probably to a second. Reed's preliminary conclusions indicated that\u003cemph render=\"italic\"\u003eCulex fasciata\u003c/emph\u003ewas the only species capable of transmitting yellow fever. [11]\u003c/p\u003e","\u003cp\u003e A last experimental regime involved subcutaneous injections of blood from positive cases of yellow fever to presumed non-immunes. Reed devised these tests to confirm the presence of the yellow fever agent in the blood of a victim during the first days of an attack, and, more importantly, to settle the\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003equestion. The same blood cultures which produced yellow fever in four volunteers also failed to grow any\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003e, conclusively invalidating Sanarelli's claim.\u003c/p\u003e","\u003cp\u003e Altogether, the mosquito inoculations and the blood injections produced fourteen cases of yellow fever. All made a full recovery.\u003c/p\u003e","\u003cp\u003e Notwithstanding the decisive medical victory -- as Reed declared, \"aside from the antitoxin of Diptheria and Koch's discovery of the tubercle bacillus, it will be regarded as the most important piece of work, scientifically, during the 19th century\" [12] -- success at Camp Lazear unfolded in its own time. Initially, Reed observed, \"the results obtained at this station were not encouraging.\" [13] The first inoculations of four volunteers over a period of two weeks proved disconcertingly negative each time. Then, on December 5, 1900, private John R. Kissinger presented his arm to the mosquitoes, and late in the evening on December 8, suffered the first chills of \"a well-marked attack of yellow fever.\" [14] Three more men in rapid succession fell victim to the insects -- Spanish volunteers Antonio Benigno, Nicanor Fernandez, and Vicente Presedo. The force of the conclusions was evident to everyone:\u003c/p\u003e","\u003cp\u003e \"It can readily be imagined,\" Reed empathetically and wryly described in his first presentation of the experiments, \"that the concurrence of 4 cases of yellow fever in our small command of 12 non-immunes within the space of 1 week, while giving rise to feelings of exultation in the hearts of the experimenters, in view of the vast importance attaching to these results, might inspire quite other sentiments in the bosoms of those who had previously consented to submit themselves to the mosquito's bite. In fact, several of our good-natured Spanish friends who had jokingly compared our mosquitoes to 'the little flies that buzzed harmlessly about their tables,' suddenly appeared to lose all interest in the progress of science, and, forgetting for the moment even their own personal aggrandizement, incontinently severed their connection with Camp Lazear. Personally, while lamenting to some extent their departure, I could not but feel that in placing themselves beyond our control they were exercising the soundest judgment.\"\u003c/p\u003e","\u003cp\u003e \"In striking contrast,\" Reed continued, the anxiety of the fomites volunteers began to melt into relief. \"[T]he countenances of these men, which had before borne the serious aspect of those who were bravely facing an unseen foe, suddenly took on the glad expression of 'schoolboys let out for a holiday,' and from this time their contempt for 'fomites' could not find sufficient expression. Thus illustrating once more, gentlemen, the old adage that familiarity, even with fomites, may breed contempt.\" [15]\u003c/p\u003e","\u003cp\u003e The question of human experimentation was indeed a serious one -- unavoidable, in actuality, as Reed had stated the previous summer to Surgeon General Sternberg. When the Commission first considered a trial of Finlay's mosquito theory, Reed, Carroll, and Lazear agreed to experiment on themselves. Agramonte, a native Cuban, had acquired immunity as a child. Doubtless Finlay's experience of many unsuccessful inoculations communicated that positive results would not be forthcoming rapidly, so before the first series of inoculations began under Lazear's direction at Columbia Barracks, Reed left Cuba for Washington, where he completed a monumental report on typhoid fever among the army corps -- left unfinished by the sudden death of co-author Edward O. Shakespeare. Carroll and Lazear both sickened while Reed was in Washington, and Lazear, young and strong, had no reason to anticipate that his case would be fatal. Reed was shocked at Lazear's death, and because of his own age -- 49, a decade and a half older than Lazear and a dozen years older than Carroll -- he resolved not to inoculate himself when he returned to Cuba on October 4, 1900. The point had already been amply demonstrated, and only a rigidly controlled experimental regime would establish the necessary proof. Carroll, however, remained embittered about this for the remainder of his life, though he evidently never communicated his objections directly to Reed.\u003c/p\u003e","\u003cp\u003e That initial series of mosquito inoculations was probably accomplished without formal documentation of informed consent. Indeed, the experiments may also have been carried forward without the full knowledge of the commanding officer of Camp Columbia, and Reed consequently shielded the identity of Private William J. Dean, the second positive experimental case, behind the pseudonym \"XY\" in the \"Preliminary Note.\" No such potentially troublesome problems arose for the experimental series at Camp Lazear; Reed obtained prior support from all of the appropriate authorities in the military and the administration, even including the Spanish Consul to Cuba. With the advice of the Commission and others, he drafted what is now one of the oldest series of extant informed consent documents. The surviving examples are in Spanish with English translations, and were signed by volunteers Antonio Benigno and Vicente Presedo, and a third with the mark of Nicanor Fernandez, who was illiterate.\u003c/p\u003e","\u003cp\u003e The documents take the form of a contract between individual volunteers and the Commission, represented by Reed. At least 25 years old, each volunteer explicitly consented to participate, and balanced the certainty of contracting yellow fever in the general population against the risks of developing an experimental case, followed by expert and timely medical care. The volunteers agreed to remain at Camp Lazear for the duration of the experiments, and as a reward for participation would receive $100 \"in American gold,\" with an additional hundred-dollar supplement for contracting yellow fever. These payments could be assigned to a survivor, and the volunteers agreed to forfeit any remuneration in cases of desertion.\u003c/p\u003e","\u003cp\u003e For the American participants no consent documents appear to survive, though in contemporary letters Reed assured his correspondents that the Commission obtained written consent from all the volunteers. The record of expenses for Camp Lazear -- maintained by Reed's friend and colleague in the medical corps, Jefferson Randolph Kean -- indicates that the same schedule of payments for participation and sickness applied to the Americans as well. Volunteers who participated in the fomites tests and in addition the later series of blood injections and the single trial of an alternative species of mosquito also earned $100 each plus the $100 supplement if yellow fever developed. Two Americans declined these gratuities, as Kean termed them, Dr. Robert P. Cooke, of the fomites tests, and John J. Moran, who had recently received an honorable discharge from the service, and was the only American civilian to participate. His was the fourth case of yellow fever to develop from mosquito inoculation. Moran eventually settled in Cuba, where he managed the Havana offices of the Sun Oil Company, and late in life became a close friend of Philip S. Hench. Together the two men rediscovered the site of Camp Lazear in 1940 -- Building Number One still intact -- and successfully lobbied the Cuban government to memorialize there the work of Finlay and the American Commission in the conquest of yellow fever.\u003c/p\u003e","\u003cp\u003e Reed informally commemorated his own experiences at Camp Lazear by commissioning a group photograph, evidently taken there shortly before he left Cuba in February 1901. A more important event occurred on the sixth of that month when Reed presented the results of the Camp Lazear yellow fever experiments to a great ovation at the Pan-American Medical Congress in Havana. Three days later he set sail for the United States, and once landed, drafted the Congress paper as\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- An Additional Note\u003c/title\u003e, published immediately in the\u003ctitle render=\"italic\"\u003eJournal of the American Medical Association\u003c/title\u003e. [16]\u003c/p\u003e","\u003cp\u003e Though his correspondence intimates a great appreciation for Cuba, Reed never returned to the warm, sunny shores of the island freed of a dreadful plague. Carroll stayed behind at Camp Lazear through February to complete the last experimental series officially bearing the imprimatur of the Yellow Fever Commission, and returned to Washington soon after March first. [17] The Medical Corps retained the lease on Camp Lazear against the possibility of continuing experiments another season, and Carroll, in fact, returned to Havana in August 1901 for a final experimental series, though he did not make use of Camp Lazear. This work involved at least three volunteers at Las Animas Hospital, Havana, who submitted to blood injections. Carroll's assignment aimed at a greater understanding of the yellow fever agent, and he proved that blood drawn from active cases of yellow fever remained virulent even after passing through fine bacteria filters. In addition, by heating contaminated blood which had previously caused cases of yellow fever, Carroll rendered it non-infective -- thereby establishing that this filterable entity, though sub-microscopic, was demonstrably present in the bloodstream. Carroll wrapped up the series in October and returned home to stay. [18] In Cuba, J. Randolph Kean made the last rental payments to Signore Rojas on October 9, 1901, and Camp Lazear, for more than a generation, slipped out of the realm of memory.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003e[1] Walter Reed and James Carroll,\u003ctitle render=\"doublequote\"\u003eBacillus Icteroides and Bacillus Cholerae Suis -- A Preliminary Note\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eMedical News\u003c/title\u003e(29 April 1899), reprinted in: United States Senate Document No. 822,\u003ctitle render=\"italic\"\u003eYellow Fever, A Compilation of Various Publications\u003c/title\u003e(Washington: Government Printing Office, 1911), p. 55.\u003c/item\u003e\n      \u003citem\u003e[2] Letter from Jesse W. Lazear to Mabel Houston Lazear, 23 August 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00341001.\u003c/item\u003e\n      \u003citem\u003e[3] Walter Reed, \"The Propagation of Yellow Fever -- Observations Based on Recent Researches,\" in United States Senate Document No. 822,\u003ctitle render=\"italic\"\u003eYellow Fever A Compilation of Various Publications\u003c/title\u003e(Washington: Government Printing Office, 1911), p. 94.\u003c/item\u003e\n      \u003citem\u003e[4] Letter from Walter Reed to George M. Sternberg, 24 July 1900, Hench Reed Yellow Fever Collection, accession number: 02064001.\u003c/item\u003e\n      \u003citem\u003e[5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- A Preliminary Note\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eProceedings of the Twenty-eighth Annual Meeting of the American Public Health Association\u003c/title\u003eIndianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\u003c/item\u003e\n      \u003citem\u003e[6] Letter from Walter Reed to James Carroll, 7 September 1900, Edward Hook Additions to the Philip S. Hench Walter Reed Yellow Fever Collection: James Carroll Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 15312004. The originals of these letters remain in a private collection.\u003c/item\u003e\n      \u003citem\u003e[7] Walter Reed, James Carroll, Aristides Agramonte,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- An Additional Note\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eJournal of the American Medical Association\u003c/title\u003e36 (16 February 1901): 431-440, reprinted in: Senate Document No. 822, p. 84.\u003c/item\u003e\n      \u003citem\u003e[8] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 99.\u003c/item\u003e\n      \u003citem\u003e[9] Henry Rose Carter,\u003ctitle render=\"doublequote\"\u003eA Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eMedical Record\u003c/title\u003e59 (15 June 1901) 24: 937.\u003c/item\u003e\n      \u003citem\u003e[10] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 101.\u003c/item\u003e\n      \u003citem\u003e[11]\u003cemph render=\"italic\"\u003eCulex fasciata\u003c/emph\u003ewas reclassified shortly after the experiments as\u003cemph render=\"italic\"\u003eStegomyia\u003c/emph\u003eand later became\u003cemph render=\"italic\"\u003eAedes aegypti.\u003c/emph\u003e\u003c/item\u003e\n      \u003citem\u003e[12] Letter to from Walter Reed to Emilie Lawrence Reed, 9 December 1900, Hench Reed Collection, accession number: 02231001.\u003c/item\u003e\n      \u003citem\u003e[13] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 97.\u003c/item\u003e\n      \u003citem\u003e[14] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 98.\u003c/item\u003e\n      \u003citem\u003e[15] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 99.\u003c/item\u003e\n      \u003citem\u003e[16] Please see note [7].\u003c/item\u003e\n      \u003citem\u003e[17] The Commission reported these concluding experiments in: Walter Reed, James Carroll, Aristides Agramonte,\u003ctitle render=\"doublequote\"\u003eExperimental Yellow Fever\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eAmerican Medicine\u003c/title\u003eII (6 July 1901) 1: 15-23.\u003c/item\u003e\n      \u003citem\u003e[18] Walter Reed, James Carroll,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever (A Supplemental Note)\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eAmerican Medicine\u003c/title\u003eIII (22 February 1902) 8: 301-305.\u003c/item\u003e\n    \u003c/list\u003e\n  ","\u003cp\u003eWalter Reed (September 13, 1851 - November 22, 1902) was a U.S. Army physician who led the army's Yellow Fever Commission 1900 and 1901. Experiments conducted by the commission confirmed a theory that yellow fever is transmitted by mosquitoes--a discovery that led to the control and eradication of this disease across much of the globe. Reed would receive much of the credit for the work of the commission because of his role as its leader, and, long after his death in 1902, he would be widely celebrated as a heroic figure in the fields of public health and medical research.\u003c/p\u003e","\u003cp\u003e Reed spent his first days in a small house which served as the parsonage for a Methodist congregation in Gloucester County, Virginia, where his father was minister.  Lemuel Sutton Reed and Pharaba White Reed welcomed young Walter into the family on September 13, 1851;  he was the youngest of their five children.  The Reeds moved to other Virginia parishes during Walter's childhood, and just after the close of the Civil War, transferred to the town of Charlottesville.  That move in 1866 placed Walter in the orbit of the University of Virginia, which he entered a year later at age sixteen under the care of his older brother Christopher, also a student at the University.  Reed attended two year-long sessions, the second devoted entirely to the medical curriculum, and he completed an M.D. degree on July 1, 1869, as one of the youngest students to graduate in the history of the medical school.\u003c/p\u003e","\u003cp\u003e At that time the School of Medicine at the University offered little opportunity for direct clinical experience, so Reed subsequently enrolled at the Bellevue Hospital Medical College, in Manhattan, New York.  There he obtained a second M.D. degree in 1870.  Reed interned at a number of hospitals in the New York metropolitan area, including the Infants' Hospital on Randall's Island and the Brooklyn City Hospital.  In 1873, he assumed the position of assistant sanitary officer for the Brooklyn Board of Health.  The large and diverse population of New York, with its many immigrant communities and dense, tenement housing, provided countless medical cases to treat and study;  these served to expose Reed to the vital importance of public health, and developed in him a lifelong interest in the field.  Yet the frenetic life of the great cities began to pall after a few years: \"Here the ever bustling day is crowded into the busy night; nor can we draw the line of separation between the two,\"[1] he wrote to Emilie Lawrence, of Murfreesboro, North Carolina, later to become Mrs. Walter Reed.  Their courtship letters reveal much of his maturing character, interests, and philosophy of life.  Increasing responsibilities with the Board of Health precluded opening a private practice, and Reed's youth proved a barrier in a culture given to offering respect more to the appearance of maturity than to its actual demonstration. Reed consequently resolved to join the Army Medical Corps, both for the professional opportunities it offered immediately and for the modest financial security it could provide to a young man without independent means.  He passed the qualifying examinations in January 1875 and proceeded to his first assignment at the military base on Willet's Point, New York Harbor.\u003c/p\u003e","\u003cp\u003e Reed remained in the Medical Corps for the rest of his life, spending many years of the '70s, '80s, and early '90s at difficult postings in the American West.  The first of these -- to the Arizona Territory -- began in the late spring of 1876, and indeed hurried along his wedding to Emilie Lawrence, on April 25, shortly before his departure.  She joined him the following November, and bore two children at frontier posts, a son Walter Lawrence and a daughter Emilie, called Blossom.\u003c/p\u003e","\u003cp\u003e Reed's other western assignments included forts in Nebraska, Dakota Territory, and Minnesota, with two eastern interludes at Baltimore, Maryland and another at Mount Vernon Barracks, Alabama.  During the second of these tours in Baltimore -- over the 1890-1891 academic year -- Reed completed advanced coursework in pathology and bacteriology in the Johns Hopkins University Hospital Pathology Laboratory.  When he returned from his last western appointment in 1893, Reed joined the faculty of the Army Medical School in Washington, D.C., where he held the professorship of Bacteriology and Clinical Microscopy.  He also became curator of the Army Medical Museum and joined the faculty of the Columbian University in Washington (later the George Washington University).  In addition, Reed maintained close ties with professor William Welch and other leading lights in the scientific community he had come to know at Hopkins a few years earlier.\u003c/p\u003e","\u003cp\u003e Beyond his teaching responsibilities for the Army and the Columbian University programs, Reed actively pursued medical research projects.  A bibliography of his publications finds entries from 1892 to the year of his untimely death a decade later, and the subjects he investigated range from erysipelas to cholera, typhoid, malaria, and yellow fever, among others.[2]   In 1896, a research trip to investigate an outbreak of smallpox took him to Key West, and there he developed a close friendship with Jefferson Randolph Kean, a fellow Virginian and colleague in the Medical Corps ten years his junior.  When Reed traveled to Cuba in 1899 to study typhoid in the army encampments of the U.S. forces, Kean was already there, and Kean was still in Cuba when Reed returned as the head of the Army board charged by Surgeon General George Miller Sternberg to examine tropical diseases including yellow fever.  Kean and his first wife Louise were great supporters of the U.S. Army Yellow Fever Commission's work, and Kean in fact served as quartermaster for the famous series of experiments at Camp Lazear.  After the dramatic and conclusive success of those experiments, Kean actively -- though unsuccessfully -- promoted Reed's candidacy for Surgeon General.\u003c/p\u003e","\u003cp\u003e Reed continued to speak and publish on yellow fever after his return from Cuba in 1901, receiving honorary degrees from Harvard and the University of Michigan in recognition of his seminal work.  In November 1902, Reed developed what had been for him recurring gastro-intestinal trouble.  This time, however, his appendix ruptured, and surgery came too late to save him from the peritonitis which developed.  He died on November 23, 1902, almost two years to the day from the opening of Camp Lazear and the stunning experimental victory there.  Kean remained a champion of his deceased friend's role in the conquest of yellow fever.  He organized the Walter Reed Memorial Association, to provide support for Reed's family and to build a suitable memorial, and was instrumental in lobbying the United States Congress to establish the Yellow Fever Roll of Honor.  In 1929, Congress mandated the annual publication of the Roll in the\u003ctitle render=\"italic\"\u003eArmy Register\u003c/title\u003e, and struck a series Congressional Gold Medals saluting the Commission members and the young Americans who bravely suffered experimental yellow fever a generation before.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003e[1] Letter from Walter Reed to Emilie Lawrence, 18 July 1874, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 01605001.\u003c/item\u003e\n      \u003citem\u003e[2] The bibliography of Reed's scientific papers may be found in: Howard Atwood Kelly,\u003ctitle render=\"italic\"\u003eWalter Reed and Yellow Fever\u003c/title\u003e(New York: McClure, Phillips and Co., 1906), pp. 281-283. Kelly's complete biography of Reed is contained on this Web site.\u003c/item\u003e\n    \u003c/list\u003e\n  ","\u003cp\u003eJesse William Lazear (May 2, 1866 - September 26, 1900) was a physician who was a member of the U.S. Army Yellow Fever Commission in 1900. Lazear's death from yellow fever at the outset of the commission's work in Cuba would lead to his elevation as a martyr for medical science in the eyes of many during the twentieth century.\u003c/p\u003e","\u003cp\u003e \"I rather think I am on the track of the real germ,\" Jesse W. Lazear wrote his wife from Cuba on September 8, 1900.[1] Seventeen days later, the fulminating case of yellow fever Lazear had contracted just over a week after writing Mabel H. Lazear suddenly ended the young scientist's life. He was 34 years old. Unlike so many other yellow fever fatalities, however, this one would lead to a direct and highly successful assault on the disease itself. Yellow fever's ascendancy, endemic in Cuba, was about to be undermined.\u003c/p\u003e","\u003cp\u003e Lazear had reported to Camp Columbia, Cuba in February 1900 for duty as an acting assistant surgeon with the U. S. Army Corps stationed on the island. Here he undertook bacteriological study of tropical diseases, particularly malaria and yellow fever, and in May he was named to the Army board charged with \"pursuing scientific investigations with reference to the infectious diseases prevalent on the island of Cuba.\"[2]\u003c/p\u003e","\u003cp\u003e These orders placed him officially in the company of Walter Reed, James Carroll, and Aristides Agramonte -- the U.S. Army Yellow Fever Commission -- though Lazear had already met Reed the preceding March on a project to evaluate the efficacy of electrozone, a disinfectant made from seawater collected off the Cuban coast. While Reed was in Cuba that March, Lazear discussed with him the recent discovery of British scientist Sir Ronald Ross concerning the mosquito vector for malaria. At Johns Hopkins Hospital in Baltimore, where he was first a medical resident and later in charge of the clinical laboratory, Lazear had followed Ross's accomplishments with great interest, and pursued field work and experimentation on the\u003cemph render=\"italic\"\u003eAnopheles\u003c/emph\u003emosquito with fellow Hopkins scientist William S. Thayer. Lazear was thus the only member of the Commission who had experience with mosquito work, and was consequently the most open to the possible verity of Cuban scientist Carlos Juan Finlay's theory of mosquito transmission for yellow fever.\u003c/p\u003e","\u003cp\u003e The record is apparently silent as to when Lazear first visited Finlay. Certainly by late June Lazear was beginning to grow mosquito larvae acquired from Finlay's laboratory, the first specimens brought to him by Henry Rose Carter, of the United States Public Health Service.[3] Not long after arriving in Cuba Lazear met Carter, whose own observations on yellow fever strongly suggested an intermediate host in the spread of the disease. However, Army Surgeon General George Miller Sternberg, who organized the Yellow Fever Commission, first charged the board members to investigate the relationship of\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003eto yellow fever -- proposed by the Italian Scientist Giuseppe Sanarelli as the actual cause of the disease. \"Dr. Reed had been in the old discussion over Sanarelli's bacillus and he still works on that subject,\" Lazear wrote his wife in July, \"I am not all interested in it but want to do work which may lead to the discovery of the real organism.\"[4] Soon he would have the opportunity. The relatively quick failure of the Bacillus icteroides inquiry opened the door to what became the ground-breaking mosquito work, and Lazear was well placed to begin.\u003c/p\u003e","\u003cp\u003e The project started in earnest on August 1, 1900. In a small pocket notebook Lazear noted the preparatory work of raising and infecting mosquitoes, and subsequently recorded the series of eleven experimental inoculations made from the 11th to the 31st of August, the last two producing cases of full-blown yellow fever. These two positive cases developed from mosquitoes allowed to ripen over a period of 12 days, and this was Lazear's crucial discovery. The epidemiological pattern was thus entirely consistent with Carter's observations of a delay between the primary and secondary outbreaks of yellow fever in an epidemic, and, in addition, explained why Finlay's experiments had been largely unsuccessful -- he had not waited long enough before inoculating his subjects.\u003c/p\u003e","\u003cp\u003e Although Lazear never directly admitted to experimenting on himself, when Reed reviewed Lazear's sketchy notations he evidently found entries strongly suggesting Lazear's case was not accidental, as officially reported. Unfortunately, the little notebook so crucial to the preparation of the Commission's famous initial paper,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- A Preliminary Note\u003c/title\u003e[5], vanished from Reed's Washington office after his own untimely death in 1902. Still, Lazear's invaluable contribution to the Commission's victory was widely recognized and elicited tributes from many quarters: \"He was a splendid, brave fellow,\" Reed said of his young colleague, \" and I lament his loss more than words can tell; but his death was not in vain- His name will live in the history of those who have benefited humanity.\" [6] \"His death was a sacrifice to scientific research of the highest character,\" stated General Leonard Wood, military Governor of Cuba.[7] \"Your husband was a martyr in the noblest of causes,\" Dr. L. O. Howard wrote to Mabel Lazear, \"and I am proud to have known him. . . . His work contributed towards one of the greatest discoveries of the century, the results of which will be of invaluable benefit to mankind.\"[8] And so they were. Though Lazear's one-year-old son and newborn daughter never knew their father, they grew up in a world liberated -- almost in its entirety -- from the disease that killed him.\u003c/p\u003e","\u003cp\u003e [1] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 8 September 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00344001.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003e[2] Military Orders for Walter Reed, James Carroll, Aristides Agramonte, and Jesse W. Lazear, 24 May 1900, Hench Reed Collection, accession number 02019001.\u003c/item\u003e\n      \u003citem\u003e[3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\u003c/item\u003e\n      \u003citem\u003e[4] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 15 July 1900, Hench Reed Collection, accession number: 00334001.\u003c/item\u003e\n      \u003citem\u003e[5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- A Preliminary Note,\u003c/title\u003e \u003ctitle render=\"italic\"\u003eProceedings of the Twenty-eighth Annual Meeting of the American Public Health Association Indianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\u003c/title\u003e\u003c/item\u003e\n      \u003citem\u003e[6] Letter from Walter Reed to Emilie Lawrence Reed, 6 October 1900, Hench Reed Collection, accession number: 02135001.\u003c/item\u003e\n      \u003citem\u003e[7] Letter from Leonard Wood to the Adjutant-General, United States Army, November 1900, Hench Reed Collection, accession number: 00375002.\u003c/item\u003e\n      \u003citem\u003e[8] Letter from Leland Ossian Howard to Mabel Houston Lazear, 7 February 1901, Hench Reed Collection, accession number: 00388001.\u003c/item\u003e\n    \u003c/list\u003e\n  ","\u003cp\u003eHenry Rose Carter (August 25, 1852 - September 14, 1925) was a prominent physician in the U.S. Public Health Service who was a leading authority in the transmission and control of tropical diseases, particularly yellow fever and malaria. During his long career as a sanitarian, Carter undertook campaigns to investigate and control the spread of tropical diseases in Cuba, the Panama Canal Zone, the Southeastern United States, and Peru.\u003c/p\u003e","\u003cp\u003e Like Walter Reed and Jefferson Randolph Kean, Henry Rose Carter was a native Virginian and a graduate of the University of Virginia. Carter obtained a civil engineering degree from Virginia in 1873 and also undertook post-graduate work in mathematics and applied chemistry the next year. Subsequently, however, Carter's interests turned towards medicine, and he completed a medical degree at the University of Maryland in 1879. The same year Assistant Surgeon Carter joined the Marine Hospital Service -- later the United States Public Health Service -- and the young surgeon rose steadily through the ranks, ultimately attaining the position of Assistant Surgeon General in 1915.\u003c/p\u003e","\u003cp\u003e Carter's initial assignments with the Hospital Service placed him at the center of the yellow fever maelstrom. In 1879 he was detailed to Memphis and other Southern cities, then in the throes of a second year of devastating epidemics. Here began, as his colleague T. H. D. Griffitts observed, Carter's \"lifelong interest in the epidemiology and control of yellow fever.\"[1] After several years of clinical practice in various Marine hospitals, Carter resumed a direct confrontation with yellow fever when his orders for duty with the Gulf Coast Maritime Quarantine assigned him to Ship Island, Mississippi, in 1888. Here and at subsequent quarantine station postings around the Gulf, he quietly championed a thorough review and rationalization of quarantine policies, with a view toward establishing uniform regulation, more thorough disinfection of vessels, and minimized interference with naval commerce. Crucial to the success of these activities was Carter's attention to the incubation period of yellow fever, which his on-site observations indicated to vary between 5 and 7 days. At the time the official literature stated with far less precision a variance of between 1 and 14 days; Carter's work consequently greatly increased the efficiency and effectiveness of quarantine operations.\u003c/p\u003e","\u003cp\u003e Nevertheless, yellow fever continued to menace the temperate coastline of the United States, and Carter ably directed the Health Service's epidemiological control efforts in numerous threatened regions. In conjunction with this sanitary work for the 1898 season, Carter made detailed notes on the development of yellow fever at Orwood and Taylor, Mississippi. The isolation of these communities enabled him to identify more reliably the phenomenon of a delay between the initial cases of yellow fever in a locality and the subsequent appearance of secondary infection -- a delay two to four times longer than the incubation period of the disease in an infected person. Carter called this interval between the primary and secondary cases \"the period of extrinsic incubation,\" and he defined its \"usual limits . . . [as ranging] from ten to seventeen days.\"[2]\u003c/p\u003e","\u003cp\u003e Before he was able to publish his conclusions, Carter took the helm of the quarantine service in war-time Cuba. There, in 1900, he met U. S. Army Yellow Fever Commission member Jesse Lazear. Carter had finally arranged for his paper's publication that year in the\u003ctitle render=\"italic\"\u003eNew Orleans Medical and Surgical Journal\u003c/title\u003e, and gave a draft to Lazear. \"If these dates are correct,\" Carter later recalled Lazear saying, \"it spells a living host.\"[3] The theory of mosquito transmission long advanced by Cuban scientist Carlos J. Finlay began to seem more likely. And indeed it was. The Commission's experiments in 1900-1901 irrefutably proved the mosquito vector and established the extrinsic incubation period at twelve days. Shortly after these successes Reed saluted Carter, \"I know of no one more competent to pass judgment on all that pertains to the subject of yellow fever. You must not forget that your own work in Mississippi did more to impress me with the importance of an intermediate host than everything else put to-gether.\"[4]\u003c/p\u003e","\u003cp\u003e Carter's long and distinguished sanitary career took him to the Panama Canal Zone in 1904, where he served as Chief Quarantine Officer and Chief of Hospitals for five years. He undertook detailed investigations and control measures of malaria in North Carolina and elsewhere in the South, and became a founder of the National Malaria Committee. With the support of the Rockefeller Foundation International Health Board, he undertook additional investigation and control measures for yellow fever in Central and South America. His expertise recommended him to the Peruvian government, which named Carter Sanitary Advisor in 1920-1921. Health problems at the end of his life compelled Carter to withdraw from active fieldwork, though he remained a highly valued consultant to the Health Board and a much-beloved and respected teacher for a new generation of sanitarians. Carter closed his career researching and writing the manuscript that his daughter Laura Armistead Carter edited and published posthumously in 1931:\u003ctitle render=\"italic\"\u003eYellow Fever: An Epidemiological and Historical Study of its Place of Origin.\u003c/title\u003e[5]\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003e[1] T. H. D. Griffitts,\u003ctitle render=\"doublequote\"\u003eHenry Rose Carter: The Scientist and the Man\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eSouthern Medical Journal\u003c/title\u003e32 (August 1939) 8: 842.\u003c/item\u003e\n      \u003citem\u003e[2] Henry Rose Carter,\u003ctitle render=\"doublequote\"\u003eA Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eMedical Record\u003c/title\u003e59 (15 June 1901) 24: 937.\u003c/item\u003e\n      \u003citem\u003e[3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\u003c/item\u003e\n      \u003citem\u003e[4] Letter from Walter Reed to Henry Rose Carter, 26 February 1901, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 02447001.\u003c/item\u003e\n      \u003citem\u003e[5] Carter, Henry Rose.\u003ctitle render=\"italic\"\u003eYellow Fever: An Epidemiological and Historical Study of its Place of Origin.\u003c/title\u003eBaltimore: The Williams and Wilkins Company, 1931.\u003c/item\u003e\n    \u003c/list\u003e\n  ","\u003cp\u003eJefferson Randolph Kean (June 27, 1860 - September 4, 1950) was a U.S. Army physician who was a leading authority in sanitation, public health, and tropical diseases. Later in his career, Kean would become widely recognized for his role in organizing and administering medical services for the U.S. armed forces during World War I.\u003c/p\u003e","\u003cp\u003e \"He possessed one of the keenest, most scholarly minds I've ever encountered,\" recalled Nobel Prize winner Philip S. Hench of Jefferson Randolph Kean. [1] Kean and Hench shared an abiding interest in the work of the United States Army Yellow Fever Commission -- Kean, as a contemporary and supporter, and Hench, as a scholar and scientist intent on accurate historical documentation. On the advice of yellow fever experiment volunteer John J. Moran, Hench first wrote Kean in 1939. From that initial contact developed a close friendship which would last for the remainder of their lives. Kean entrusted Hench not only with numerous period documents, including original letters, accounts, fever charts, and other items, but also with the freely-given counsel and insight of a trusted friend.\u003c/p\u003e","\u003cp\u003e Like Walter Reed and Henry Rose Carter before him, Jefferson Randolph Kean was an alumnus of the University of Virginia, completing the medical program there in 1883. Kean joined the U.S. Army Medical Corps in 1884, and after forty years in the service, retired with the rank of Colonel. Congress awarded him a promotion to Brigadier General, retired, in 1930. The early years of Kean's career passed in medical postings in the American West, and no doubt offered him experiences similar to those of Walter Reed, whom he met not on the frontier, but in Florida in 1896. Kean became an expert in tropical diseases and sanitation during his five-year assignment in the Florida tropics, an expertise which served him well over two terms of service later in Cuba. During the Spanish-American War and subsequent U. S. occupation of Cuba, Kean was Chief Surgeon for the Department of Havana, then Superintendent of the Department of Charities -- from 1898 to 1902. After a four-year interlude as an assistant to the Surgeon General in Washington, D.C., Kean again returned to Cuba as an advisor to the Department of Sanitation from 1906-1909.\u003c/p\u003e","\u003cp\u003e Kean himself stated: \"Reed and I were good friends before the Yellow Fever Board came to Cuba in June 1900, and [Reed] located himself at Marianao, 8 miles S. W. of Havana,\" to be within the medical and administrative jurisdiction overseen by Kean. [2] The Chief Surgeon did indeed offer significant assistance, and was an early convert to Carlos Finlay's mosquito theory of transmission, which the Yellow Fever Board's experiments ultimately proved true in the late autumn and winter of 1900-1901. As early as October 13, 1900 -- after the Board's preliminary work, but before the final convincing demonstrations -- Kean issued \"Circular No. 8,\" concerning the latest scholarship on the mosquito vector for disease. [3] The circular contained a set of instructions for the entire command on mosquito eradication. Kean subsequently served as quartermaster and financial administrator for the famous series of yellow fever experiments at Camp Lazear and, for the rest of his life, Kean remained a strong proponent of the Commission's conclusions. He worked tirelessly not only to apply them in the field, but also to accord proper public recognition to the Commission's work.\u003c/p\u003e","\u003cp\u003e In addition to his career as a sanitarian, Kean organized the department of military relief of the American Red Cross, and during World War One served as Chief of the U. S. Ambulance Service with the French Army and Deputy Chief Surgeon of the American forces. France named him an Officier de la Légion d'Honneur in recognition for these services. Cuban authorities as well offered Kean recognition with the grand cross of the Order of Merit Carlos J. Finlay, and he received both a Distinguished Service Medal from the United States government and the Gorgas Medal from the Association of Military Surgeons. For a decade after his retirement from active duty, Kean edited this last organization's medical journal,\u003ctitle render=\"italic\"\u003eThe Military Surgeon\u003c/title\u003e, and served on the Surgeon General's editorial board for the multi-volume history of the medical department in World War One. A great-grandson of Thomas Jefferson, Kean also took a seat with the government commission established to build the Jefferson Memorial in Washington, D.C. He held charter membership in the Walter Reed Memorial Association, and remained active in its affairs until his death in 1950.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003e[1] Telegram from Philip Showalter Hench and Mary Hench to Cornelia Knox Kean, September 5, 1950, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 06501173.\u003c/item\u003e\n      \u003citem\u003e[2] Letter from Jefferson Randolph Kean to Philip Showalter Hench, October 31, 1939, Hench Reed Yellow Fever Collection, accession number: 06282022.\u003c/item\u003e\n      \u003citem\u003e[3] Military Orders to Commanding Officers, October 15, 1900, Hench Reed Yellow Fever Collection, accession number: 02140001.\u003c/item\u003e\n    \u003c/list\u003e\n  ","\u003cp\u003ePhilip Showalter Hench (February 28, 1896 - March 30, 1965) was a U.S. physician who in 1950 was awarded the Nobel Prize for Physiology and Medicine for his role in the discovery of the hormone cortisone. In addition to his medical research, Hench spent almost three decades of his life studying the history of the U.S. Army Yellow Fever Commission and became a leading authority in the subject.\u003c/p\u003e","\u003cp\u003e Philip Showalter Hench was born in Pittsburgh, Pennsylvania, the son of Jacob Bixler Hench and Clara Showalter. After attending local schools, Hench entered Lafayette College and graduated from the school 1916 with a Bachelor of Arts. Hench completed his medical degree at the University of Pittsburgh in 1920, and subsequently entered a residency program at St. Francis Hospital, Pittsburgh. His association with the Mayo Clinic began in 1921 as a fellow at the institution. Two years later he would become an assistant at the clinic, and then, in 1926, he would be made the head of its Department of Rheumatic Diseases After pursuing post-graduate study in Germany in 1928-1929, Hench obtained a Masters of Science in Internal Medicine at the University of Minnesota in 1931, and a Doctor of Science degree from Lafayette College in 1940. Hench remained for the duration of his career at the Mayo Clinic, where his life-long passion for meticulous research and analysis brought him the Nobel Prize for Physiology and Medicine in 1950, which he shared with Edward C. Kendall and Tadeus Reichstein, for the discovery of cortisone.\u003c/p\u003e","\u003cp\u003e The same persistence and determination present in his professional life is also evident in Hench's research on the U. S. Army Yellow Fever Commission's famous experiments. \"As a physician particularly interested in medical history,\" he stated to experiment volunteer John J. Moran in 1937, \"I have been long interested in the story of the yellow fever work in John J. Moran, Ralph C. Hutchison, Havana.\" [1] So began a remarkable odyssey. At the request of his friend Ralph Cooper Hutchison, then president of Washington and Jefferson College, Hench had written Moran to gather information for the dedication of the College's new chemistry building, named for Commission member and former Washington and Jefferson student Jesse W. Lazear. Hench also began a correspondence with another of the yellow fever experiment's original volunteers, John R. Kissinger. Moran's and Kissinger's recollections proved so intriguing that Hench initially offered to edit and publish them. However, in the course of his research Hench discovered that much general information on the topic was inaccurate. Conflicting assertions concerning the participants and unverified claims by medical and governmental authorities in the United States and Cuba -- often politically motivated -- clouded interpretation of the facts. \"May I suggest,\" Moran consequently urged in 1938, \"that a clearing up of the REED-FINLAY-CONQUEST-OF-YELLOW-FEVER, or an effort to do so, on your part, is a task far more pressing than publishing the Kissinger-Moran stories or memoirs.\" [2] Hench resolved to document every aspect of the \"Conquest of Yellow-Fever\" and to write a much needed accurate and comprehensive history.\u003c/p\u003e","\u003cp\u003e For the next two decades, Hench tirelessly combed through public archive collections and personal papers in the United States and Cuba. He met and interviewed surviving participants of the experiments and others associated with the project, as well as family members of the Yellow Fever Commission. He sought out physicians and scientists who had worked with the principal players or who had applied the results in the campaign to eradicate yellow fever. He identified and photographed sites associated with the yellow fever story, and he successfully petitioned politicians in the United States and Cuba to commemorate the work. In the process, Hench became the trusted friend and advisor of many of these same individuals, and they, in turn, presented him with much of the surviving original material for safekeeping.\u003c/p\u003e","\u003cp\u003e In short, Hench came to be the world's expert on the yellow fever story and the steward of thousands of original letters and documents. His premature death at age 69 found him still hoping to uncover important missing evidence, his book unwritten. Hench's widow Mary Kahler Hench gave his yellow fever collection to the University of Virginia, Walter Reed's alma mater, and this extensive personal archive forms the most detailed and accurate record available on the Conquest of Yellow Fever.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003e[1] Letter from Philip S. Hench to John J. Moran, 6 July 1937, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 03419001.\u003c/item\u003e\n      \u003citem\u003e[2] Letter from John J. Moran to Philip S. Hench, 30 October 1938, Hench Reed Yellow Fever Collection, accession number: 03476001.\u003c/item\u003e\n    \u003c/list\u003e\n  "]}]}},"label":"Breadcrumbs"}}},"links":{"self":"https://arvasarchive.org/catalog/viu_repositories_7_resources_1710_c03"}},{"id":"viu_repositories_7_resources_1710_c01","type":"Series","attributes":{"title":"Series I. Jesse W. Lazear, 1800/1956, bulk 1863/1943","abstract_or_scope":{"id":"https://arvasarchive.org/catalog/viu_repositories_7_resources_1710_c01#abstract_or_scope","type":"document_value","attributes":{"value":"\u003cp\u003eSeries I. Jesse W. Lazear consists of materials relating to Lazear that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1800 to 1956 with the bulk of the items dating from 1863 to 1943. Much of the series consists of the correspondence of Jesse W. Lazear and his wife Mabel H. Lazear. Jesse's correspondence dates from his time as a student at Johns Hopkins University to his death in 1900. Researchers can learn a great deal about Jesse from these letters, including his relationships with friends and family, his educational background, and his professional life. Mabel's correspondence dates from the time she met Jesse to her death in 1946. This correspondence primarily concern her husband's historical legacy and a campaign to secure a pension from the U.S. government for herself and her family.\u003c/p\u003e","label":"Abstract Or Scope"}},"breadcrumbs":{"id":"https://arvasarchive.org/catalog/viu_repositories_7_resources_1710_c01#breadcrumbs","type":"document_value","attributes":{"value":{"ref_ssi":"viu_repositories_7_resources_1710_c01","ref_ssm":["viu_repositories_7_resources_1710_c01"],"id":"viu_repositories_7_resources_1710_c01","ead_ssi":"viu_repositories_7_resources_1710","_root_":"viu_repositories_7_resources_1710","_nest_parent_":"viu_repositories_7_resources_1710","parent_ssi":"viu_repositories_7_resources_1710","parent_ssim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"parent_ids_ssim":["viu_repositories_7_resources_1710"],"title_filing_ssi":"Series I. Jesse W. Lazear","title_ssm":["Series I. Jesse W. Lazear"],"title_tesim":["Series I. Jesse W. Lazear"],"normalized_title_ssm":["Series I. Jesse W. Lazear, 1800/1956, bulk 1863/1943"],"text":["Series I. Jesse W. Lazear, 1800/1956, bulk 1863/1943","Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974","box 1-6","announcements","articles","bills (legislative records)","biographies (documents)","booklets","books","certificates","charts (graphic documents)","clippings (information artifacts)","contracts","conveyances","death records","deeds","diaries","envelopes","Estate administration records","genealogical tables","genealogies (histories)","hair","ivory (tooth component)","journals (periodicals)","keys (hardware)","Legal documents","letters (correspondence)","magazines (periodicals)","medical records","microscope slide","microscopes","military records","newspapers","notes","oaths","obituaries","pamphlets","postcards","reports","reprints","speeches","telegrams","testimonials","Wills","Series I. Jesse W. Lazear consists of materials relating to Lazear that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1800 to 1956 with the bulk of the items dating from 1863 to 1943. Much of the series consists of the correspondence of Jesse W. Lazear and his wife Mabel H. Lazear. Jesse's correspondence dates from his time as a student at Johns Hopkins University to his death in 1900. Researchers can learn a great deal about Jesse from these letters, including his relationships with friends and family, his educational background, and his professional life. Mabel's correspondence dates from the time she met Jesse to her death in 1946. This correspondence primarily concern her husband's historical legacy and a campaign to secure a pension from the U.S. government for herself and her family.","In addition to Jesse and Mabel's correspondence, the series contains other materials relating to them and their families including, but not limited to the following:","the diaries documenting the travels of Jesse and Mabel's mothers in Europe;correspondence of other Lazear family members (e.g. Jesse's parents);genealogical summaries and tables relating to the Lazear family;legal documents (e.g. wills, certificates, deeds);military records relating to Jesse;certificates, reports, and other materials documenting Jesse's educational background and achievements;obituaries;copies of congressional bills and reports concerning the provision of a federal pension for Mabel H. Lazear;newspaper articles;a microscope and sets of microscope slides owned by Jesse;and a medical chart that shows the progression of the yellow fever infection that killed Jesse."],"parent_unittitles_ssm":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"parent_unittitles_tesim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"normalized_date_ssm":["1800/1956, bulk 1863/1943"],"unitdate_inclusive_ssm":["circa 1800-1956"],"unitdate_bulk_ssim":["bulk 1863-1943"],"level_ssm":["Series"],"level_ssim":["Series"],"component_level_isim":[1],"sort_isi":1,"repository_ssim":["University of Virginia, Special Collections Dept."],"collection_ssim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"extent_ssm":["6 boxes"],"extent_tesim":["6 boxes"],"containers_ssim":["box 1-6"],"has_online_content_ssim":["false"],"child_component_count_isi":344,"parent_access_restrict_tesm":["There are no restrictions on user access to any of the materials in the collection except where noted in the container list."],"parent_access_terms_tesm":["Copyright restrictions may apply for some materials in the collection."],"access_subjects_ssim":["announcements","articles","bills (legislative records)","biographies (documents)","booklets","books","certificates","charts (graphic documents)","clippings (information artifacts)","contracts","conveyances","death records","deeds","diaries","envelopes","Estate administration records","genealogical tables","genealogies (histories)","hair","ivory (tooth component)","journals (periodicals)","keys (hardware)","Legal documents","letters (correspondence)","magazines (periodicals)","medical records","microscope slide","microscopes","military records","newspapers","notes","oaths","obituaries","pamphlets","postcards","reports","reprints","speeches","telegrams","testimonials","Wills"],"access_subjects_ssm":["announcements","articles","bills (legislative records)","biographies (documents)","booklets","books","certificates","charts (graphic documents)","clippings (information artifacts)","contracts","conveyances","death records","deeds","diaries","envelopes","Estate administration records","genealogical tables","genealogies (histories)","hair","ivory (tooth component)","journals (periodicals)","keys (hardware)","Legal documents","letters (correspondence)","magazines (periodicals)","medical records","microscope slide","microscopes","military records","newspapers","notes","oaths","obituaries","pamphlets","postcards","reports","reprints","speeches","telegrams","testimonials","Wills"],"date_range_isim":[1800,1801,1802,1803,1804,1805,1806,1807,1808,1809,1810,1811,1812,1813,1814,1815,1816,1817,1818,1819,1820,1821,1822,1823,1824,1825,1826,1827,1828,1829,1830,1831,1832,1833,1834,1835,1836,1837,1838,1839,1840,1841,1842,1843,1844,1845,1846,1847,1848,1849,1850,1851,1852,1853,1854,1855,1856,1857,1858,1859,1860,1861,1862,1863,1864,1865,1866,1867,1868,1869,1870,1871,1872,1873,1874,1875,1876,1877,1878,1879,1880,1881,1882,1883,1884,1885,1886,1887,1888,1889,1890,1891,1892,1893,1894,1895,1896,1897,1898,1899,1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935,1936,1937,1938,1939,1940,1941,1942,1943,1944,1945,1946,1947,1948,1949,1950,1951,1952,1953,1954,1955,1956],"scopecontent_html_tesm":["\u003cp\u003eSeries I. Jesse W. Lazear consists of materials relating to Lazear that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1800 to 1956 with the bulk of the items dating from 1863 to 1943. Much of the series consists of the correspondence of Jesse W. Lazear and his wife Mabel H. Lazear. Jesse's correspondence dates from his time as a student at Johns Hopkins University to his death in 1900. Researchers can learn a great deal about Jesse from these letters, including his relationships with friends and family, his educational background, and his professional life. Mabel's correspondence dates from the time she met Jesse to her death in 1946. This correspondence primarily concern her husband's historical legacy and a campaign to secure a pension from the U.S. government for herself and her family.\u003c/p\u003e","\u003cp\u003e In addition to Jesse and Mabel's correspondence, the series contains other materials relating to them and their families including, but not limited to the following:\u003c/p\u003e","\u003clist type=\"ordered\"\u003e\u003citem\u003ethe diaries documenting the travels of Jesse and Mabel's mothers in Europe;\u003c/item\u003e\u003citem\u003ecorrespondence of other Lazear family members (e.g. Jesse's parents);\u003c/item\u003e\u003citem\u003egenealogical summaries and tables relating to the Lazear family;\u003c/item\u003e\u003citem\u003elegal documents (e.g. wills, certificates, deeds);\u003c/item\u003e\u003citem\u003emilitary records relating to Jesse;\u003c/item\u003e\u003citem\u003ecertificates, reports, and other materials documenting Jesse's educational background and achievements;\u003c/item\u003e\u003citem\u003eobituaries;\u003c/item\u003e\u003citem\u003ecopies of congressional bills and reports concerning the provision of a federal pension for Mabel H. Lazear;\u003c/item\u003e\u003citem\u003enewspaper articles;\u003c/item\u003e\u003citem\u003ea microscope and sets of microscope slides owned by Jesse;\u003c/item\u003e\u003citem\u003eand a medical chart that shows the progression of the yellow fever infection that killed Jesse.\u003c/item\u003e\u003c/list\u003e"],"scopecontent_heading_ssm":["Scope and Contents"],"scopecontent_tesim":["Series I. Jesse W. Lazear consists of materials relating to Lazear that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1800 to 1956 with the bulk of the items dating from 1863 to 1943. Much of the series consists of the correspondence of Jesse W. Lazear and his wife Mabel H. Lazear. Jesse's correspondence dates from his time as a student at Johns Hopkins University to his death in 1900. Researchers can learn a great deal about Jesse from these letters, including his relationships with friends and family, his educational background, and his professional life. Mabel's correspondence dates from the time she met Jesse to her death in 1946. This correspondence primarily concern her husband's historical legacy and a campaign to secure a pension from the U.S. government for herself and her family.","In addition to Jesse and Mabel's correspondence, the series contains other materials relating to them and their families including, but not limited to the following:","the diaries documenting the travels of Jesse and Mabel's mothers in Europe;correspondence of other Lazear family members (e.g. Jesse's parents);genealogical summaries and tables relating to the Lazear family;legal documents (e.g. wills, certificates, deeds);military records relating to Jesse;certificates, reports, and other materials documenting Jesse's educational background and achievements;obituaries;copies of congressional bills and reports concerning the provision of a federal pension for Mabel H. Lazear;newspaper articles;a microscope and sets of microscope slides owned by Jesse;and a medical chart that shows the progression of the yellow fever infection that killed Jesse."],"_nest_path_":"/components#0","timestamp":"2026-08-14T22:54:59.526Z","collection":{"numFound":1,"start":0,"numFoundExact":true,"docs":[{"id":"viu_repositories_7_resources_1710","ead_ssi":"viu_repositories_7_resources_1710","_root_":"viu_repositories_7_resources_1710","_nest_parent_":"viu_repositories_7_resources_1710","ead_source_url_ssi":"data/oai/UVA/repositories_7_resources_1710.xml","aspace_url_ssi":"https://archives.lib.virginia.edu/ark:/59853/202324","title_ssm":["Philip S. Hench Walter Reed Yellow Fever collection"],"title_tesim":["Philip S. Hench Walter Reed Yellow Fever collection"],"unitdate_ssm":["circa 1800-circa 1998","bulk 1863-1974"],"unitdate_inclusive_ssm":["circa 1800-circa 1998"],"unitdate_bulk_ssim":["bulk 1863-1974"],"normalized_date_ssm":["1800/1998, bulk 1863/1974"],"normalized_title_ssm":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"text":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974","MS.1","Archival Resource Key","/repositories/7/resources/1710","Human Experimentation","Military Medicine","Physicians","Public health","Tropical medicine","Yellow Fever","There are no restrictions on user access to any of the materials in the collection except where noted in the container list.","The Philip S. Hench Walter Reed Yellow Fever Collection is organized in 16 series:","I. Jesse W. Lazear\n      II. Henry Rose Carter\n      III. Walter Reed\n      IV. Philip Showalter Hench\n      V. Maps\n      VI. Alphabetical files\n      VII. Truby-Kean-Hench\n      VIII. Miscellany\n      IX. Photographs\n      X. Photographic negatives\n      XI. Reprints\n      XII. Houston Academy of Medicine/Texas Medical Center additions\n      XIII. Reed family additions\n      XIV. P. Kahler Hench additions\n      XV. Laura Wood\n      XVI. Edward Hook additions","The U.S. Army Yellow Fever Commission (1900-1901) was a board of physicians that the U.S. government formed in order to determine how yellow fever was transmitted between hosts. Ultimately, the commission's experiments in Cuba proved that mosquitoes transmit yellow fever--a discovery that would spur successful campaigns to control and eradicate yellow fever throughout much of the globe.","When Major Walter Reed and Acting Assistant Surgeons James Carroll, Aristides Agramonte, and Jesse Lazear gathered on the porch of the Columbia Barracks Hospital in June of 1900, they became the fourth successive board of U.S. medical officers to grapple with the appalling plague that was yellow fever.","The persistence of this disease across the Cuban archipelago and its periodic re-emergence along the coastlines and great river drainages of the Americas was taking countless thousands of lives. Lack of precise knowledge as to its cause and transmission had augmented yellow fever's extraordinarily high mortality rate and had given rise to quarantine regulations which constituted substantial impediments to efficient regional trade. Endemic in the tropics, yellow fever imposed high humanitarian and economic costs upon the entire region. Specialists regarded Cuba as one of the principal foci of the disease, and the island consequently attracted considerable attention from the medical sciences.","In 1879, one year after a devastating epidemic swept up the Mississippi valley from New Orleans, Tulane University Professor Stanford E. Chaille led the first investigatory commission to Havana, Rio de Janeiro, and the West Indies. The Chaille Commission remained in Havana three months, and its members -- including George Miller Sternberg, who became Surgeon General of the Army, and Juan Guiteras, later Director of Public Health for Havana -- consulted with Cuban scientist Carlos J. Finlay. They concluded that the causal agent for yellow fever was possibly a living entity in the atmosphere, an assertion which set Finlay on the path to the mosquito theory he developed in 1881.","Louis Pasteur's foundational and highly successful work in modern immunology in 1880 and 1881 gave a renewed impetus to investigations aimed at discovering the \"yellow fever germ.\" Over the middle years of the 1880s several scientists advanced different theories, all readily refuted by bacteriological work Sternberg undertook in Brazil and Mexico in 1887 and again in Havana in 1888 and 1889. In 1897, Italian scientist Giuseppe Sanarelli argued thatBacillus icteroideswas the culprit, and the following year a third scientific team sailed to Cuba for additional tests. Eugene Wasdin and Henry D. Geddings appeared to confirm Sanarelli's assertion, though Sternberg, by then Surgeon General, remained skeptical.","Despite Wasdin and Geddings' insistence, theB. icteroidestheory garnered significant opposition. In fact, a few months before the third commission's report reached the public, Walter Reed and James Carroll -- Reed's assistant at the Columbian University (later George Washington University) bacteriology laboratories in Washington, D.C. -- published a thorough refutation of theicteroidesproposal: the bacteria was not a unique cause of yellow fever, but a variety of the hog cholera bacillus, \"a secondary invader in yellow fever,\" Reed determined, unrelated to its etiology. [1] Dispute continued, however, and when Sternberg organized the fourth investigatory board, he charged Reed and his associates to settle theB. icteroidesquestion once and for all, then to proceed with analysis of other blood cultures and intestinal flora from yellow fever cases.","Reed and Carroll had considerable experience in bacteriological analysis, and, Sternberg reasoned, might well be able to find the specific agent of the disease. Aristides Agramonte, a Cuban scientist who had worked in Reed's lab at the Columbian University in 1898, was also an accomplished bacteriologist; he had identifiedB. icteroidesin tissue samples from cases other than yellow fever, providing further evidence opposed to Sanarelli's thesis. Jesse Lazear, a scientist from Johns Hopkins University in Baltimore, Maryland, had joined the Army Medical Corps to study tropical diseases at their point of origin; he received orders for Cuba in February 1900. Lazear impressed Reed with his abilities when the two men became acquainted in March. No doubt with Reed's advice, Sternberg assembled a crack team -- all experienced in scientific research, but each with interests as diverse as their temperaments. The mix of talent and personalities generated spectacular results.","What causes yellow fever? This simple, even obvious question had dictated yellow fever research for over two decades, and so it guided Reed in organizing the work of the commission.Bacillus icteroidesand other bacteriological sampling dominated their work for the first months. \"Reed and Carroll have been at that for a long time,\" Lazear wrote with some impatience to his wife on August 23, \". . . I would rather try to find the germ without bothering about Sanarelli.\" [2] Again and again, tests for the bacteria proved negative, and at the same time, perplexing cases of yellow fever were developing in the region. Agramonte and Reed investigated an epidemic at Pinar del Rio, 110 miles southwest of Havana; Lazear followed later to collect more specimens, and he also assessed the situation at Guanjay thirty miles southwest. To \"my very great surprise,\" Reed admitted, the specific circumstances of the appearance and development of these cases gave strong evidence against the widely-accepted notion that the excreta of patients spread the disease. The theory of fomites -- infection from contaminated clothing and bedding -- and indeed even infection from airborne particles seemed altogether untrue. \"At this stage of our investigation,\" Reed concluded, \". . . the time had arrived when the plan of our work should be radically changed.\" [3] The fundamental question underwent a subtle but critical transformation: from what causes yellow fever to what transmits it. A clear and accurate understanding of how the disease was spread would open a new avenue to its specific cause.","\"Personally, I feel that only can experimentation on human beings serve to clear the field for further effective work,\" Reed stated to Surgeon General Sternberg, who concurred. [4] Evidence gathering around them pointed strongly to an intermediate host, and the Commission resolved to test Carlos Finlay's mosquito theory -- then not generally accepted -- on human volunteers. Nine times from August 11 to August 25, 1900, mosquitoes landed on the arms of volunteers and proceeded to feed. Nine times the results were negative. On August 27, Lazear placed a mosquito on the doubting Dr. Carroll, and four days later on William J. Dean, a soldier designated XY in the \"Preliminary Note.\" [5] Both promptly developed yellow fever. Significantly, their mosquitoes had fed on cases within the initial three days of an attack and had been allowed to ripen for at least twelve days before the inoculations. Carroll vitiated the results of his experimental sickness by traveling off the post to Havana, a contaminated zone, even as Reed, ecstatic, wrote from Washington in a confidential letter: \"Did the Mosquito do it?\" [6] Dean's case seemed to prove it, since he claimed not to have left the garrison before becoming ill. Lazear also developed a case of yellow fever, almost certainly experimental in origin, though he never revealed the actual circumstances of his inoculation. His severe bout of fever took a fatal turn on September 25, 1900.","Nevertheless, these results could not have been more dramatic or convincing for the Commission. Reed quickly assembled a \"Preliminary Note,\" which he presented to the annual meeting of the American Public Health Association in Indianapolis, Indiana, October 23, 1900. After initial consultations in Cuba with General Leonard Wood, military governor of the island, and with Surgeon General Sternberg in Washington, he returned to Cuba with authorization and funding to design and carry forward a fully defensible series of experiments. His aim was confirmation of the mosquito theory and invalidation of the long-held belief in fomites.","On open terrain beyond the precincts of Columbia Barracks -- the American military base just west of Havana near the adjacent suburban towns of Quemados and Marianao (also called Quemados de Marianao) -- Reed established the quarantined experimental station. Camp Lazear, as the Commission dedicated it, took form in the rolling fields of the Finca San Jose, on the farm of Dr. Ignacio Rojas, who leased the land to the Americans. Here Reed designed two small wood-frame buildings, each 14 by 20 feet, for the experimental work, and nearby raised a group of seven tents for the accommodation and support of the volunteers. The buildings faced each other across a small swale, about 80 yards apart, and stood 75 yards from the tent encampment. Building Number One, called the Infected Clothing Building, was a single room tightly constructed to contain as much foul air as possible. A small stove kept the temperature and humidity at tropical levels, and carefully attached screening secured the pair of doorways in a vestibule against intrusion by mosquitoes. Wooden blinds on two small sealed windows shielded the room from direct sun. Building Number Two, the Infected Mosquito Building, contained a principal room, divided into two sections by a floor-to-ceiling wire mesh screen. A door direct to the exterior let into one section, while a vestibule with a solid exterior door and pair of successive screened doors opened to the other, so configured to keep infected mosquitoes inside that section alone. The spare furnishings in both sections -- cots with bedding -- were steam sterilized. Windows exposed the entire room to the clean, steady ocean breezes and to sunlight. Like the doorways, they were carefully screened. A secondary room attached to the building but not communicating with the experimental spaces sheltered the small, heated laboratory where the Commission members raised and stored the mosquitoes to be used.","These two experimental buildings presented alternate environments -- one conspicuously clean and well ventilated, the other filthy and fetid. Contemporary theories of disease held that yellow fever developed in unclean conditions, and consequently much time and money had been devoted to sanitation projects. Workers steamed clothing, burned sulphur in ships' holds, and thoroughly scrubbed surfaces with disinfectant. In cases of severe epidemic, entire buildings presumed to be infected were set afire along with their contents. Thus the extraordinary -- and intentional -- paradox of the Commission's experimental regime: Reed expected yellow fever to develop not in the unsanitary environment, but in the one thought to be most healthful.","Camp Lazear went into quarantine the day of its completion, November 20, 1900, with a command of four immune and nine non-immune individuals, all save one U.S. Army personnel. Soon a group of recent Spanish immigrants to Cuba augmented the non-immune numbers, bringing the resident total to about twenty. Reed strictly controlled access to the camp and ordered regular temperature recording for each volunteer to eliminate any unanticipated source of infection and to identify the onset of any case of yellow fever as early as possible. As a result, non-immunes were barred from returning should they leave the precinct, and two of the Spaniards who developed intermittent fevers shortly after arrival were immediately transferred with their baggage to Columbia Barracks Hospital. The immune members of the detachment oversaw medical treatments and drove the teams of mules that pulled supply wagons and the ambulance. Experimentation did not begin until each volunteer had passed the incubation period for yellow fever in perfect health.","Reed took as much care with the design of the experimental protocol as he had with the configuration of the camp and its buildings. Each evening, the occupants of the infected clothing building unpacked trunks and boxes of bed linens and blankets, nightshirts and other clothing recently worn and soiled by cases from the wards of Columbia Barracks Hospital and Las Animas Hospital in Havana. These they shook out and spread around the room to permeate the atmosphere. The stench was overpowering. Yellow fever causes severe internal hemorrhaging, and its unfortunate victims often suffer from black vomit and other bloody discharges. One routine delivery proved so putrid the volunteers \"retreated from the house,\" Reed stated. \"They pluckily returned, however, within a short time, and spent the night as usual.\" [7] In two succeeding trials the protocol became progressively more daring , as the volunteers then wore the clothing and slept on the mattresses used by yellow fever patients, and finally put towels on their bedding smeared with blood drawn from cases in the early stages of an attack. Each morning, the volunteers carefully repacked the rank, encrusted materials into boxes and emerged to an adjacent tent where they spent the day quarantined from the rest of the company. Three trials of twenty days each involved seven men altogether, lead by Robert P. Cooke, a physician in the Army Medical Corps. None developed yellow fever.","The Commission's mosquito experiments proceeded in four series. First, Reed sought to demonstrate that mosquitoes of the varietyCulex fasciata(later calledStegomyia fasciata, and later stillAedes aegypti) could in fact transmit yellow fever, as Carlos J. Finlay had argued and the initial experiments at Camp Columbia strongly suggested. Here the Commission members simply applied infected mosquitoes contained in test tubes or jars to the skin of the initial volunteers. Success in these tests raised a number of questions, each one addressed in the subsequent series:","How could a building become infected?\n      When does a mosquito develop the ability to transmit the disease?\n      Over what length of time can a mosquito retain this capacity to infect?","The second series consequently employed the specialized \"Infected Mosquito Building\" to indicate how a structure could be considered infected with yellow fever. This experiment required two groups of volunteers, one to be inoculated and another to serve as controls. \"Loaded\" mosquitoes, as the men called them, were released into the screened section of Building Two -- on the side with the protected vestibule entry. One or more non-immune men then entered the opposite section of the room through the direct exterior door, and lay down on bunks adjacent to the wire mesh screen in the center of the room. Now the young man to be inoculated walked through the vestibule into the mosquito side of the room and proceeded to lie on a bunk adjacent to the wire screen separating him from the controls. The inoculation volunteer remained in the building for about twenty minutes -- enough time to suffer several mosquito bites -- he then exited to a quarantine tent outside. The controls spent the remainder of the evening and night in the uninfected side of the room, and indeed returned to sleep in the room for as many as eighteen more nights. As Reed stated, absence of yellow fever in the controls showed \"that the essential factor in the infection of a building with yellow fever is the presence therein of [infected] mosquitoes,\" and nothing more. [8] The degree of sanitation, so long considered critical, was utterly irrelevant.","The third series of mosquito experiments confirmed what Henry Rose Carter, of the U.S. Public Health Service, called the \"period of extrinsic incubation,\" [9] the length of time required for secondary cases of yellow fever to develop after an initial intrusion of the disease into a locality. In this series, a single volunteer underwent three successive inoculations by the same mosquitoes, each group of inoculations interrupted by a period of time equal in length to the typical incubation period of the disease in humans, about five days. In this manner, the volunteer's illness could be specifically attributed to a single inoculation group. The use of the same mosquitoes and the same volunteer concurrently demonstrated that no peculiar personal immunity was at play, since logic dictates that a person susceptible to yellow fever on day 17 of a mosquito's contamination -- as happened in the experiment -- could not have been immune to yellow fever on day 11 or day 4. It was thus only the mosquito's capacity to infect which changed, and that occurred no less than 11 days after contamination.","The duration of time over which these \"fully ripened\" mosquitoes remained infective comprised the fourth series of experiments. For this series the Commission kept alive a group of infected mosquitoes for as long as possible, and proceeded to inoculate three volunteers -- on the 39th, 51st, and 57th day after contamination. Each developed yellow fever. A fourth volunteer declined to be bitten on day 65, and the last two mosquitoes of the group, \"deprived of further opportunity to feed on human blood\" [10] expired on day 69 and day 71, clear evidence that even a sparsely populated region may retain the potential for new infections more than two months after the first appearance of the disease.","Although it went unrecorded in the published papers, Reed organized a supplemental experiment to test another species of mosquito.Culex pungensfailed to transmit yellow fever to at least one volunteer and probably to a second. Reed's preliminary conclusions indicated thatCulex fasciatawas the only species capable of transmitting yellow fever. [11]","A last experimental regime involved subcutaneous injections of blood from positive cases of yellow fever to presumed non-immunes. Reed devised these tests to confirm the presence of the yellow fever agent in the blood of a victim during the first days of an attack, and, more importantly, to settle theBacillus icteroidesquestion. The same blood cultures which produced yellow fever in four volunteers also failed to grow anyB. icteroides, conclusively invalidating Sanarelli's claim.","Altogether, the mosquito inoculations and the blood injections produced fourteen cases of yellow fever. All made a full recovery.","Notwithstanding the decisive medical victory -- as Reed declared, \"aside from the antitoxin of Diptheria and Koch's discovery of the tubercle bacillus, it will be regarded as the most important piece of work, scientifically, during the 19th century\" [12] -- success at Camp Lazear unfolded in its own time. Initially, Reed observed, \"the results obtained at this station were not encouraging.\" [13] The first inoculations of four volunteers over a period of two weeks proved disconcertingly negative each time. Then, on December 5, 1900, private John R. Kissinger presented his arm to the mosquitoes, and late in the evening on December 8, suffered the first chills of \"a well-marked attack of yellow fever.\" [14] Three more men in rapid succession fell victim to the insects -- Spanish volunteers Antonio Benigno, Nicanor Fernandez, and Vicente Presedo. The force of the conclusions was evident to everyone:","\"It can readily be imagined,\" Reed empathetically and wryly described in his first presentation of the experiments, \"that the concurrence of 4 cases of yellow fever in our small command of 12 non-immunes within the space of 1 week, while giving rise to feelings of exultation in the hearts of the experimenters, in view of the vast importance attaching to these results, might inspire quite other sentiments in the bosoms of those who had previously consented to submit themselves to the mosquito's bite. In fact, several of our good-natured Spanish friends who had jokingly compared our mosquitoes to 'the little flies that buzzed harmlessly about their tables,' suddenly appeared to lose all interest in the progress of science, and, forgetting for the moment even their own personal aggrandizement, incontinently severed their connection with Camp Lazear. Personally, while lamenting to some extent their departure, I could not but feel that in placing themselves beyond our control they were exercising the soundest judgment.\"","\"In striking contrast,\" Reed continued, the anxiety of the fomites volunteers began to melt into relief. \"[T]he countenances of these men, which had before borne the serious aspect of those who were bravely facing an unseen foe, suddenly took on the glad expression of 'schoolboys let out for a holiday,' and from this time their contempt for 'fomites' could not find sufficient expression. Thus illustrating once more, gentlemen, the old adage that familiarity, even with fomites, may breed contempt.\" [15]","The question of human experimentation was indeed a serious one -- unavoidable, in actuality, as Reed had stated the previous summer to Surgeon General Sternberg. When the Commission first considered a trial of Finlay's mosquito theory, Reed, Carroll, and Lazear agreed to experiment on themselves. Agramonte, a native Cuban, had acquired immunity as a child. Doubtless Finlay's experience of many unsuccessful inoculations communicated that positive results would not be forthcoming rapidly, so before the first series of inoculations began under Lazear's direction at Columbia Barracks, Reed left Cuba for Washington, where he completed a monumental report on typhoid fever among the army corps -- left unfinished by the sudden death of co-author Edward O. Shakespeare. Carroll and Lazear both sickened while Reed was in Washington, and Lazear, young and strong, had no reason to anticipate that his case would be fatal. Reed was shocked at Lazear's death, and because of his own age -- 49, a decade and a half older than Lazear and a dozen years older than Carroll -- he resolved not to inoculate himself when he returned to Cuba on October 4, 1900. The point had already been amply demonstrated, and only a rigidly controlled experimental regime would establish the necessary proof. Carroll, however, remained embittered about this for the remainder of his life, though he evidently never communicated his objections directly to Reed.","That initial series of mosquito inoculations was probably accomplished without formal documentation of informed consent. Indeed, the experiments may also have been carried forward without the full knowledge of the commanding officer of Camp Columbia, and Reed consequently shielded the identity of Private William J. Dean, the second positive experimental case, behind the pseudonym \"XY\" in the \"Preliminary Note.\" No such potentially troublesome problems arose for the experimental series at Camp Lazear; Reed obtained prior support from all of the appropriate authorities in the military and the administration, even including the Spanish Consul to Cuba. With the advice of the Commission and others, he drafted what is now one of the oldest series of extant informed consent documents. The surviving examples are in Spanish with English translations, and were signed by volunteers Antonio Benigno and Vicente Presedo, and a third with the mark of Nicanor Fernandez, who was illiterate.","The documents take the form of a contract between individual volunteers and the Commission, represented by Reed. At least 25 years old, each volunteer explicitly consented to participate, and balanced the certainty of contracting yellow fever in the general population against the risks of developing an experimental case, followed by expert and timely medical care. The volunteers agreed to remain at Camp Lazear for the duration of the experiments, and as a reward for participation would receive $100 \"in American gold,\" with an additional hundred-dollar supplement for contracting yellow fever. These payments could be assigned to a survivor, and the volunteers agreed to forfeit any remuneration in cases of desertion.","For the American participants no consent documents appear to survive, though in contemporary letters Reed assured his correspondents that the Commission obtained written consent from all the volunteers. The record of expenses for Camp Lazear -- maintained by Reed's friend and colleague in the medical corps, Jefferson Randolph Kean -- indicates that the same schedule of payments for participation and sickness applied to the Americans as well. Volunteers who participated in the fomites tests and in addition the later series of blood injections and the single trial of an alternative species of mosquito also earned $100 each plus the $100 supplement if yellow fever developed. Two Americans declined these gratuities, as Kean termed them, Dr. Robert P. Cooke, of the fomites tests, and John J. Moran, who had recently received an honorable discharge from the service, and was the only American civilian to participate. His was the fourth case of yellow fever to develop from mosquito inoculation. Moran eventually settled in Cuba, where he managed the Havana offices of the Sun Oil Company, and late in life became a close friend of Philip S. Hench. Together the two men rediscovered the site of Camp Lazear in 1940 -- Building Number One still intact -- and successfully lobbied the Cuban government to memorialize there the work of Finlay and the American Commission in the conquest of yellow fever.","Reed informally commemorated his own experiences at Camp Lazear by commissioning a group photograph, evidently taken there shortly before he left Cuba in February 1901. A more important event occurred on the sixth of that month when Reed presented the results of the Camp Lazear yellow fever experiments to a great ovation at the Pan-American Medical Congress in Havana. Three days later he set sail for the United States, and once landed, drafted the Congress paper asThe Etiology of Yellow Fever -- An Additional Note, published immediately in theJournal of the American Medical Association. [16]","Though his correspondence intimates a great appreciation for Cuba, Reed never returned to the warm, sunny shores of the island freed of a dreadful plague. Carroll stayed behind at Camp Lazear through February to complete the last experimental series officially bearing the imprimatur of the Yellow Fever Commission, and returned to Washington soon after March first. [17] The Medical Corps retained the lease on Camp Lazear against the possibility of continuing experiments another season, and Carroll, in fact, returned to Havana in August 1901 for a final experimental series, though he did not make use of Camp Lazear. This work involved at least three volunteers at Las Animas Hospital, Havana, who submitted to blood injections. Carroll's assignment aimed at a greater understanding of the yellow fever agent, and he proved that blood drawn from active cases of yellow fever remained virulent even after passing through fine bacteria filters. In addition, by heating contaminated blood which had previously caused cases of yellow fever, Carroll rendered it non-infective -- thereby establishing that this filterable entity, though sub-microscopic, was demonstrably present in the bloodstream. Carroll wrapped up the series in October and returned home to stay. [18] In Cuba, J. Randolph Kean made the last rental payments to Signore Rojas on October 9, 1901, and Camp Lazear, for more than a generation, slipped out of the realm of memory.","Sources:","[1] Walter Reed and James Carroll,Bacillus Icteroides and Bacillus Cholerae Suis -- A Preliminary Note,Medical News(29 April 1899), reprinted in: United States Senate Document No. 822,Yellow Fever, A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 55.\n      [2] Letter from Jesse W. Lazear to Mabel Houston Lazear, 23 August 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00341001.\n      [3] Walter Reed, \"The Propagation of Yellow Fever -- Observations Based on Recent Researches,\" in United States Senate Document No. 822,Yellow Fever A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 94.\n      [4] Letter from Walter Reed to George M. Sternberg, 24 July 1900, Hench Reed Yellow Fever Collection, accession number: 02064001.\n      [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note,Proceedings of the Twenty-eighth Annual Meeting of the American Public Health AssociationIndianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n      [6] Letter from Walter Reed to James Carroll, 7 September 1900, Edward Hook Additions to the Philip S. Hench Walter Reed Yellow Fever Collection: James Carroll Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 15312004. The originals of these letters remain in a private collection.\n      [7] Walter Reed, James Carroll, Aristides Agramonte,The Etiology of Yellow Fever -- An Additional Note,Journal of the American Medical Association36 (16 February 1901): 431-440, reprinted in: Senate Document No. 822, p. 84.\n      [8] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n      [9] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n      [10] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 101.\n      [11]Culex fasciatawas reclassified shortly after the experiments asStegomyiaand later becameAedes aegypti.\n      [12] Letter to from Walter Reed to Emilie Lawrence Reed, 9 December 1900, Hench Reed Collection, accession number: 02231001.\n      [13] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 97.\n      [14] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 98.\n      [15] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n      [16] Please see note [7].\n      [17] The Commission reported these concluding experiments in: Walter Reed, James Carroll, Aristides Agramonte,Experimental Yellow Fever,American MedicineII (6 July 1901) 1: 15-23.\n      [18] Walter Reed, James Carroll,The Etiology of Yellow Fever (A Supplemental Note),American MedicineIII (22 February 1902) 8: 301-305.","Walter Reed (September 13, 1851 - November 22, 1902) was a U.S. Army physician who led the army's Yellow Fever Commission 1900 and 1901. Experiments conducted by the commission confirmed a theory that yellow fever is transmitted by mosquitoes--a discovery that led to the control and eradication of this disease across much of the globe. Reed would receive much of the credit for the work of the commission because of his role as its leader, and, long after his death in 1902, he would be widely celebrated as a heroic figure in the fields of public health and medical research.","Reed spent his first days in a small house which served as the parsonage for a Methodist congregation in Gloucester County, Virginia, where his father was minister.  Lemuel Sutton Reed and Pharaba White Reed welcomed young Walter into the family on September 13, 1851;  he was the youngest of their five children.  The Reeds moved to other Virginia parishes during Walter's childhood, and just after the close of the Civil War, transferred to the town of Charlottesville.  That move in 1866 placed Walter in the orbit of the University of Virginia, which he entered a year later at age sixteen under the care of his older brother Christopher, also a student at the University.  Reed attended two year-long sessions, the second devoted entirely to the medical curriculum, and he completed an M.D. degree on July 1, 1869, as one of the youngest students to graduate in the history of the medical school.","At that time the School of Medicine at the University offered little opportunity for direct clinical experience, so Reed subsequently enrolled at the Bellevue Hospital Medical College, in Manhattan, New York.  There he obtained a second M.D. degree in 1870.  Reed interned at a number of hospitals in the New York metropolitan area, including the Infants' Hospital on Randall's Island and the Brooklyn City Hospital.  In 1873, he assumed the position of assistant sanitary officer for the Brooklyn Board of Health.  The large and diverse population of New York, with its many immigrant communities and dense, tenement housing, provided countless medical cases to treat and study;  these served to expose Reed to the vital importance of public health, and developed in him a lifelong interest in the field.  Yet the frenetic life of the great cities began to pall after a few years: \"Here the ever bustling day is crowded into the busy night; nor can we draw the line of separation between the two,\"[1] he wrote to Emilie Lawrence, of Murfreesboro, North Carolina, later to become Mrs. Walter Reed.  Their courtship letters reveal much of his maturing character, interests, and philosophy of life.  Increasing responsibilities with the Board of Health precluded opening a private practice, and Reed's youth proved a barrier in a culture given to offering respect more to the appearance of maturity than to its actual demonstration. Reed consequently resolved to join the Army Medical Corps, both for the professional opportunities it offered immediately and for the modest financial security it could provide to a young man without independent means.  He passed the qualifying examinations in January 1875 and proceeded to his first assignment at the military base on Willet's Point, New York Harbor.","Reed remained in the Medical Corps for the rest of his life, spending many years of the '70s, '80s, and early '90s at difficult postings in the American West.  The first of these -- to the Arizona Territory -- began in the late spring of 1876, and indeed hurried along his wedding to Emilie Lawrence, on April 25, shortly before his departure.  She joined him the following November, and bore two children at frontier posts, a son Walter Lawrence and a daughter Emilie, called Blossom.","Reed's other western assignments included forts in Nebraska, Dakota Territory, and Minnesota, with two eastern interludes at Baltimore, Maryland and another at Mount Vernon Barracks, Alabama.  During the second of these tours in Baltimore -- over the 1890-1891 academic year -- Reed completed advanced coursework in pathology and bacteriology in the Johns Hopkins University Hospital Pathology Laboratory.  When he returned from his last western appointment in 1893, Reed joined the faculty of the Army Medical School in Washington, D.C., where he held the professorship of Bacteriology and Clinical Microscopy.  He also became curator of the Army Medical Museum and joined the faculty of the Columbian University in Washington (later the George Washington University).  In addition, Reed maintained close ties with professor William Welch and other leading lights in the scientific community he had come to know at Hopkins a few years earlier.","Beyond his teaching responsibilities for the Army and the Columbian University programs, Reed actively pursued medical research projects.  A bibliography of his publications finds entries from 1892 to the year of his untimely death a decade later, and the subjects he investigated range from erysipelas to cholera, typhoid, malaria, and yellow fever, among others.[2]   In 1896, a research trip to investigate an outbreak of smallpox took him to Key West, and there he developed a close friendship with Jefferson Randolph Kean, a fellow Virginian and colleague in the Medical Corps ten years his junior.  When Reed traveled to Cuba in 1899 to study typhoid in the army encampments of the U.S. forces, Kean was already there, and Kean was still in Cuba when Reed returned as the head of the Army board charged by Surgeon General George Miller Sternberg to examine tropical diseases including yellow fever.  Kean and his first wife Louise were great supporters of the U.S. Army Yellow Fever Commission's work, and Kean in fact served as quartermaster for the famous series of experiments at Camp Lazear.  After the dramatic and conclusive success of those experiments, Kean actively -- though unsuccessfully -- promoted Reed's candidacy for Surgeon General.","Reed continued to speak and publish on yellow fever after his return from Cuba in 1901, receiving honorary degrees from Harvard and the University of Michigan in recognition of his seminal work.  In November 1902, Reed developed what had been for him recurring gastro-intestinal trouble.  This time, however, his appendix ruptured, and surgery came too late to save him from the peritonitis which developed.  He died on November 23, 1902, almost two years to the day from the opening of Camp Lazear and the stunning experimental victory there.  Kean remained a champion of his deceased friend's role in the conquest of yellow fever.  He organized the Walter Reed Memorial Association, to provide support for Reed's family and to build a suitable memorial, and was instrumental in lobbying the United States Congress to establish the Yellow Fever Roll of Honor.  In 1929, Congress mandated the annual publication of the Roll in theArmy Register, and struck a series Congressional Gold Medals saluting the Commission members and the young Americans who bravely suffered experimental yellow fever a generation before.","Sources:","[1] Letter from Walter Reed to Emilie Lawrence, 18 July 1874, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 01605001.\n      [2] The bibliography of Reed's scientific papers may be found in: Howard Atwood Kelly,Walter Reed and Yellow Fever(New York: McClure, Phillips and Co., 1906), pp. 281-283. Kelly's complete biography of Reed is contained on this Web site.","Jesse William Lazear (May 2, 1866 - September 26, 1900) was a physician who was a member of the U.S. Army Yellow Fever Commission in 1900. Lazear's death from yellow fever at the outset of the commission's work in Cuba would lead to his elevation as a martyr for medical science in the eyes of many during the twentieth century.","\"I rather think I am on the track of the real germ,\" Jesse W. Lazear wrote his wife from Cuba on September 8, 1900.[1] Seventeen days later, the fulminating case of yellow fever Lazear had contracted just over a week after writing Mabel H. Lazear suddenly ended the young scientist's life. He was 34 years old. Unlike so many other yellow fever fatalities, however, this one would lead to a direct and highly successful assault on the disease itself. Yellow fever's ascendancy, endemic in Cuba, was about to be undermined.","Lazear had reported to Camp Columbia, Cuba in February 1900 for duty as an acting assistant surgeon with the U. S. Army Corps stationed on the island. Here he undertook bacteriological study of tropical diseases, particularly malaria and yellow fever, and in May he was named to the Army board charged with \"pursuing scientific investigations with reference to the infectious diseases prevalent on the island of Cuba.\"[2]","These orders placed him officially in the company of Walter Reed, James Carroll, and Aristides Agramonte -- the U.S. Army Yellow Fever Commission -- though Lazear had already met Reed the preceding March on a project to evaluate the efficacy of electrozone, a disinfectant made from seawater collected off the Cuban coast. While Reed was in Cuba that March, Lazear discussed with him the recent discovery of British scientist Sir Ronald Ross concerning the mosquito vector for malaria. At Johns Hopkins Hospital in Baltimore, where he was first a medical resident and later in charge of the clinical laboratory, Lazear had followed Ross's accomplishments with great interest, and pursued field work and experimentation on theAnophelesmosquito with fellow Hopkins scientist William S. Thayer. Lazear was thus the only member of the Commission who had experience with mosquito work, and was consequently the most open to the possible verity of Cuban scientist Carlos Juan Finlay's theory of mosquito transmission for yellow fever.","The record is apparently silent as to when Lazear first visited Finlay. Certainly by late June Lazear was beginning to grow mosquito larvae acquired from Finlay's laboratory, the first specimens brought to him by Henry Rose Carter, of the United States Public Health Service.[3] Not long after arriving in Cuba Lazear met Carter, whose own observations on yellow fever strongly suggested an intermediate host in the spread of the disease. However, Army Surgeon General George Miller Sternberg, who organized the Yellow Fever Commission, first charged the board members to investigate the relationship ofBacillus icteroidesto yellow fever -- proposed by the Italian Scientist Giuseppe Sanarelli as the actual cause of the disease. \"Dr. Reed had been in the old discussion over Sanarelli's bacillus and he still works on that subject,\" Lazear wrote his wife in July, \"I am not all interested in it but want to do work which may lead to the discovery of the real organism.\"[4] Soon he would have the opportunity. The relatively quick failure of the Bacillus icteroides inquiry opened the door to what became the ground-breaking mosquito work, and Lazear was well placed to begin.","The project started in earnest on August 1, 1900. In a small pocket notebook Lazear noted the preparatory work of raising and infecting mosquitoes, and subsequently recorded the series of eleven experimental inoculations made from the 11th to the 31st of August, the last two producing cases of full-blown yellow fever. These two positive cases developed from mosquitoes allowed to ripen over a period of 12 days, and this was Lazear's crucial discovery. The epidemiological pattern was thus entirely consistent with Carter's observations of a delay between the primary and secondary outbreaks of yellow fever in an epidemic, and, in addition, explained why Finlay's experiments had been largely unsuccessful -- he had not waited long enough before inoculating his subjects.","Although Lazear never directly admitted to experimenting on himself, when Reed reviewed Lazear's sketchy notations he evidently found entries strongly suggesting Lazear's case was not accidental, as officially reported. Unfortunately, the little notebook so crucial to the preparation of the Commission's famous initial paper,The Etiology of Yellow Fever -- A Preliminary Note[5], vanished from Reed's Washington office after his own untimely death in 1902. Still, Lazear's invaluable contribution to the Commission's victory was widely recognized and elicited tributes from many quarters: \"He was a splendid, brave fellow,\" Reed said of his young colleague, \" and I lament his loss more than words can tell; but his death was not in vain- His name will live in the history of those who have benefited humanity.\" [6] \"His death was a sacrifice to scientific research of the highest character,\" stated General Leonard Wood, military Governor of Cuba.[7] \"Your husband was a martyr in the noblest of causes,\" Dr. L. O. Howard wrote to Mabel Lazear, \"and I am proud to have known him. . . . His work contributed towards one of the greatest discoveries of the century, the results of which will be of invaluable benefit to mankind.\"[8] And so they were. Though Lazear's one-year-old son and newborn daughter never knew their father, they grew up in a world liberated -- almost in its entirety -- from the disease that killed him.","[1] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 8 September 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00344001.","Sources:","[2] Military Orders for Walter Reed, James Carroll, Aristides Agramonte, and Jesse W. Lazear, 24 May 1900, Hench Reed Collection, accession number 02019001.\n      [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n      [4] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 15 July 1900, Hench Reed Collection, accession number: 00334001.\n      [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note, Proceedings of the Twenty-eighth Annual Meeting of the American Public Health Association Indianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n      [6] Letter from Walter Reed to Emilie Lawrence Reed, 6 October 1900, Hench Reed Collection, accession number: 02135001.\n      [7] Letter from Leonard Wood to the Adjutant-General, United States Army, November 1900, Hench Reed Collection, accession number: 00375002.\n      [8] Letter from Leland Ossian Howard to Mabel Houston Lazear, 7 February 1901, Hench Reed Collection, accession number: 00388001.","Henry Rose Carter (August 25, 1852 - September 14, 1925) was a prominent physician in the U.S. Public Health Service who was a leading authority in the transmission and control of tropical diseases, particularly yellow fever and malaria. During his long career as a sanitarian, Carter undertook campaigns to investigate and control the spread of tropical diseases in Cuba, the Panama Canal Zone, the Southeastern United States, and Peru.","Like Walter Reed and Jefferson Randolph Kean, Henry Rose Carter was a native Virginian and a graduate of the University of Virginia. Carter obtained a civil engineering degree from Virginia in 1873 and also undertook post-graduate work in mathematics and applied chemistry the next year. Subsequently, however, Carter's interests turned towards medicine, and he completed a medical degree at the University of Maryland in 1879. The same year Assistant Surgeon Carter joined the Marine Hospital Service -- later the United States Public Health Service -- and the young surgeon rose steadily through the ranks, ultimately attaining the position of Assistant Surgeon General in 1915.","Carter's initial assignments with the Hospital Service placed him at the center of the yellow fever maelstrom. In 1879 he was detailed to Memphis and other Southern cities, then in the throes of a second year of devastating epidemics. Here began, as his colleague T. H. D. Griffitts observed, Carter's \"lifelong interest in the epidemiology and control of yellow fever.\"[1] After several years of clinical practice in various Marine hospitals, Carter resumed a direct confrontation with yellow fever when his orders for duty with the Gulf Coast Maritime Quarantine assigned him to Ship Island, Mississippi, in 1888. Here and at subsequent quarantine station postings around the Gulf, he quietly championed a thorough review and rationalization of quarantine policies, with a view toward establishing uniform regulation, more thorough disinfection of vessels, and minimized interference with naval commerce. Crucial to the success of these activities was Carter's attention to the incubation period of yellow fever, which his on-site observations indicated to vary between 5 and 7 days. At the time the official literature stated with far less precision a variance of between 1 and 14 days; Carter's work consequently greatly increased the efficiency and effectiveness of quarantine operations.","Nevertheless, yellow fever continued to menace the temperate coastline of the United States, and Carter ably directed the Health Service's epidemiological control efforts in numerous threatened regions. In conjunction with this sanitary work for the 1898 season, Carter made detailed notes on the development of yellow fever at Orwood and Taylor, Mississippi. The isolation of these communities enabled him to identify more reliably the phenomenon of a delay between the initial cases of yellow fever in a locality and the subsequent appearance of secondary infection -- a delay two to four times longer than the incubation period of the disease in an infected person. Carter called this interval between the primary and secondary cases \"the period of extrinsic incubation,\" and he defined its \"usual limits . . . [as ranging] from ten to seventeen days.\"[2]","Before he was able to publish his conclusions, Carter took the helm of the quarantine service in war-time Cuba. There, in 1900, he met U. S. Army Yellow Fever Commission member Jesse Lazear. Carter had finally arranged for his paper's publication that year in theNew Orleans Medical and Surgical Journal, and gave a draft to Lazear. \"If these dates are correct,\" Carter later recalled Lazear saying, \"it spells a living host.\"[3] The theory of mosquito transmission long advanced by Cuban scientist Carlos J. Finlay began to seem more likely. And indeed it was. The Commission's experiments in 1900-1901 irrefutably proved the mosquito vector and established the extrinsic incubation period at twelve days. Shortly after these successes Reed saluted Carter, \"I know of no one more competent to pass judgment on all that pertains to the subject of yellow fever. You must not forget that your own work in Mississippi did more to impress me with the importance of an intermediate host than everything else put to-gether.\"[4]","Carter's long and distinguished sanitary career took him to the Panama Canal Zone in 1904, where he served as Chief Quarantine Officer and Chief of Hospitals for five years. He undertook detailed investigations and control measures of malaria in North Carolina and elsewhere in the South, and became a founder of the National Malaria Committee. With the support of the Rockefeller Foundation International Health Board, he undertook additional investigation and control measures for yellow fever in Central and South America. His expertise recommended him to the Peruvian government, which named Carter Sanitary Advisor in 1920-1921. Health problems at the end of his life compelled Carter to withdraw from active fieldwork, though he remained a highly valued consultant to the Health Board and a much-beloved and respected teacher for a new generation of sanitarians. Carter closed his career researching and writing the manuscript that his daughter Laura Armistead Carter edited and published posthumously in 1931:Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.[5]","Sources:","[1] T. H. D. Griffitts,Henry Rose Carter: The Scientist and the Man,Southern Medical Journal32 (August 1939) 8: 842.\n      [2] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n      [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n      [4] Letter from Walter Reed to Henry Rose Carter, 26 February 1901, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 02447001.\n      [5] Carter, Henry Rose.Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.Baltimore: The Williams and Wilkins Company, 1931.","Jefferson Randolph Kean (June 27, 1860 - September 4, 1950) was a U.S. Army physician who was a leading authority in sanitation, public health, and tropical diseases. Later in his career, Kean would become widely recognized for his role in organizing and administering medical services for the U.S. armed forces during World War I.","\"He possessed one of the keenest, most scholarly minds I've ever encountered,\" recalled Nobel Prize winner Philip S. Hench of Jefferson Randolph Kean. [1] Kean and Hench shared an abiding interest in the work of the United States Army Yellow Fever Commission -- Kean, as a contemporary and supporter, and Hench, as a scholar and scientist intent on accurate historical documentation. On the advice of yellow fever experiment volunteer John J. Moran, Hench first wrote Kean in 1939. From that initial contact developed a close friendship which would last for the remainder of their lives. Kean entrusted Hench not only with numerous period documents, including original letters, accounts, fever charts, and other items, but also with the freely-given counsel and insight of a trusted friend.","Like Walter Reed and Henry Rose Carter before him, Jefferson Randolph Kean was an alumnus of the University of Virginia, completing the medical program there in 1883. Kean joined the U.S. Army Medical Corps in 1884, and after forty years in the service, retired with the rank of Colonel. Congress awarded him a promotion to Brigadier General, retired, in 1930. The early years of Kean's career passed in medical postings in the American West, and no doubt offered him experiences similar to those of Walter Reed, whom he met not on the frontier, but in Florida in 1896. Kean became an expert in tropical diseases and sanitation during his five-year assignment in the Florida tropics, an expertise which served him well over two terms of service later in Cuba. During the Spanish-American War and subsequent U. S. occupation of Cuba, Kean was Chief Surgeon for the Department of Havana, then Superintendent of the Department of Charities -- from 1898 to 1902. After a four-year interlude as an assistant to the Surgeon General in Washington, D.C., Kean again returned to Cuba as an advisor to the Department of Sanitation from 1906-1909.","Kean himself stated: \"Reed and I were good friends before the Yellow Fever Board came to Cuba in June 1900, and [Reed] located himself at Marianao, 8 miles S. W. of Havana,\" to be within the medical and administrative jurisdiction overseen by Kean. [2] The Chief Surgeon did indeed offer significant assistance, and was an early convert to Carlos Finlay's mosquito theory of transmission, which the Yellow Fever Board's experiments ultimately proved true in the late autumn and winter of 1900-1901. As early as October 13, 1900 -- after the Board's preliminary work, but before the final convincing demonstrations -- Kean issued \"Circular No. 8,\" concerning the latest scholarship on the mosquito vector for disease. [3] The circular contained a set of instructions for the entire command on mosquito eradication. Kean subsequently served as quartermaster and financial administrator for the famous series of yellow fever experiments at Camp Lazear and, for the rest of his life, Kean remained a strong proponent of the Commission's conclusions. He worked tirelessly not only to apply them in the field, but also to accord proper public recognition to the Commission's work.","In addition to his career as a sanitarian, Kean organized the department of military relief of the American Red Cross, and during World War One served as Chief of the U. S. Ambulance Service with the French Army and Deputy Chief Surgeon of the American forces. France named him an Officier de la Légion d'Honneur in recognition for these services. Cuban authorities as well offered Kean recognition with the grand cross of the Order of Merit Carlos J. Finlay, and he received both a Distinguished Service Medal from the United States government and the Gorgas Medal from the Association of Military Surgeons. For a decade after his retirement from active duty, Kean edited this last organization's medical journal,The Military Surgeon, and served on the Surgeon General's editorial board for the multi-volume history of the medical department in World War One. A great-grandson of Thomas Jefferson, Kean also took a seat with the government commission established to build the Jefferson Memorial in Washington, D.C. He held charter membership in the Walter Reed Memorial Association, and remained active in its affairs until his death in 1950.","Sources:","[1] Telegram from Philip Showalter Hench and Mary Hench to Cornelia Knox Kean, September 5, 1950, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 06501173.\n      [2] Letter from Jefferson Randolph Kean to Philip Showalter Hench, October 31, 1939, Hench Reed Yellow Fever Collection, accession number: 06282022.\n      [3] Military Orders to Commanding Officers, October 15, 1900, Hench Reed Yellow Fever Collection, accession number: 02140001.","Philip Showalter Hench (February 28, 1896 - March 30, 1965) was a U.S. physician who in 1950 was awarded the Nobel Prize for Physiology and Medicine for his role in the discovery of the hormone cortisone. In addition to his medical research, Hench spent almost three decades of his life studying the history of the U.S. Army Yellow Fever Commission and became a leading authority in the subject.","Philip Showalter Hench was born in Pittsburgh, Pennsylvania, the son of Jacob Bixler Hench and Clara Showalter. After attending local schools, Hench entered Lafayette College and graduated from the school 1916 with a Bachelor of Arts. Hench completed his medical degree at the University of Pittsburgh in 1920, and subsequently entered a residency program at St. Francis Hospital, Pittsburgh. His association with the Mayo Clinic began in 1921 as a fellow at the institution. Two years later he would become an assistant at the clinic, and then, in 1926, he would be made the head of its Department of Rheumatic Diseases After pursuing post-graduate study in Germany in 1928-1929, Hench obtained a Masters of Science in Internal Medicine at the University of Minnesota in 1931, and a Doctor of Science degree from Lafayette College in 1940. Hench remained for the duration of his career at the Mayo Clinic, where his life-long passion for meticulous research and analysis brought him the Nobel Prize for Physiology and Medicine in 1950, which he shared with Edward C. Kendall and Tadeus Reichstein, for the discovery of cortisone.","The same persistence and determination present in his professional life is also evident in Hench's research on the U. S. Army Yellow Fever Commission's famous experiments. \"As a physician particularly interested in medical history,\" he stated to experiment volunteer John J. Moran in 1937, \"I have been long interested in the story of the yellow fever work in John J. Moran, Ralph C. Hutchison, Havana.\" [1] So began a remarkable odyssey. At the request of his friend Ralph Cooper Hutchison, then president of Washington and Jefferson College, Hench had written Moran to gather information for the dedication of the College's new chemistry building, named for Commission member and former Washington and Jefferson student Jesse W. Lazear. Hench also began a correspondence with another of the yellow fever experiment's original volunteers, John R. Kissinger. Moran's and Kissinger's recollections proved so intriguing that Hench initially offered to edit and publish them. However, in the course of his research Hench discovered that much general information on the topic was inaccurate. Conflicting assertions concerning the participants and unverified claims by medical and governmental authorities in the United States and Cuba -- often politically motivated -- clouded interpretation of the facts. \"May I suggest,\" Moran consequently urged in 1938, \"that a clearing up of the REED-FINLAY-CONQUEST-OF-YELLOW-FEVER, or an effort to do so, on your part, is a task far more pressing than publishing the Kissinger-Moran stories or memoirs.\" [2] Hench resolved to document every aspect of the \"Conquest of Yellow-Fever\" and to write a much needed accurate and comprehensive history.","For the next two decades, Hench tirelessly combed through public archive collections and personal papers in the United States and Cuba. He met and interviewed surviving participants of the experiments and others associated with the project, as well as family members of the Yellow Fever Commission. He sought out physicians and scientists who had worked with the principal players or who had applied the results in the campaign to eradicate yellow fever. He identified and photographed sites associated with the yellow fever story, and he successfully petitioned politicians in the United States and Cuba to commemorate the work. In the process, Hench became the trusted friend and advisor of many of these same individuals, and they, in turn, presented him with much of the surviving original material for safekeeping.","In short, Hench came to be the world's expert on the yellow fever story and the steward of thousands of original letters and documents. His premature death at age 69 found him still hoping to uncover important missing evidence, his book unwritten. Hench's widow Mary Kahler Hench gave his yellow fever collection to the University of Virginia, Walter Reed's alma mater, and this extensive personal archive forms the most detailed and accurate record available on the Conquest of Yellow Fever.","Sources:","[1] Letter from Philip S. Hench to John J. Moran, 6 July 1937, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 03419001.\n      [2] Letter from John J. Moran to Philip S. Hench, 30 October 1938, Hench Reed Yellow Fever Collection, accession number: 03476001.","Materials from the following series were initially deposited at the University of Virginia's Alderman Library. In 1982, they were moved to the Claude Moore Health Sciences Library under the terms of a gift agreement that required the transferral of Mary K. Hench's donation to the library when adequate storage space for the collection could be found there.","Series I. Jesse W. Lazear\n      Series II. Henry Rose Carter\n      Series III. Walter Reed\n      Series IV. Philip Showalter Hench\n      Series V. Maps\n      Series VI. Alphabetical files\n      Series VII. Truby-Kean-Hench\n      Series VIII. Miscellany\n      Series IX. Photographs\n      Series X. Negatives\n      Series XI. Reprints\n      Series XIII. Reed family additions\n      Series XV. Laura Wood","Materials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were initially deposited in the HAM/TMC and were a part of the Philip S. Hench papers. In 1991, the materials were transferred from HAM/TMC to the Claude Moore Health Sciences Library after both repositories agreed that it would be more appropriate to include them in the Philip S. Hench Walter Reed Yellow Fever Collection.","Materials from Series XVI. Edward Hook additions were transferred from the Papers of Dr. Edward Watson Hook, Jr. to the Philip S. Hench Walter Reed Yellow Fever Collection around the late 1990s and early 2000s.","Processed by:\n        Historical Collections Staff","Mary K. Hench's donation arrived in Charlottesville in a number of large crates which were packed much as the collection had been found in Philip Showalter Hench's home in Rochester, Minnesota. Some confusion about Dr. Hench's filing order had been created while the collection was packed for shipping, and thus the Manuscripts Department of the University of Virginia Library found it necessary to perform some sorting and arrangement to make the collection more accessible.","Around 1968, William Bennett Bean was hired by the University of Virginia as a visiting scholar in residence to begin work on a new biography of Walter Reed. Dr. Bean found that the order of the collection was not such that he could readily use it for biographical purposes. He employed a former assistant in the Manuscripts Department, sought and received permission to refile the collection, and had his assistant perform this task. The refiling of the collection had been finished by the fall of 1969, but Bean and his assistant had no time to prepare a finding aid.","In the fall of 1969 Donna L. Purvis of the Manuscripts Department staff began writing the first edition of the collection's finding aid. During this project, Mrs. Purvis found some problems with Dr. Bean's description and arrangement of the collection and felt that it was necessary to reprocess parts of it.","Around 1990 staff members in the Claude Moore Health Sciences Library processed additions to the collection donated by Philip Showalter Hench's son, P. Kahler Hench.","Between 1999 and 2004, the Claude Moore Health Sciences Library digitized a significant portion of the collection and made the digitized files available to users in an online exhibit. During this project, over 8,000 items from the collection were scanned, transcribed, and described at the item level. Metadata for the digitized items was recorded in XML files using the TEI 2 standard.","In 2001, the Claude Moore Health Sciences Library processed additions that had been made to the collection since 1982, excepting the materials donated by P. Kahler Hench. Staff members also processed significant portions of Mary K. Hench's original donation that had not been described in the first edition of the collection finding aid. This work led to the development of a second edition finding aid that was coded in EAD and ingested into the Virginia Heritage database. This finding aid contained both new metadata and metadata that had been migrated from a Microsoft Access file.","In the 2000s the Claude Moore Health Sciences Library processed the materials in Series XV. Edward Hook additions.","In 2009, staff members in the Claude Moore Health Sciences Library processed Box 154 of the collection.","In 2013, staff members in the Claude Moore Health Sciences Library produced a third edition of the finding aid using EAD that merged collection description from four sources (the first edition finding aid, the second edition finding aid, the online exhibit, and the physical collection). When possible, metadata from the existing online exhibit's TEI files and metadata from the second edition finding aid were transformed with XSL and included in the EAD file. However, staff members sometimes found it necessary to create new metadata for the collection. The new finding aid was structured in such a way to facilitate the migration of the collection's digital files and metadata into the University of Virginia's digital repository and make it available to users via the library's online catalog.","The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audio cassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). All of these materials are arranged in 16 series: I. Jesse W. Lazear, II. Henry Rose Carter, III. Walter Reed, IV. Philip Showalter Hench, V. Maps, VI. Alphabetical files, VII. Truby-Kean-Hench, VIII. Miscellany, IX. Photographs, X. Photographic negatives, XI. Reprints, XII. Houston Academy of Medicine/Texas Medical Center additions, XIII. Reed family additions, XIV. P. Kahler Hench additions, XV. Laura Wood, and XVI. Edward Hook additions.","Series I. Jesse W. Lazear consists of materials relating to Lazear that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1800 to 1956 with the bulk of the items dating from 1863 to 1943. Much of the series consists of the correspondence of Jesse W. Lazear and his wife Mabel H. Lazear. Jesse's correspondence dates from his time as a student at Johns Hopkins University to his death in 1900. Researchers can learn a great deal about Jesse from these letters, including his relationships with friends and family, his educational background, and his professional life. Mabel's correspondence dates from the time she met Jesse to her death in 1946. This correspondence primarily concern her husband's historical legacy and a campaign to secure a pension from the U.S. government for herself and her family.","In addition to Jesse and Mabel's correspondence, the series contains other materials relating to them and their families including, but not limited to the following:","the diaries documenting the travels of Jesse and Mabel's mothers in Europe;\n      correspondence of other Lazear family members (e.g. Jesse's parents);\n      genealogical summaries and tables relating to the Lazear family;\n      legal documents (e.g. wills, certificates, deeds);\n      military records relating to Jesse;\n      certificates, reports, and other materials documenting Jesse's educational background and achievements;\n      obituaries;\n      copies of congressional bills and reports concerning the provision of a federal pension for Mabel H. Lazear;\n      newspaper articles;\n      a microscope and sets of microscope slides owned by Jesse;\n      and a medical chart that shows the progression of the yellow fever infection that killed Jesse.","Series II. Henry Rose Carter consists of materials relating to Henry Rose Carter that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1880 to 1932 with the bulk of the materials dating from 1883 to 1932. The series is particularly rich in materials that document Henry Rose Carter's professional activities in the last eleven years of his life (1914-1925). These materials include, but are not limited to the following:","correspondence with colleagues in the medical and scientific community including Rupert E. Blue, Hideyo Noguchi, Henry Hanson, Joseph A. LePrince, Frederick F. Russell, T.H.D. Griffitts, and Lunsford D. Fricks;\n      scientific, medical, and government reports relating to the study and eradication of yellow fever and malaria in North America, South America, and Africa;\n      journal articles concerning the study and eradication of yellow fever and malaria;\n      research notes written by Henry Rose Carter;\n      and photographs of Henry Rose Carter at work and with professional colleagues.","Series II. also contains correspondence between Henry Rose Carter and members of his family that date from 1880 to 1925. The family members with whom Henry corresponds most frequently in this series are his mother, Emma Coleman Carter; his wife, Laura Eugenia Hook Carter; his daughter, Laura Armistead Carter; and his son, Henry Rose Carter, Jr. These letters are not only a rich source of information about Carter's personal views and family life, they also provide valuable insights into his professional activities such as his experiences aboard vessels and in ports while working for the U.S. Marine Hospital Service and his public health work in Cuba, Panama, and Peru.","In addition to the materials that were produced during Henry Rose Carter's lifetime, the Series II. contains materials that were produced between 1925 and 1940 (after Henry Rose Carter's death) including, but not limited to the following:","copies of obituaries for Henry Rose Carter;\n      condolence letters for Henry Rose Carter's family after Henry's death;\n      and the correspondence of Laura Armistead Carter relating to her father and other members of the Carter family.","Series III. Walter Reed consists of materials that document the life of Walter Reed as well as the work and legacy of the U.S. Army Yellow Fever Commission. Items in the series date from 1806 to around 1955 with the bulk of the items dating from 1874 to 1936. The series is particularly rich in materials that document the professional and personal life of Walter Reed from 1874 to his death in 1902. These materials include, but are not limited to the following:","correspondence between Walter Reed and members of his immediate family that cover a wide range of topics including Reed's courtship of Emilie Lawrence Reed, family life, Walter Reed's work in the Western United States, and Walter Reed's work in Cuba;\n      military records relating to Walter Reed including military orders for Reed, Reed's performance reviews, and reports of Reed's work for army officials;\n      Walter Reed's correspondence with professional colleagues including members of the U.S. Army Yellow Fever Commission, military doctors, and medical researchers interested in the study of yellow fever;\n      medical records (e.g. fever charts of experiment participants), military orders, administrative records, reports, and publications documenting the results of the U.S. Army Yellow Fever Commission's experiments in Cuba;\n      articles announcing the death of Walter Reed;\n      and the shoulder boards from Walter Reed's U.S. Army uniform.","In addition to the above items, Series III. contains materials that document campaigns, spanning from 1902 to 1937, to publicly honor members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments. These materials include, but are not limited to the following:","articles and editorials relating to efforts to memorialize and provide pensions for members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments;\n      biographical sketches of members of the U.S. Army Yellow Fever Commission and experiment participants;\n      records relating to the Walter Reed Memorial Association (e.g. correspondence, donor lists);\n      copies of Congressional bills and resolutions to honor members of the U.S. Army Yellow Fever Commission and experiment participants;\n      and letters, reviews, and other materials relating to the production of Sidney Coe Howard's play,Yellow Jack.","Finally, Series III. also consists of materials that document the history of yellow fever during the nineteenth and early twentieth century. These materials include, but are not limited to the following:","items (e.g. correspondence, reports, reviews, and articles) relating to U.S. efforts to eradicate yellow fever in the Panama Canal Zone;\n      materials (e.g. correspondence, reports, and articles) documenting early twentieth century efforts to eradicate yellow fever in Peru;\n      scientific reports and publications related to the study and eradication of yellow fever and malaria;\n      and newspaper articles describing various outbreaks of yellow fever epidemics.","Series IV. Philip Showalter Hench primarily consists of materials that Hench created or collected while researching the U.S. Army Yellow Fever Commission. Items in this series date from around 1850 to around 1865 with the bulk of the items dating from 1937 to 1960. Researchers who are studying the yellow fever experiments will be particularly interested in the materials (e.g. interviews, autobiographies) that document first-hand accounts of the events surrounding the experiments. Other researchers may be interested in items that document Hench's role in shaping public memory of the commission and its experiments. The materials in this series include, but are not limited to the following:","Hench's correspondence and interviews with participants in the yellow fever experiments and their families including: Emilie Lawrence Reed, Emilie M. (Blossom) Reed, Walter Lawrence Reed, John J. Moran, Albert E. Truby, Jefferson Randolph Kean, John H. Andrus, and John R. Kissinger;\n      autobiographical accounts of the experiment's participants and their families;\n      notes, reports, correspondence and other materials relating to Hench's search for the original site of Camp Lazear in Cuba;\n      correspondence with Cuban government officials and members of the scientific community relating to Hench's campaign to build a Camp Lazear memorial;\n      correspondence and other materials relating to ceremonies honoring Jesse W. Lazear at Washington and Jefferson College;\n      newspaper articles, magazine articles, and other printed matter concerning the yellow fever experiments and its participants;\n      drafts of speeches and presentations Hench gave on the history of the yellow fever experiments to various audiences;\n      meeting minutes and other materials that document Hench's relationship with and participation in the Walter Reed Memorial Association;\n      scripts for radio programs relating to the yellow fever experiments;\n      notes, outlines, lists, correspondence, and other materials that document Hench's research about the yellow fever experiments and a book he had planned to write on the subject;\n      and the gold medal that Congress posthumously awarded to Walter Reed for his work with yellow fever.","Series V. Maps primarily consists of maps and floor plans that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1960 with the bulk of the items dating from 1899 to 1951. The maps and floor plans often include annotations and illustrate a wide range of locations including, but not limited to the following:","Havana and its environs;\n      Cuba;\n      sites associated with the yellow fever experiments;\n      and military installations in the United States.","In addition to the maps and floor plans, Series V. also consists of a few newspaper and magazine clippings that contain information relating to the yellow fever experiments.","Series VI. Alphabetical files primarily consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1860 to around 1966 with the bulk of the items dating from 1940 to 1956. All of these items have been arranged thematically into biographical files. Each file contains materials created by or relating to people who were either involved with the yellow fever experiments or aided Philip Showalter Hench in his research of the subject. These people include, but are not limited to: John J. Moran, Carlos E. Finlay, Laura Wood Roper, Mabel Lazear, Clara Maas, John R. Kissinger, Roger Post Ames, James C. Carroll, and Carlos J. Finlay. The files are arranged alphabetically by the last names of the individuals listed on the files and it is unclear whether the overall arrangement was made by Hench or by staff members at the University of Virginia. The biographical files contain a wide range of different materials that pertain to the individuals listed on the files. These materials include, but are not limited to the following:","correspondence between Philip Showalter Hench and the individuals;\n      other correspondence;\n      newspaper and magazine clippings;\n      unpublished manuscripts;\n      biographical and autobiographical accounts;\n      transcripts of oral history interviews that were conducted by Philip Showalter Hench;\n      and copies of medical charts for volunteers in the yellow fever experiments that shows the progression of the disease.","In addition to the materials that Hench created or collected during his lifetime, the biographical files in Series VI. also contain items that were added by staff at the University of Virginia Library during the late 1960s and early 1970s.","Series VII. Truby-Kean-Hench primarily consists of materials relating to Albert E. Truby and Jefferson Randolph Kean that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1879 to around 1960 with the bulk of the items dating from 1900 to 1954. These items include, but are not limited to the following:","correspondence of Jefferson Randolph Kean dating from 1900 to 1950 that relates to his personal life, the yellow fever experiments, public health initiatives, his publications, the legacy of the yellow fever experiments, Kean's work in World War I, and other topics;\n      Philip Showalter Hench's correspondence with people related to the yellow fever experiments, particularly Albert E. Truby and Jefferson Randolph Kean primarily from between 1940 and 1955;\n      a scrapbook and other materials that relate to Truby's book,Memoir of Walter Reed: the Yellow Fever Episode;\n      and Philip Showalter Hench's interviews and questionnaires for Kean and Truby from the 1940s.","In addition to the materials relating to Kean and Truby, Series VII. also includes the following:","notes from Philip Showalter Hench's research of the yellow fever experiments;\n      the recollections, autobiographies, and reports of other people involved with the yellow fever experiments including John Andrus and A.S. Pinto;\n      articles and clippings related to the yellow fever experiments;\n      a short biography of Lemuel S. Reed;\n      and a sketch Philip Showalter Hench made of a proposed museum at the Camp Lazear site.","Series VIII. Miscellany consists of oversize and miscellaneous materials in the Philip S. Hench Walter Reed yellow fever collection that were, for various reasons, not included in any of the other series in the collection. Items in this series date from around 1849 to 1982 with the bulk of the materials dating from 1885 to 1974. These materials include, but are not limited to the following:","informed consent agreements for volunteers in the yellow fever experiments;\n      diplomas and certificates for Walter Reed and Jesse W. Lazear;\n      copies and sketches of Dean Cornwell's painting,Conquerors of Yellow Fever;\n      artifacts, including a wooden board from Camp Lazear and a U.S. flag;\n      copies of correspondence, reports, medical records, and military orders from the U.S. National Archives relating to the yellow fever experiments;\n      manuscripts and related notes for published works and research relating to Walter Reed and the yellow fever experiments;\n      correspondence of Philip Showalter Hench from circa 1940 to 1966;\n      articles and clippings relating to the yellow fever experiments, the experiments' participants, and the Philip S. Hench Walter Reed yellow fever collection;\n      correspondence of Atcheson Laughlin Hench and members of the University of Virginia community relating to the Philip S. Hench Walter Reed yellow fever collection;\n      items that document the provenance and custodial history of some materials in the Philip S. Hench Walter Reed yellow fever collection;\n      photographs relating to Cuba and the yellow fever experiments;\n      notes for photographs and photographic negatives housed in Series IX. and Series X. of this collection.","Series IX. Photographs consists primarily of photographs that Philip Showalter Hench created and collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1966 with the bulk of the items dating from around 1870 to around 1960. The subjects shown in the photographs include, but are not limited to the following:","physicians, military personnel, nurses, and volunteers associated with the experiments including Walter Reed, Jesse W. Lazear, Jefferson Randolph Kean, and Aristides Agramonte;\n      family members of people associated with the yellow fever experiments including their spouses, children, and grandchildren.\n      Camp Lazear, Camp Columbia, and other locations in Cuba related to the yellow fever experiments between 1900 and 1960;\n      the U.S.S.Maineand the Spanish-American War;\n      aerial views of Havana, Cuba and its environs from the 1940s and 1950s;\n      scenes of daily life in Cuba generally from between 1898 and 1960;\n      the 1952 dedication of the Camp Lazear National Monument in Cuba;\n      the creation and unveiling of Dean Cornwell's painting,Conquerors of Yellow Fever;\n      still scenes from the movies,Yellow JackandJezebel;\n      other events and works of art commemorating the work of the participants in the yellow fever experiments;\n      documents and maps that Philip Showalter Hench copied for his research;\n      and Philip Showalter Hench and his family.","Series IX. also includes a watercolor that was painted by Emilie Lawrence Reed.","Series X. Photographic negatives consists of a mix of original and copy negatives that Philip Showalter Hench collected while researching the yellow fever experiments. Although the original images recorded on the negatives date from between the 1860s and the 1960s, it appears that the negatives themselves were produced during a narrower time frame, most likely between 1930 and 1966.","The negatives in Series X. record images associated with the yellow fever experiments and many of them are related to photographic prints found in Series VIII. Where a match between a negative and a print from these series has been made, the negative number has been written on the folder of the print in the physical collection. Finally, the negatives are generally arranged in numerical order by identification numbers that were most likely assigned by Philip Showalter Hench.","Series XI. Reprints consists of reprints and photocopies of journal articles, book extracts, book reviews and other published works that were primarily collected by Philip Showalter Hench while researching the yellow fever experiments. Items in this series date from 1856 to 1971 and cover a wide range of topics related to the study and eradication of yellow fever, including, but not limited to the following:","the results of the U.S. Army Yellow Fever Commission's work in Cuba;\n      biographical accounts of various people who had an association with the yellow fever experiments;\n      the research of people associated with the experiments including Walter Reed, Jesse W. Lazear, Aristides Agramonte, and James Carroll;\n      scientific and medical research related to yellow fever and malaria;\n      and events honoring the work of those involved with the yellow fever experiments.","Series XII. Houston Academy of Medicine/Texas Medical Center additions consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1901 to around 1966. These materials were originally a part of the Philip S. Hench papers in the John P. McGovern Historical Collections and Research Center at the Texas Medical Center Library, but they were transferred to the University of Virginia in 1991. These items include, but are not limited to the following:","correspondence between Philip Showalter Hench and people connected with the yellow fever experiments including John J. Moran and Walter Reed's children;\n      newspaper clippings relating to the death or commemoration of individuals associated with the yellow fever experiments;\n      photographs of the Camp Lazear Memorial, everyday scenes in Cuba, and John J. Moran;\n      and journal articles, booklets, and other printed matter relating to the yellow fever experiments and its participants.","Series XIII. Reed family additions consists of materials relating to the yellow fever experiments that several different donors gave to the University of Virginia. Items in the series date from around 1850 to 1967 with the bulk of the items dating from 1868 to 1949. The largest portion of the series is comprised of correspondence written by Walter Reed and his family between 1877 and 1902 that provide insights into their relationships and personal lives.","In addition to the Reed family's correspondence, the series also contains other materials relating to the Reed family and the yellow fever experiments including, but not limited to the following:","a flag that was flown over Camp Lazear;\n      newspaper clippings and articles relating to the yellow fever experiments;\n      a chemistry notebook that was owned by Walter Reed;\n      correspondence of and works by Philip Showalter Hench;\n      an inventory of materials in Series XIII. and information about their accession into the Claude Moore Health Sciences Library;\n      and materials from an exhibit on the yellow fever experiments that was hosted in Alderman Library at the University of Virginia.","Series XIV. P. Kahler Hench additions consists of original and photocopied materials that Philip Showalter Hench's son, P. Kahler Hench, donated to the University of Virginia in 1988 and 1989. Items in the series date from around 1860 to 1965 with the bulk of the materials dating from 1898 to 1965. Most of these items were collected or created by Philip Showalter Hench while researching the yellow fever experiments. These items include the following:","the correspondence of experiment participants;\n      correspondence between Philip Showalter Hench and the experiment participants;\n      correspondence between Philip Showalter Hench and families of the experiment participants;\n      press clippings relating to the experiments and the experiment participants;\n      oral history interviews conducted by Philip Showalter Hench;\n      scientific articles related to the study of yellow fever;\n      photographs of Havana, Camp Columbia, and Camp Lazear;\n      genealogical tables and summaries for the family of Jesse W. Lazear;\n      autobiographical accounts written by experiment participants;\n      unpublished manuscripts;\n      artifacts (e.g. a wooden board) from Camp Lazear;\n      Philip Showalter Hench's research notes.","Series XIV. also contains correspondence and financial records that record the transfer of collection items from the Reed family to Philip Showalter Hench and later from the Hench family to the University of Virginia.","Series XV. Laura Wood primarily consists of Laura Wood's correspondence relating to her research for a Walter Reed biography that she wrote. The series also includes, but is not limited to the following materials:","photocopies of two letters written by Walter Reed;\n      a journal article by George Sternberg;\n      and a short work that Laura Wood wrote about Walter Reed entitled,Walter Reed and yellow Fever.","Items in Series XV. date from 1875 to 1946 with the bulk of the items dating from 1941 to 1946.","Series XVI. Edward Hook additions consists of copies of letters, articles, and photographs relating to the yellow fever experiments that had been collected by Edward W. Hook, Jr, a professor of medicine at the University of Virginia. The bulk of this series is comprised of copies of a small collection of James Carroll's correspondence. The original versions of Carroll's correspondence are not housed at the University of Virginia. In addition to the Carroll letters, this series also includes, but is not limited to the following:","photographs of Walter Reed and others related to the yellow fever experiments;\n      copies of some of Theodore E. Woodward's works relating to James Carroll and yellow fever;\n      and exhibition materials.","Items in Series XVI. date from around 1880 to around 1998 with the bulk of the items dating from 1898 to 1901.","Copyright restrictions may apply for some materials in the collection.","The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audiocassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). Most of the materials in the collection were collected or created by Nobel laureate Philip Showalter Hench while researching the history of the U.S. Army Yellow Fever Commission.","Claude Moore Health Sciences Library","Collection is predominantly in English; other materials in the collection are in Spanish, French, and Portuguese."],"collection_title_tesim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"collection_ssim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"level_ssm":["collection"],"level_ssim":["Collection"],"unitid_ssm":["MS.1","Archival Resource Key","/repositories/7/resources/1710"],"unitid_tesim":["MS.1","Archival Resource Key","/repositories/7/resources/1710"],"repository_ssm":["University of Virginia, Special Collections Dept."],"repository_ssim":["University of Virginia, Special Collections Dept."],"creator_corpname_ssim":["Claude Moore Health Sciences Library"],"creators_ssim":["Claude Moore Health Sciences Library"],"access_terms_ssm":["Copyright restrictions may apply for some materials in the collection."],"acqinfo_ssim":["Materials from the following series were donated to the University of Virginia's Alderman Library in the fall of 1966 and the summer of 1970 by Philip Showalter Hench's widow, Mary Kahler Hench, with the approval of his estate:","Series I. Jesse W. Lazear\n      Series II. Henry Rose Carter\n      Series III. Walter Reed\n      Series IV. Philip Showalter Hench\n      Series V. Maps\n      Series VI. Alphabetical files\n      Series VII. Truby-Kean-Hench\n      Series VIII. Miscellany\n      Series IX. Photographs\n      Series X. Negatives\n      Series XI. Reprints","Materials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were donated to the HAM/TMC by Philip Showalter Hench as a small part of a larger collection of materials.","Materials from Series XIII. Reed family additions were donated by various individuals to Alderman Library between 1947 and 1972. Box 139, Folder 1 contains a list that describes each of these donations in detail.","Materials from Series XIV. P. Kahler Hench were donated to the Claude Moore Health Sciences Library by Philip Showalter Hench's son, P. Kahler Hench, in 1988 and 1989.","Materials from Series XV. Laura Wood were most likely donated to Alderman Library between 1972 and 1982.","Materials from Series XVI. Edward Hook additions were donated to the Claude Moore Health Sciences Library as a part of the Papers of Dr. Edward Watson Hook, Jr."],"access_subjects_ssim":["Human Experimentation","Military Medicine","Physicians","Public health","Tropical medicine","Yellow Fever"],"access_subjects_ssm":["Human Experimentation","Military Medicine","Physicians","Public health","Tropical medicine","Yellow Fever"],"has_online_content_ssim":["false"],"extent_ssm":["67 Linear Feet 154 boxes"],"extent_tesim":["67 Linear Feet 154 boxes"],"date_range_isim":[1800,1801,1802,1803,1804,1805,1806,1807,1808,1809,1810,1811,1812,1813,1814,1815,1816,1817,1818,1819,1820,1821,1822,1823,1824,1825,1826,1827,1828,1829,1830,1831,1832,1833,1834,1835,1836,1837,1838,1839,1840,1841,1842,1843,1844,1845,1846,1847,1848,1849,1850,1851,1852,1853,1854,1855,1856,1857,1858,1859,1860,1861,1862,1863,1864,1865,1866,1867,1868,1869,1870,1871,1872,1873,1874,1875,1876,1877,1878,1879,1880,1881,1882,1883,1884,1885,1886,1887,1888,1889,1890,1891,1892,1893,1894,1895,1896,1897,1898,1899,1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935,1936,1937,1938,1939,1940,1941,1942,1943,1944,1945,1946,1947,1948,1949,1950,1951,1952,1953,1954,1955,1956,1957,1958,1959,1960,1961,1962,1963,1964,1965,1966,1967,1968,1969,1970,1971,1972,1973,1974,1975,1976,1977,1978,1979,1980,1981,1982,1983,1984,1985,1986,1987,1988,1989,1990,1991,1992,1993,1994,1995,1996,1997,1998],"accessrestrict_html_tesm":["\u003cp\u003eThere are no restrictions on user access to any of the materials in the collection except where noted in the container list.\u003c/p\u003e  "],"accessrestrict_heading_ssm":["Access"],"accessrestrict_tesim":["There are no restrictions on user access to any of the materials in the collection except where noted in the container list."],"arrangement_html_tesm":["\u003cp\u003eThe Philip S. Hench Walter Reed Yellow Fever Collection is organized in 16 series:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003eI. Jesse W. Lazear\u003c/item\u003e\n      \u003citem\u003eII. Henry Rose Carter\u003c/item\u003e\n      \u003citem\u003eIII. Walter Reed\u003c/item\u003e\n      \u003citem\u003eIV. Philip Showalter Hench\u003c/item\u003e\n      \u003citem\u003eV. Maps\u003c/item\u003e\n      \u003citem\u003eVI. Alphabetical files\u003c/item\u003e\n      \u003citem\u003eVII. Truby-Kean-Hench\u003c/item\u003e\n      \u003citem\u003eVIII. Miscellany\u003c/item\u003e\n      \u003citem\u003eIX. Photographs\u003c/item\u003e\n      \u003citem\u003eX. Photographic negatives\u003c/item\u003e\n      \u003citem\u003eXI. Reprints\u003c/item\u003e\n      \u003citem\u003eXII. Houston Academy of Medicine/Texas Medical Center additions\u003c/item\u003e\n      \u003citem\u003eXIII. Reed family additions\u003c/item\u003e\n      \u003citem\u003eXIV. P. Kahler Hench additions\u003c/item\u003e\n      \u003citem\u003eXV. Laura Wood\u003c/item\u003e\n      \u003citem\u003eXVI. Edward Hook additions\u003c/item\u003e\n    \u003c/list\u003e\n  "],"arrangement_heading_ssm":["Organization of the Collection"],"arrangement_tesim":["The Philip S. Hench Walter Reed Yellow Fever Collection is organized in 16 series:","I. Jesse W. Lazear\n      II. Henry Rose Carter\n      III. Walter Reed\n      IV. Philip Showalter Hench\n      V. Maps\n      VI. Alphabetical files\n      VII. Truby-Kean-Hench\n      VIII. Miscellany\n      IX. Photographs\n      X. Photographic negatives\n      XI. Reprints\n      XII. Houston Academy of Medicine/Texas Medical Center additions\n      XIII. Reed family additions\n      XIV. P. Kahler Hench additions\n      XV. Laura Wood\n      XVI. Edward Hook additions"],"bioghist_heading_ssm":["Historical Information for the U.S. Army Yellow Fever Commission","Biographical Information for Walter Reed","Biographical Information for Jesse W. Lazear","Biographical Information for Henry Rose Carter","Biographical Information for Jefferson Randolph Kean","Biographical Information for Philip Showalter Hench"],"bioghist_tesim":["The U.S. Army Yellow Fever Commission (1900-1901) was a board of physicians that the U.S. government formed in order to determine how yellow fever was transmitted between hosts. Ultimately, the commission's experiments in Cuba proved that mosquitoes transmit yellow fever--a discovery that would spur successful campaigns to control and eradicate yellow fever throughout much of the globe.","When Major Walter Reed and Acting Assistant Surgeons James Carroll, Aristides Agramonte, and Jesse Lazear gathered on the porch of the Columbia Barracks Hospital in June of 1900, they became the fourth successive board of U.S. medical officers to grapple with the appalling plague that was yellow fever.","The persistence of this disease across the Cuban archipelago and its periodic re-emergence along the coastlines and great river drainages of the Americas was taking countless thousands of lives. Lack of precise knowledge as to its cause and transmission had augmented yellow fever's extraordinarily high mortality rate and had given rise to quarantine regulations which constituted substantial impediments to efficient regional trade. Endemic in the tropics, yellow fever imposed high humanitarian and economic costs upon the entire region. Specialists regarded Cuba as one of the principal foci of the disease, and the island consequently attracted considerable attention from the medical sciences.","In 1879, one year after a devastating epidemic swept up the Mississippi valley from New Orleans, Tulane University Professor Stanford E. Chaille led the first investigatory commission to Havana, Rio de Janeiro, and the West Indies. The Chaille Commission remained in Havana three months, and its members -- including George Miller Sternberg, who became Surgeon General of the Army, and Juan Guiteras, later Director of Public Health for Havana -- consulted with Cuban scientist Carlos J. Finlay. They concluded that the causal agent for yellow fever was possibly a living entity in the atmosphere, an assertion which set Finlay on the path to the mosquito theory he developed in 1881.","Louis Pasteur's foundational and highly successful work in modern immunology in 1880 and 1881 gave a renewed impetus to investigations aimed at discovering the \"yellow fever germ.\" Over the middle years of the 1880s several scientists advanced different theories, all readily refuted by bacteriological work Sternberg undertook in Brazil and Mexico in 1887 and again in Havana in 1888 and 1889. In 1897, Italian scientist Giuseppe Sanarelli argued thatBacillus icteroideswas the culprit, and the following year a third scientific team sailed to Cuba for additional tests. Eugene Wasdin and Henry D. Geddings appeared to confirm Sanarelli's assertion, though Sternberg, by then Surgeon General, remained skeptical.","Despite Wasdin and Geddings' insistence, theB. icteroidestheory garnered significant opposition. In fact, a few months before the third commission's report reached the public, Walter Reed and James Carroll -- Reed's assistant at the Columbian University (later George Washington University) bacteriology laboratories in Washington, D.C. -- published a thorough refutation of theicteroidesproposal: the bacteria was not a unique cause of yellow fever, but a variety of the hog cholera bacillus, \"a secondary invader in yellow fever,\" Reed determined, unrelated to its etiology. [1] Dispute continued, however, and when Sternberg organized the fourth investigatory board, he charged Reed and his associates to settle theB. icteroidesquestion once and for all, then to proceed with analysis of other blood cultures and intestinal flora from yellow fever cases.","Reed and Carroll had considerable experience in bacteriological analysis, and, Sternberg reasoned, might well be able to find the specific agent of the disease. Aristides Agramonte, a Cuban scientist who had worked in Reed's lab at the Columbian University in 1898, was also an accomplished bacteriologist; he had identifiedB. icteroidesin tissue samples from cases other than yellow fever, providing further evidence opposed to Sanarelli's thesis. Jesse Lazear, a scientist from Johns Hopkins University in Baltimore, Maryland, had joined the Army Medical Corps to study tropical diseases at their point of origin; he received orders for Cuba in February 1900. Lazear impressed Reed with his abilities when the two men became acquainted in March. No doubt with Reed's advice, Sternberg assembled a crack team -- all experienced in scientific research, but each with interests as diverse as their temperaments. The mix of talent and personalities generated spectacular results.","What causes yellow fever? This simple, even obvious question had dictated yellow fever research for over two decades, and so it guided Reed in organizing the work of the commission.Bacillus icteroidesand other bacteriological sampling dominated their work for the first months. \"Reed and Carroll have been at that for a long time,\" Lazear wrote with some impatience to his wife on August 23, \". . . I would rather try to find the germ without bothering about Sanarelli.\" [2] Again and again, tests for the bacteria proved negative, and at the same time, perplexing cases of yellow fever were developing in the region. Agramonte and Reed investigated an epidemic at Pinar del Rio, 110 miles southwest of Havana; Lazear followed later to collect more specimens, and he also assessed the situation at Guanjay thirty miles southwest. To \"my very great surprise,\" Reed admitted, the specific circumstances of the appearance and development of these cases gave strong evidence against the widely-accepted notion that the excreta of patients spread the disease. The theory of fomites -- infection from contaminated clothing and bedding -- and indeed even infection from airborne particles seemed altogether untrue. \"At this stage of our investigation,\" Reed concluded, \". . . the time had arrived when the plan of our work should be radically changed.\" [3] The fundamental question underwent a subtle but critical transformation: from what causes yellow fever to what transmits it. A clear and accurate understanding of how the disease was spread would open a new avenue to its specific cause.","\"Personally, I feel that only can experimentation on human beings serve to clear the field for further effective work,\" Reed stated to Surgeon General Sternberg, who concurred. [4] Evidence gathering around them pointed strongly to an intermediate host, and the Commission resolved to test Carlos Finlay's mosquito theory -- then not generally accepted -- on human volunteers. Nine times from August 11 to August 25, 1900, mosquitoes landed on the arms of volunteers and proceeded to feed. Nine times the results were negative. On August 27, Lazear placed a mosquito on the doubting Dr. Carroll, and four days later on William J. Dean, a soldier designated XY in the \"Preliminary Note.\" [5] Both promptly developed yellow fever. Significantly, their mosquitoes had fed on cases within the initial three days of an attack and had been allowed to ripen for at least twelve days before the inoculations. Carroll vitiated the results of his experimental sickness by traveling off the post to Havana, a contaminated zone, even as Reed, ecstatic, wrote from Washington in a confidential letter: \"Did the Mosquito do it?\" [6] Dean's case seemed to prove it, since he claimed not to have left the garrison before becoming ill. Lazear also developed a case of yellow fever, almost certainly experimental in origin, though he never revealed the actual circumstances of his inoculation. His severe bout of fever took a fatal turn on September 25, 1900.","Nevertheless, these results could not have been more dramatic or convincing for the Commission. Reed quickly assembled a \"Preliminary Note,\" which he presented to the annual meeting of the American Public Health Association in Indianapolis, Indiana, October 23, 1900. After initial consultations in Cuba with General Leonard Wood, military governor of the island, and with Surgeon General Sternberg in Washington, he returned to Cuba with authorization and funding to design and carry forward a fully defensible series of experiments. His aim was confirmation of the mosquito theory and invalidation of the long-held belief in fomites.","On open terrain beyond the precincts of Columbia Barracks -- the American military base just west of Havana near the adjacent suburban towns of Quemados and Marianao (also called Quemados de Marianao) -- Reed established the quarantined experimental station. Camp Lazear, as the Commission dedicated it, took form in the rolling fields of the Finca San Jose, on the farm of Dr. Ignacio Rojas, who leased the land to the Americans. Here Reed designed two small wood-frame buildings, each 14 by 20 feet, for the experimental work, and nearby raised a group of seven tents for the accommodation and support of the volunteers. The buildings faced each other across a small swale, about 80 yards apart, and stood 75 yards from the tent encampment. Building Number One, called the Infected Clothing Building, was a single room tightly constructed to contain as much foul air as possible. A small stove kept the temperature and humidity at tropical levels, and carefully attached screening secured the pair of doorways in a vestibule against intrusion by mosquitoes. Wooden blinds on two small sealed windows shielded the room from direct sun. Building Number Two, the Infected Mosquito Building, contained a principal room, divided into two sections by a floor-to-ceiling wire mesh screen. A door direct to the exterior let into one section, while a vestibule with a solid exterior door and pair of successive screened doors opened to the other, so configured to keep infected mosquitoes inside that section alone. The spare furnishings in both sections -- cots with bedding -- were steam sterilized. Windows exposed the entire room to the clean, steady ocean breezes and to sunlight. Like the doorways, they were carefully screened. A secondary room attached to the building but not communicating with the experimental spaces sheltered the small, heated laboratory where the Commission members raised and stored the mosquitoes to be used.","These two experimental buildings presented alternate environments -- one conspicuously clean and well ventilated, the other filthy and fetid. Contemporary theories of disease held that yellow fever developed in unclean conditions, and consequently much time and money had been devoted to sanitation projects. Workers steamed clothing, burned sulphur in ships' holds, and thoroughly scrubbed surfaces with disinfectant. In cases of severe epidemic, entire buildings presumed to be infected were set afire along with their contents. Thus the extraordinary -- and intentional -- paradox of the Commission's experimental regime: Reed expected yellow fever to develop not in the unsanitary environment, but in the one thought to be most healthful.","Camp Lazear went into quarantine the day of its completion, November 20, 1900, with a command of four immune and nine non-immune individuals, all save one U.S. Army personnel. Soon a group of recent Spanish immigrants to Cuba augmented the non-immune numbers, bringing the resident total to about twenty. Reed strictly controlled access to the camp and ordered regular temperature recording for each volunteer to eliminate any unanticipated source of infection and to identify the onset of any case of yellow fever as early as possible. As a result, non-immunes were barred from returning should they leave the precinct, and two of the Spaniards who developed intermittent fevers shortly after arrival were immediately transferred with their baggage to Columbia Barracks Hospital. The immune members of the detachment oversaw medical treatments and drove the teams of mules that pulled supply wagons and the ambulance. Experimentation did not begin until each volunteer had passed the incubation period for yellow fever in perfect health.","Reed took as much care with the design of the experimental protocol as he had with the configuration of the camp and its buildings. Each evening, the occupants of the infected clothing building unpacked trunks and boxes of bed linens and blankets, nightshirts and other clothing recently worn and soiled by cases from the wards of Columbia Barracks Hospital and Las Animas Hospital in Havana. These they shook out and spread around the room to permeate the atmosphere. The stench was overpowering. Yellow fever causes severe internal hemorrhaging, and its unfortunate victims often suffer from black vomit and other bloody discharges. One routine delivery proved so putrid the volunteers \"retreated from the house,\" Reed stated. \"They pluckily returned, however, within a short time, and spent the night as usual.\" [7] In two succeeding trials the protocol became progressively more daring , as the volunteers then wore the clothing and slept on the mattresses used by yellow fever patients, and finally put towels on their bedding smeared with blood drawn from cases in the early stages of an attack. Each morning, the volunteers carefully repacked the rank, encrusted materials into boxes and emerged to an adjacent tent where they spent the day quarantined from the rest of the company. Three trials of twenty days each involved seven men altogether, lead by Robert P. Cooke, a physician in the Army Medical Corps. None developed yellow fever.","The Commission's mosquito experiments proceeded in four series. First, Reed sought to demonstrate that mosquitoes of the varietyCulex fasciata(later calledStegomyia fasciata, and later stillAedes aegypti) could in fact transmit yellow fever, as Carlos J. Finlay had argued and the initial experiments at Camp Columbia strongly suggested. Here the Commission members simply applied infected mosquitoes contained in test tubes or jars to the skin of the initial volunteers. Success in these tests raised a number of questions, each one addressed in the subsequent series:","How could a building become infected?\n      When does a mosquito develop the ability to transmit the disease?\n      Over what length of time can a mosquito retain this capacity to infect?","The second series consequently employed the specialized \"Infected Mosquito Building\" to indicate how a structure could be considered infected with yellow fever. This experiment required two groups of volunteers, one to be inoculated and another to serve as controls. \"Loaded\" mosquitoes, as the men called them, were released into the screened section of Building Two -- on the side with the protected vestibule entry. One or more non-immune men then entered the opposite section of the room through the direct exterior door, and lay down on bunks adjacent to the wire mesh screen in the center of the room. Now the young man to be inoculated walked through the vestibule into the mosquito side of the room and proceeded to lie on a bunk adjacent to the wire screen separating him from the controls. The inoculation volunteer remained in the building for about twenty minutes -- enough time to suffer several mosquito bites -- he then exited to a quarantine tent outside. The controls spent the remainder of the evening and night in the uninfected side of the room, and indeed returned to sleep in the room for as many as eighteen more nights. As Reed stated, absence of yellow fever in the controls showed \"that the essential factor in the infection of a building with yellow fever is the presence therein of [infected] mosquitoes,\" and nothing more. [8] The degree of sanitation, so long considered critical, was utterly irrelevant.","The third series of mosquito experiments confirmed what Henry Rose Carter, of the U.S. Public Health Service, called the \"period of extrinsic incubation,\" [9] the length of time required for secondary cases of yellow fever to develop after an initial intrusion of the disease into a locality. In this series, a single volunteer underwent three successive inoculations by the same mosquitoes, each group of inoculations interrupted by a period of time equal in length to the typical incubation period of the disease in humans, about five days. In this manner, the volunteer's illness could be specifically attributed to a single inoculation group. The use of the same mosquitoes and the same volunteer concurrently demonstrated that no peculiar personal immunity was at play, since logic dictates that a person susceptible to yellow fever on day 17 of a mosquito's contamination -- as happened in the experiment -- could not have been immune to yellow fever on day 11 or day 4. It was thus only the mosquito's capacity to infect which changed, and that occurred no less than 11 days after contamination.","The duration of time over which these \"fully ripened\" mosquitoes remained infective comprised the fourth series of experiments. For this series the Commission kept alive a group of infected mosquitoes for as long as possible, and proceeded to inoculate three volunteers -- on the 39th, 51st, and 57th day after contamination. Each developed yellow fever. A fourth volunteer declined to be bitten on day 65, and the last two mosquitoes of the group, \"deprived of further opportunity to feed on human blood\" [10] expired on day 69 and day 71, clear evidence that even a sparsely populated region may retain the potential for new infections more than two months after the first appearance of the disease.","Although it went unrecorded in the published papers, Reed organized a supplemental experiment to test another species of mosquito.Culex pungensfailed to transmit yellow fever to at least one volunteer and probably to a second. Reed's preliminary conclusions indicated thatCulex fasciatawas the only species capable of transmitting yellow fever. [11]","A last experimental regime involved subcutaneous injections of blood from positive cases of yellow fever to presumed non-immunes. Reed devised these tests to confirm the presence of the yellow fever agent in the blood of a victim during the first days of an attack, and, more importantly, to settle theBacillus icteroidesquestion. The same blood cultures which produced yellow fever in four volunteers also failed to grow anyB. icteroides, conclusively invalidating Sanarelli's claim.","Altogether, the mosquito inoculations and the blood injections produced fourteen cases of yellow fever. All made a full recovery.","Notwithstanding the decisive medical victory -- as Reed declared, \"aside from the antitoxin of Diptheria and Koch's discovery of the tubercle bacillus, it will be regarded as the most important piece of work, scientifically, during the 19th century\" [12] -- success at Camp Lazear unfolded in its own time. Initially, Reed observed, \"the results obtained at this station were not encouraging.\" [13] The first inoculations of four volunteers over a period of two weeks proved disconcertingly negative each time. Then, on December 5, 1900, private John R. Kissinger presented his arm to the mosquitoes, and late in the evening on December 8, suffered the first chills of \"a well-marked attack of yellow fever.\" [14] Three more men in rapid succession fell victim to the insects -- Spanish volunteers Antonio Benigno, Nicanor Fernandez, and Vicente Presedo. The force of the conclusions was evident to everyone:","\"It can readily be imagined,\" Reed empathetically and wryly described in his first presentation of the experiments, \"that the concurrence of 4 cases of yellow fever in our small command of 12 non-immunes within the space of 1 week, while giving rise to feelings of exultation in the hearts of the experimenters, in view of the vast importance attaching to these results, might inspire quite other sentiments in the bosoms of those who had previously consented to submit themselves to the mosquito's bite. In fact, several of our good-natured Spanish friends who had jokingly compared our mosquitoes to 'the little flies that buzzed harmlessly about their tables,' suddenly appeared to lose all interest in the progress of science, and, forgetting for the moment even their own personal aggrandizement, incontinently severed their connection with Camp Lazear. Personally, while lamenting to some extent their departure, I could not but feel that in placing themselves beyond our control they were exercising the soundest judgment.\"","\"In striking contrast,\" Reed continued, the anxiety of the fomites volunteers began to melt into relief. \"[T]he countenances of these men, which had before borne the serious aspect of those who were bravely facing an unseen foe, suddenly took on the glad expression of 'schoolboys let out for a holiday,' and from this time their contempt for 'fomites' could not find sufficient expression. Thus illustrating once more, gentlemen, the old adage that familiarity, even with fomites, may breed contempt.\" [15]","The question of human experimentation was indeed a serious one -- unavoidable, in actuality, as Reed had stated the previous summer to Surgeon General Sternberg. When the Commission first considered a trial of Finlay's mosquito theory, Reed, Carroll, and Lazear agreed to experiment on themselves. Agramonte, a native Cuban, had acquired immunity as a child. Doubtless Finlay's experience of many unsuccessful inoculations communicated that positive results would not be forthcoming rapidly, so before the first series of inoculations began under Lazear's direction at Columbia Barracks, Reed left Cuba for Washington, where he completed a monumental report on typhoid fever among the army corps -- left unfinished by the sudden death of co-author Edward O. Shakespeare. Carroll and Lazear both sickened while Reed was in Washington, and Lazear, young and strong, had no reason to anticipate that his case would be fatal. Reed was shocked at Lazear's death, and because of his own age -- 49, a decade and a half older than Lazear and a dozen years older than Carroll -- he resolved not to inoculate himself when he returned to Cuba on October 4, 1900. The point had already been amply demonstrated, and only a rigidly controlled experimental regime would establish the necessary proof. Carroll, however, remained embittered about this for the remainder of his life, though he evidently never communicated his objections directly to Reed.","That initial series of mosquito inoculations was probably accomplished without formal documentation of informed consent. Indeed, the experiments may also have been carried forward without the full knowledge of the commanding officer of Camp Columbia, and Reed consequently shielded the identity of Private William J. Dean, the second positive experimental case, behind the pseudonym \"XY\" in the \"Preliminary Note.\" No such potentially troublesome problems arose for the experimental series at Camp Lazear; Reed obtained prior support from all of the appropriate authorities in the military and the administration, even including the Spanish Consul to Cuba. With the advice of the Commission and others, he drafted what is now one of the oldest series of extant informed consent documents. The surviving examples are in Spanish with English translations, and were signed by volunteers Antonio Benigno and Vicente Presedo, and a third with the mark of Nicanor Fernandez, who was illiterate.","The documents take the form of a contract between individual volunteers and the Commission, represented by Reed. At least 25 years old, each volunteer explicitly consented to participate, and balanced the certainty of contracting yellow fever in the general population against the risks of developing an experimental case, followed by expert and timely medical care. The volunteers agreed to remain at Camp Lazear for the duration of the experiments, and as a reward for participation would receive $100 \"in American gold,\" with an additional hundred-dollar supplement for contracting yellow fever. These payments could be assigned to a survivor, and the volunteers agreed to forfeit any remuneration in cases of desertion.","For the American participants no consent documents appear to survive, though in contemporary letters Reed assured his correspondents that the Commission obtained written consent from all the volunteers. The record of expenses for Camp Lazear -- maintained by Reed's friend and colleague in the medical corps, Jefferson Randolph Kean -- indicates that the same schedule of payments for participation and sickness applied to the Americans as well. Volunteers who participated in the fomites tests and in addition the later series of blood injections and the single trial of an alternative species of mosquito also earned $100 each plus the $100 supplement if yellow fever developed. Two Americans declined these gratuities, as Kean termed them, Dr. Robert P. Cooke, of the fomites tests, and John J. Moran, who had recently received an honorable discharge from the service, and was the only American civilian to participate. His was the fourth case of yellow fever to develop from mosquito inoculation. Moran eventually settled in Cuba, where he managed the Havana offices of the Sun Oil Company, and late in life became a close friend of Philip S. Hench. Together the two men rediscovered the site of Camp Lazear in 1940 -- Building Number One still intact -- and successfully lobbied the Cuban government to memorialize there the work of Finlay and the American Commission in the conquest of yellow fever.","Reed informally commemorated his own experiences at Camp Lazear by commissioning a group photograph, evidently taken there shortly before he left Cuba in February 1901. A more important event occurred on the sixth of that month when Reed presented the results of the Camp Lazear yellow fever experiments to a great ovation at the Pan-American Medical Congress in Havana. Three days later he set sail for the United States, and once landed, drafted the Congress paper asThe Etiology of Yellow Fever -- An Additional Note, published immediately in theJournal of the American Medical Association. [16]","Though his correspondence intimates a great appreciation for Cuba, Reed never returned to the warm, sunny shores of the island freed of a dreadful plague. Carroll stayed behind at Camp Lazear through February to complete the last experimental series officially bearing the imprimatur of the Yellow Fever Commission, and returned to Washington soon after March first. [17] The Medical Corps retained the lease on Camp Lazear against the possibility of continuing experiments another season, and Carroll, in fact, returned to Havana in August 1901 for a final experimental series, though he did not make use of Camp Lazear. This work involved at least three volunteers at Las Animas Hospital, Havana, who submitted to blood injections. Carroll's assignment aimed at a greater understanding of the yellow fever agent, and he proved that blood drawn from active cases of yellow fever remained virulent even after passing through fine bacteria filters. In addition, by heating contaminated blood which had previously caused cases of yellow fever, Carroll rendered it non-infective -- thereby establishing that this filterable entity, though sub-microscopic, was demonstrably present in the bloodstream. Carroll wrapped up the series in October and returned home to stay. [18] In Cuba, J. Randolph Kean made the last rental payments to Signore Rojas on October 9, 1901, and Camp Lazear, for more than a generation, slipped out of the realm of memory.","Sources:","[1] Walter Reed and James Carroll,Bacillus Icteroides and Bacillus Cholerae Suis -- A Preliminary Note,Medical News(29 April 1899), reprinted in: United States Senate Document No. 822,Yellow Fever, A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 55.\n      [2] Letter from Jesse W. Lazear to Mabel Houston Lazear, 23 August 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00341001.\n      [3] Walter Reed, \"The Propagation of Yellow Fever -- Observations Based on Recent Researches,\" in United States Senate Document No. 822,Yellow Fever A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 94.\n      [4] Letter from Walter Reed to George M. Sternberg, 24 July 1900, Hench Reed Yellow Fever Collection, accession number: 02064001.\n      [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note,Proceedings of the Twenty-eighth Annual Meeting of the American Public Health AssociationIndianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n      [6] Letter from Walter Reed to James Carroll, 7 September 1900, Edward Hook Additions to the Philip S. Hench Walter Reed Yellow Fever Collection: James Carroll Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 15312004. The originals of these letters remain in a private collection.\n      [7] Walter Reed, James Carroll, Aristides Agramonte,The Etiology of Yellow Fever -- An Additional Note,Journal of the American Medical Association36 (16 February 1901): 431-440, reprinted in: Senate Document No. 822, p. 84.\n      [8] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n      [9] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n      [10] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 101.\n      [11]Culex fasciatawas reclassified shortly after the experiments asStegomyiaand later becameAedes aegypti.\n      [12] Letter to from Walter Reed to Emilie Lawrence Reed, 9 December 1900, Hench Reed Collection, accession number: 02231001.\n      [13] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 97.\n      [14] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 98.\n      [15] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n      [16] Please see note [7].\n      [17] The Commission reported these concluding experiments in: Walter Reed, James Carroll, Aristides Agramonte,Experimental Yellow Fever,American MedicineII (6 July 1901) 1: 15-23.\n      [18] Walter Reed, James Carroll,The Etiology of Yellow Fever (A Supplemental Note),American MedicineIII (22 February 1902) 8: 301-305.","Walter Reed (September 13, 1851 - November 22, 1902) was a U.S. Army physician who led the army's Yellow Fever Commission 1900 and 1901. Experiments conducted by the commission confirmed a theory that yellow fever is transmitted by mosquitoes--a discovery that led to the control and eradication of this disease across much of the globe. Reed would receive much of the credit for the work of the commission because of his role as its leader, and, long after his death in 1902, he would be widely celebrated as a heroic figure in the fields of public health and medical research.","Reed spent his first days in a small house which served as the parsonage for a Methodist congregation in Gloucester County, Virginia, where his father was minister.  Lemuel Sutton Reed and Pharaba White Reed welcomed young Walter into the family on September 13, 1851;  he was the youngest of their five children.  The Reeds moved to other Virginia parishes during Walter's childhood, and just after the close of the Civil War, transferred to the town of Charlottesville.  That move in 1866 placed Walter in the orbit of the University of Virginia, which he entered a year later at age sixteen under the care of his older brother Christopher, also a student at the University.  Reed attended two year-long sessions, the second devoted entirely to the medical curriculum, and he completed an M.D. degree on July 1, 1869, as one of the youngest students to graduate in the history of the medical school.","At that time the School of Medicine at the University offered little opportunity for direct clinical experience, so Reed subsequently enrolled at the Bellevue Hospital Medical College, in Manhattan, New York.  There he obtained a second M.D. degree in 1870.  Reed interned at a number of hospitals in the New York metropolitan area, including the Infants' Hospital on Randall's Island and the Brooklyn City Hospital.  In 1873, he assumed the position of assistant sanitary officer for the Brooklyn Board of Health.  The large and diverse population of New York, with its many immigrant communities and dense, tenement housing, provided countless medical cases to treat and study;  these served to expose Reed to the vital importance of public health, and developed in him a lifelong interest in the field.  Yet the frenetic life of the great cities began to pall after a few years: \"Here the ever bustling day is crowded into the busy night; nor can we draw the line of separation between the two,\"[1] he wrote to Emilie Lawrence, of Murfreesboro, North Carolina, later to become Mrs. Walter Reed.  Their courtship letters reveal much of his maturing character, interests, and philosophy of life.  Increasing responsibilities with the Board of Health precluded opening a private practice, and Reed's youth proved a barrier in a culture given to offering respect more to the appearance of maturity than to its actual demonstration. Reed consequently resolved to join the Army Medical Corps, both for the professional opportunities it offered immediately and for the modest financial security it could provide to a young man without independent means.  He passed the qualifying examinations in January 1875 and proceeded to his first assignment at the military base on Willet's Point, New York Harbor.","Reed remained in the Medical Corps for the rest of his life, spending many years of the '70s, '80s, and early '90s at difficult postings in the American West.  The first of these -- to the Arizona Territory -- began in the late spring of 1876, and indeed hurried along his wedding to Emilie Lawrence, on April 25, shortly before his departure.  She joined him the following November, and bore two children at frontier posts, a son Walter Lawrence and a daughter Emilie, called Blossom.","Reed's other western assignments included forts in Nebraska, Dakota Territory, and Minnesota, with two eastern interludes at Baltimore, Maryland and another at Mount Vernon Barracks, Alabama.  During the second of these tours in Baltimore -- over the 1890-1891 academic year -- Reed completed advanced coursework in pathology and bacteriology in the Johns Hopkins University Hospital Pathology Laboratory.  When he returned from his last western appointment in 1893, Reed joined the faculty of the Army Medical School in Washington, D.C., where he held the professorship of Bacteriology and Clinical Microscopy.  He also became curator of the Army Medical Museum and joined the faculty of the Columbian University in Washington (later the George Washington University).  In addition, Reed maintained close ties with professor William Welch and other leading lights in the scientific community he had come to know at Hopkins a few years earlier.","Beyond his teaching responsibilities for the Army and the Columbian University programs, Reed actively pursued medical research projects.  A bibliography of his publications finds entries from 1892 to the year of his untimely death a decade later, and the subjects he investigated range from erysipelas to cholera, typhoid, malaria, and yellow fever, among others.[2]   In 1896, a research trip to investigate an outbreak of smallpox took him to Key West, and there he developed a close friendship with Jefferson Randolph Kean, a fellow Virginian and colleague in the Medical Corps ten years his junior.  When Reed traveled to Cuba in 1899 to study typhoid in the army encampments of the U.S. forces, Kean was already there, and Kean was still in Cuba when Reed returned as the head of the Army board charged by Surgeon General George Miller Sternberg to examine tropical diseases including yellow fever.  Kean and his first wife Louise were great supporters of the U.S. Army Yellow Fever Commission's work, and Kean in fact served as quartermaster for the famous series of experiments at Camp Lazear.  After the dramatic and conclusive success of those experiments, Kean actively -- though unsuccessfully -- promoted Reed's candidacy for Surgeon General.","Reed continued to speak and publish on yellow fever after his return from Cuba in 1901, receiving honorary degrees from Harvard and the University of Michigan in recognition of his seminal work.  In November 1902, Reed developed what had been for him recurring gastro-intestinal trouble.  This time, however, his appendix ruptured, and surgery came too late to save him from the peritonitis which developed.  He died on November 23, 1902, almost two years to the day from the opening of Camp Lazear and the stunning experimental victory there.  Kean remained a champion of his deceased friend's role in the conquest of yellow fever.  He organized the Walter Reed Memorial Association, to provide support for Reed's family and to build a suitable memorial, and was instrumental in lobbying the United States Congress to establish the Yellow Fever Roll of Honor.  In 1929, Congress mandated the annual publication of the Roll in theArmy Register, and struck a series Congressional Gold Medals saluting the Commission members and the young Americans who bravely suffered experimental yellow fever a generation before.","Sources:","[1] Letter from Walter Reed to Emilie Lawrence, 18 July 1874, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 01605001.\n      [2] The bibliography of Reed's scientific papers may be found in: Howard Atwood Kelly,Walter Reed and Yellow Fever(New York: McClure, Phillips and Co., 1906), pp. 281-283. Kelly's complete biography of Reed is contained on this Web site.","Jesse William Lazear (May 2, 1866 - September 26, 1900) was a physician who was a member of the U.S. Army Yellow Fever Commission in 1900. Lazear's death from yellow fever at the outset of the commission's work in Cuba would lead to his elevation as a martyr for medical science in the eyes of many during the twentieth century.","\"I rather think I am on the track of the real germ,\" Jesse W. Lazear wrote his wife from Cuba on September 8, 1900.[1] Seventeen days later, the fulminating case of yellow fever Lazear had contracted just over a week after writing Mabel H. Lazear suddenly ended the young scientist's life. He was 34 years old. Unlike so many other yellow fever fatalities, however, this one would lead to a direct and highly successful assault on the disease itself. Yellow fever's ascendancy, endemic in Cuba, was about to be undermined.","Lazear had reported to Camp Columbia, Cuba in February 1900 for duty as an acting assistant surgeon with the U. S. Army Corps stationed on the island. Here he undertook bacteriological study of tropical diseases, particularly malaria and yellow fever, and in May he was named to the Army board charged with \"pursuing scientific investigations with reference to the infectious diseases prevalent on the island of Cuba.\"[2]","These orders placed him officially in the company of Walter Reed, James Carroll, and Aristides Agramonte -- the U.S. Army Yellow Fever Commission -- though Lazear had already met Reed the preceding March on a project to evaluate the efficacy of electrozone, a disinfectant made from seawater collected off the Cuban coast. While Reed was in Cuba that March, Lazear discussed with him the recent discovery of British scientist Sir Ronald Ross concerning the mosquito vector for malaria. At Johns Hopkins Hospital in Baltimore, where he was first a medical resident and later in charge of the clinical laboratory, Lazear had followed Ross's accomplishments with great interest, and pursued field work and experimentation on theAnophelesmosquito with fellow Hopkins scientist William S. Thayer. Lazear was thus the only member of the Commission who had experience with mosquito work, and was consequently the most open to the possible verity of Cuban scientist Carlos Juan Finlay's theory of mosquito transmission for yellow fever.","The record is apparently silent as to when Lazear first visited Finlay. Certainly by late June Lazear was beginning to grow mosquito larvae acquired from Finlay's laboratory, the first specimens brought to him by Henry Rose Carter, of the United States Public Health Service.[3] Not long after arriving in Cuba Lazear met Carter, whose own observations on yellow fever strongly suggested an intermediate host in the spread of the disease. However, Army Surgeon General George Miller Sternberg, who organized the Yellow Fever Commission, first charged the board members to investigate the relationship ofBacillus icteroidesto yellow fever -- proposed by the Italian Scientist Giuseppe Sanarelli as the actual cause of the disease. \"Dr. Reed had been in the old discussion over Sanarelli's bacillus and he still works on that subject,\" Lazear wrote his wife in July, \"I am not all interested in it but want to do work which may lead to the discovery of the real organism.\"[4] Soon he would have the opportunity. The relatively quick failure of the Bacillus icteroides inquiry opened the door to what became the ground-breaking mosquito work, and Lazear was well placed to begin.","The project started in earnest on August 1, 1900. In a small pocket notebook Lazear noted the preparatory work of raising and infecting mosquitoes, and subsequently recorded the series of eleven experimental inoculations made from the 11th to the 31st of August, the last two producing cases of full-blown yellow fever. These two positive cases developed from mosquitoes allowed to ripen over a period of 12 days, and this was Lazear's crucial discovery. The epidemiological pattern was thus entirely consistent with Carter's observations of a delay between the primary and secondary outbreaks of yellow fever in an epidemic, and, in addition, explained why Finlay's experiments had been largely unsuccessful -- he had not waited long enough before inoculating his subjects.","Although Lazear never directly admitted to experimenting on himself, when Reed reviewed Lazear's sketchy notations he evidently found entries strongly suggesting Lazear's case was not accidental, as officially reported. Unfortunately, the little notebook so crucial to the preparation of the Commission's famous initial paper,The Etiology of Yellow Fever -- A Preliminary Note[5], vanished from Reed's Washington office after his own untimely death in 1902. Still, Lazear's invaluable contribution to the Commission's victory was widely recognized and elicited tributes from many quarters: \"He was a splendid, brave fellow,\" Reed said of his young colleague, \" and I lament his loss more than words can tell; but his death was not in vain- His name will live in the history of those who have benefited humanity.\" [6] \"His death was a sacrifice to scientific research of the highest character,\" stated General Leonard Wood, military Governor of Cuba.[7] \"Your husband was a martyr in the noblest of causes,\" Dr. L. O. Howard wrote to Mabel Lazear, \"and I am proud to have known him. . . . His work contributed towards one of the greatest discoveries of the century, the results of which will be of invaluable benefit to mankind.\"[8] And so they were. Though Lazear's one-year-old son and newborn daughter never knew their father, they grew up in a world liberated -- almost in its entirety -- from the disease that killed him.","[1] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 8 September 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00344001.","Sources:","[2] Military Orders for Walter Reed, James Carroll, Aristides Agramonte, and Jesse W. Lazear, 24 May 1900, Hench Reed Collection, accession number 02019001.\n      [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n      [4] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 15 July 1900, Hench Reed Collection, accession number: 00334001.\n      [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note, Proceedings of the Twenty-eighth Annual Meeting of the American Public Health Association Indianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n      [6] Letter from Walter Reed to Emilie Lawrence Reed, 6 October 1900, Hench Reed Collection, accession number: 02135001.\n      [7] Letter from Leonard Wood to the Adjutant-General, United States Army, November 1900, Hench Reed Collection, accession number: 00375002.\n      [8] Letter from Leland Ossian Howard to Mabel Houston Lazear, 7 February 1901, Hench Reed Collection, accession number: 00388001.","Henry Rose Carter (August 25, 1852 - September 14, 1925) was a prominent physician in the U.S. Public Health Service who was a leading authority in the transmission and control of tropical diseases, particularly yellow fever and malaria. During his long career as a sanitarian, Carter undertook campaigns to investigate and control the spread of tropical diseases in Cuba, the Panama Canal Zone, the Southeastern United States, and Peru.","Like Walter Reed and Jefferson Randolph Kean, Henry Rose Carter was a native Virginian and a graduate of the University of Virginia. Carter obtained a civil engineering degree from Virginia in 1873 and also undertook post-graduate work in mathematics and applied chemistry the next year. Subsequently, however, Carter's interests turned towards medicine, and he completed a medical degree at the University of Maryland in 1879. The same year Assistant Surgeon Carter joined the Marine Hospital Service -- later the United States Public Health Service -- and the young surgeon rose steadily through the ranks, ultimately attaining the position of Assistant Surgeon General in 1915.","Carter's initial assignments with the Hospital Service placed him at the center of the yellow fever maelstrom. In 1879 he was detailed to Memphis and other Southern cities, then in the throes of a second year of devastating epidemics. Here began, as his colleague T. H. D. Griffitts observed, Carter's \"lifelong interest in the epidemiology and control of yellow fever.\"[1] After several years of clinical practice in various Marine hospitals, Carter resumed a direct confrontation with yellow fever when his orders for duty with the Gulf Coast Maritime Quarantine assigned him to Ship Island, Mississippi, in 1888. Here and at subsequent quarantine station postings around the Gulf, he quietly championed a thorough review and rationalization of quarantine policies, with a view toward establishing uniform regulation, more thorough disinfection of vessels, and minimized interference with naval commerce. Crucial to the success of these activities was Carter's attention to the incubation period of yellow fever, which his on-site observations indicated to vary between 5 and 7 days. At the time the official literature stated with far less precision a variance of between 1 and 14 days; Carter's work consequently greatly increased the efficiency and effectiveness of quarantine operations.","Nevertheless, yellow fever continued to menace the temperate coastline of the United States, and Carter ably directed the Health Service's epidemiological control efforts in numerous threatened regions. In conjunction with this sanitary work for the 1898 season, Carter made detailed notes on the development of yellow fever at Orwood and Taylor, Mississippi. The isolation of these communities enabled him to identify more reliably the phenomenon of a delay between the initial cases of yellow fever in a locality and the subsequent appearance of secondary infection -- a delay two to four times longer than the incubation period of the disease in an infected person. Carter called this interval between the primary and secondary cases \"the period of extrinsic incubation,\" and he defined its \"usual limits . . . [as ranging] from ten to seventeen days.\"[2]","Before he was able to publish his conclusions, Carter took the helm of the quarantine service in war-time Cuba. There, in 1900, he met U. S. Army Yellow Fever Commission member Jesse Lazear. Carter had finally arranged for his paper's publication that year in theNew Orleans Medical and Surgical Journal, and gave a draft to Lazear. \"If these dates are correct,\" Carter later recalled Lazear saying, \"it spells a living host.\"[3] The theory of mosquito transmission long advanced by Cuban scientist Carlos J. Finlay began to seem more likely. And indeed it was. The Commission's experiments in 1900-1901 irrefutably proved the mosquito vector and established the extrinsic incubation period at twelve days. Shortly after these successes Reed saluted Carter, \"I know of no one more competent to pass judgment on all that pertains to the subject of yellow fever. You must not forget that your own work in Mississippi did more to impress me with the importance of an intermediate host than everything else put to-gether.\"[4]","Carter's long and distinguished sanitary career took him to the Panama Canal Zone in 1904, where he served as Chief Quarantine Officer and Chief of Hospitals for five years. He undertook detailed investigations and control measures of malaria in North Carolina and elsewhere in the South, and became a founder of the National Malaria Committee. With the support of the Rockefeller Foundation International Health Board, he undertook additional investigation and control measures for yellow fever in Central and South America. His expertise recommended him to the Peruvian government, which named Carter Sanitary Advisor in 1920-1921. Health problems at the end of his life compelled Carter to withdraw from active fieldwork, though he remained a highly valued consultant to the Health Board and a much-beloved and respected teacher for a new generation of sanitarians. Carter closed his career researching and writing the manuscript that his daughter Laura Armistead Carter edited and published posthumously in 1931:Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.[5]","Sources:","[1] T. H. D. Griffitts,Henry Rose Carter: The Scientist and the Man,Southern Medical Journal32 (August 1939) 8: 842.\n      [2] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n      [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n      [4] Letter from Walter Reed to Henry Rose Carter, 26 February 1901, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 02447001.\n      [5] Carter, Henry Rose.Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.Baltimore: The Williams and Wilkins Company, 1931.","Jefferson Randolph Kean (June 27, 1860 - September 4, 1950) was a U.S. Army physician who was a leading authority in sanitation, public health, and tropical diseases. Later in his career, Kean would become widely recognized for his role in organizing and administering medical services for the U.S. armed forces during World War I.","\"He possessed one of the keenest, most scholarly minds I've ever encountered,\" recalled Nobel Prize winner Philip S. Hench of Jefferson Randolph Kean. [1] Kean and Hench shared an abiding interest in the work of the United States Army Yellow Fever Commission -- Kean, as a contemporary and supporter, and Hench, as a scholar and scientist intent on accurate historical documentation. On the advice of yellow fever experiment volunteer John J. Moran, Hench first wrote Kean in 1939. From that initial contact developed a close friendship which would last for the remainder of their lives. Kean entrusted Hench not only with numerous period documents, including original letters, accounts, fever charts, and other items, but also with the freely-given counsel and insight of a trusted friend.","Like Walter Reed and Henry Rose Carter before him, Jefferson Randolph Kean was an alumnus of the University of Virginia, completing the medical program there in 1883. Kean joined the U.S. Army Medical Corps in 1884, and after forty years in the service, retired with the rank of Colonel. Congress awarded him a promotion to Brigadier General, retired, in 1930. The early years of Kean's career passed in medical postings in the American West, and no doubt offered him experiences similar to those of Walter Reed, whom he met not on the frontier, but in Florida in 1896. Kean became an expert in tropical diseases and sanitation during his five-year assignment in the Florida tropics, an expertise which served him well over two terms of service later in Cuba. During the Spanish-American War and subsequent U. S. occupation of Cuba, Kean was Chief Surgeon for the Department of Havana, then Superintendent of the Department of Charities -- from 1898 to 1902. After a four-year interlude as an assistant to the Surgeon General in Washington, D.C., Kean again returned to Cuba as an advisor to the Department of Sanitation from 1906-1909.","Kean himself stated: \"Reed and I were good friends before the Yellow Fever Board came to Cuba in June 1900, and [Reed] located himself at Marianao, 8 miles S. W. of Havana,\" to be within the medical and administrative jurisdiction overseen by Kean. [2] The Chief Surgeon did indeed offer significant assistance, and was an early convert to Carlos Finlay's mosquito theory of transmission, which the Yellow Fever Board's experiments ultimately proved true in the late autumn and winter of 1900-1901. As early as October 13, 1900 -- after the Board's preliminary work, but before the final convincing demonstrations -- Kean issued \"Circular No. 8,\" concerning the latest scholarship on the mosquito vector for disease. [3] The circular contained a set of instructions for the entire command on mosquito eradication. Kean subsequently served as quartermaster and financial administrator for the famous series of yellow fever experiments at Camp Lazear and, for the rest of his life, Kean remained a strong proponent of the Commission's conclusions. He worked tirelessly not only to apply them in the field, but also to accord proper public recognition to the Commission's work.","In addition to his career as a sanitarian, Kean organized the department of military relief of the American Red Cross, and during World War One served as Chief of the U. S. Ambulance Service with the French Army and Deputy Chief Surgeon of the American forces. France named him an Officier de la Légion d'Honneur in recognition for these services. Cuban authorities as well offered Kean recognition with the grand cross of the Order of Merit Carlos J. Finlay, and he received both a Distinguished Service Medal from the United States government and the Gorgas Medal from the Association of Military Surgeons. For a decade after his retirement from active duty, Kean edited this last organization's medical journal,The Military Surgeon, and served on the Surgeon General's editorial board for the multi-volume history of the medical department in World War One. A great-grandson of Thomas Jefferson, Kean also took a seat with the government commission established to build the Jefferson Memorial in Washington, D.C. He held charter membership in the Walter Reed Memorial Association, and remained active in its affairs until his death in 1950.","Sources:","[1] Telegram from Philip Showalter Hench and Mary Hench to Cornelia Knox Kean, September 5, 1950, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 06501173.\n      [2] Letter from Jefferson Randolph Kean to Philip Showalter Hench, October 31, 1939, Hench Reed Yellow Fever Collection, accession number: 06282022.\n      [3] Military Orders to Commanding Officers, October 15, 1900, Hench Reed Yellow Fever Collection, accession number: 02140001.","Philip Showalter Hench (February 28, 1896 - March 30, 1965) was a U.S. physician who in 1950 was awarded the Nobel Prize for Physiology and Medicine for his role in the discovery of the hormone cortisone. In addition to his medical research, Hench spent almost three decades of his life studying the history of the U.S. Army Yellow Fever Commission and became a leading authority in the subject.","Philip Showalter Hench was born in Pittsburgh, Pennsylvania, the son of Jacob Bixler Hench and Clara Showalter. After attending local schools, Hench entered Lafayette College and graduated from the school 1916 with a Bachelor of Arts. Hench completed his medical degree at the University of Pittsburgh in 1920, and subsequently entered a residency program at St. Francis Hospital, Pittsburgh. His association with the Mayo Clinic began in 1921 as a fellow at the institution. Two years later he would become an assistant at the clinic, and then, in 1926, he would be made the head of its Department of Rheumatic Diseases After pursuing post-graduate study in Germany in 1928-1929, Hench obtained a Masters of Science in Internal Medicine at the University of Minnesota in 1931, and a Doctor of Science degree from Lafayette College in 1940. Hench remained for the duration of his career at the Mayo Clinic, where his life-long passion for meticulous research and analysis brought him the Nobel Prize for Physiology and Medicine in 1950, which he shared with Edward C. Kendall and Tadeus Reichstein, for the discovery of cortisone.","The same persistence and determination present in his professional life is also evident in Hench's research on the U. S. Army Yellow Fever Commission's famous experiments. \"As a physician particularly interested in medical history,\" he stated to experiment volunteer John J. Moran in 1937, \"I have been long interested in the story of the yellow fever work in John J. Moran, Ralph C. Hutchison, Havana.\" [1] So began a remarkable odyssey. At the request of his friend Ralph Cooper Hutchison, then president of Washington and Jefferson College, Hench had written Moran to gather information for the dedication of the College's new chemistry building, named for Commission member and former Washington and Jefferson student Jesse W. Lazear. Hench also began a correspondence with another of the yellow fever experiment's original volunteers, John R. Kissinger. Moran's and Kissinger's recollections proved so intriguing that Hench initially offered to edit and publish them. However, in the course of his research Hench discovered that much general information on the topic was inaccurate. Conflicting assertions concerning the participants and unverified claims by medical and governmental authorities in the United States and Cuba -- often politically motivated -- clouded interpretation of the facts. \"May I suggest,\" Moran consequently urged in 1938, \"that a clearing up of the REED-FINLAY-CONQUEST-OF-YELLOW-FEVER, or an effort to do so, on your part, is a task far more pressing than publishing the Kissinger-Moran stories or memoirs.\" [2] Hench resolved to document every aspect of the \"Conquest of Yellow-Fever\" and to write a much needed accurate and comprehensive history.","For the next two decades, Hench tirelessly combed through public archive collections and personal papers in the United States and Cuba. He met and interviewed surviving participants of the experiments and others associated with the project, as well as family members of the Yellow Fever Commission. He sought out physicians and scientists who had worked with the principal players or who had applied the results in the campaign to eradicate yellow fever. He identified and photographed sites associated with the yellow fever story, and he successfully petitioned politicians in the United States and Cuba to commemorate the work. In the process, Hench became the trusted friend and advisor of many of these same individuals, and they, in turn, presented him with much of the surviving original material for safekeeping.","In short, Hench came to be the world's expert on the yellow fever story and the steward of thousands of original letters and documents. His premature death at age 69 found him still hoping to uncover important missing evidence, his book unwritten. Hench's widow Mary Kahler Hench gave his yellow fever collection to the University of Virginia, Walter Reed's alma mater, and this extensive personal archive forms the most detailed and accurate record available on the Conquest of Yellow Fever.","Sources:","[1] Letter from Philip S. Hench to John J. Moran, 6 July 1937, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 03419001.\n      [2] Letter from John J. Moran to Philip S. Hench, 30 October 1938, Hench Reed Yellow Fever Collection, accession number: 03476001."],"custodhist_html_tesm":["\u003cp\u003eMaterials from the following series were initially deposited at the University of Virginia's Alderman Library. In 1982, they were moved to the Claude Moore Health Sciences Library under the terms of a gift agreement that required the transferral of Mary K. Hench's donation to the library when adequate storage space for the collection could be found there.\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003eSeries I. Jesse W. Lazear\u003c/item\u003e\n      \u003citem\u003eSeries II. Henry Rose Carter\u003c/item\u003e\n      \u003citem\u003eSeries III. Walter Reed\u003c/item\u003e\n      \u003citem\u003eSeries IV. Philip Showalter Hench\u003c/item\u003e\n      \u003citem\u003eSeries V. Maps\u003c/item\u003e\n      \u003citem\u003eSeries VI. Alphabetical files\u003c/item\u003e\n      \u003citem\u003eSeries VII. Truby-Kean-Hench\u003c/item\u003e\n      \u003citem\u003eSeries VIII. Miscellany\u003c/item\u003e\n      \u003citem\u003eSeries IX. Photographs\u003c/item\u003e\n      \u003citem\u003eSeries X. Negatives\u003c/item\u003e\n      \u003citem\u003eSeries XI. Reprints\u003c/item\u003e\n      \u003citem\u003eSeries XIII. Reed family additions\u003c/item\u003e\n      \u003citem\u003eSeries XV. Laura Wood\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eMaterials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were initially deposited in the HAM/TMC and were a part of the Philip S. Hench papers. In 1991, the materials were transferred from HAM/TMC to the Claude Moore Health Sciences Library after both repositories agreed that it would be more appropriate to include them in the Philip S. Hench Walter Reed Yellow Fever Collection.\u003c/p\u003e","\u003cp\u003e Materials from Series XVI. Edward Hook additions were transferred from the Papers of Dr. Edward Watson Hook, Jr. to the Philip S. Hench Walter Reed Yellow Fever Collection around the late 1990s and early 2000s.\u003c/p\u003e  "],"custodhist_heading_ssm":["Custodial History"],"custodhist_tesim":["Materials from the following series were initially deposited at the University of Virginia's Alderman Library. In 1982, they were moved to the Claude Moore Health Sciences Library under the terms of a gift agreement that required the transferral of Mary K. Hench's donation to the library when adequate storage space for the collection could be found there.","Series I. Jesse W. Lazear\n      Series II. Henry Rose Carter\n      Series III. Walter Reed\n      Series IV. Philip Showalter Hench\n      Series V. Maps\n      Series VI. Alphabetical files\n      Series VII. Truby-Kean-Hench\n      Series VIII. Miscellany\n      Series IX. Photographs\n      Series X. Negatives\n      Series XI. Reprints\n      Series XIII. Reed family additions\n      Series XV. Laura Wood","Materials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were initially deposited in the HAM/TMC and were a part of the Philip S. Hench papers. In 1991, the materials were transferred from HAM/TMC to the Claude Moore Health Sciences Library after both repositories agreed that it would be more appropriate to include them in the Philip S. Hench Walter Reed Yellow Fever Collection.","Materials from Series XVI. Edward Hook additions were transferred from the Papers of Dr. Edward Watson Hook, Jr. to the Philip S. Hench Walter Reed Yellow Fever Collection around the late 1990s and early 2000s."],"odd_html_tesm":["\u003clist type=\"deflist\"\u003e\n      \u003cdefitem\u003e\n        \u003clabel\u003eProcessed by:\u003c/label\u003e\n        \u003citem\u003eHistorical Collections Staff\u003c/item\u003e\n      \u003c/defitem\u003e\n    \u003c/list\u003e\n  "],"odd_heading_ssm":["General"],"odd_tesim":["Processed by:\n        Historical Collections Staff"],"prefercite_html_tesm":["\u003cp\u003ePhilip S. Hench Walter Reed Yellow Fever Collection, 1800-1998, MS-1, Claude Moore Health Sciences Library, Historical Collections and Services, University of Virginia\u003c/p\u003e  "],"prefercite_tesim":["Philip S. Hench Walter Reed Yellow Fever Collection, 1800-1998, MS-1, Claude Moore Health Sciences Library, Historical Collections and Services, University of Virginia"],"processinfo_html_tesm":["\u003cp\u003eMary K. Hench's donation arrived in Charlottesville in a number of large crates which were packed much as the collection had been found in Philip Showalter Hench's home in Rochester, Minnesota. Some confusion about Dr. Hench's filing order had been created while the collection was packed for shipping, and thus the Manuscripts Department of the University of Virginia Library found it necessary to perform some sorting and arrangement to make the collection more accessible.\u003c/p\u003e","\u003cp\u003e Around 1968, William Bennett Bean was hired by the University of Virginia as a visiting scholar in residence to begin work on a new biography of Walter Reed. Dr. Bean found that the order of the collection was not such that he could readily use it for biographical purposes. He employed a former assistant in the Manuscripts Department, sought and received permission to refile the collection, and had his assistant perform this task. The refiling of the collection had been finished by the fall of 1969, but Bean and his assistant had no time to prepare a finding aid.\u003c/p\u003e","\u003cp\u003e In the fall of 1969 Donna L. Purvis of the Manuscripts Department staff began writing the first edition of the collection's finding aid. During this project, Mrs. Purvis found some problems with Dr. Bean's description and arrangement of the collection and felt that it was necessary to reprocess parts of it.\u003c/p\u003e","\u003cp\u003e Around 1990 staff members in the Claude Moore Health Sciences Library processed additions to the collection donated by Philip Showalter Hench's son, P. Kahler Hench.\u003c/p\u003e","\u003cp\u003e Between 1999 and 2004, the Claude Moore Health Sciences Library digitized a significant portion of the collection and made the digitized files available to users in an online exhibit. During this project, over 8,000 items from the collection were scanned, transcribed, and described at the item level. Metadata for the digitized items was recorded in XML files using the TEI 2 standard.\u003c/p\u003e","\u003cp\u003e In 2001, the Claude Moore Health Sciences Library processed additions that had been made to the collection since 1982, excepting the materials donated by P. Kahler Hench. Staff members also processed significant portions of Mary K. Hench's original donation that had not been described in the first edition of the collection finding aid. This work led to the development of a second edition finding aid that was coded in EAD and ingested into the Virginia Heritage database. This finding aid contained both new metadata and metadata that had been migrated from a Microsoft Access file.\u003c/p\u003e","\u003cp\u003e In the 2000s the Claude Moore Health Sciences Library processed the materials in Series XV. Edward Hook additions.\u003c/p\u003e","\u003cp\u003e In 2009, staff members in the Claude Moore Health Sciences Library processed Box 154 of the collection.\u003c/p\u003e","\u003cp\u003e In 2013, staff members in the Claude Moore Health Sciences Library produced a third edition of the finding aid using EAD that merged collection description from four sources (the first edition finding aid, the second edition finding aid, the online exhibit, and the physical collection). When possible, metadata from the existing online exhibit's TEI files and metadata from the second edition finding aid were transformed with XSL and included in the EAD file. However, staff members sometimes found it necessary to create new metadata for the collection. The new finding aid was structured in such a way to facilitate the migration of the collection's digital files and metadata into the University of Virginia's digital repository and make it available to users via the library's online catalog.\u003c/p\u003e  "],"processinfo_heading_ssm":["Processing History"],"processinfo_tesim":["Mary K. Hench's donation arrived in Charlottesville in a number of large crates which were packed much as the collection had been found in Philip Showalter Hench's home in Rochester, Minnesota. Some confusion about Dr. Hench's filing order had been created while the collection was packed for shipping, and thus the Manuscripts Department of the University of Virginia Library found it necessary to perform some sorting and arrangement to make the collection more accessible.","Around 1968, William Bennett Bean was hired by the University of Virginia as a visiting scholar in residence to begin work on a new biography of Walter Reed. Dr. Bean found that the order of the collection was not such that he could readily use it for biographical purposes. He employed a former assistant in the Manuscripts Department, sought and received permission to refile the collection, and had his assistant perform this task. The refiling of the collection had been finished by the fall of 1969, but Bean and his assistant had no time to prepare a finding aid.","In the fall of 1969 Donna L. Purvis of the Manuscripts Department staff began writing the first edition of the collection's finding aid. During this project, Mrs. Purvis found some problems with Dr. Bean's description and arrangement of the collection and felt that it was necessary to reprocess parts of it.","Around 1990 staff members in the Claude Moore Health Sciences Library processed additions to the collection donated by Philip Showalter Hench's son, P. Kahler Hench.","Between 1999 and 2004, the Claude Moore Health Sciences Library digitized a significant portion of the collection and made the digitized files available to users in an online exhibit. During this project, over 8,000 items from the collection were scanned, transcribed, and described at the item level. Metadata for the digitized items was recorded in XML files using the TEI 2 standard.","In 2001, the Claude Moore Health Sciences Library processed additions that had been made to the collection since 1982, excepting the materials donated by P. Kahler Hench. Staff members also processed significant portions of Mary K. Hench's original donation that had not been described in the first edition of the collection finding aid. This work led to the development of a second edition finding aid that was coded in EAD and ingested into the Virginia Heritage database. This finding aid contained both new metadata and metadata that had been migrated from a Microsoft Access file.","In the 2000s the Claude Moore Health Sciences Library processed the materials in Series XV. Edward Hook additions.","In 2009, staff members in the Claude Moore Health Sciences Library processed Box 154 of the collection.","In 2013, staff members in the Claude Moore Health Sciences Library produced a third edition of the finding aid using EAD that merged collection description from four sources (the first edition finding aid, the second edition finding aid, the online exhibit, and the physical collection). When possible, metadata from the existing online exhibit's TEI files and metadata from the second edition finding aid were transformed with XSL and included in the EAD file. However, staff members sometimes found it necessary to create new metadata for the collection. The new finding aid was structured in such a way to facilitate the migration of the collection's digital files and metadata into the University of Virginia's digital repository and make it available to users via the library's online catalog."],"scopecontent_html_tesm":["\u003cp\u003eThe Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audio cassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). All of these materials are arranged in 16 series: I. Jesse W. Lazear, II. Henry Rose Carter, III. Walter Reed, IV. Philip Showalter Hench, V. Maps, VI. Alphabetical files, VII. Truby-Kean-Hench, VIII. Miscellany, IX. Photographs, X. Photographic negatives, XI. Reprints, XII. Houston Academy of Medicine/Texas Medical Center additions, XIII. Reed family additions, XIV. P. Kahler Hench additions, XV. Laura Wood, and XVI. Edward Hook additions.\u003c/p\u003e","\u003cp\u003e Series I. Jesse W. Lazear consists of materials relating to Lazear that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1800 to 1956 with the bulk of the items dating from 1863 to 1943. Much of the series consists of the correspondence of Jesse W. Lazear and his wife Mabel H. Lazear. Jesse's correspondence dates from his time as a student at Johns Hopkins University to his death in 1900. Researchers can learn a great deal about Jesse from these letters, including his relationships with friends and family, his educational background, and his professional life. Mabel's correspondence dates from the time she met Jesse to her death in 1946. This correspondence primarily concern her husband's historical legacy and a campaign to secure a pension from the U.S. government for herself and her family.\u003c/p\u003e","\u003cp\u003e In addition to Jesse and Mabel's correspondence, the series contains other materials relating to them and their families including, but not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ethe diaries documenting the travels of Jesse and Mabel's mothers in Europe;\u003c/item\u003e\n      \u003citem\u003ecorrespondence of other Lazear family members (e.g. Jesse's parents);\u003c/item\u003e\n      \u003citem\u003egenealogical summaries and tables relating to the Lazear family;\u003c/item\u003e\n      \u003citem\u003elegal documents (e.g. wills, certificates, deeds);\u003c/item\u003e\n      \u003citem\u003emilitary records relating to Jesse;\u003c/item\u003e\n      \u003citem\u003ecertificates, reports, and other materials documenting Jesse's educational background and achievements;\u003c/item\u003e\n      \u003citem\u003eobituaries;\u003c/item\u003e\n      \u003citem\u003ecopies of congressional bills and reports concerning the provision of a federal pension for Mabel H. Lazear;\u003c/item\u003e\n      \u003citem\u003enewspaper articles;\u003c/item\u003e\n      \u003citem\u003ea microscope and sets of microscope slides owned by Jesse;\u003c/item\u003e\n      \u003citem\u003eand a medical chart that shows the progression of the yellow fever infection that killed Jesse.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries II. Henry Rose Carter consists of materials relating to Henry Rose Carter that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1880 to 1932 with the bulk of the materials dating from 1883 to 1932. The series is particularly rich in materials that document Henry Rose Carter's professional activities in the last eleven years of his life (1914-1925). These materials include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ecorrespondence with colleagues in the medical and scientific community including Rupert E. Blue, Hideyo Noguchi, Henry Hanson, Joseph A. LePrince, Frederick F. Russell, T.H.D. Griffitts, and Lunsford D. Fricks;\u003c/item\u003e\n      \u003citem\u003escientific, medical, and government reports relating to the study and eradication of yellow fever and malaria in North America, South America, and Africa;\u003c/item\u003e\n      \u003citem\u003ejournal articles concerning the study and eradication of yellow fever and malaria;\u003c/item\u003e\n      \u003citem\u003eresearch notes written by Henry Rose Carter;\u003c/item\u003e\n      \u003citem\u003eand photographs of Henry Rose Carter at work and with professional colleagues.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries II. also contains correspondence between Henry Rose Carter and members of his family that date from 1880 to 1925. The family members with whom Henry corresponds most frequently in this series are his mother, Emma Coleman Carter; his wife, Laura Eugenia Hook Carter; his daughter, Laura Armistead Carter; and his son, Henry Rose Carter, Jr. These letters are not only a rich source of information about Carter's personal views and family life, they also provide valuable insights into his professional activities such as his experiences aboard vessels and in ports while working for the U.S. Marine Hospital Service and his public health work in Cuba, Panama, and Peru.\u003c/p\u003e","\u003cp\u003e In addition to the materials that were produced during Henry Rose Carter's lifetime, the Series II. contains materials that were produced between 1925 and 1940 (after Henry Rose Carter's death) including, but not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ecopies of obituaries for Henry Rose Carter;\u003c/item\u003e\n      \u003citem\u003econdolence letters for Henry Rose Carter's family after Henry's death;\u003c/item\u003e\n      \u003citem\u003eand the correspondence of Laura Armistead Carter relating to her father and other members of the Carter family.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries III. Walter Reed consists of materials that document the life of Walter Reed as well as the work and legacy of the U.S. Army Yellow Fever Commission. Items in the series date from 1806 to around 1955 with the bulk of the items dating from 1874 to 1936. The series is particularly rich in materials that document the professional and personal life of Walter Reed from 1874 to his death in 1902. These materials include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ecorrespondence between Walter Reed and members of his immediate family that cover a wide range of topics including Reed's courtship of Emilie Lawrence Reed, family life, Walter Reed's work in the Western United States, and Walter Reed's work in Cuba;\u003c/item\u003e\n      \u003citem\u003emilitary records relating to Walter Reed including military orders for Reed, Reed's performance reviews, and reports of Reed's work for army officials;\u003c/item\u003e\n      \u003citem\u003eWalter Reed's correspondence with professional colleagues including members of the U.S. Army Yellow Fever Commission, military doctors, and medical researchers interested in the study of yellow fever;\u003c/item\u003e\n      \u003citem\u003emedical records (e.g. fever charts of experiment participants), military orders, administrative records, reports, and publications documenting the results of the U.S. Army Yellow Fever Commission's experiments in Cuba;\u003c/item\u003e\n      \u003citem\u003earticles announcing the death of Walter Reed;\u003c/item\u003e\n      \u003citem\u003eand the shoulder boards from Walter Reed's U.S. Army uniform.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eIn addition to the above items, Series III. contains materials that document campaigns, spanning from 1902 to 1937, to publicly honor members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments. These materials include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003earticles and editorials relating to efforts to memorialize and provide pensions for members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments;\u003c/item\u003e\n      \u003citem\u003ebiographical sketches of members of the U.S. Army Yellow Fever Commission and experiment participants;\u003c/item\u003e\n      \u003citem\u003erecords relating to the Walter Reed Memorial Association (e.g. correspondence, donor lists);\u003c/item\u003e\n      \u003citem\u003ecopies of Congressional bills and resolutions to honor members of the U.S. Army Yellow Fever Commission and experiment participants;\u003c/item\u003e\n      \u003citem\u003eand letters, reviews, and other materials relating to the production of Sidney Coe Howard's play,\u003ctitle render=\"italic\"\u003eYellow Jack\u003c/title\u003e.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eFinally, Series III. also consists of materials that document the history of yellow fever during the nineteenth and early twentieth century. These materials include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003eitems (e.g. correspondence, reports, reviews, and articles) relating to U.S. efforts to eradicate yellow fever in the Panama Canal Zone;\u003c/item\u003e\n      \u003citem\u003ematerials (e.g. correspondence, reports, and articles) documenting early twentieth century efforts to eradicate yellow fever in Peru;\u003c/item\u003e\n      \u003citem\u003escientific reports and publications related to the study and eradication of yellow fever and malaria;\u003c/item\u003e\n      \u003citem\u003eand newspaper articles describing various outbreaks of yellow fever epidemics.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries IV. Philip Showalter Hench primarily consists of materials that Hench created or collected while researching the U.S. Army Yellow Fever Commission. Items in this series date from around 1850 to around 1865 with the bulk of the items dating from 1937 to 1960. Researchers who are studying the yellow fever experiments will be particularly interested in the materials (e.g. interviews, autobiographies) that document first-hand accounts of the events surrounding the experiments. Other researchers may be interested in items that document Hench's role in shaping public memory of the commission and its experiments. The materials in this series include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003eHench's correspondence and interviews with participants in the yellow fever experiments and their families including: Emilie Lawrence Reed, Emilie M. (Blossom) Reed, Walter Lawrence Reed, John J. Moran, Albert E. Truby, Jefferson Randolph Kean, John H. Andrus, and John R. Kissinger;\u003c/item\u003e\n      \u003citem\u003eautobiographical accounts of the experiment's participants and their families;\u003c/item\u003e\n      \u003citem\u003enotes, reports, correspondence and other materials relating to Hench's search for the original site of Camp Lazear in Cuba;\u003c/item\u003e\n      \u003citem\u003ecorrespondence with Cuban government officials and members of the scientific community relating to Hench's campaign to build a Camp Lazear memorial;\u003c/item\u003e\n      \u003citem\u003ecorrespondence and other materials relating to ceremonies honoring Jesse W. Lazear at Washington and Jefferson College;\u003c/item\u003e\n      \u003citem\u003enewspaper articles, magazine articles, and other printed matter concerning the yellow fever experiments and its participants;\u003c/item\u003e\n      \u003citem\u003edrafts of speeches and presentations Hench gave on the history of the yellow fever experiments to various audiences;\u003c/item\u003e\n      \u003citem\u003emeeting minutes and other materials that document Hench's relationship with and participation in the Walter Reed Memorial Association;\u003c/item\u003e\n      \u003citem\u003escripts for radio programs relating to the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003enotes, outlines, lists, correspondence, and other materials that document Hench's research about the yellow fever experiments and a book he had planned to write on the subject;\u003c/item\u003e\n      \u003citem\u003eand the gold medal that Congress posthumously awarded to Walter Reed for his work with yellow fever.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries V. Maps primarily consists of maps and floor plans that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1960 with the bulk of the items dating from 1899 to 1951. The maps and floor plans often include annotations and illustrate a wide range of locations including, but not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003eHavana and its environs;\u003c/item\u003e\n      \u003citem\u003eCuba;\u003c/item\u003e\n      \u003citem\u003esites associated with the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003eand military installations in the United States.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eIn addition to the maps and floor plans, Series V. also consists of a few newspaper and magazine clippings that contain information relating to the yellow fever experiments.\u003c/p\u003e","\u003cp\u003e Series VI. Alphabetical files primarily consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1860 to around 1966 with the bulk of the items dating from 1940 to 1956. All of these items have been arranged thematically into biographical files. Each file contains materials created by or relating to people who were either involved with the yellow fever experiments or aided Philip Showalter Hench in his research of the subject. These people include, but are not limited to: John J. Moran, Carlos E. Finlay, Laura Wood Roper, Mabel Lazear, Clara Maas, John R. Kissinger, Roger Post Ames, James C. Carroll, and Carlos J. Finlay. The files are arranged alphabetically by the last names of the individuals listed on the files and it is unclear whether the overall arrangement was made by Hench or by staff members at the University of Virginia. The biographical files contain a wide range of different materials that pertain to the individuals listed on the files. These materials include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ecorrespondence between Philip Showalter Hench and the individuals;\u003c/item\u003e\n      \u003citem\u003eother correspondence;\u003c/item\u003e\n      \u003citem\u003enewspaper and magazine clippings;\u003c/item\u003e\n      \u003citem\u003eunpublished manuscripts;\u003c/item\u003e\n      \u003citem\u003ebiographical and autobiographical accounts;\u003c/item\u003e\n      \u003citem\u003etranscripts of oral history interviews that were conducted by Philip Showalter Hench;\u003c/item\u003e\n      \u003citem\u003eand copies of medical charts for volunteers in the yellow fever experiments that shows the progression of the disease.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eIn addition to the materials that Hench created or collected during his lifetime, the biographical files in Series VI. also contain items that were added by staff at the University of Virginia Library during the late 1960s and early 1970s.\u003c/p\u003e","\u003cp\u003e Series VII. Truby-Kean-Hench primarily consists of materials relating to Albert E. Truby and Jefferson Randolph Kean that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1879 to around 1960 with the bulk of the items dating from 1900 to 1954. These items include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ecorrespondence of Jefferson Randolph Kean dating from 1900 to 1950 that relates to his personal life, the yellow fever experiments, public health initiatives, his publications, the legacy of the yellow fever experiments, Kean's work in World War I, and other topics;\u003c/item\u003e\n      \u003citem\u003ePhilip Showalter Hench's correspondence with people related to the yellow fever experiments, particularly Albert E. Truby and Jefferson Randolph Kean primarily from between 1940 and 1955;\u003c/item\u003e\n      \u003citem\u003ea scrapbook and other materials that relate to Truby's book,\u003ctitle render=\"italic\"\u003eMemoir of Walter Reed: the Yellow Fever Episode\u003c/title\u003e;\u003c/item\u003e\n      \u003citem\u003eand Philip Showalter Hench's interviews and questionnaires for Kean and Truby from the 1940s.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eIn addition to the materials relating to Kean and Truby, Series VII. also includes the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003enotes from Philip Showalter Hench's research of the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ethe recollections, autobiographies, and reports of other people involved with the yellow fever experiments including John Andrus and A.S. Pinto;\u003c/item\u003e\n      \u003citem\u003earticles and clippings related to the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ea short biography of Lemuel S. Reed;\u003c/item\u003e\n      \u003citem\u003eand a sketch Philip Showalter Hench made of a proposed museum at the Camp Lazear site.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries VIII. Miscellany consists of oversize and miscellaneous materials in the Philip S. Hench Walter Reed yellow fever collection that were, for various reasons, not included in any of the other series in the collection. Items in this series date from around 1849 to 1982 with the bulk of the materials dating from 1885 to 1974. These materials include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003einformed consent agreements for volunteers in the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ediplomas and certificates for Walter Reed and Jesse W. Lazear;\u003c/item\u003e\n      \u003citem\u003ecopies and sketches of Dean Cornwell's painting,\u003ctitle render=\"italic\"\u003eConquerors of Yellow Fever\u003c/title\u003e;\u003c/item\u003e\n      \u003citem\u003eartifacts, including a wooden board from Camp Lazear and a U.S. flag;\u003c/item\u003e\n      \u003citem\u003ecopies of correspondence, reports, medical records, and military orders from the U.S. National Archives relating to the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003emanuscripts and related notes for published works and research relating to Walter Reed and the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ecorrespondence of Philip Showalter Hench from circa 1940 to 1966;\u003c/item\u003e\n      \u003citem\u003earticles and clippings relating to the yellow fever experiments, the experiments' participants, and the Philip S. Hench Walter Reed yellow fever collection;\u003c/item\u003e\n      \u003citem\u003ecorrespondence of Atcheson Laughlin Hench and members of the University of Virginia community relating to the Philip S. Hench Walter Reed yellow fever collection;\u003c/item\u003e\n      \u003citem\u003eitems that document the provenance and custodial history of some materials in the Philip S. Hench Walter Reed yellow fever collection;\u003c/item\u003e\n      \u003citem\u003ephotographs relating to Cuba and the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003enotes for photographs and photographic negatives housed in Series IX. and Series X. of this collection.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries IX. Photographs consists primarily of photographs that Philip Showalter Hench created and collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1966 with the bulk of the items dating from around 1870 to around 1960. The subjects shown in the photographs include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ephysicians, military personnel, nurses, and volunteers associated with the experiments including Walter Reed, Jesse W. Lazear, Jefferson Randolph Kean, and Aristides Agramonte;\u003c/item\u003e\n      \u003citem\u003efamily members of people associated with the yellow fever experiments including their spouses, children, and grandchildren.\u003c/item\u003e\n      \u003citem\u003eCamp Lazear, Camp Columbia, and other locations in Cuba related to the yellow fever experiments between 1900 and 1960;\u003c/item\u003e\n      \u003citem\u003ethe U.S.S.\u003cemph render=\"italic\"\u003eMaine\u003c/emph\u003eand the Spanish-American War;\u003c/item\u003e\n      \u003citem\u003eaerial views of Havana, Cuba and its environs from the 1940s and 1950s;\u003c/item\u003e\n      \u003citem\u003escenes of daily life in Cuba generally from between 1898 and 1960;\u003c/item\u003e\n      \u003citem\u003ethe 1952 dedication of the Camp Lazear National Monument in Cuba;\u003c/item\u003e\n      \u003citem\u003ethe creation and unveiling of Dean Cornwell's painting,\u003ctitle render=\"italic\"\u003eConquerors of Yellow Fever\u003c/title\u003e;\u003c/item\u003e\n      \u003citem\u003estill scenes from the movies,\u003ctitle render=\"italic\"\u003eYellow Jack\u003c/title\u003eand\u003ctitle render=\"italic\"\u003eJezebel\u003c/title\u003e;\u003c/item\u003e\n      \u003citem\u003eother events and works of art commemorating the work of the participants in the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003edocuments and maps that Philip Showalter Hench copied for his research;\u003c/item\u003e\n      \u003citem\u003eand Philip Showalter Hench and his family.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries IX. also includes a watercolor that was painted by Emilie Lawrence Reed.\u003c/p\u003e","\u003cp\u003e Series X. Photographic negatives consists of a mix of original and copy negatives that Philip Showalter Hench collected while researching the yellow fever experiments. Although the original images recorded on the negatives date from between the 1860s and the 1960s, it appears that the negatives themselves were produced during a narrower time frame, most likely between 1930 and 1966.\u003c/p\u003e","\u003cp\u003e The negatives in Series X. record images associated with the yellow fever experiments and many of them are related to photographic prints found in Series VIII. Where a match between a negative and a print from these series has been made, the negative number has been written on the folder of the print in the physical collection. Finally, the negatives are generally arranged in numerical order by identification numbers that were most likely assigned by Philip Showalter Hench.\u003c/p\u003e","\u003cp\u003e Series XI. Reprints consists of reprints and photocopies of journal articles, book extracts, book reviews and other published works that were primarily collected by Philip Showalter Hench while researching the yellow fever experiments. Items in this series date from 1856 to 1971 and cover a wide range of topics related to the study and eradication of yellow fever, including, but not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ethe results of the U.S. Army Yellow Fever Commission's work in Cuba;\u003c/item\u003e\n      \u003citem\u003ebiographical accounts of various people who had an association with the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ethe research of people associated with the experiments including Walter Reed, Jesse W. Lazear, Aristides Agramonte, and James Carroll;\u003c/item\u003e\n      \u003citem\u003escientific and medical research related to yellow fever and malaria;\u003c/item\u003e\n      \u003citem\u003eand events honoring the work of those involved with the yellow fever experiments.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries XII. Houston Academy of Medicine/Texas Medical Center additions consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1901 to around 1966. These materials were originally a part of the Philip S. Hench papers in the John P. McGovern Historical Collections and Research Center at the Texas Medical Center Library, but they were transferred to the University of Virginia in 1991. These items include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ecorrespondence between Philip Showalter Hench and people connected with the yellow fever experiments including John J. Moran and Walter Reed's children;\u003c/item\u003e\n      \u003citem\u003enewspaper clippings relating to the death or commemoration of individuals associated with the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ephotographs of the Camp Lazear Memorial, everyday scenes in Cuba, and John J. Moran;\u003c/item\u003e\n      \u003citem\u003eand journal articles, booklets, and other printed matter relating to the yellow fever experiments and its participants.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries XIII. Reed family additions consists of materials relating to the yellow fever experiments that several different donors gave to the University of Virginia. Items in the series date from around 1850 to 1967 with the bulk of the items dating from 1868 to 1949. The largest portion of the series is comprised of correspondence written by Walter Reed and his family between 1877 and 1902 that provide insights into their relationships and personal lives.\u003c/p\u003e","\u003cp\u003e In addition to the Reed family's correspondence, the series also contains other materials relating to the Reed family and the yellow fever experiments including, but not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ea flag that was flown over Camp Lazear;\u003c/item\u003e\n      \u003citem\u003enewspaper clippings and articles relating to the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ea chemistry notebook that was owned by Walter Reed;\u003c/item\u003e\n      \u003citem\u003ecorrespondence of and works by Philip Showalter Hench;\u003c/item\u003e\n      \u003citem\u003ean inventory of materials in Series XIII. and information about their accession into the Claude Moore Health Sciences Library;\u003c/item\u003e\n      \u003citem\u003eand materials from an exhibit on the yellow fever experiments that was hosted in Alderman Library at the University of Virginia.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries XIV. P. Kahler Hench additions consists of original and photocopied materials that Philip Showalter Hench's son, P. Kahler Hench, donated to the University of Virginia in 1988 and 1989. Items in the series date from around 1860 to 1965 with the bulk of the materials dating from 1898 to 1965. Most of these items were collected or created by Philip Showalter Hench while researching the yellow fever experiments. These items include the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ethe correspondence of experiment participants;\u003c/item\u003e\n      \u003citem\u003ecorrespondence between Philip Showalter Hench and the experiment participants;\u003c/item\u003e\n      \u003citem\u003ecorrespondence between Philip Showalter Hench and families of the experiment participants;\u003c/item\u003e\n      \u003citem\u003epress clippings relating to the experiments and the experiment participants;\u003c/item\u003e\n      \u003citem\u003eoral history interviews conducted by Philip Showalter Hench;\u003c/item\u003e\n      \u003citem\u003escientific articles related to the study of yellow fever;\u003c/item\u003e\n      \u003citem\u003ephotographs of Havana, Camp Columbia, and Camp Lazear;\u003c/item\u003e\n      \u003citem\u003egenealogical tables and summaries for the family of Jesse W. Lazear;\u003c/item\u003e\n      \u003citem\u003eautobiographical accounts written by experiment participants;\u003c/item\u003e\n      \u003citem\u003eunpublished manuscripts;\u003c/item\u003e\n      \u003citem\u003eartifacts (e.g. a wooden board) from Camp Lazear;\u003c/item\u003e\n      \u003citem\u003ePhilip Showalter Hench's research notes.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries XIV. also contains correspondence and financial records that record the transfer of collection items from the Reed family to Philip Showalter Hench and later from the Hench family to the University of Virginia.\u003c/p\u003e","\u003cp\u003e Series XV. Laura Wood primarily consists of Laura Wood's correspondence relating to her research for a Walter Reed biography that she wrote. The series also includes, but is not limited to the following materials:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ephotocopies of two letters written by Walter Reed;\u003c/item\u003e\n      \u003citem\u003ea journal article by George Sternberg;\u003c/item\u003e\n      \u003citem\u003eand a short work that Laura Wood wrote about Walter Reed entitled,\u003ctitle render=\"italic\"\u003eWalter Reed and yellow Fever\u003c/title\u003e.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eItems in Series XV. date from 1875 to 1946 with the bulk of the items dating from 1941 to 1946.\u003c/p\u003e","\u003cp\u003e Series XVI. Edward Hook additions consists of copies of letters, articles, and photographs relating to the yellow fever experiments that had been collected by Edward W. Hook, Jr, a professor of medicine at the University of Virginia. The bulk of this series is comprised of copies of a small collection of James Carroll's correspondence. The original versions of Carroll's correspondence are not housed at the University of Virginia. In addition to the Carroll letters, this series also includes, but is not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ephotographs of Walter Reed and others related to the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ecopies of some of Theodore E. Woodward's works relating to James Carroll and yellow fever;\u003c/item\u003e\n      \u003citem\u003eand exhibition materials.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eItems in Series XVI. date from around 1880 to around 1998 with the bulk of the items dating from 1898 to 1901.\u003c/p\u003e  "],"scopecontent_heading_ssm":["Scope and Content Information"],"scopecontent_tesim":["The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audio cassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). All of these materials are arranged in 16 series: I. Jesse W. Lazear, II. Henry Rose Carter, III. Walter Reed, IV. Philip Showalter Hench, V. Maps, VI. Alphabetical files, VII. Truby-Kean-Hench, VIII. Miscellany, IX. Photographs, X. Photographic negatives, XI. Reprints, XII. Houston Academy of Medicine/Texas Medical Center additions, XIII. Reed family additions, XIV. P. Kahler Hench additions, XV. Laura Wood, and XVI. Edward Hook additions.","Series I. Jesse W. Lazear consists of materials relating to Lazear that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1800 to 1956 with the bulk of the items dating from 1863 to 1943. Much of the series consists of the correspondence of Jesse W. Lazear and his wife Mabel H. Lazear. Jesse's correspondence dates from his time as a student at Johns Hopkins University to his death in 1900. Researchers can learn a great deal about Jesse from these letters, including his relationships with friends and family, his educational background, and his professional life. Mabel's correspondence dates from the time she met Jesse to her death in 1946. This correspondence primarily concern her husband's historical legacy and a campaign to secure a pension from the U.S. government for herself and her family.","In addition to Jesse and Mabel's correspondence, the series contains other materials relating to them and their families including, but not limited to the following:","the diaries documenting the travels of Jesse and Mabel's mothers in Europe;\n      correspondence of other Lazear family members (e.g. Jesse's parents);\n      genealogical summaries and tables relating to the Lazear family;\n      legal documents (e.g. wills, certificates, deeds);\n      military records relating to Jesse;\n      certificates, reports, and other materials documenting Jesse's educational background and achievements;\n      obituaries;\n      copies of congressional bills and reports concerning the provision of a federal pension for Mabel H. Lazear;\n      newspaper articles;\n      a microscope and sets of microscope slides owned by Jesse;\n      and a medical chart that shows the progression of the yellow fever infection that killed Jesse.","Series II. Henry Rose Carter consists of materials relating to Henry Rose Carter that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1880 to 1932 with the bulk of the materials dating from 1883 to 1932. The series is particularly rich in materials that document Henry Rose Carter's professional activities in the last eleven years of his life (1914-1925). These materials include, but are not limited to the following:","correspondence with colleagues in the medical and scientific community including Rupert E. Blue, Hideyo Noguchi, Henry Hanson, Joseph A. LePrince, Frederick F. Russell, T.H.D. Griffitts, and Lunsford D. Fricks;\n      scientific, medical, and government reports relating to the study and eradication of yellow fever and malaria in North America, South America, and Africa;\n      journal articles concerning the study and eradication of yellow fever and malaria;\n      research notes written by Henry Rose Carter;\n      and photographs of Henry Rose Carter at work and with professional colleagues.","Series II. also contains correspondence between Henry Rose Carter and members of his family that date from 1880 to 1925. The family members with whom Henry corresponds most frequently in this series are his mother, Emma Coleman Carter; his wife, Laura Eugenia Hook Carter; his daughter, Laura Armistead Carter; and his son, Henry Rose Carter, Jr. These letters are not only a rich source of information about Carter's personal views and family life, they also provide valuable insights into his professional activities such as his experiences aboard vessels and in ports while working for the U.S. Marine Hospital Service and his public health work in Cuba, Panama, and Peru.","In addition to the materials that were produced during Henry Rose Carter's lifetime, the Series II. contains materials that were produced between 1925 and 1940 (after Henry Rose Carter's death) including, but not limited to the following:","copies of obituaries for Henry Rose Carter;\n      condolence letters for Henry Rose Carter's family after Henry's death;\n      and the correspondence of Laura Armistead Carter relating to her father and other members of the Carter family.","Series III. Walter Reed consists of materials that document the life of Walter Reed as well as the work and legacy of the U.S. Army Yellow Fever Commission. Items in the series date from 1806 to around 1955 with the bulk of the items dating from 1874 to 1936. The series is particularly rich in materials that document the professional and personal life of Walter Reed from 1874 to his death in 1902. These materials include, but are not limited to the following:","correspondence between Walter Reed and members of his immediate family that cover a wide range of topics including Reed's courtship of Emilie Lawrence Reed, family life, Walter Reed's work in the Western United States, and Walter Reed's work in Cuba;\n      military records relating to Walter Reed including military orders for Reed, Reed's performance reviews, and reports of Reed's work for army officials;\n      Walter Reed's correspondence with professional colleagues including members of the U.S. Army Yellow Fever Commission, military doctors, and medical researchers interested in the study of yellow fever;\n      medical records (e.g. fever charts of experiment participants), military orders, administrative records, reports, and publications documenting the results of the U.S. Army Yellow Fever Commission's experiments in Cuba;\n      articles announcing the death of Walter Reed;\n      and the shoulder boards from Walter Reed's U.S. Army uniform.","In addition to the above items, Series III. contains materials that document campaigns, spanning from 1902 to 1937, to publicly honor members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments. These materials include, but are not limited to the following:","articles and editorials relating to efforts to memorialize and provide pensions for members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments;\n      biographical sketches of members of the U.S. Army Yellow Fever Commission and experiment participants;\n      records relating to the Walter Reed Memorial Association (e.g. correspondence, donor lists);\n      copies of Congressional bills and resolutions to honor members of the U.S. Army Yellow Fever Commission and experiment participants;\n      and letters, reviews, and other materials relating to the production of Sidney Coe Howard's play,Yellow Jack.","Finally, Series III. also consists of materials that document the history of yellow fever during the nineteenth and early twentieth century. These materials include, but are not limited to the following:","items (e.g. correspondence, reports, reviews, and articles) relating to U.S. efforts to eradicate yellow fever in the Panama Canal Zone;\n      materials (e.g. correspondence, reports, and articles) documenting early twentieth century efforts to eradicate yellow fever in Peru;\n      scientific reports and publications related to the study and eradication of yellow fever and malaria;\n      and newspaper articles describing various outbreaks of yellow fever epidemics.","Series IV. Philip Showalter Hench primarily consists of materials that Hench created or collected while researching the U.S. Army Yellow Fever Commission. Items in this series date from around 1850 to around 1865 with the bulk of the items dating from 1937 to 1960. Researchers who are studying the yellow fever experiments will be particularly interested in the materials (e.g. interviews, autobiographies) that document first-hand accounts of the events surrounding the experiments. Other researchers may be interested in items that document Hench's role in shaping public memory of the commission and its experiments. The materials in this series include, but are not limited to the following:","Hench's correspondence and interviews with participants in the yellow fever experiments and their families including: Emilie Lawrence Reed, Emilie M. (Blossom) Reed, Walter Lawrence Reed, John J. Moran, Albert E. Truby, Jefferson Randolph Kean, John H. Andrus, and John R. Kissinger;\n      autobiographical accounts of the experiment's participants and their families;\n      notes, reports, correspondence and other materials relating to Hench's search for the original site of Camp Lazear in Cuba;\n      correspondence with Cuban government officials and members of the scientific community relating to Hench's campaign to build a Camp Lazear memorial;\n      correspondence and other materials relating to ceremonies honoring Jesse W. Lazear at Washington and Jefferson College;\n      newspaper articles, magazine articles, and other printed matter concerning the yellow fever experiments and its participants;\n      drafts of speeches and presentations Hench gave on the history of the yellow fever experiments to various audiences;\n      meeting minutes and other materials that document Hench's relationship with and participation in the Walter Reed Memorial Association;\n      scripts for radio programs relating to the yellow fever experiments;\n      notes, outlines, lists, correspondence, and other materials that document Hench's research about the yellow fever experiments and a book he had planned to write on the subject;\n      and the gold medal that Congress posthumously awarded to Walter Reed for his work with yellow fever.","Series V. Maps primarily consists of maps and floor plans that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1960 with the bulk of the items dating from 1899 to 1951. The maps and floor plans often include annotations and illustrate a wide range of locations including, but not limited to the following:","Havana and its environs;\n      Cuba;\n      sites associated with the yellow fever experiments;\n      and military installations in the United States.","In addition to the maps and floor plans, Series V. also consists of a few newspaper and magazine clippings that contain information relating to the yellow fever experiments.","Series VI. Alphabetical files primarily consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1860 to around 1966 with the bulk of the items dating from 1940 to 1956. All of these items have been arranged thematically into biographical files. Each file contains materials created by or relating to people who were either involved with the yellow fever experiments or aided Philip Showalter Hench in his research of the subject. These people include, but are not limited to: John J. Moran, Carlos E. Finlay, Laura Wood Roper, Mabel Lazear, Clara Maas, John R. Kissinger, Roger Post Ames, James C. Carroll, and Carlos J. Finlay. The files are arranged alphabetically by the last names of the individuals listed on the files and it is unclear whether the overall arrangement was made by Hench or by staff members at the University of Virginia. The biographical files contain a wide range of different materials that pertain to the individuals listed on the files. These materials include, but are not limited to the following:","correspondence between Philip Showalter Hench and the individuals;\n      other correspondence;\n      newspaper and magazine clippings;\n      unpublished manuscripts;\n      biographical and autobiographical accounts;\n      transcripts of oral history interviews that were conducted by Philip Showalter Hench;\n      and copies of medical charts for volunteers in the yellow fever experiments that shows the progression of the disease.","In addition to the materials that Hench created or collected during his lifetime, the biographical files in Series VI. also contain items that were added by staff at the University of Virginia Library during the late 1960s and early 1970s.","Series VII. Truby-Kean-Hench primarily consists of materials relating to Albert E. Truby and Jefferson Randolph Kean that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1879 to around 1960 with the bulk of the items dating from 1900 to 1954. These items include, but are not limited to the following:","correspondence of Jefferson Randolph Kean dating from 1900 to 1950 that relates to his personal life, the yellow fever experiments, public health initiatives, his publications, the legacy of the yellow fever experiments, Kean's work in World War I, and other topics;\n      Philip Showalter Hench's correspondence with people related to the yellow fever experiments, particularly Albert E. Truby and Jefferson Randolph Kean primarily from between 1940 and 1955;\n      a scrapbook and other materials that relate to Truby's book,Memoir of Walter Reed: the Yellow Fever Episode;\n      and Philip Showalter Hench's interviews and questionnaires for Kean and Truby from the 1940s.","In addition to the materials relating to Kean and Truby, Series VII. also includes the following:","notes from Philip Showalter Hench's research of the yellow fever experiments;\n      the recollections, autobiographies, and reports of other people involved with the yellow fever experiments including John Andrus and A.S. Pinto;\n      articles and clippings related to the yellow fever experiments;\n      a short biography of Lemuel S. Reed;\n      and a sketch Philip Showalter Hench made of a proposed museum at the Camp Lazear site.","Series VIII. Miscellany consists of oversize and miscellaneous materials in the Philip S. Hench Walter Reed yellow fever collection that were, for various reasons, not included in any of the other series in the collection. Items in this series date from around 1849 to 1982 with the bulk of the materials dating from 1885 to 1974. These materials include, but are not limited to the following:","informed consent agreements for volunteers in the yellow fever experiments;\n      diplomas and certificates for Walter Reed and Jesse W. Lazear;\n      copies and sketches of Dean Cornwell's painting,Conquerors of Yellow Fever;\n      artifacts, including a wooden board from Camp Lazear and a U.S. flag;\n      copies of correspondence, reports, medical records, and military orders from the U.S. National Archives relating to the yellow fever experiments;\n      manuscripts and related notes for published works and research relating to Walter Reed and the yellow fever experiments;\n      correspondence of Philip Showalter Hench from circa 1940 to 1966;\n      articles and clippings relating to the yellow fever experiments, the experiments' participants, and the Philip S. Hench Walter Reed yellow fever collection;\n      correspondence of Atcheson Laughlin Hench and members of the University of Virginia community relating to the Philip S. Hench Walter Reed yellow fever collection;\n      items that document the provenance and custodial history of some materials in the Philip S. Hench Walter Reed yellow fever collection;\n      photographs relating to Cuba and the yellow fever experiments;\n      notes for photographs and photographic negatives housed in Series IX. and Series X. of this collection.","Series IX. Photographs consists primarily of photographs that Philip Showalter Hench created and collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1966 with the bulk of the items dating from around 1870 to around 1960. The subjects shown in the photographs include, but are not limited to the following:","physicians, military personnel, nurses, and volunteers associated with the experiments including Walter Reed, Jesse W. Lazear, Jefferson Randolph Kean, and Aristides Agramonte;\n      family members of people associated with the yellow fever experiments including their spouses, children, and grandchildren.\n      Camp Lazear, Camp Columbia, and other locations in Cuba related to the yellow fever experiments between 1900 and 1960;\n      the U.S.S.Maineand the Spanish-American War;\n      aerial views of Havana, Cuba and its environs from the 1940s and 1950s;\n      scenes of daily life in Cuba generally from between 1898 and 1960;\n      the 1952 dedication of the Camp Lazear National Monument in Cuba;\n      the creation and unveiling of Dean Cornwell's painting,Conquerors of Yellow Fever;\n      still scenes from the movies,Yellow JackandJezebel;\n      other events and works of art commemorating the work of the participants in the yellow fever experiments;\n      documents and maps that Philip Showalter Hench copied for his research;\n      and Philip Showalter Hench and his family.","Series IX. also includes a watercolor that was painted by Emilie Lawrence Reed.","Series X. Photographic negatives consists of a mix of original and copy negatives that Philip Showalter Hench collected while researching the yellow fever experiments. Although the original images recorded on the negatives date from between the 1860s and the 1960s, it appears that the negatives themselves were produced during a narrower time frame, most likely between 1930 and 1966.","The negatives in Series X. record images associated with the yellow fever experiments and many of them are related to photographic prints found in Series VIII. Where a match between a negative and a print from these series has been made, the negative number has been written on the folder of the print in the physical collection. Finally, the negatives are generally arranged in numerical order by identification numbers that were most likely assigned by Philip Showalter Hench.","Series XI. Reprints consists of reprints and photocopies of journal articles, book extracts, book reviews and other published works that were primarily collected by Philip Showalter Hench while researching the yellow fever experiments. Items in this series date from 1856 to 1971 and cover a wide range of topics related to the study and eradication of yellow fever, including, but not limited to the following:","the results of the U.S. Army Yellow Fever Commission's work in Cuba;\n      biographical accounts of various people who had an association with the yellow fever experiments;\n      the research of people associated with the experiments including Walter Reed, Jesse W. Lazear, Aristides Agramonte, and James Carroll;\n      scientific and medical research related to yellow fever and malaria;\n      and events honoring the work of those involved with the yellow fever experiments.","Series XII. Houston Academy of Medicine/Texas Medical Center additions consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1901 to around 1966. These materials were originally a part of the Philip S. Hench papers in the John P. McGovern Historical Collections and Research Center at the Texas Medical Center Library, but they were transferred to the University of Virginia in 1991. These items include, but are not limited to the following:","correspondence between Philip Showalter Hench and people connected with the yellow fever experiments including John J. Moran and Walter Reed's children;\n      newspaper clippings relating to the death or commemoration of individuals associated with the yellow fever experiments;\n      photographs of the Camp Lazear Memorial, everyday scenes in Cuba, and John J. Moran;\n      and journal articles, booklets, and other printed matter relating to the yellow fever experiments and its participants.","Series XIII. Reed family additions consists of materials relating to the yellow fever experiments that several different donors gave to the University of Virginia. Items in the series date from around 1850 to 1967 with the bulk of the items dating from 1868 to 1949. The largest portion of the series is comprised of correspondence written by Walter Reed and his family between 1877 and 1902 that provide insights into their relationships and personal lives.","In addition to the Reed family's correspondence, the series also contains other materials relating to the Reed family and the yellow fever experiments including, but not limited to the following:","a flag that was flown over Camp Lazear;\n      newspaper clippings and articles relating to the yellow fever experiments;\n      a chemistry notebook that was owned by Walter Reed;\n      correspondence of and works by Philip Showalter Hench;\n      an inventory of materials in Series XIII. and information about their accession into the Claude Moore Health Sciences Library;\n      and materials from an exhibit on the yellow fever experiments that was hosted in Alderman Library at the University of Virginia.","Series XIV. P. Kahler Hench additions consists of original and photocopied materials that Philip Showalter Hench's son, P. Kahler Hench, donated to the University of Virginia in 1988 and 1989. Items in the series date from around 1860 to 1965 with the bulk of the materials dating from 1898 to 1965. Most of these items were collected or created by Philip Showalter Hench while researching the yellow fever experiments. These items include the following:","the correspondence of experiment participants;\n      correspondence between Philip Showalter Hench and the experiment participants;\n      correspondence between Philip Showalter Hench and families of the experiment participants;\n      press clippings relating to the experiments and the experiment participants;\n      oral history interviews conducted by Philip Showalter Hench;\n      scientific articles related to the study of yellow fever;\n      photographs of Havana, Camp Columbia, and Camp Lazear;\n      genealogical tables and summaries for the family of Jesse W. Lazear;\n      autobiographical accounts written by experiment participants;\n      unpublished manuscripts;\n      artifacts (e.g. a wooden board) from Camp Lazear;\n      Philip Showalter Hench's research notes.","Series XIV. also contains correspondence and financial records that record the transfer of collection items from the Reed family to Philip Showalter Hench and later from the Hench family to the University of Virginia.","Series XV. Laura Wood primarily consists of Laura Wood's correspondence relating to her research for a Walter Reed biography that she wrote. The series also includes, but is not limited to the following materials:","photocopies of two letters written by Walter Reed;\n      a journal article by George Sternberg;\n      and a short work that Laura Wood wrote about Walter Reed entitled,Walter Reed and yellow Fever.","Items in Series XV. date from 1875 to 1946 with the bulk of the items dating from 1941 to 1946.","Series XVI. Edward Hook additions consists of copies of letters, articles, and photographs relating to the yellow fever experiments that had been collected by Edward W. Hook, Jr, a professor of medicine at the University of Virginia. The bulk of this series is comprised of copies of a small collection of James Carroll's correspondence. The original versions of Carroll's correspondence are not housed at the University of Virginia. In addition to the Carroll letters, this series also includes, but is not limited to the following:","photographs of Walter Reed and others related to the yellow fever experiments;\n      copies of some of Theodore E. Woodward's works relating to James Carroll and yellow fever;\n      and exhibition materials.","Items in Series XVI. date from around 1880 to around 1998 with the bulk of the items dating from 1898 to 1901."],"userestrict_html_tesm":["\u003cp\u003eCopyright restrictions may apply for some materials in the collection.\u003c/p\u003e  "],"userestrict_heading_ssm":["Copyright Status"],"userestrict_tesim":["Copyright restrictions may apply for some materials in the collection."],"abstract_html_tesm":["\u003cabstract id=\"aspace_98fe81a152b4be0b7388b1814ffaf4bd\"\u003eThe Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audiocassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). Most of the materials in the collection were collected or created by Nobel laureate Philip Showalter Hench while researching the history of the U.S. Army Yellow Fever Commission.\u003c/abstract\u003e\n    "],"abstract_tesim":["The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audiocassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). Most of the materials in the collection were collected or created by Nobel laureate Philip Showalter Hench while researching the history of the U.S. Army Yellow Fever Commission."],"corpname_ssim":["Claude Moore Health Sciences Library"],"names_ssim":["Claude Moore Health Sciences Library"],"language_ssim":["Collection is predominantly in English; other materials in the collection are in Spanish, French, and Portuguese."],"descrules_ssm":["Describing Archives: A Content Standard"],"total_component_count_is":10452,"online_item_count_is":0,"component_level_isim":[0],"sort_isi":0,"timestamp":"2026-08-14T22:54:59.526Z","bioghist_html_tesm":["\u003cp\u003eThe U.S. Army Yellow Fever Commission (1900-1901) was a board of physicians that the U.S. government formed in order to determine how yellow fever was transmitted between hosts. Ultimately, the commission's experiments in Cuba proved that mosquitoes transmit yellow fever--a discovery that would spur successful campaigns to control and eradicate yellow fever throughout much of the globe.\u003c/p\u003e","\u003cp\u003e When Major Walter Reed and Acting Assistant Surgeons James Carroll, Aristides Agramonte, and Jesse Lazear gathered on the porch of the Columbia Barracks Hospital in June of 1900, they became the fourth successive board of U.S. medical officers to grapple with the appalling plague that was yellow fever.\u003c/p\u003e","\u003cp\u003e The persistence of this disease across the Cuban archipelago and its periodic re-emergence along the coastlines and great river drainages of the Americas was taking countless thousands of lives. Lack of precise knowledge as to its cause and transmission had augmented yellow fever's extraordinarily high mortality rate and had given rise to quarantine regulations which constituted substantial impediments to efficient regional trade. Endemic in the tropics, yellow fever imposed high humanitarian and economic costs upon the entire region. Specialists regarded Cuba as one of the principal foci of the disease, and the island consequently attracted considerable attention from the medical sciences.\u003c/p\u003e","\u003cp\u003e In 1879, one year after a devastating epidemic swept up the Mississippi valley from New Orleans, Tulane University Professor Stanford E. Chaille led the first investigatory commission to Havana, Rio de Janeiro, and the West Indies. The Chaille Commission remained in Havana three months, and its members -- including George Miller Sternberg, who became Surgeon General of the Army, and Juan Guiteras, later Director of Public Health for Havana -- consulted with Cuban scientist Carlos J. Finlay. They concluded that the causal agent for yellow fever was possibly a living entity in the atmosphere, an assertion which set Finlay on the path to the mosquito theory he developed in 1881.\u003c/p\u003e","\u003cp\u003e Louis Pasteur's foundational and highly successful work in modern immunology in 1880 and 1881 gave a renewed impetus to investigations aimed at discovering the \"yellow fever germ.\" Over the middle years of the 1880s several scientists advanced different theories, all readily refuted by bacteriological work Sternberg undertook in Brazil and Mexico in 1887 and again in Havana in 1888 and 1889. In 1897, Italian scientist Giuseppe Sanarelli argued that\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003ewas the culprit, and the following year a third scientific team sailed to Cuba for additional tests. Eugene Wasdin and Henry D. Geddings appeared to confirm Sanarelli's assertion, though Sternberg, by then Surgeon General, remained skeptical.\u003c/p\u003e","\u003cp\u003e Despite Wasdin and Geddings' insistence, the\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003etheory garnered significant opposition. In fact, a few months before the third commission's report reached the public, Walter Reed and James Carroll -- Reed's assistant at the Columbian University (later George Washington University) bacteriology laboratories in Washington, D.C. -- published a thorough refutation of the\u003cemph render=\"italic\"\u003eicteroides\u003c/emph\u003eproposal: the bacteria was not a unique cause of yellow fever, but a variety of the hog cholera bacillus, \"a secondary invader in yellow fever,\" Reed determined, unrelated to its etiology. [1] Dispute continued, however, and when Sternberg organized the fourth investigatory board, he charged Reed and his associates to settle the\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003equestion once and for all, then to proceed with analysis of other blood cultures and intestinal flora from yellow fever cases.\u003c/p\u003e","\u003cp\u003e Reed and Carroll had considerable experience in bacteriological analysis, and, Sternberg reasoned, might well be able to find the specific agent of the disease. Aristides Agramonte, a Cuban scientist who had worked in Reed's lab at the Columbian University in 1898, was also an accomplished bacteriologist; he had identified\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003ein tissue samples from cases other than yellow fever, providing further evidence opposed to Sanarelli's thesis. Jesse Lazear, a scientist from Johns Hopkins University in Baltimore, Maryland, had joined the Army Medical Corps to study tropical diseases at their point of origin; he received orders for Cuba in February 1900. Lazear impressed Reed with his abilities when the two men became acquainted in March. No doubt with Reed's advice, Sternberg assembled a crack team -- all experienced in scientific research, but each with interests as diverse as their temperaments. The mix of talent and personalities generated spectacular results.\u003c/p\u003e","\u003cp\u003e What causes yellow fever? This simple, even obvious question had dictated yellow fever research for over two decades, and so it guided Reed in organizing the work of the commission.\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003eand other bacteriological sampling dominated their work for the first months. \"Reed and Carroll have been at that for a long time,\" Lazear wrote with some impatience to his wife on August 23, \". . . I would rather try to find the germ without bothering about Sanarelli.\" [2] Again and again, tests for the bacteria proved negative, and at the same time, perplexing cases of yellow fever were developing in the region. Agramonte and Reed investigated an epidemic at Pinar del Rio, 110 miles southwest of Havana; Lazear followed later to collect more specimens, and he also assessed the situation at Guanjay thirty miles southwest. To \"my very great surprise,\" Reed admitted, the specific circumstances of the appearance and development of these cases gave strong evidence against the widely-accepted notion that the excreta of patients spread the disease. The theory of fomites -- infection from contaminated clothing and bedding -- and indeed even infection from airborne particles seemed altogether untrue. \"At this stage of our investigation,\" Reed concluded, \". . . the time had arrived when the plan of our work should be radically changed.\" [3] The fundamental question underwent a subtle but critical transformation: from what causes yellow fever to what transmits it. A clear and accurate understanding of how the disease was spread would open a new avenue to its specific cause.\u003c/p\u003e","\u003cp\u003e \"Personally, I feel that only can experimentation on human beings serve to clear the field for further effective work,\" Reed stated to Surgeon General Sternberg, who concurred. [4] Evidence gathering around them pointed strongly to an intermediate host, and the Commission resolved to test Carlos Finlay's mosquito theory -- then not generally accepted -- on human volunteers. Nine times from August 11 to August 25, 1900, mosquitoes landed on the arms of volunteers and proceeded to feed. Nine times the results were negative. On August 27, Lazear placed a mosquito on the doubting Dr. Carroll, and four days later on William J. Dean, a soldier designated XY in the \"Preliminary Note.\" [5] Both promptly developed yellow fever. Significantly, their mosquitoes had fed on cases within the initial three days of an attack and had been allowed to ripen for at least twelve days before the inoculations. Carroll vitiated the results of his experimental sickness by traveling off the post to Havana, a contaminated zone, even as Reed, ecstatic, wrote from Washington in a confidential letter: \"Did the Mosquito do it?\" [6] Dean's case seemed to prove it, since he claimed not to have left the garrison before becoming ill. Lazear also developed a case of yellow fever, almost certainly experimental in origin, though he never revealed the actual circumstances of his inoculation. His severe bout of fever took a fatal turn on September 25, 1900.\u003c/p\u003e","\u003cp\u003e Nevertheless, these results could not have been more dramatic or convincing for the Commission. Reed quickly assembled a \"Preliminary Note,\" which he presented to the annual meeting of the American Public Health Association in Indianapolis, Indiana, October 23, 1900. After initial consultations in Cuba with General Leonard Wood, military governor of the island, and with Surgeon General Sternberg in Washington, he returned to Cuba with authorization and funding to design and carry forward a fully defensible series of experiments. His aim was confirmation of the mosquito theory and invalidation of the long-held belief in fomites.\u003c/p\u003e","\u003cp\u003e On open terrain beyond the precincts of Columbia Barracks -- the American military base just west of Havana near the adjacent suburban towns of Quemados and Marianao (also called Quemados de Marianao) -- Reed established the quarantined experimental station. Camp Lazear, as the Commission dedicated it, took form in the rolling fields of the Finca San Jose, on the farm of Dr. Ignacio Rojas, who leased the land to the Americans. Here Reed designed two small wood-frame buildings, each 14 by 20 feet, for the experimental work, and nearby raised a group of seven tents for the accommodation and support of the volunteers. The buildings faced each other across a small swale, about 80 yards apart, and stood 75 yards from the tent encampment. Building Number One, called the Infected Clothing Building, was a single room tightly constructed to contain as much foul air as possible. A small stove kept the temperature and humidity at tropical levels, and carefully attached screening secured the pair of doorways in a vestibule against intrusion by mosquitoes. Wooden blinds on two small sealed windows shielded the room from direct sun. Building Number Two, the Infected Mosquito Building, contained a principal room, divided into two sections by a floor-to-ceiling wire mesh screen. A door direct to the exterior let into one section, while a vestibule with a solid exterior door and pair of successive screened doors opened to the other, so configured to keep infected mosquitoes inside that section alone. The spare furnishings in both sections -- cots with bedding -- were steam sterilized. Windows exposed the entire room to the clean, steady ocean breezes and to sunlight. Like the doorways, they were carefully screened. A secondary room attached to the building but not communicating with the experimental spaces sheltered the small, heated laboratory where the Commission members raised and stored the mosquitoes to be used.\u003c/p\u003e","\u003cp\u003e These two experimental buildings presented alternate environments -- one conspicuously clean and well ventilated, the other filthy and fetid. Contemporary theories of disease held that yellow fever developed in unclean conditions, and consequently much time and money had been devoted to sanitation projects. Workers steamed clothing, burned sulphur in ships' holds, and thoroughly scrubbed surfaces with disinfectant. In cases of severe epidemic, entire buildings presumed to be infected were set afire along with their contents. Thus the extraordinary -- and intentional -- paradox of the Commission's experimental regime: Reed expected yellow fever to develop not in the unsanitary environment, but in the one thought to be most healthful.\u003c/p\u003e","\u003cp\u003e Camp Lazear went into quarantine the day of its completion, November 20, 1900, with a command of four immune and nine non-immune individuals, all save one U.S. Army personnel. Soon a group of recent Spanish immigrants to Cuba augmented the non-immune numbers, bringing the resident total to about twenty. Reed strictly controlled access to the camp and ordered regular temperature recording for each volunteer to eliminate any unanticipated source of infection and to identify the onset of any case of yellow fever as early as possible. As a result, non-immunes were barred from returning should they leave the precinct, and two of the Spaniards who developed intermittent fevers shortly after arrival were immediately transferred with their baggage to Columbia Barracks Hospital. The immune members of the detachment oversaw medical treatments and drove the teams of mules that pulled supply wagons and the ambulance. Experimentation did not begin until each volunteer had passed the incubation period for yellow fever in perfect health.\u003c/p\u003e","\u003cp\u003e Reed took as much care with the design of the experimental protocol as he had with the configuration of the camp and its buildings. Each evening, the occupants of the infected clothing building unpacked trunks and boxes of bed linens and blankets, nightshirts and other clothing recently worn and soiled by cases from the wards of Columbia Barracks Hospital and Las Animas Hospital in Havana. These they shook out and spread around the room to permeate the atmosphere. The stench was overpowering. Yellow fever causes severe internal hemorrhaging, and its unfortunate victims often suffer from black vomit and other bloody discharges. One routine delivery proved so putrid the volunteers \"retreated from the house,\" Reed stated. \"They pluckily returned, however, within a short time, and spent the night as usual.\" [7] In two succeeding trials the protocol became progressively more daring , as the volunteers then wore the clothing and slept on the mattresses used by yellow fever patients, and finally put towels on their bedding smeared with blood drawn from cases in the early stages of an attack. Each morning, the volunteers carefully repacked the rank, encrusted materials into boxes and emerged to an adjacent tent where they spent the day quarantined from the rest of the company. Three trials of twenty days each involved seven men altogether, lead by Robert P. Cooke, a physician in the Army Medical Corps. None developed yellow fever.\u003c/p\u003e","\u003cp\u003e The Commission's mosquito experiments proceeded in four series. First, Reed sought to demonstrate that mosquitoes of the variety\u003cemph render=\"italic\"\u003eCulex fasciata\u003c/emph\u003e(later called\u003cemph render=\"italic\"\u003eStegomyia fasciata\u003c/emph\u003e, and later still\u003cemph render=\"italic\"\u003eAedes aegypti\u003c/emph\u003e) could in fact transmit yellow fever, as Carlos J. Finlay had argued and the initial experiments at Camp Columbia strongly suggested. Here the Commission members simply applied infected mosquitoes contained in test tubes or jars to the skin of the initial volunteers. Success in these tests raised a number of questions, each one addressed in the subsequent series:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003eHow could a building become infected?\u003c/item\u003e\n      \u003citem\u003eWhen does a mosquito develop the ability to transmit the disease?\u003c/item\u003e\n      \u003citem\u003eOver what length of time can a mosquito retain this capacity to infect?\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eThe second series consequently employed the specialized \"Infected Mosquito Building\" to indicate how a structure could be considered infected with yellow fever. This experiment required two groups of volunteers, one to be inoculated and another to serve as controls. \"Loaded\" mosquitoes, as the men called them, were released into the screened section of Building Two -- on the side with the protected vestibule entry. One or more non-immune men then entered the opposite section of the room through the direct exterior door, and lay down on bunks adjacent to the wire mesh screen in the center of the room. Now the young man to be inoculated walked through the vestibule into the mosquito side of the room and proceeded to lie on a bunk adjacent to the wire screen separating him from the controls. The inoculation volunteer remained in the building for about twenty minutes -- enough time to suffer several mosquito bites -- he then exited to a quarantine tent outside. The controls spent the remainder of the evening and night in the uninfected side of the room, and indeed returned to sleep in the room for as many as eighteen more nights. As Reed stated, absence of yellow fever in the controls showed \"that the essential factor in the infection of a building with yellow fever is the presence therein of [infected] mosquitoes,\" and nothing more. [8] The degree of sanitation, so long considered critical, was utterly irrelevant.\u003c/p\u003e","\u003cp\u003e The third series of mosquito experiments confirmed what Henry Rose Carter, of the U.S. Public Health Service, called the \"period of extrinsic incubation,\" [9] the length of time required for secondary cases of yellow fever to develop after an initial intrusion of the disease into a locality. In this series, a single volunteer underwent three successive inoculations by the same mosquitoes, each group of inoculations interrupted by a period of time equal in length to the typical incubation period of the disease in humans, about five days. In this manner, the volunteer's illness could be specifically attributed to a single inoculation group. The use of the same mosquitoes and the same volunteer concurrently demonstrated that no peculiar personal immunity was at play, since logic dictates that a person susceptible to yellow fever on day 17 of a mosquito's contamination -- as happened in the experiment -- could not have been immune to yellow fever on day 11 or day 4. It was thus only the mosquito's capacity to infect which changed, and that occurred no less than 11 days after contamination.\u003c/p\u003e","\u003cp\u003e The duration of time over which these \"fully ripened\" mosquitoes remained infective comprised the fourth series of experiments. For this series the Commission kept alive a group of infected mosquitoes for as long as possible, and proceeded to inoculate three volunteers -- on the 39th, 51st, and 57th day after contamination. Each developed yellow fever. A fourth volunteer declined to be bitten on day 65, and the last two mosquitoes of the group, \"deprived of further opportunity to feed on human blood\" [10] expired on day 69 and day 71, clear evidence that even a sparsely populated region may retain the potential for new infections more than two months after the first appearance of the disease.\u003c/p\u003e","\u003cp\u003e Although it went unrecorded in the published papers, Reed organized a supplemental experiment to test another species of mosquito.\u003cemph render=\"italic\"\u003eCulex pungens\u003c/emph\u003efailed to transmit yellow fever to at least one volunteer and probably to a second. Reed's preliminary conclusions indicated that\u003cemph render=\"italic\"\u003eCulex fasciata\u003c/emph\u003ewas the only species capable of transmitting yellow fever. [11]\u003c/p\u003e","\u003cp\u003e A last experimental regime involved subcutaneous injections of blood from positive cases of yellow fever to presumed non-immunes. Reed devised these tests to confirm the presence of the yellow fever agent in the blood of a victim during the first days of an attack, and, more importantly, to settle the\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003equestion. The same blood cultures which produced yellow fever in four volunteers also failed to grow any\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003e, conclusively invalidating Sanarelli's claim.\u003c/p\u003e","\u003cp\u003e Altogether, the mosquito inoculations and the blood injections produced fourteen cases of yellow fever. All made a full recovery.\u003c/p\u003e","\u003cp\u003e Notwithstanding the decisive medical victory -- as Reed declared, \"aside from the antitoxin of Diptheria and Koch's discovery of the tubercle bacillus, it will be regarded as the most important piece of work, scientifically, during the 19th century\" [12] -- success at Camp Lazear unfolded in its own time. Initially, Reed observed, \"the results obtained at this station were not encouraging.\" [13] The first inoculations of four volunteers over a period of two weeks proved disconcertingly negative each time. Then, on December 5, 1900, private John R. Kissinger presented his arm to the mosquitoes, and late in the evening on December 8, suffered the first chills of \"a well-marked attack of yellow fever.\" [14] Three more men in rapid succession fell victim to the insects -- Spanish volunteers Antonio Benigno, Nicanor Fernandez, and Vicente Presedo. The force of the conclusions was evident to everyone:\u003c/p\u003e","\u003cp\u003e \"It can readily be imagined,\" Reed empathetically and wryly described in his first presentation of the experiments, \"that the concurrence of 4 cases of yellow fever in our small command of 12 non-immunes within the space of 1 week, while giving rise to feelings of exultation in the hearts of the experimenters, in view of the vast importance attaching to these results, might inspire quite other sentiments in the bosoms of those who had previously consented to submit themselves to the mosquito's bite. In fact, several of our good-natured Spanish friends who had jokingly compared our mosquitoes to 'the little flies that buzzed harmlessly about their tables,' suddenly appeared to lose all interest in the progress of science, and, forgetting for the moment even their own personal aggrandizement, incontinently severed their connection with Camp Lazear. Personally, while lamenting to some extent their departure, I could not but feel that in placing themselves beyond our control they were exercising the soundest judgment.\"\u003c/p\u003e","\u003cp\u003e \"In striking contrast,\" Reed continued, the anxiety of the fomites volunteers began to melt into relief. \"[T]he countenances of these men, which had before borne the serious aspect of those who were bravely facing an unseen foe, suddenly took on the glad expression of 'schoolboys let out for a holiday,' and from this time their contempt for 'fomites' could not find sufficient expression. Thus illustrating once more, gentlemen, the old adage that familiarity, even with fomites, may breed contempt.\" [15]\u003c/p\u003e","\u003cp\u003e The question of human experimentation was indeed a serious one -- unavoidable, in actuality, as Reed had stated the previous summer to Surgeon General Sternberg. When the Commission first considered a trial of Finlay's mosquito theory, Reed, Carroll, and Lazear agreed to experiment on themselves. Agramonte, a native Cuban, had acquired immunity as a child. Doubtless Finlay's experience of many unsuccessful inoculations communicated that positive results would not be forthcoming rapidly, so before the first series of inoculations began under Lazear's direction at Columbia Barracks, Reed left Cuba for Washington, where he completed a monumental report on typhoid fever among the army corps -- left unfinished by the sudden death of co-author Edward O. Shakespeare. Carroll and Lazear both sickened while Reed was in Washington, and Lazear, young and strong, had no reason to anticipate that his case would be fatal. Reed was shocked at Lazear's death, and because of his own age -- 49, a decade and a half older than Lazear and a dozen years older than Carroll -- he resolved not to inoculate himself when he returned to Cuba on October 4, 1900. The point had already been amply demonstrated, and only a rigidly controlled experimental regime would establish the necessary proof. Carroll, however, remained embittered about this for the remainder of his life, though he evidently never communicated his objections directly to Reed.\u003c/p\u003e","\u003cp\u003e That initial series of mosquito inoculations was probably accomplished without formal documentation of informed consent. Indeed, the experiments may also have been carried forward without the full knowledge of the commanding officer of Camp Columbia, and Reed consequently shielded the identity of Private William J. Dean, the second positive experimental case, behind the pseudonym \"XY\" in the \"Preliminary Note.\" No such potentially troublesome problems arose for the experimental series at Camp Lazear; Reed obtained prior support from all of the appropriate authorities in the military and the administration, even including the Spanish Consul to Cuba. With the advice of the Commission and others, he drafted what is now one of the oldest series of extant informed consent documents. The surviving examples are in Spanish with English translations, and were signed by volunteers Antonio Benigno and Vicente Presedo, and a third with the mark of Nicanor Fernandez, who was illiterate.\u003c/p\u003e","\u003cp\u003e The documents take the form of a contract between individual volunteers and the Commission, represented by Reed. At least 25 years old, each volunteer explicitly consented to participate, and balanced the certainty of contracting yellow fever in the general population against the risks of developing an experimental case, followed by expert and timely medical care. The volunteers agreed to remain at Camp Lazear for the duration of the experiments, and as a reward for participation would receive $100 \"in American gold,\" with an additional hundred-dollar supplement for contracting yellow fever. These payments could be assigned to a survivor, and the volunteers agreed to forfeit any remuneration in cases of desertion.\u003c/p\u003e","\u003cp\u003e For the American participants no consent documents appear to survive, though in contemporary letters Reed assured his correspondents that the Commission obtained written consent from all the volunteers. The record of expenses for Camp Lazear -- maintained by Reed's friend and colleague in the medical corps, Jefferson Randolph Kean -- indicates that the same schedule of payments for participation and sickness applied to the Americans as well. Volunteers who participated in the fomites tests and in addition the later series of blood injections and the single trial of an alternative species of mosquito also earned $100 each plus the $100 supplement if yellow fever developed. Two Americans declined these gratuities, as Kean termed them, Dr. Robert P. Cooke, of the fomites tests, and John J. Moran, who had recently received an honorable discharge from the service, and was the only American civilian to participate. His was the fourth case of yellow fever to develop from mosquito inoculation. Moran eventually settled in Cuba, where he managed the Havana offices of the Sun Oil Company, and late in life became a close friend of Philip S. Hench. Together the two men rediscovered the site of Camp Lazear in 1940 -- Building Number One still intact -- and successfully lobbied the Cuban government to memorialize there the work of Finlay and the American Commission in the conquest of yellow fever.\u003c/p\u003e","\u003cp\u003e Reed informally commemorated his own experiences at Camp Lazear by commissioning a group photograph, evidently taken there shortly before he left Cuba in February 1901. A more important event occurred on the sixth of that month when Reed presented the results of the Camp Lazear yellow fever experiments to a great ovation at the Pan-American Medical Congress in Havana. Three days later he set sail for the United States, and once landed, drafted the Congress paper as\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- An Additional Note\u003c/title\u003e, published immediately in the\u003ctitle render=\"italic\"\u003eJournal of the American Medical Association\u003c/title\u003e. [16]\u003c/p\u003e","\u003cp\u003e Though his correspondence intimates a great appreciation for Cuba, Reed never returned to the warm, sunny shores of the island freed of a dreadful plague. Carroll stayed behind at Camp Lazear through February to complete the last experimental series officially bearing the imprimatur of the Yellow Fever Commission, and returned to Washington soon after March first. [17] The Medical Corps retained the lease on Camp Lazear against the possibility of continuing experiments another season, and Carroll, in fact, returned to Havana in August 1901 for a final experimental series, though he did not make use of Camp Lazear. This work involved at least three volunteers at Las Animas Hospital, Havana, who submitted to blood injections. Carroll's assignment aimed at a greater understanding of the yellow fever agent, and he proved that blood drawn from active cases of yellow fever remained virulent even after passing through fine bacteria filters. In addition, by heating contaminated blood which had previously caused cases of yellow fever, Carroll rendered it non-infective -- thereby establishing that this filterable entity, though sub-microscopic, was demonstrably present in the bloodstream. Carroll wrapped up the series in October and returned home to stay. [18] In Cuba, J. Randolph Kean made the last rental payments to Signore Rojas on October 9, 1901, and Camp Lazear, for more than a generation, slipped out of the realm of memory.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003e[1] Walter Reed and James Carroll,\u003ctitle render=\"doublequote\"\u003eBacillus Icteroides and Bacillus Cholerae Suis -- A Preliminary Note\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eMedical News\u003c/title\u003e(29 April 1899), reprinted in: United States Senate Document No. 822,\u003ctitle render=\"italic\"\u003eYellow Fever, A Compilation of Various Publications\u003c/title\u003e(Washington: Government Printing Office, 1911), p. 55.\u003c/item\u003e\n      \u003citem\u003e[2] Letter from Jesse W. Lazear to Mabel Houston Lazear, 23 August 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00341001.\u003c/item\u003e\n      \u003citem\u003e[3] Walter Reed, \"The Propagation of Yellow Fever -- Observations Based on Recent Researches,\" in United States Senate Document No. 822,\u003ctitle render=\"italic\"\u003eYellow Fever A Compilation of Various Publications\u003c/title\u003e(Washington: Government Printing Office, 1911), p. 94.\u003c/item\u003e\n      \u003citem\u003e[4] Letter from Walter Reed to George M. Sternberg, 24 July 1900, Hench Reed Yellow Fever Collection, accession number: 02064001.\u003c/item\u003e\n      \u003citem\u003e[5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- A Preliminary Note\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eProceedings of the Twenty-eighth Annual Meeting of the American Public Health Association\u003c/title\u003eIndianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\u003c/item\u003e\n      \u003citem\u003e[6] Letter from Walter Reed to James Carroll, 7 September 1900, Edward Hook Additions to the Philip S. Hench Walter Reed Yellow Fever Collection: James Carroll Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 15312004. The originals of these letters remain in a private collection.\u003c/item\u003e\n      \u003citem\u003e[7] Walter Reed, James Carroll, Aristides Agramonte,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- An Additional Note\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eJournal of the American Medical Association\u003c/title\u003e36 (16 February 1901): 431-440, reprinted in: Senate Document No. 822, p. 84.\u003c/item\u003e\n      \u003citem\u003e[8] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 99.\u003c/item\u003e\n      \u003citem\u003e[9] Henry Rose Carter,\u003ctitle render=\"doublequote\"\u003eA Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eMedical Record\u003c/title\u003e59 (15 June 1901) 24: 937.\u003c/item\u003e\n      \u003citem\u003e[10] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 101.\u003c/item\u003e\n      \u003citem\u003e[11]\u003cemph render=\"italic\"\u003eCulex fasciata\u003c/emph\u003ewas reclassified shortly after the experiments as\u003cemph render=\"italic\"\u003eStegomyia\u003c/emph\u003eand later became\u003cemph render=\"italic\"\u003eAedes aegypti.\u003c/emph\u003e\u003c/item\u003e\n      \u003citem\u003e[12] Letter to from Walter Reed to Emilie Lawrence Reed, 9 December 1900, Hench Reed Collection, accession number: 02231001.\u003c/item\u003e\n      \u003citem\u003e[13] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 97.\u003c/item\u003e\n      \u003citem\u003e[14] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 98.\u003c/item\u003e\n      \u003citem\u003e[15] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 99.\u003c/item\u003e\n      \u003citem\u003e[16] Please see note [7].\u003c/item\u003e\n      \u003citem\u003e[17] The Commission reported these concluding experiments in: Walter Reed, James Carroll, Aristides Agramonte,\u003ctitle render=\"doublequote\"\u003eExperimental Yellow Fever\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eAmerican Medicine\u003c/title\u003eII (6 July 1901) 1: 15-23.\u003c/item\u003e\n      \u003citem\u003e[18] Walter Reed, James Carroll,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever (A Supplemental Note)\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eAmerican Medicine\u003c/title\u003eIII (22 February 1902) 8: 301-305.\u003c/item\u003e\n    \u003c/list\u003e\n  ","\u003cp\u003eWalter Reed (September 13, 1851 - November 22, 1902) was a U.S. Army physician who led the army's Yellow Fever Commission 1900 and 1901. Experiments conducted by the commission confirmed a theory that yellow fever is transmitted by mosquitoes--a discovery that led to the control and eradication of this disease across much of the globe. Reed would receive much of the credit for the work of the commission because of his role as its leader, and, long after his death in 1902, he would be widely celebrated as a heroic figure in the fields of public health and medical research.\u003c/p\u003e","\u003cp\u003e Reed spent his first days in a small house which served as the parsonage for a Methodist congregation in Gloucester County, Virginia, where his father was minister.  Lemuel Sutton Reed and Pharaba White Reed welcomed young Walter into the family on September 13, 1851;  he was the youngest of their five children.  The Reeds moved to other Virginia parishes during Walter's childhood, and just after the close of the Civil War, transferred to the town of Charlottesville.  That move in 1866 placed Walter in the orbit of the University of Virginia, which he entered a year later at age sixteen under the care of his older brother Christopher, also a student at the University.  Reed attended two year-long sessions, the second devoted entirely to the medical curriculum, and he completed an M.D. degree on July 1, 1869, as one of the youngest students to graduate in the history of the medical school.\u003c/p\u003e","\u003cp\u003e At that time the School of Medicine at the University offered little opportunity for direct clinical experience, so Reed subsequently enrolled at the Bellevue Hospital Medical College, in Manhattan, New York.  There he obtained a second M.D. degree in 1870.  Reed interned at a number of hospitals in the New York metropolitan area, including the Infants' Hospital on Randall's Island and the Brooklyn City Hospital.  In 1873, he assumed the position of assistant sanitary officer for the Brooklyn Board of Health.  The large and diverse population of New York, with its many immigrant communities and dense, tenement housing, provided countless medical cases to treat and study;  these served to expose Reed to the vital importance of public health, and developed in him a lifelong interest in the field.  Yet the frenetic life of the great cities began to pall after a few years: \"Here the ever bustling day is crowded into the busy night; nor can we draw the line of separation between the two,\"[1] he wrote to Emilie Lawrence, of Murfreesboro, North Carolina, later to become Mrs. Walter Reed.  Their courtship letters reveal much of his maturing character, interests, and philosophy of life.  Increasing responsibilities with the Board of Health precluded opening a private practice, and Reed's youth proved a barrier in a culture given to offering respect more to the appearance of maturity than to its actual demonstration. Reed consequently resolved to join the Army Medical Corps, both for the professional opportunities it offered immediately and for the modest financial security it could provide to a young man without independent means.  He passed the qualifying examinations in January 1875 and proceeded to his first assignment at the military base on Willet's Point, New York Harbor.\u003c/p\u003e","\u003cp\u003e Reed remained in the Medical Corps for the rest of his life, spending many years of the '70s, '80s, and early '90s at difficult postings in the American West.  The first of these -- to the Arizona Territory -- began in the late spring of 1876, and indeed hurried along his wedding to Emilie Lawrence, on April 25, shortly before his departure.  She joined him the following November, and bore two children at frontier posts, a son Walter Lawrence and a daughter Emilie, called Blossom.\u003c/p\u003e","\u003cp\u003e Reed's other western assignments included forts in Nebraska, Dakota Territory, and Minnesota, with two eastern interludes at Baltimore, Maryland and another at Mount Vernon Barracks, Alabama.  During the second of these tours in Baltimore -- over the 1890-1891 academic year -- Reed completed advanced coursework in pathology and bacteriology in the Johns Hopkins University Hospital Pathology Laboratory.  When he returned from his last western appointment in 1893, Reed joined the faculty of the Army Medical School in Washington, D.C., where he held the professorship of Bacteriology and Clinical Microscopy.  He also became curator of the Army Medical Museum and joined the faculty of the Columbian University in Washington (later the George Washington University).  In addition, Reed maintained close ties with professor William Welch and other leading lights in the scientific community he had come to know at Hopkins a few years earlier.\u003c/p\u003e","\u003cp\u003e Beyond his teaching responsibilities for the Army and the Columbian University programs, Reed actively pursued medical research projects.  A bibliography of his publications finds entries from 1892 to the year of his untimely death a decade later, and the subjects he investigated range from erysipelas to cholera, typhoid, malaria, and yellow fever, among others.[2]   In 1896, a research trip to investigate an outbreak of smallpox took him to Key West, and there he developed a close friendship with Jefferson Randolph Kean, a fellow Virginian and colleague in the Medical Corps ten years his junior.  When Reed traveled to Cuba in 1899 to study typhoid in the army encampments of the U.S. forces, Kean was already there, and Kean was still in Cuba when Reed returned as the head of the Army board charged by Surgeon General George Miller Sternberg to examine tropical diseases including yellow fever.  Kean and his first wife Louise were great supporters of the U.S. Army Yellow Fever Commission's work, and Kean in fact served as quartermaster for the famous series of experiments at Camp Lazear.  After the dramatic and conclusive success of those experiments, Kean actively -- though unsuccessfully -- promoted Reed's candidacy for Surgeon General.\u003c/p\u003e","\u003cp\u003e Reed continued to speak and publish on yellow fever after his return from Cuba in 1901, receiving honorary degrees from Harvard and the University of Michigan in recognition of his seminal work.  In November 1902, Reed developed what had been for him recurring gastro-intestinal trouble.  This time, however, his appendix ruptured, and surgery came too late to save him from the peritonitis which developed.  He died on November 23, 1902, almost two years to the day from the opening of Camp Lazear and the stunning experimental victory there.  Kean remained a champion of his deceased friend's role in the conquest of yellow fever.  He organized the Walter Reed Memorial Association, to provide support for Reed's family and to build a suitable memorial, and was instrumental in lobbying the United States Congress to establish the Yellow Fever Roll of Honor.  In 1929, Congress mandated the annual publication of the Roll in the\u003ctitle render=\"italic\"\u003eArmy Register\u003c/title\u003e, and struck a series Congressional Gold Medals saluting the Commission members and the young Americans who bravely suffered experimental yellow fever a generation before.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003e[1] Letter from Walter Reed to Emilie Lawrence, 18 July 1874, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 01605001.\u003c/item\u003e\n      \u003citem\u003e[2] The bibliography of Reed's scientific papers may be found in: Howard Atwood Kelly,\u003ctitle render=\"italic\"\u003eWalter Reed and Yellow Fever\u003c/title\u003e(New York: McClure, Phillips and Co., 1906), pp. 281-283. Kelly's complete biography of Reed is contained on this Web site.\u003c/item\u003e\n    \u003c/list\u003e\n  ","\u003cp\u003eJesse William Lazear (May 2, 1866 - September 26, 1900) was a physician who was a member of the U.S. Army Yellow Fever Commission in 1900. Lazear's death from yellow fever at the outset of the commission's work in Cuba would lead to his elevation as a martyr for medical science in the eyes of many during the twentieth century.\u003c/p\u003e","\u003cp\u003e \"I rather think I am on the track of the real germ,\" Jesse W. Lazear wrote his wife from Cuba on September 8, 1900.[1] Seventeen days later, the fulminating case of yellow fever Lazear had contracted just over a week after writing Mabel H. Lazear suddenly ended the young scientist's life. He was 34 years old. Unlike so many other yellow fever fatalities, however, this one would lead to a direct and highly successful assault on the disease itself. Yellow fever's ascendancy, endemic in Cuba, was about to be undermined.\u003c/p\u003e","\u003cp\u003e Lazear had reported to Camp Columbia, Cuba in February 1900 for duty as an acting assistant surgeon with the U. S. Army Corps stationed on the island. Here he undertook bacteriological study of tropical diseases, particularly malaria and yellow fever, and in May he was named to the Army board charged with \"pursuing scientific investigations with reference to the infectious diseases prevalent on the island of Cuba.\"[2]\u003c/p\u003e","\u003cp\u003e These orders placed him officially in the company of Walter Reed, James Carroll, and Aristides Agramonte -- the U.S. Army Yellow Fever Commission -- though Lazear had already met Reed the preceding March on a project to evaluate the efficacy of electrozone, a disinfectant made from seawater collected off the Cuban coast. While Reed was in Cuba that March, Lazear discussed with him the recent discovery of British scientist Sir Ronald Ross concerning the mosquito vector for malaria. At Johns Hopkins Hospital in Baltimore, where he was first a medical resident and later in charge of the clinical laboratory, Lazear had followed Ross's accomplishments with great interest, and pursued field work and experimentation on the\u003cemph render=\"italic\"\u003eAnopheles\u003c/emph\u003emosquito with fellow Hopkins scientist William S. Thayer. Lazear was thus the only member of the Commission who had experience with mosquito work, and was consequently the most open to the possible verity of Cuban scientist Carlos Juan Finlay's theory of mosquito transmission for yellow fever.\u003c/p\u003e","\u003cp\u003e The record is apparently silent as to when Lazear first visited Finlay. Certainly by late June Lazear was beginning to grow mosquito larvae acquired from Finlay's laboratory, the first specimens brought to him by Henry Rose Carter, of the United States Public Health Service.[3] Not long after arriving in Cuba Lazear met Carter, whose own observations on yellow fever strongly suggested an intermediate host in the spread of the disease. However, Army Surgeon General George Miller Sternberg, who organized the Yellow Fever Commission, first charged the board members to investigate the relationship of\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003eto yellow fever -- proposed by the Italian Scientist Giuseppe Sanarelli as the actual cause of the disease. \"Dr. Reed had been in the old discussion over Sanarelli's bacillus and he still works on that subject,\" Lazear wrote his wife in July, \"I am not all interested in it but want to do work which may lead to the discovery of the real organism.\"[4] Soon he would have the opportunity. The relatively quick failure of the Bacillus icteroides inquiry opened the door to what became the ground-breaking mosquito work, and Lazear was well placed to begin.\u003c/p\u003e","\u003cp\u003e The project started in earnest on August 1, 1900. In a small pocket notebook Lazear noted the preparatory work of raising and infecting mosquitoes, and subsequently recorded the series of eleven experimental inoculations made from the 11th to the 31st of August, the last two producing cases of full-blown yellow fever. These two positive cases developed from mosquitoes allowed to ripen over a period of 12 days, and this was Lazear's crucial discovery. The epidemiological pattern was thus entirely consistent with Carter's observations of a delay between the primary and secondary outbreaks of yellow fever in an epidemic, and, in addition, explained why Finlay's experiments had been largely unsuccessful -- he had not waited long enough before inoculating his subjects.\u003c/p\u003e","\u003cp\u003e Although Lazear never directly admitted to experimenting on himself, when Reed reviewed Lazear's sketchy notations he evidently found entries strongly suggesting Lazear's case was not accidental, as officially reported. Unfortunately, the little notebook so crucial to the preparation of the Commission's famous initial paper,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- A Preliminary Note\u003c/title\u003e[5], vanished from Reed's Washington office after his own untimely death in 1902. Still, Lazear's invaluable contribution to the Commission's victory was widely recognized and elicited tributes from many quarters: \"He was a splendid, brave fellow,\" Reed said of his young colleague, \" and I lament his loss more than words can tell; but his death was not in vain- His name will live in the history of those who have benefited humanity.\" [6] \"His death was a sacrifice to scientific research of the highest character,\" stated General Leonard Wood, military Governor of Cuba.[7] \"Your husband was a martyr in the noblest of causes,\" Dr. L. O. Howard wrote to Mabel Lazear, \"and I am proud to have known him. . . . His work contributed towards one of the greatest discoveries of the century, the results of which will be of invaluable benefit to mankind.\"[8] And so they were. Though Lazear's one-year-old son and newborn daughter never knew their father, they grew up in a world liberated -- almost in its entirety -- from the disease that killed him.\u003c/p\u003e","\u003cp\u003e [1] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 8 September 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00344001.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003e[2] Military Orders for Walter Reed, James Carroll, Aristides Agramonte, and Jesse W. Lazear, 24 May 1900, Hench Reed Collection, accession number 02019001.\u003c/item\u003e\n      \u003citem\u003e[3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\u003c/item\u003e\n      \u003citem\u003e[4] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 15 July 1900, Hench Reed Collection, accession number: 00334001.\u003c/item\u003e\n      \u003citem\u003e[5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- A Preliminary Note,\u003c/title\u003e \u003ctitle render=\"italic\"\u003eProceedings of the Twenty-eighth Annual Meeting of the American Public Health Association Indianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\u003c/title\u003e\u003c/item\u003e\n      \u003citem\u003e[6] Letter from Walter Reed to Emilie Lawrence Reed, 6 October 1900, Hench Reed Collection, accession number: 02135001.\u003c/item\u003e\n      \u003citem\u003e[7] Letter from Leonard Wood to the Adjutant-General, United States Army, November 1900, Hench Reed Collection, accession number: 00375002.\u003c/item\u003e\n      \u003citem\u003e[8] Letter from Leland Ossian Howard to Mabel Houston Lazear, 7 February 1901, Hench Reed Collection, accession number: 00388001.\u003c/item\u003e\n    \u003c/list\u003e\n  ","\u003cp\u003eHenry Rose Carter (August 25, 1852 - September 14, 1925) was a prominent physician in the U.S. Public Health Service who was a leading authority in the transmission and control of tropical diseases, particularly yellow fever and malaria. During his long career as a sanitarian, Carter undertook campaigns to investigate and control the spread of tropical diseases in Cuba, the Panama Canal Zone, the Southeastern United States, and Peru.\u003c/p\u003e","\u003cp\u003e Like Walter Reed and Jefferson Randolph Kean, Henry Rose Carter was a native Virginian and a graduate of the University of Virginia. Carter obtained a civil engineering degree from Virginia in 1873 and also undertook post-graduate work in mathematics and applied chemistry the next year. Subsequently, however, Carter's interests turned towards medicine, and he completed a medical degree at the University of Maryland in 1879. The same year Assistant Surgeon Carter joined the Marine Hospital Service -- later the United States Public Health Service -- and the young surgeon rose steadily through the ranks, ultimately attaining the position of Assistant Surgeon General in 1915.\u003c/p\u003e","\u003cp\u003e Carter's initial assignments with the Hospital Service placed him at the center of the yellow fever maelstrom. In 1879 he was detailed to Memphis and other Southern cities, then in the throes of a second year of devastating epidemics. Here began, as his colleague T. H. D. Griffitts observed, Carter's \"lifelong interest in the epidemiology and control of yellow fever.\"[1] After several years of clinical practice in various Marine hospitals, Carter resumed a direct confrontation with yellow fever when his orders for duty with the Gulf Coast Maritime Quarantine assigned him to Ship Island, Mississippi, in 1888. Here and at subsequent quarantine station postings around the Gulf, he quietly championed a thorough review and rationalization of quarantine policies, with a view toward establishing uniform regulation, more thorough disinfection of vessels, and minimized interference with naval commerce. Crucial to the success of these activities was Carter's attention to the incubation period of yellow fever, which his on-site observations indicated to vary between 5 and 7 days. At the time the official literature stated with far less precision a variance of between 1 and 14 days; Carter's work consequently greatly increased the efficiency and effectiveness of quarantine operations.\u003c/p\u003e","\u003cp\u003e Nevertheless, yellow fever continued to menace the temperate coastline of the United States, and Carter ably directed the Health Service's epidemiological control efforts in numerous threatened regions. In conjunction with this sanitary work for the 1898 season, Carter made detailed notes on the development of yellow fever at Orwood and Taylor, Mississippi. The isolation of these communities enabled him to identify more reliably the phenomenon of a delay between the initial cases of yellow fever in a locality and the subsequent appearance of secondary infection -- a delay two to four times longer than the incubation period of the disease in an infected person. Carter called this interval between the primary and secondary cases \"the period of extrinsic incubation,\" and he defined its \"usual limits . . . [as ranging] from ten to seventeen days.\"[2]\u003c/p\u003e","\u003cp\u003e Before he was able to publish his conclusions, Carter took the helm of the quarantine service in war-time Cuba. There, in 1900, he met U. S. Army Yellow Fever Commission member Jesse Lazear. Carter had finally arranged for his paper's publication that year in the\u003ctitle render=\"italic\"\u003eNew Orleans Medical and Surgical Journal\u003c/title\u003e, and gave a draft to Lazear. \"If these dates are correct,\" Carter later recalled Lazear saying, \"it spells a living host.\"[3] The theory of mosquito transmission long advanced by Cuban scientist Carlos J. Finlay began to seem more likely. And indeed it was. The Commission's experiments in 1900-1901 irrefutably proved the mosquito vector and established the extrinsic incubation period at twelve days. Shortly after these successes Reed saluted Carter, \"I know of no one more competent to pass judgment on all that pertains to the subject of yellow fever. You must not forget that your own work in Mississippi did more to impress me with the importance of an intermediate host than everything else put to-gether.\"[4]\u003c/p\u003e","\u003cp\u003e Carter's long and distinguished sanitary career took him to the Panama Canal Zone in 1904, where he served as Chief Quarantine Officer and Chief of Hospitals for five years. He undertook detailed investigations and control measures of malaria in North Carolina and elsewhere in the South, and became a founder of the National Malaria Committee. With the support of the Rockefeller Foundation International Health Board, he undertook additional investigation and control measures for yellow fever in Central and South America. His expertise recommended him to the Peruvian government, which named Carter Sanitary Advisor in 1920-1921. Health problems at the end of his life compelled Carter to withdraw from active fieldwork, though he remained a highly valued consultant to the Health Board and a much-beloved and respected teacher for a new generation of sanitarians. Carter closed his career researching and writing the manuscript that his daughter Laura Armistead Carter edited and published posthumously in 1931:\u003ctitle render=\"italic\"\u003eYellow Fever: An Epidemiological and Historical Study of its Place of Origin.\u003c/title\u003e[5]\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003e[1] T. H. D. Griffitts,\u003ctitle render=\"doublequote\"\u003eHenry Rose Carter: The Scientist and the Man\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eSouthern Medical Journal\u003c/title\u003e32 (August 1939) 8: 842.\u003c/item\u003e\n      \u003citem\u003e[2] Henry Rose Carter,\u003ctitle render=\"doublequote\"\u003eA Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eMedical Record\u003c/title\u003e59 (15 June 1901) 24: 937.\u003c/item\u003e\n      \u003citem\u003e[3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\u003c/item\u003e\n      \u003citem\u003e[4] Letter from Walter Reed to Henry Rose Carter, 26 February 1901, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 02447001.\u003c/item\u003e\n      \u003citem\u003e[5] Carter, Henry Rose.\u003ctitle render=\"italic\"\u003eYellow Fever: An Epidemiological and Historical Study of its Place of Origin.\u003c/title\u003eBaltimore: The Williams and Wilkins Company, 1931.\u003c/item\u003e\n    \u003c/list\u003e\n  ","\u003cp\u003eJefferson Randolph Kean (June 27, 1860 - September 4, 1950) was a U.S. Army physician who was a leading authority in sanitation, public health, and tropical diseases. Later in his career, Kean would become widely recognized for his role in organizing and administering medical services for the U.S. armed forces during World War I.\u003c/p\u003e","\u003cp\u003e \"He possessed one of the keenest, most scholarly minds I've ever encountered,\" recalled Nobel Prize winner Philip S. Hench of Jefferson Randolph Kean. [1] Kean and Hench shared an abiding interest in the work of the United States Army Yellow Fever Commission -- Kean, as a contemporary and supporter, and Hench, as a scholar and scientist intent on accurate historical documentation. On the advice of yellow fever experiment volunteer John J. Moran, Hench first wrote Kean in 1939. From that initial contact developed a close friendship which would last for the remainder of their lives. Kean entrusted Hench not only with numerous period documents, including original letters, accounts, fever charts, and other items, but also with the freely-given counsel and insight of a trusted friend.\u003c/p\u003e","\u003cp\u003e Like Walter Reed and Henry Rose Carter before him, Jefferson Randolph Kean was an alumnus of the University of Virginia, completing the medical program there in 1883. Kean joined the U.S. Army Medical Corps in 1884, and after forty years in the service, retired with the rank of Colonel. Congress awarded him a promotion to Brigadier General, retired, in 1930. The early years of Kean's career passed in medical postings in the American West, and no doubt offered him experiences similar to those of Walter Reed, whom he met not on the frontier, but in Florida in 1896. Kean became an expert in tropical diseases and sanitation during his five-year assignment in the Florida tropics, an expertise which served him well over two terms of service later in Cuba. During the Spanish-American War and subsequent U. S. occupation of Cuba, Kean was Chief Surgeon for the Department of Havana, then Superintendent of the Department of Charities -- from 1898 to 1902. After a four-year interlude as an assistant to the Surgeon General in Washington, D.C., Kean again returned to Cuba as an advisor to the Department of Sanitation from 1906-1909.\u003c/p\u003e","\u003cp\u003e Kean himself stated: \"Reed and I were good friends before the Yellow Fever Board came to Cuba in June 1900, and [Reed] located himself at Marianao, 8 miles S. W. of Havana,\" to be within the medical and administrative jurisdiction overseen by Kean. [2] The Chief Surgeon did indeed offer significant assistance, and was an early convert to Carlos Finlay's mosquito theory of transmission, which the Yellow Fever Board's experiments ultimately proved true in the late autumn and winter of 1900-1901. As early as October 13, 1900 -- after the Board's preliminary work, but before the final convincing demonstrations -- Kean issued \"Circular No. 8,\" concerning the latest scholarship on the mosquito vector for disease. [3] The circular contained a set of instructions for the entire command on mosquito eradication. Kean subsequently served as quartermaster and financial administrator for the famous series of yellow fever experiments at Camp Lazear and, for the rest of his life, Kean remained a strong proponent of the Commission's conclusions. He worked tirelessly not only to apply them in the field, but also to accord proper public recognition to the Commission's work.\u003c/p\u003e","\u003cp\u003e In addition to his career as a sanitarian, Kean organized the department of military relief of the American Red Cross, and during World War One served as Chief of the U. S. Ambulance Service with the French Army and Deputy Chief Surgeon of the American forces. France named him an Officier de la Légion d'Honneur in recognition for these services. Cuban authorities as well offered Kean recognition with the grand cross of the Order of Merit Carlos J. Finlay, and he received both a Distinguished Service Medal from the United States government and the Gorgas Medal from the Association of Military Surgeons. For a decade after his retirement from active duty, Kean edited this last organization's medical journal,\u003ctitle render=\"italic\"\u003eThe Military Surgeon\u003c/title\u003e, and served on the Surgeon General's editorial board for the multi-volume history of the medical department in World War One. A great-grandson of Thomas Jefferson, Kean also took a seat with the government commission established to build the Jefferson Memorial in Washington, D.C. He held charter membership in the Walter Reed Memorial Association, and remained active in its affairs until his death in 1950.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003e[1] Telegram from Philip Showalter Hench and Mary Hench to Cornelia Knox Kean, September 5, 1950, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 06501173.\u003c/item\u003e\n      \u003citem\u003e[2] Letter from Jefferson Randolph Kean to Philip Showalter Hench, October 31, 1939, Hench Reed Yellow Fever Collection, accession number: 06282022.\u003c/item\u003e\n      \u003citem\u003e[3] Military Orders to Commanding Officers, October 15, 1900, Hench Reed Yellow Fever Collection, accession number: 02140001.\u003c/item\u003e\n    \u003c/list\u003e\n  ","\u003cp\u003ePhilip Showalter Hench (February 28, 1896 - March 30, 1965) was a U.S. physician who in 1950 was awarded the Nobel Prize for Physiology and Medicine for his role in the discovery of the hormone cortisone. In addition to his medical research, Hench spent almost three decades of his life studying the history of the U.S. Army Yellow Fever Commission and became a leading authority in the subject.\u003c/p\u003e","\u003cp\u003e Philip Showalter Hench was born in Pittsburgh, Pennsylvania, the son of Jacob Bixler Hench and Clara Showalter. After attending local schools, Hench entered Lafayette College and graduated from the school 1916 with a Bachelor of Arts. Hench completed his medical degree at the University of Pittsburgh in 1920, and subsequently entered a residency program at St. Francis Hospital, Pittsburgh. His association with the Mayo Clinic began in 1921 as a fellow at the institution. Two years later he would become an assistant at the clinic, and then, in 1926, he would be made the head of its Department of Rheumatic Diseases After pursuing post-graduate study in Germany in 1928-1929, Hench obtained a Masters of Science in Internal Medicine at the University of Minnesota in 1931, and a Doctor of Science degree from Lafayette College in 1940. Hench remained for the duration of his career at the Mayo Clinic, where his life-long passion for meticulous research and analysis brought him the Nobel Prize for Physiology and Medicine in 1950, which he shared with Edward C. Kendall and Tadeus Reichstein, for the discovery of cortisone.\u003c/p\u003e","\u003cp\u003e The same persistence and determination present in his professional life is also evident in Hench's research on the U. S. Army Yellow Fever Commission's famous experiments. \"As a physician particularly interested in medical history,\" he stated to experiment volunteer John J. Moran in 1937, \"I have been long interested in the story of the yellow fever work in John J. Moran, Ralph C. Hutchison, Havana.\" [1] So began a remarkable odyssey. At the request of his friend Ralph Cooper Hutchison, then president of Washington and Jefferson College, Hench had written Moran to gather information for the dedication of the College's new chemistry building, named for Commission member and former Washington and Jefferson student Jesse W. Lazear. Hench also began a correspondence with another of the yellow fever experiment's original volunteers, John R. Kissinger. Moran's and Kissinger's recollections proved so intriguing that Hench initially offered to edit and publish them. However, in the course of his research Hench discovered that much general information on the topic was inaccurate. Conflicting assertions concerning the participants and unverified claims by medical and governmental authorities in the United States and Cuba -- often politically motivated -- clouded interpretation of the facts. \"May I suggest,\" Moran consequently urged in 1938, \"that a clearing up of the REED-FINLAY-CONQUEST-OF-YELLOW-FEVER, or an effort to do so, on your part, is a task far more pressing than publishing the Kissinger-Moran stories or memoirs.\" [2] Hench resolved to document every aspect of the \"Conquest of Yellow-Fever\" and to write a much needed accurate and comprehensive history.\u003c/p\u003e","\u003cp\u003e For the next two decades, Hench tirelessly combed through public archive collections and personal papers in the United States and Cuba. He met and interviewed surviving participants of the experiments and others associated with the project, as well as family members of the Yellow Fever Commission. He sought out physicians and scientists who had worked with the principal players or who had applied the results in the campaign to eradicate yellow fever. He identified and photographed sites associated with the yellow fever story, and he successfully petitioned politicians in the United States and Cuba to commemorate the work. In the process, Hench became the trusted friend and advisor of many of these same individuals, and they, in turn, presented him with much of the surviving original material for safekeeping.\u003c/p\u003e","\u003cp\u003e In short, Hench came to be the world's expert on the yellow fever story and the steward of thousands of original letters and documents. His premature death at age 69 found him still hoping to uncover important missing evidence, his book unwritten. Hench's widow Mary Kahler Hench gave his yellow fever collection to the University of Virginia, Walter Reed's alma mater, and this extensive personal archive forms the most detailed and accurate record available on the Conquest of Yellow Fever.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003e[1] Letter from Philip S. Hench to John J. Moran, 6 July 1937, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 03419001.\u003c/item\u003e\n      \u003citem\u003e[2] Letter from John J. Moran to Philip S. Hench, 30 October 1938, Hench Reed Yellow Fever Collection, accession number: 03476001.\u003c/item\u003e\n    \u003c/list\u003e\n  "]}]}},"label":"Breadcrumbs"}}},"links":{"self":"https://arvasarchive.org/catalog/viu_repositories_7_resources_1710_c01"}},{"id":"viu_repositories_7_resources_1710_c04","type":"Series","attributes":{"title":"Series IV. Philip Showalter Hench, 1850/1966, bulk 1837/1960","abstract_or_scope":{"id":"https://arvasarchive.org/catalog/viu_repositories_7_resources_1710_c04#abstract_or_scope","type":"document_value","attributes":{"value":"\u003cp\u003eSeries IV. Philip Showalter Hench primarily consists of materials that Hench created or collected while researching the U.S. Army Yellow Fever Commission. Items in this series date from around 1850 to around 1865 with the bulk of the items dating from 1937 to 1960. Researchers who are studying the yellow fever experiments will be particularly interested in the materials (e.g. interviews, autobiographies) that document first-hand accounts of the events surrounding the experiments. Other researchers may be interested in items that document Hench's role in shaping public memory of the commission and its experiments. The materials in this series include, but are not limited to the following:\u003c/p\u003e","label":"Abstract Or Scope"}},"breadcrumbs":{"id":"https://arvasarchive.org/catalog/viu_repositories_7_resources_1710_c04#breadcrumbs","type":"document_value","attributes":{"value":{"ref_ssi":"viu_repositories_7_resources_1710_c04","ref_ssm":["viu_repositories_7_resources_1710_c04"],"id":"viu_repositories_7_resources_1710_c04","ead_ssi":"viu_repositories_7_resources_1710","_root_":"viu_repositories_7_resources_1710","_nest_parent_":"viu_repositories_7_resources_1710","parent_ssi":"viu_repositories_7_resources_1710","parent_ssim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"parent_ids_ssim":["viu_repositories_7_resources_1710"],"title_filing_ssi":"Series IV. Philip Showalter Hench","title_ssm":["Series IV. Philip Showalter Hench"],"title_tesim":["Series IV. Philip Showalter Hench"],"normalized_title_ssm":["Series IV. Philip Showalter Hench, 1850/1966, bulk 1837/1960"],"text":["Series IV. Philip Showalter Hench, 1850/1966, bulk 1837/1960","Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974","box 34-55","advertisements","announcements","articles","bibliographies","bills (legislative records)","biographies (documents)","booklets","business cards","caps (closures)","cards (information artifacts)","certificates","checks (bank checks)","citations (bibliographic)","clippings (information artifacts)","color prints (prints)","comics (documents)","contracts","corkscrews","Daybooks","drawings (visual works)","editorials","envelopes","epitaphs","essays","extracts","filmstrips","greeting cards","interviews","inventories","invitations","invoices","journals (periodicals)","leases","letter openers","letters (correspondence)","letters to the editor","lists (document genres)","magazines (periodicals)","manuscripts (document genre)","maps (documents)","medals","Memorandums","Microfilms","military records","minutes (administrative records)","Newsletters","newspaper columns","newspapers","notes","obituaries","oral histories (document genres)","order forms","outlines (documents)","pamphlets","phonograph records","photographs","pins (jewelry)","playbills","poems","postcards","press releases","price lists","print advertising","proceedings","programs (documents)","proposals","questionnaires","radio scripts","receipts (financial records)","recipes","references","registers (lists)","reports","reprints","Resolutions (administrative records)","Reviews","rubber stamps","Scrapbooks","scripts (documents)","seating","shipping records","sketches","speeches","telegrams","title pages","Series IV. Philip Showalter Hench primarily consists of materials that Hench created or collected while researching the U.S. Army Yellow Fever Commission. Items in this series date from around 1850 to around 1865 with the bulk of the items dating from 1937 to 1960. Researchers who are studying the yellow fever experiments will be particularly interested in the materials (e.g. interviews, autobiographies) that document first-hand accounts of the events surrounding the experiments. Other researchers may be interested in items that document Hench's role in shaping public memory of the commission and its experiments. The materials in this series include, but are not limited to the following:","Hench's correspondence and interviews with participants in the yellow fever experiments and their families including: Emilie Lawrence Reed, Emilie M. (Blossom) Reed, Walter Lawrence Reed, John J. Moran, Albert E. Truby, Jefferson Randolph Kean, John H. Andrus, and John R. Kissinger;autobiographical accounts of the experiment's participants and their families;notes, reports, correspondence and other materials relating to Hench's search for the original site of Camp Lazear in Cuba;correspondence with Cuban government officials and members of the scientific community relating to Hench's campaign to build a Camp Lazear memorial;correspondence and other materials relating to ceremonies honoring Jesse W. Lazear at Washington and Jefferson College;newspaper articles, magazine articles, and other printed matter concerning the yellow fever experiments and its participants;drafts of speeches and presentations Hench gave on the history of the yellow fever experiments to various audiences;meeting minutes and other materials that document Hench's relationship with and participation in the Walter Reed Memorial Association;scripts for radio programs relating to the yellow fever experiments;notes, outlines, lists, correspondence, and other materials that document Hench's research about the yellow fever experiments and a book he had planned to write on the subject;and the gold medal that Congress posthumously awarded to Walter Reed for his work with yellow fever.","Materials housed in boxes 34-49 are generally arranged in chronological order by their date of creation. Materials housed in the remaining boxes of this series do not appear to have been arranged in a systematic fashion."],"parent_unittitles_ssm":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"parent_unittitles_tesim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"normalized_date_ssm":["1850/1966, bulk 1837/1960"],"unitdate_inclusive_ssm":["circa 1850-circa 1966"],"unitdate_bulk_ssim":["bulk 1937-1960"],"level_ssm":["Series"],"level_ssim":["Series"],"component_level_isim":[1],"sort_isi":3898,"repository_ssim":["University of Virginia, Special Collections Dept."],"collection_ssim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"extent_ssm":["21 boxes"],"extent_tesim":["21 boxes"],"containers_ssim":["box 34-55"],"has_online_content_ssim":["false"],"child_component_count_isi":790,"parent_access_restrict_tesm":["There are no restrictions on user access to any of the materials in the collection except where noted in the container list."],"parent_access_terms_tesm":["Copyright restrictions may apply for some materials in the collection."],"access_subjects_ssim":["advertisements","announcements","articles","bibliographies","bills (legislative records)","biographies (documents)","booklets","business cards","caps (closures)","cards (information artifacts)","certificates","checks (bank checks)","citations (bibliographic)","clippings (information artifacts)","color prints (prints)","comics (documents)","contracts","corkscrews","Daybooks","drawings (visual works)","editorials","envelopes","epitaphs","essays","extracts","filmstrips","greeting cards","interviews","inventories","invitations","invoices","journals (periodicals)","leases","letter openers","letters (correspondence)","letters to the editor","lists (document genres)","magazines (periodicals)","manuscripts (document genre)","maps (documents)","medals","Memorandums","Microfilms","military records","minutes (administrative records)","Newsletters","newspaper columns","newspapers","notes","obituaries","oral histories (document genres)","order forms","outlines (documents)","pamphlets","phonograph records","photographs","pins (jewelry)","playbills","poems","postcards","press releases","price lists","print advertising","proceedings","programs (documents)","proposals","questionnaires","radio scripts","receipts (financial records)","recipes","references","registers (lists)","reports","reprints","Resolutions (administrative records)","Reviews","rubber stamps","Scrapbooks","scripts (documents)","seating","shipping records","sketches","speeches","telegrams","title pages"],"access_subjects_ssm":["advertisements","announcements","articles","bibliographies","bills (legislative records)","biographies (documents)","booklets","business cards","caps (closures)","cards (information artifacts)","certificates","checks (bank checks)","citations (bibliographic)","clippings (information artifacts)","color prints (prints)","comics (documents)","contracts","corkscrews","Daybooks","drawings (visual works)","editorials","envelopes","epitaphs","essays","extracts","filmstrips","greeting cards","interviews","inventories","invitations","invoices","journals (periodicals)","leases","letter openers","letters (correspondence)","letters to the editor","lists (document genres)","magazines (periodicals)","manuscripts (document genre)","maps (documents)","medals","Memorandums","Microfilms","military records","minutes (administrative records)","Newsletters","newspaper columns","newspapers","notes","obituaries","oral histories (document genres)","order forms","outlines (documents)","pamphlets","phonograph records","photographs","pins (jewelry)","playbills","poems","postcards","press releases","price lists","print advertising","proceedings","programs (documents)","proposals","questionnaires","radio scripts","receipts (financial records)","recipes","references","registers (lists)","reports","reprints","Resolutions (administrative records)","Reviews","rubber stamps","Scrapbooks","scripts (documents)","seating","shipping records","sketches","speeches","telegrams","title pages"],"date_range_isim":[1837,1838,1839,1840,1841,1842,1843,1844,1845,1846,1847,1848,1849,1850,1851,1852,1853,1854,1855,1856,1857,1858,1859,1860,1861,1862,1863,1864,1865,1866,1867,1868,1869,1870,1871,1872,1873,1874,1875,1876,1877,1878,1879,1880,1881,1882,1883,1884,1885,1886,1887,1888,1889,1890,1891,1892,1893,1894,1895,1896,1897,1898,1899,1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935,1936,1937,1938,1939,1940,1941,1942,1943,1944,1945,1946,1947,1948,1949,1950,1951,1952,1953,1954,1955,1956,1957,1958,1959,1960,1961,1962,1963,1964,1965,1966],"scopecontent_html_tesm":["\u003cp\u003eSeries IV. Philip Showalter Hench primarily consists of materials that Hench created or collected while researching the U.S. Army Yellow Fever Commission. Items in this series date from around 1850 to around 1865 with the bulk of the items dating from 1937 to 1960. Researchers who are studying the yellow fever experiments will be particularly interested in the materials (e.g. interviews, autobiographies) that document first-hand accounts of the events surrounding the experiments. Other researchers may be interested in items that document Hench's role in shaping public memory of the commission and its experiments. The materials in this series include, but are not limited to the following:\u003c/p\u003e","\u003clist type=\"ordered\"\u003e\u003citem\u003eHench's correspondence and interviews with participants in the yellow fever experiments and their families including: Emilie Lawrence Reed, Emilie M. (Blossom) Reed, Walter Lawrence Reed, John J. Moran, Albert E. Truby, Jefferson Randolph Kean, John H. Andrus, and John R. Kissinger;\u003c/item\u003e\u003citem\u003eautobiographical accounts of the experiment's participants and their families;\u003c/item\u003e\u003citem\u003enotes, reports, correspondence and other materials relating to Hench's search for the original site of Camp Lazear in Cuba;\u003c/item\u003e\u003citem\u003ecorrespondence with Cuban government officials and members of the scientific community relating to Hench's campaign to build a Camp Lazear memorial;\u003c/item\u003e\u003citem\u003ecorrespondence and other materials relating to ceremonies honoring Jesse W. Lazear at Washington and Jefferson College;\u003c/item\u003e\u003citem\u003enewspaper articles, magazine articles, and other printed matter concerning the yellow fever experiments and its participants;\u003c/item\u003e\u003citem\u003edrafts of speeches and presentations Hench gave on the history of the yellow fever experiments to various audiences;\u003c/item\u003e\u003citem\u003emeeting minutes and other materials that document Hench's relationship with and participation in the Walter Reed Memorial Association;\u003c/item\u003e\u003citem\u003escripts for radio programs relating to the yellow fever experiments;\u003c/item\u003e\u003citem\u003enotes, outlines, lists, correspondence, and other materials that document Hench's research about the yellow fever experiments and a book he had planned to write on the subject;\u003c/item\u003e\u003citem\u003eand the gold medal that Congress posthumously awarded to Walter Reed for his work with yellow fever.\u003c/item\u003e\u003c/list\u003e","\u003cp\u003eMaterials housed in boxes 34-49 are generally arranged in chronological order by their date of creation. Materials housed in the remaining boxes of this series do not appear to have been arranged in a systematic fashion.\u003c/p\u003e"],"scopecontent_heading_ssm":["Scope and Contents"],"scopecontent_tesim":["Series IV. Philip Showalter Hench primarily consists of materials that Hench created or collected while researching the U.S. Army Yellow Fever Commission. Items in this series date from around 1850 to around 1865 with the bulk of the items dating from 1937 to 1960. Researchers who are studying the yellow fever experiments will be particularly interested in the materials (e.g. interviews, autobiographies) that document first-hand accounts of the events surrounding the experiments. Other researchers may be interested in items that document Hench's role in shaping public memory of the commission and its experiments. The materials in this series include, but are not limited to the following:","Hench's correspondence and interviews with participants in the yellow fever experiments and their families including: Emilie Lawrence Reed, Emilie M. (Blossom) Reed, Walter Lawrence Reed, John J. Moran, Albert E. Truby, Jefferson Randolph Kean, John H. Andrus, and John R. Kissinger;autobiographical accounts of the experiment's participants and their families;notes, reports, correspondence and other materials relating to Hench's search for the original site of Camp Lazear in Cuba;correspondence with Cuban government officials and members of the scientific community relating to Hench's campaign to build a Camp Lazear memorial;correspondence and other materials relating to ceremonies honoring Jesse W. Lazear at Washington and Jefferson College;newspaper articles, magazine articles, and other printed matter concerning the yellow fever experiments and its participants;drafts of speeches and presentations Hench gave on the history of the yellow fever experiments to various audiences;meeting minutes and other materials that document Hench's relationship with and participation in the Walter Reed Memorial Association;scripts for radio programs relating to the yellow fever experiments;notes, outlines, lists, correspondence, and other materials that document Hench's research about the yellow fever experiments and a book he had planned to write on the subject;and the gold medal that Congress posthumously awarded to Walter Reed for his work with yellow fever.","Materials housed in boxes 34-49 are generally arranged in chronological order by their date of creation. Materials housed in the remaining boxes of this series do not appear to have been arranged in a systematic fashion."],"_nest_path_":"/components#3","timestamp":"2026-08-14T22:54:59.526Z","collection":{"numFound":1,"start":0,"numFoundExact":true,"docs":[{"id":"viu_repositories_7_resources_1710","ead_ssi":"viu_repositories_7_resources_1710","_root_":"viu_repositories_7_resources_1710","_nest_parent_":"viu_repositories_7_resources_1710","ead_source_url_ssi":"data/oai/UVA/repositories_7_resources_1710.xml","aspace_url_ssi":"https://archives.lib.virginia.edu/ark:/59853/202324","title_ssm":["Philip S. Hench Walter Reed Yellow Fever collection"],"title_tesim":["Philip S. Hench Walter Reed Yellow Fever collection"],"unitdate_ssm":["circa 1800-circa 1998","bulk 1863-1974"],"unitdate_inclusive_ssm":["circa 1800-circa 1998"],"unitdate_bulk_ssim":["bulk 1863-1974"],"normalized_date_ssm":["1800/1998, bulk 1863/1974"],"normalized_title_ssm":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"text":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974","MS.1","Archival Resource Key","/repositories/7/resources/1710","Human Experimentation","Military Medicine","Physicians","Public health","Tropical medicine","Yellow Fever","There are no restrictions on user access to any of the materials in the collection except where noted in the container list.","The Philip S. Hench Walter Reed Yellow Fever Collection is organized in 16 series:","I. Jesse W. Lazear\n      II. Henry Rose Carter\n      III. Walter Reed\n      IV. Philip Showalter Hench\n      V. Maps\n      VI. Alphabetical files\n      VII. Truby-Kean-Hench\n      VIII. Miscellany\n      IX. Photographs\n      X. Photographic negatives\n      XI. Reprints\n      XII. Houston Academy of Medicine/Texas Medical Center additions\n      XIII. Reed family additions\n      XIV. P. Kahler Hench additions\n      XV. Laura Wood\n      XVI. Edward Hook additions","The U.S. Army Yellow Fever Commission (1900-1901) was a board of physicians that the U.S. government formed in order to determine how yellow fever was transmitted between hosts. Ultimately, the commission's experiments in Cuba proved that mosquitoes transmit yellow fever--a discovery that would spur successful campaigns to control and eradicate yellow fever throughout much of the globe.","When Major Walter Reed and Acting Assistant Surgeons James Carroll, Aristides Agramonte, and Jesse Lazear gathered on the porch of the Columbia Barracks Hospital in June of 1900, they became the fourth successive board of U.S. medical officers to grapple with the appalling plague that was yellow fever.","The persistence of this disease across the Cuban archipelago and its periodic re-emergence along the coastlines and great river drainages of the Americas was taking countless thousands of lives. Lack of precise knowledge as to its cause and transmission had augmented yellow fever's extraordinarily high mortality rate and had given rise to quarantine regulations which constituted substantial impediments to efficient regional trade. Endemic in the tropics, yellow fever imposed high humanitarian and economic costs upon the entire region. Specialists regarded Cuba as one of the principal foci of the disease, and the island consequently attracted considerable attention from the medical sciences.","In 1879, one year after a devastating epidemic swept up the Mississippi valley from New Orleans, Tulane University Professor Stanford E. Chaille led the first investigatory commission to Havana, Rio de Janeiro, and the West Indies. The Chaille Commission remained in Havana three months, and its members -- including George Miller Sternberg, who became Surgeon General of the Army, and Juan Guiteras, later Director of Public Health for Havana -- consulted with Cuban scientist Carlos J. Finlay. They concluded that the causal agent for yellow fever was possibly a living entity in the atmosphere, an assertion which set Finlay on the path to the mosquito theory he developed in 1881.","Louis Pasteur's foundational and highly successful work in modern immunology in 1880 and 1881 gave a renewed impetus to investigations aimed at discovering the \"yellow fever germ.\" Over the middle years of the 1880s several scientists advanced different theories, all readily refuted by bacteriological work Sternberg undertook in Brazil and Mexico in 1887 and again in Havana in 1888 and 1889. In 1897, Italian scientist Giuseppe Sanarelli argued thatBacillus icteroideswas the culprit, and the following year a third scientific team sailed to Cuba for additional tests. Eugene Wasdin and Henry D. Geddings appeared to confirm Sanarelli's assertion, though Sternberg, by then Surgeon General, remained skeptical.","Despite Wasdin and Geddings' insistence, theB. icteroidestheory garnered significant opposition. In fact, a few months before the third commission's report reached the public, Walter Reed and James Carroll -- Reed's assistant at the Columbian University (later George Washington University) bacteriology laboratories in Washington, D.C. -- published a thorough refutation of theicteroidesproposal: the bacteria was not a unique cause of yellow fever, but a variety of the hog cholera bacillus, \"a secondary invader in yellow fever,\" Reed determined, unrelated to its etiology. [1] Dispute continued, however, and when Sternberg organized the fourth investigatory board, he charged Reed and his associates to settle theB. icteroidesquestion once and for all, then to proceed with analysis of other blood cultures and intestinal flora from yellow fever cases.","Reed and Carroll had considerable experience in bacteriological analysis, and, Sternberg reasoned, might well be able to find the specific agent of the disease. Aristides Agramonte, a Cuban scientist who had worked in Reed's lab at the Columbian University in 1898, was also an accomplished bacteriologist; he had identifiedB. icteroidesin tissue samples from cases other than yellow fever, providing further evidence opposed to Sanarelli's thesis. Jesse Lazear, a scientist from Johns Hopkins University in Baltimore, Maryland, had joined the Army Medical Corps to study tropical diseases at their point of origin; he received orders for Cuba in February 1900. Lazear impressed Reed with his abilities when the two men became acquainted in March. No doubt with Reed's advice, Sternberg assembled a crack team -- all experienced in scientific research, but each with interests as diverse as their temperaments. The mix of talent and personalities generated spectacular results.","What causes yellow fever? This simple, even obvious question had dictated yellow fever research for over two decades, and so it guided Reed in organizing the work of the commission.Bacillus icteroidesand other bacteriological sampling dominated their work for the first months. \"Reed and Carroll have been at that for a long time,\" Lazear wrote with some impatience to his wife on August 23, \". . . I would rather try to find the germ without bothering about Sanarelli.\" [2] Again and again, tests for the bacteria proved negative, and at the same time, perplexing cases of yellow fever were developing in the region. Agramonte and Reed investigated an epidemic at Pinar del Rio, 110 miles southwest of Havana; Lazear followed later to collect more specimens, and he also assessed the situation at Guanjay thirty miles southwest. To \"my very great surprise,\" Reed admitted, the specific circumstances of the appearance and development of these cases gave strong evidence against the widely-accepted notion that the excreta of patients spread the disease. The theory of fomites -- infection from contaminated clothing and bedding -- and indeed even infection from airborne particles seemed altogether untrue. \"At this stage of our investigation,\" Reed concluded, \". . . the time had arrived when the plan of our work should be radically changed.\" [3] The fundamental question underwent a subtle but critical transformation: from what causes yellow fever to what transmits it. A clear and accurate understanding of how the disease was spread would open a new avenue to its specific cause.","\"Personally, I feel that only can experimentation on human beings serve to clear the field for further effective work,\" Reed stated to Surgeon General Sternberg, who concurred. [4] Evidence gathering around them pointed strongly to an intermediate host, and the Commission resolved to test Carlos Finlay's mosquito theory -- then not generally accepted -- on human volunteers. Nine times from August 11 to August 25, 1900, mosquitoes landed on the arms of volunteers and proceeded to feed. Nine times the results were negative. On August 27, Lazear placed a mosquito on the doubting Dr. Carroll, and four days later on William J. Dean, a soldier designated XY in the \"Preliminary Note.\" [5] Both promptly developed yellow fever. Significantly, their mosquitoes had fed on cases within the initial three days of an attack and had been allowed to ripen for at least twelve days before the inoculations. Carroll vitiated the results of his experimental sickness by traveling off the post to Havana, a contaminated zone, even as Reed, ecstatic, wrote from Washington in a confidential letter: \"Did the Mosquito do it?\" [6] Dean's case seemed to prove it, since he claimed not to have left the garrison before becoming ill. Lazear also developed a case of yellow fever, almost certainly experimental in origin, though he never revealed the actual circumstances of his inoculation. His severe bout of fever took a fatal turn on September 25, 1900.","Nevertheless, these results could not have been more dramatic or convincing for the Commission. Reed quickly assembled a \"Preliminary Note,\" which he presented to the annual meeting of the American Public Health Association in Indianapolis, Indiana, October 23, 1900. After initial consultations in Cuba with General Leonard Wood, military governor of the island, and with Surgeon General Sternberg in Washington, he returned to Cuba with authorization and funding to design and carry forward a fully defensible series of experiments. His aim was confirmation of the mosquito theory and invalidation of the long-held belief in fomites.","On open terrain beyond the precincts of Columbia Barracks -- the American military base just west of Havana near the adjacent suburban towns of Quemados and Marianao (also called Quemados de Marianao) -- Reed established the quarantined experimental station. Camp Lazear, as the Commission dedicated it, took form in the rolling fields of the Finca San Jose, on the farm of Dr. Ignacio Rojas, who leased the land to the Americans. Here Reed designed two small wood-frame buildings, each 14 by 20 feet, for the experimental work, and nearby raised a group of seven tents for the accommodation and support of the volunteers. The buildings faced each other across a small swale, about 80 yards apart, and stood 75 yards from the tent encampment. Building Number One, called the Infected Clothing Building, was a single room tightly constructed to contain as much foul air as possible. A small stove kept the temperature and humidity at tropical levels, and carefully attached screening secured the pair of doorways in a vestibule against intrusion by mosquitoes. Wooden blinds on two small sealed windows shielded the room from direct sun. Building Number Two, the Infected Mosquito Building, contained a principal room, divided into two sections by a floor-to-ceiling wire mesh screen. A door direct to the exterior let into one section, while a vestibule with a solid exterior door and pair of successive screened doors opened to the other, so configured to keep infected mosquitoes inside that section alone. The spare furnishings in both sections -- cots with bedding -- were steam sterilized. Windows exposed the entire room to the clean, steady ocean breezes and to sunlight. Like the doorways, they were carefully screened. A secondary room attached to the building but not communicating with the experimental spaces sheltered the small, heated laboratory where the Commission members raised and stored the mosquitoes to be used.","These two experimental buildings presented alternate environments -- one conspicuously clean and well ventilated, the other filthy and fetid. Contemporary theories of disease held that yellow fever developed in unclean conditions, and consequently much time and money had been devoted to sanitation projects. Workers steamed clothing, burned sulphur in ships' holds, and thoroughly scrubbed surfaces with disinfectant. In cases of severe epidemic, entire buildings presumed to be infected were set afire along with their contents. Thus the extraordinary -- and intentional -- paradox of the Commission's experimental regime: Reed expected yellow fever to develop not in the unsanitary environment, but in the one thought to be most healthful.","Camp Lazear went into quarantine the day of its completion, November 20, 1900, with a command of four immune and nine non-immune individuals, all save one U.S. Army personnel. Soon a group of recent Spanish immigrants to Cuba augmented the non-immune numbers, bringing the resident total to about twenty. Reed strictly controlled access to the camp and ordered regular temperature recording for each volunteer to eliminate any unanticipated source of infection and to identify the onset of any case of yellow fever as early as possible. As a result, non-immunes were barred from returning should they leave the precinct, and two of the Spaniards who developed intermittent fevers shortly after arrival were immediately transferred with their baggage to Columbia Barracks Hospital. The immune members of the detachment oversaw medical treatments and drove the teams of mules that pulled supply wagons and the ambulance. Experimentation did not begin until each volunteer had passed the incubation period for yellow fever in perfect health.","Reed took as much care with the design of the experimental protocol as he had with the configuration of the camp and its buildings. Each evening, the occupants of the infected clothing building unpacked trunks and boxes of bed linens and blankets, nightshirts and other clothing recently worn and soiled by cases from the wards of Columbia Barracks Hospital and Las Animas Hospital in Havana. These they shook out and spread around the room to permeate the atmosphere. The stench was overpowering. Yellow fever causes severe internal hemorrhaging, and its unfortunate victims often suffer from black vomit and other bloody discharges. One routine delivery proved so putrid the volunteers \"retreated from the house,\" Reed stated. \"They pluckily returned, however, within a short time, and spent the night as usual.\" [7] In two succeeding trials the protocol became progressively more daring , as the volunteers then wore the clothing and slept on the mattresses used by yellow fever patients, and finally put towels on their bedding smeared with blood drawn from cases in the early stages of an attack. Each morning, the volunteers carefully repacked the rank, encrusted materials into boxes and emerged to an adjacent tent where they spent the day quarantined from the rest of the company. Three trials of twenty days each involved seven men altogether, lead by Robert P. Cooke, a physician in the Army Medical Corps. None developed yellow fever.","The Commission's mosquito experiments proceeded in four series. First, Reed sought to demonstrate that mosquitoes of the varietyCulex fasciata(later calledStegomyia fasciata, and later stillAedes aegypti) could in fact transmit yellow fever, as Carlos J. Finlay had argued and the initial experiments at Camp Columbia strongly suggested. Here the Commission members simply applied infected mosquitoes contained in test tubes or jars to the skin of the initial volunteers. Success in these tests raised a number of questions, each one addressed in the subsequent series:","How could a building become infected?\n      When does a mosquito develop the ability to transmit the disease?\n      Over what length of time can a mosquito retain this capacity to infect?","The second series consequently employed the specialized \"Infected Mosquito Building\" to indicate how a structure could be considered infected with yellow fever. This experiment required two groups of volunteers, one to be inoculated and another to serve as controls. \"Loaded\" mosquitoes, as the men called them, were released into the screened section of Building Two -- on the side with the protected vestibule entry. One or more non-immune men then entered the opposite section of the room through the direct exterior door, and lay down on bunks adjacent to the wire mesh screen in the center of the room. Now the young man to be inoculated walked through the vestibule into the mosquito side of the room and proceeded to lie on a bunk adjacent to the wire screen separating him from the controls. The inoculation volunteer remained in the building for about twenty minutes -- enough time to suffer several mosquito bites -- he then exited to a quarantine tent outside. The controls spent the remainder of the evening and night in the uninfected side of the room, and indeed returned to sleep in the room for as many as eighteen more nights. As Reed stated, absence of yellow fever in the controls showed \"that the essential factor in the infection of a building with yellow fever is the presence therein of [infected] mosquitoes,\" and nothing more. [8] The degree of sanitation, so long considered critical, was utterly irrelevant.","The third series of mosquito experiments confirmed what Henry Rose Carter, of the U.S. Public Health Service, called the \"period of extrinsic incubation,\" [9] the length of time required for secondary cases of yellow fever to develop after an initial intrusion of the disease into a locality. In this series, a single volunteer underwent three successive inoculations by the same mosquitoes, each group of inoculations interrupted by a period of time equal in length to the typical incubation period of the disease in humans, about five days. In this manner, the volunteer's illness could be specifically attributed to a single inoculation group. The use of the same mosquitoes and the same volunteer concurrently demonstrated that no peculiar personal immunity was at play, since logic dictates that a person susceptible to yellow fever on day 17 of a mosquito's contamination -- as happened in the experiment -- could not have been immune to yellow fever on day 11 or day 4. It was thus only the mosquito's capacity to infect which changed, and that occurred no less than 11 days after contamination.","The duration of time over which these \"fully ripened\" mosquitoes remained infective comprised the fourth series of experiments. For this series the Commission kept alive a group of infected mosquitoes for as long as possible, and proceeded to inoculate three volunteers -- on the 39th, 51st, and 57th day after contamination. Each developed yellow fever. A fourth volunteer declined to be bitten on day 65, and the last two mosquitoes of the group, \"deprived of further opportunity to feed on human blood\" [10] expired on day 69 and day 71, clear evidence that even a sparsely populated region may retain the potential for new infections more than two months after the first appearance of the disease.","Although it went unrecorded in the published papers, Reed organized a supplemental experiment to test another species of mosquito.Culex pungensfailed to transmit yellow fever to at least one volunteer and probably to a second. Reed's preliminary conclusions indicated thatCulex fasciatawas the only species capable of transmitting yellow fever. [11]","A last experimental regime involved subcutaneous injections of blood from positive cases of yellow fever to presumed non-immunes. Reed devised these tests to confirm the presence of the yellow fever agent in the blood of a victim during the first days of an attack, and, more importantly, to settle theBacillus icteroidesquestion. The same blood cultures which produced yellow fever in four volunteers also failed to grow anyB. icteroides, conclusively invalidating Sanarelli's claim.","Altogether, the mosquito inoculations and the blood injections produced fourteen cases of yellow fever. All made a full recovery.","Notwithstanding the decisive medical victory -- as Reed declared, \"aside from the antitoxin of Diptheria and Koch's discovery of the tubercle bacillus, it will be regarded as the most important piece of work, scientifically, during the 19th century\" [12] -- success at Camp Lazear unfolded in its own time. Initially, Reed observed, \"the results obtained at this station were not encouraging.\" [13] The first inoculations of four volunteers over a period of two weeks proved disconcertingly negative each time. Then, on December 5, 1900, private John R. Kissinger presented his arm to the mosquitoes, and late in the evening on December 8, suffered the first chills of \"a well-marked attack of yellow fever.\" [14] Three more men in rapid succession fell victim to the insects -- Spanish volunteers Antonio Benigno, Nicanor Fernandez, and Vicente Presedo. The force of the conclusions was evident to everyone:","\"It can readily be imagined,\" Reed empathetically and wryly described in his first presentation of the experiments, \"that the concurrence of 4 cases of yellow fever in our small command of 12 non-immunes within the space of 1 week, while giving rise to feelings of exultation in the hearts of the experimenters, in view of the vast importance attaching to these results, might inspire quite other sentiments in the bosoms of those who had previously consented to submit themselves to the mosquito's bite. In fact, several of our good-natured Spanish friends who had jokingly compared our mosquitoes to 'the little flies that buzzed harmlessly about their tables,' suddenly appeared to lose all interest in the progress of science, and, forgetting for the moment even their own personal aggrandizement, incontinently severed their connection with Camp Lazear. Personally, while lamenting to some extent their departure, I could not but feel that in placing themselves beyond our control they were exercising the soundest judgment.\"","\"In striking contrast,\" Reed continued, the anxiety of the fomites volunteers began to melt into relief. \"[T]he countenances of these men, which had before borne the serious aspect of those who were bravely facing an unseen foe, suddenly took on the glad expression of 'schoolboys let out for a holiday,' and from this time their contempt for 'fomites' could not find sufficient expression. Thus illustrating once more, gentlemen, the old adage that familiarity, even with fomites, may breed contempt.\" [15]","The question of human experimentation was indeed a serious one -- unavoidable, in actuality, as Reed had stated the previous summer to Surgeon General Sternberg. When the Commission first considered a trial of Finlay's mosquito theory, Reed, Carroll, and Lazear agreed to experiment on themselves. Agramonte, a native Cuban, had acquired immunity as a child. Doubtless Finlay's experience of many unsuccessful inoculations communicated that positive results would not be forthcoming rapidly, so before the first series of inoculations began under Lazear's direction at Columbia Barracks, Reed left Cuba for Washington, where he completed a monumental report on typhoid fever among the army corps -- left unfinished by the sudden death of co-author Edward O. Shakespeare. Carroll and Lazear both sickened while Reed was in Washington, and Lazear, young and strong, had no reason to anticipate that his case would be fatal. Reed was shocked at Lazear's death, and because of his own age -- 49, a decade and a half older than Lazear and a dozen years older than Carroll -- he resolved not to inoculate himself when he returned to Cuba on October 4, 1900. The point had already been amply demonstrated, and only a rigidly controlled experimental regime would establish the necessary proof. Carroll, however, remained embittered about this for the remainder of his life, though he evidently never communicated his objections directly to Reed.","That initial series of mosquito inoculations was probably accomplished without formal documentation of informed consent. Indeed, the experiments may also have been carried forward without the full knowledge of the commanding officer of Camp Columbia, and Reed consequently shielded the identity of Private William J. Dean, the second positive experimental case, behind the pseudonym \"XY\" in the \"Preliminary Note.\" No such potentially troublesome problems arose for the experimental series at Camp Lazear; Reed obtained prior support from all of the appropriate authorities in the military and the administration, even including the Spanish Consul to Cuba. With the advice of the Commission and others, he drafted what is now one of the oldest series of extant informed consent documents. The surviving examples are in Spanish with English translations, and were signed by volunteers Antonio Benigno and Vicente Presedo, and a third with the mark of Nicanor Fernandez, who was illiterate.","The documents take the form of a contract between individual volunteers and the Commission, represented by Reed. At least 25 years old, each volunteer explicitly consented to participate, and balanced the certainty of contracting yellow fever in the general population against the risks of developing an experimental case, followed by expert and timely medical care. The volunteers agreed to remain at Camp Lazear for the duration of the experiments, and as a reward for participation would receive $100 \"in American gold,\" with an additional hundred-dollar supplement for contracting yellow fever. These payments could be assigned to a survivor, and the volunteers agreed to forfeit any remuneration in cases of desertion.","For the American participants no consent documents appear to survive, though in contemporary letters Reed assured his correspondents that the Commission obtained written consent from all the volunteers. The record of expenses for Camp Lazear -- maintained by Reed's friend and colleague in the medical corps, Jefferson Randolph Kean -- indicates that the same schedule of payments for participation and sickness applied to the Americans as well. Volunteers who participated in the fomites tests and in addition the later series of blood injections and the single trial of an alternative species of mosquito also earned $100 each plus the $100 supplement if yellow fever developed. Two Americans declined these gratuities, as Kean termed them, Dr. Robert P. Cooke, of the fomites tests, and John J. Moran, who had recently received an honorable discharge from the service, and was the only American civilian to participate. His was the fourth case of yellow fever to develop from mosquito inoculation. Moran eventually settled in Cuba, where he managed the Havana offices of the Sun Oil Company, and late in life became a close friend of Philip S. Hench. Together the two men rediscovered the site of Camp Lazear in 1940 -- Building Number One still intact -- and successfully lobbied the Cuban government to memorialize there the work of Finlay and the American Commission in the conquest of yellow fever.","Reed informally commemorated his own experiences at Camp Lazear by commissioning a group photograph, evidently taken there shortly before he left Cuba in February 1901. A more important event occurred on the sixth of that month when Reed presented the results of the Camp Lazear yellow fever experiments to a great ovation at the Pan-American Medical Congress in Havana. Three days later he set sail for the United States, and once landed, drafted the Congress paper asThe Etiology of Yellow Fever -- An Additional Note, published immediately in theJournal of the American Medical Association. [16]","Though his correspondence intimates a great appreciation for Cuba, Reed never returned to the warm, sunny shores of the island freed of a dreadful plague. Carroll stayed behind at Camp Lazear through February to complete the last experimental series officially bearing the imprimatur of the Yellow Fever Commission, and returned to Washington soon after March first. [17] The Medical Corps retained the lease on Camp Lazear against the possibility of continuing experiments another season, and Carroll, in fact, returned to Havana in August 1901 for a final experimental series, though he did not make use of Camp Lazear. This work involved at least three volunteers at Las Animas Hospital, Havana, who submitted to blood injections. Carroll's assignment aimed at a greater understanding of the yellow fever agent, and he proved that blood drawn from active cases of yellow fever remained virulent even after passing through fine bacteria filters. In addition, by heating contaminated blood which had previously caused cases of yellow fever, Carroll rendered it non-infective -- thereby establishing that this filterable entity, though sub-microscopic, was demonstrably present in the bloodstream. Carroll wrapped up the series in October and returned home to stay. [18] In Cuba, J. Randolph Kean made the last rental payments to Signore Rojas on October 9, 1901, and Camp Lazear, for more than a generation, slipped out of the realm of memory.","Sources:","[1] Walter Reed and James Carroll,Bacillus Icteroides and Bacillus Cholerae Suis -- A Preliminary Note,Medical News(29 April 1899), reprinted in: United States Senate Document No. 822,Yellow Fever, A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 55.\n      [2] Letter from Jesse W. Lazear to Mabel Houston Lazear, 23 August 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00341001.\n      [3] Walter Reed, \"The Propagation of Yellow Fever -- Observations Based on Recent Researches,\" in United States Senate Document No. 822,Yellow Fever A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 94.\n      [4] Letter from Walter Reed to George M. Sternberg, 24 July 1900, Hench Reed Yellow Fever Collection, accession number: 02064001.\n      [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note,Proceedings of the Twenty-eighth Annual Meeting of the American Public Health AssociationIndianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n      [6] Letter from Walter Reed to James Carroll, 7 September 1900, Edward Hook Additions to the Philip S. Hench Walter Reed Yellow Fever Collection: James Carroll Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 15312004. The originals of these letters remain in a private collection.\n      [7] Walter Reed, James Carroll, Aristides Agramonte,The Etiology of Yellow Fever -- An Additional Note,Journal of the American Medical Association36 (16 February 1901): 431-440, reprinted in: Senate Document No. 822, p. 84.\n      [8] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n      [9] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n      [10] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 101.\n      [11]Culex fasciatawas reclassified shortly after the experiments asStegomyiaand later becameAedes aegypti.\n      [12] Letter to from Walter Reed to Emilie Lawrence Reed, 9 December 1900, Hench Reed Collection, accession number: 02231001.\n      [13] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 97.\n      [14] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 98.\n      [15] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n      [16] Please see note [7].\n      [17] The Commission reported these concluding experiments in: Walter Reed, James Carroll, Aristides Agramonte,Experimental Yellow Fever,American MedicineII (6 July 1901) 1: 15-23.\n      [18] Walter Reed, James Carroll,The Etiology of Yellow Fever (A Supplemental Note),American MedicineIII (22 February 1902) 8: 301-305.","Walter Reed (September 13, 1851 - November 22, 1902) was a U.S. Army physician who led the army's Yellow Fever Commission 1900 and 1901. Experiments conducted by the commission confirmed a theory that yellow fever is transmitted by mosquitoes--a discovery that led to the control and eradication of this disease across much of the globe. Reed would receive much of the credit for the work of the commission because of his role as its leader, and, long after his death in 1902, he would be widely celebrated as a heroic figure in the fields of public health and medical research.","Reed spent his first days in a small house which served as the parsonage for a Methodist congregation in Gloucester County, Virginia, where his father was minister.  Lemuel Sutton Reed and Pharaba White Reed welcomed young Walter into the family on September 13, 1851;  he was the youngest of their five children.  The Reeds moved to other Virginia parishes during Walter's childhood, and just after the close of the Civil War, transferred to the town of Charlottesville.  That move in 1866 placed Walter in the orbit of the University of Virginia, which he entered a year later at age sixteen under the care of his older brother Christopher, also a student at the University.  Reed attended two year-long sessions, the second devoted entirely to the medical curriculum, and he completed an M.D. degree on July 1, 1869, as one of the youngest students to graduate in the history of the medical school.","At that time the School of Medicine at the University offered little opportunity for direct clinical experience, so Reed subsequently enrolled at the Bellevue Hospital Medical College, in Manhattan, New York.  There he obtained a second M.D. degree in 1870.  Reed interned at a number of hospitals in the New York metropolitan area, including the Infants' Hospital on Randall's Island and the Brooklyn City Hospital.  In 1873, he assumed the position of assistant sanitary officer for the Brooklyn Board of Health.  The large and diverse population of New York, with its many immigrant communities and dense, tenement housing, provided countless medical cases to treat and study;  these served to expose Reed to the vital importance of public health, and developed in him a lifelong interest in the field.  Yet the frenetic life of the great cities began to pall after a few years: \"Here the ever bustling day is crowded into the busy night; nor can we draw the line of separation between the two,\"[1] he wrote to Emilie Lawrence, of Murfreesboro, North Carolina, later to become Mrs. Walter Reed.  Their courtship letters reveal much of his maturing character, interests, and philosophy of life.  Increasing responsibilities with the Board of Health precluded opening a private practice, and Reed's youth proved a barrier in a culture given to offering respect more to the appearance of maturity than to its actual demonstration. Reed consequently resolved to join the Army Medical Corps, both for the professional opportunities it offered immediately and for the modest financial security it could provide to a young man without independent means.  He passed the qualifying examinations in January 1875 and proceeded to his first assignment at the military base on Willet's Point, New York Harbor.","Reed remained in the Medical Corps for the rest of his life, spending many years of the '70s, '80s, and early '90s at difficult postings in the American West.  The first of these -- to the Arizona Territory -- began in the late spring of 1876, and indeed hurried along his wedding to Emilie Lawrence, on April 25, shortly before his departure.  She joined him the following November, and bore two children at frontier posts, a son Walter Lawrence and a daughter Emilie, called Blossom.","Reed's other western assignments included forts in Nebraska, Dakota Territory, and Minnesota, with two eastern interludes at Baltimore, Maryland and another at Mount Vernon Barracks, Alabama.  During the second of these tours in Baltimore -- over the 1890-1891 academic year -- Reed completed advanced coursework in pathology and bacteriology in the Johns Hopkins University Hospital Pathology Laboratory.  When he returned from his last western appointment in 1893, Reed joined the faculty of the Army Medical School in Washington, D.C., where he held the professorship of Bacteriology and Clinical Microscopy.  He also became curator of the Army Medical Museum and joined the faculty of the Columbian University in Washington (later the George Washington University).  In addition, Reed maintained close ties with professor William Welch and other leading lights in the scientific community he had come to know at Hopkins a few years earlier.","Beyond his teaching responsibilities for the Army and the Columbian University programs, Reed actively pursued medical research projects.  A bibliography of his publications finds entries from 1892 to the year of his untimely death a decade later, and the subjects he investigated range from erysipelas to cholera, typhoid, malaria, and yellow fever, among others.[2]   In 1896, a research trip to investigate an outbreak of smallpox took him to Key West, and there he developed a close friendship with Jefferson Randolph Kean, a fellow Virginian and colleague in the Medical Corps ten years his junior.  When Reed traveled to Cuba in 1899 to study typhoid in the army encampments of the U.S. forces, Kean was already there, and Kean was still in Cuba when Reed returned as the head of the Army board charged by Surgeon General George Miller Sternberg to examine tropical diseases including yellow fever.  Kean and his first wife Louise were great supporters of the U.S. Army Yellow Fever Commission's work, and Kean in fact served as quartermaster for the famous series of experiments at Camp Lazear.  After the dramatic and conclusive success of those experiments, Kean actively -- though unsuccessfully -- promoted Reed's candidacy for Surgeon General.","Reed continued to speak and publish on yellow fever after his return from Cuba in 1901, receiving honorary degrees from Harvard and the University of Michigan in recognition of his seminal work.  In November 1902, Reed developed what had been for him recurring gastro-intestinal trouble.  This time, however, his appendix ruptured, and surgery came too late to save him from the peritonitis which developed.  He died on November 23, 1902, almost two years to the day from the opening of Camp Lazear and the stunning experimental victory there.  Kean remained a champion of his deceased friend's role in the conquest of yellow fever.  He organized the Walter Reed Memorial Association, to provide support for Reed's family and to build a suitable memorial, and was instrumental in lobbying the United States Congress to establish the Yellow Fever Roll of Honor.  In 1929, Congress mandated the annual publication of the Roll in theArmy Register, and struck a series Congressional Gold Medals saluting the Commission members and the young Americans who bravely suffered experimental yellow fever a generation before.","Sources:","[1] Letter from Walter Reed to Emilie Lawrence, 18 July 1874, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 01605001.\n      [2] The bibliography of Reed's scientific papers may be found in: Howard Atwood Kelly,Walter Reed and Yellow Fever(New York: McClure, Phillips and Co., 1906), pp. 281-283. Kelly's complete biography of Reed is contained on this Web site.","Jesse William Lazear (May 2, 1866 - September 26, 1900) was a physician who was a member of the U.S. Army Yellow Fever Commission in 1900. Lazear's death from yellow fever at the outset of the commission's work in Cuba would lead to his elevation as a martyr for medical science in the eyes of many during the twentieth century.","\"I rather think I am on the track of the real germ,\" Jesse W. Lazear wrote his wife from Cuba on September 8, 1900.[1] Seventeen days later, the fulminating case of yellow fever Lazear had contracted just over a week after writing Mabel H. Lazear suddenly ended the young scientist's life. He was 34 years old. Unlike so many other yellow fever fatalities, however, this one would lead to a direct and highly successful assault on the disease itself. Yellow fever's ascendancy, endemic in Cuba, was about to be undermined.","Lazear had reported to Camp Columbia, Cuba in February 1900 for duty as an acting assistant surgeon with the U. S. Army Corps stationed on the island. Here he undertook bacteriological study of tropical diseases, particularly malaria and yellow fever, and in May he was named to the Army board charged with \"pursuing scientific investigations with reference to the infectious diseases prevalent on the island of Cuba.\"[2]","These orders placed him officially in the company of Walter Reed, James Carroll, and Aristides Agramonte -- the U.S. Army Yellow Fever Commission -- though Lazear had already met Reed the preceding March on a project to evaluate the efficacy of electrozone, a disinfectant made from seawater collected off the Cuban coast. While Reed was in Cuba that March, Lazear discussed with him the recent discovery of British scientist Sir Ronald Ross concerning the mosquito vector for malaria. At Johns Hopkins Hospital in Baltimore, where he was first a medical resident and later in charge of the clinical laboratory, Lazear had followed Ross's accomplishments with great interest, and pursued field work and experimentation on theAnophelesmosquito with fellow Hopkins scientist William S. Thayer. Lazear was thus the only member of the Commission who had experience with mosquito work, and was consequently the most open to the possible verity of Cuban scientist Carlos Juan Finlay's theory of mosquito transmission for yellow fever.","The record is apparently silent as to when Lazear first visited Finlay. Certainly by late June Lazear was beginning to grow mosquito larvae acquired from Finlay's laboratory, the first specimens brought to him by Henry Rose Carter, of the United States Public Health Service.[3] Not long after arriving in Cuba Lazear met Carter, whose own observations on yellow fever strongly suggested an intermediate host in the spread of the disease. However, Army Surgeon General George Miller Sternberg, who organized the Yellow Fever Commission, first charged the board members to investigate the relationship ofBacillus icteroidesto yellow fever -- proposed by the Italian Scientist Giuseppe Sanarelli as the actual cause of the disease. \"Dr. Reed had been in the old discussion over Sanarelli's bacillus and he still works on that subject,\" Lazear wrote his wife in July, \"I am not all interested in it but want to do work which may lead to the discovery of the real organism.\"[4] Soon he would have the opportunity. The relatively quick failure of the Bacillus icteroides inquiry opened the door to what became the ground-breaking mosquito work, and Lazear was well placed to begin.","The project started in earnest on August 1, 1900. In a small pocket notebook Lazear noted the preparatory work of raising and infecting mosquitoes, and subsequently recorded the series of eleven experimental inoculations made from the 11th to the 31st of August, the last two producing cases of full-blown yellow fever. These two positive cases developed from mosquitoes allowed to ripen over a period of 12 days, and this was Lazear's crucial discovery. The epidemiological pattern was thus entirely consistent with Carter's observations of a delay between the primary and secondary outbreaks of yellow fever in an epidemic, and, in addition, explained why Finlay's experiments had been largely unsuccessful -- he had not waited long enough before inoculating his subjects.","Although Lazear never directly admitted to experimenting on himself, when Reed reviewed Lazear's sketchy notations he evidently found entries strongly suggesting Lazear's case was not accidental, as officially reported. Unfortunately, the little notebook so crucial to the preparation of the Commission's famous initial paper,The Etiology of Yellow Fever -- A Preliminary Note[5], vanished from Reed's Washington office after his own untimely death in 1902. Still, Lazear's invaluable contribution to the Commission's victory was widely recognized and elicited tributes from many quarters: \"He was a splendid, brave fellow,\" Reed said of his young colleague, \" and I lament his loss more than words can tell; but his death was not in vain- His name will live in the history of those who have benefited humanity.\" [6] \"His death was a sacrifice to scientific research of the highest character,\" stated General Leonard Wood, military Governor of Cuba.[7] \"Your husband was a martyr in the noblest of causes,\" Dr. L. O. Howard wrote to Mabel Lazear, \"and I am proud to have known him. . . . His work contributed towards one of the greatest discoveries of the century, the results of which will be of invaluable benefit to mankind.\"[8] And so they were. Though Lazear's one-year-old son and newborn daughter never knew their father, they grew up in a world liberated -- almost in its entirety -- from the disease that killed him.","[1] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 8 September 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00344001.","Sources:","[2] Military Orders for Walter Reed, James Carroll, Aristides Agramonte, and Jesse W. Lazear, 24 May 1900, Hench Reed Collection, accession number 02019001.\n      [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n      [4] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 15 July 1900, Hench Reed Collection, accession number: 00334001.\n      [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note, Proceedings of the Twenty-eighth Annual Meeting of the American Public Health Association Indianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n      [6] Letter from Walter Reed to Emilie Lawrence Reed, 6 October 1900, Hench Reed Collection, accession number: 02135001.\n      [7] Letter from Leonard Wood to the Adjutant-General, United States Army, November 1900, Hench Reed Collection, accession number: 00375002.\n      [8] Letter from Leland Ossian Howard to Mabel Houston Lazear, 7 February 1901, Hench Reed Collection, accession number: 00388001.","Henry Rose Carter (August 25, 1852 - September 14, 1925) was a prominent physician in the U.S. Public Health Service who was a leading authority in the transmission and control of tropical diseases, particularly yellow fever and malaria. During his long career as a sanitarian, Carter undertook campaigns to investigate and control the spread of tropical diseases in Cuba, the Panama Canal Zone, the Southeastern United States, and Peru.","Like Walter Reed and Jefferson Randolph Kean, Henry Rose Carter was a native Virginian and a graduate of the University of Virginia. Carter obtained a civil engineering degree from Virginia in 1873 and also undertook post-graduate work in mathematics and applied chemistry the next year. Subsequently, however, Carter's interests turned towards medicine, and he completed a medical degree at the University of Maryland in 1879. The same year Assistant Surgeon Carter joined the Marine Hospital Service -- later the United States Public Health Service -- and the young surgeon rose steadily through the ranks, ultimately attaining the position of Assistant Surgeon General in 1915.","Carter's initial assignments with the Hospital Service placed him at the center of the yellow fever maelstrom. In 1879 he was detailed to Memphis and other Southern cities, then in the throes of a second year of devastating epidemics. Here began, as his colleague T. H. D. Griffitts observed, Carter's \"lifelong interest in the epidemiology and control of yellow fever.\"[1] After several years of clinical practice in various Marine hospitals, Carter resumed a direct confrontation with yellow fever when his orders for duty with the Gulf Coast Maritime Quarantine assigned him to Ship Island, Mississippi, in 1888. Here and at subsequent quarantine station postings around the Gulf, he quietly championed a thorough review and rationalization of quarantine policies, with a view toward establishing uniform regulation, more thorough disinfection of vessels, and minimized interference with naval commerce. Crucial to the success of these activities was Carter's attention to the incubation period of yellow fever, which his on-site observations indicated to vary between 5 and 7 days. At the time the official literature stated with far less precision a variance of between 1 and 14 days; Carter's work consequently greatly increased the efficiency and effectiveness of quarantine operations.","Nevertheless, yellow fever continued to menace the temperate coastline of the United States, and Carter ably directed the Health Service's epidemiological control efforts in numerous threatened regions. In conjunction with this sanitary work for the 1898 season, Carter made detailed notes on the development of yellow fever at Orwood and Taylor, Mississippi. The isolation of these communities enabled him to identify more reliably the phenomenon of a delay between the initial cases of yellow fever in a locality and the subsequent appearance of secondary infection -- a delay two to four times longer than the incubation period of the disease in an infected person. Carter called this interval between the primary and secondary cases \"the period of extrinsic incubation,\" and he defined its \"usual limits . . . [as ranging] from ten to seventeen days.\"[2]","Before he was able to publish his conclusions, Carter took the helm of the quarantine service in war-time Cuba. There, in 1900, he met U. S. Army Yellow Fever Commission member Jesse Lazear. Carter had finally arranged for his paper's publication that year in theNew Orleans Medical and Surgical Journal, and gave a draft to Lazear. \"If these dates are correct,\" Carter later recalled Lazear saying, \"it spells a living host.\"[3] The theory of mosquito transmission long advanced by Cuban scientist Carlos J. Finlay began to seem more likely. And indeed it was. The Commission's experiments in 1900-1901 irrefutably proved the mosquito vector and established the extrinsic incubation period at twelve days. Shortly after these successes Reed saluted Carter, \"I know of no one more competent to pass judgment on all that pertains to the subject of yellow fever. You must not forget that your own work in Mississippi did more to impress me with the importance of an intermediate host than everything else put to-gether.\"[4]","Carter's long and distinguished sanitary career took him to the Panama Canal Zone in 1904, where he served as Chief Quarantine Officer and Chief of Hospitals for five years. He undertook detailed investigations and control measures of malaria in North Carolina and elsewhere in the South, and became a founder of the National Malaria Committee. With the support of the Rockefeller Foundation International Health Board, he undertook additional investigation and control measures for yellow fever in Central and South America. His expertise recommended him to the Peruvian government, which named Carter Sanitary Advisor in 1920-1921. Health problems at the end of his life compelled Carter to withdraw from active fieldwork, though he remained a highly valued consultant to the Health Board and a much-beloved and respected teacher for a new generation of sanitarians. Carter closed his career researching and writing the manuscript that his daughter Laura Armistead Carter edited and published posthumously in 1931:Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.[5]","Sources:","[1] T. H. D. Griffitts,Henry Rose Carter: The Scientist and the Man,Southern Medical Journal32 (August 1939) 8: 842.\n      [2] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n      [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n      [4] Letter from Walter Reed to Henry Rose Carter, 26 February 1901, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 02447001.\n      [5] Carter, Henry Rose.Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.Baltimore: The Williams and Wilkins Company, 1931.","Jefferson Randolph Kean (June 27, 1860 - September 4, 1950) was a U.S. Army physician who was a leading authority in sanitation, public health, and tropical diseases. Later in his career, Kean would become widely recognized for his role in organizing and administering medical services for the U.S. armed forces during World War I.","\"He possessed one of the keenest, most scholarly minds I've ever encountered,\" recalled Nobel Prize winner Philip S. Hench of Jefferson Randolph Kean. [1] Kean and Hench shared an abiding interest in the work of the United States Army Yellow Fever Commission -- Kean, as a contemporary and supporter, and Hench, as a scholar and scientist intent on accurate historical documentation. On the advice of yellow fever experiment volunteer John J. Moran, Hench first wrote Kean in 1939. From that initial contact developed a close friendship which would last for the remainder of their lives. Kean entrusted Hench not only with numerous period documents, including original letters, accounts, fever charts, and other items, but also with the freely-given counsel and insight of a trusted friend.","Like Walter Reed and Henry Rose Carter before him, Jefferson Randolph Kean was an alumnus of the University of Virginia, completing the medical program there in 1883. Kean joined the U.S. Army Medical Corps in 1884, and after forty years in the service, retired with the rank of Colonel. Congress awarded him a promotion to Brigadier General, retired, in 1930. The early years of Kean's career passed in medical postings in the American West, and no doubt offered him experiences similar to those of Walter Reed, whom he met not on the frontier, but in Florida in 1896. Kean became an expert in tropical diseases and sanitation during his five-year assignment in the Florida tropics, an expertise which served him well over two terms of service later in Cuba. During the Spanish-American War and subsequent U. S. occupation of Cuba, Kean was Chief Surgeon for the Department of Havana, then Superintendent of the Department of Charities -- from 1898 to 1902. After a four-year interlude as an assistant to the Surgeon General in Washington, D.C., Kean again returned to Cuba as an advisor to the Department of Sanitation from 1906-1909.","Kean himself stated: \"Reed and I were good friends before the Yellow Fever Board came to Cuba in June 1900, and [Reed] located himself at Marianao, 8 miles S. W. of Havana,\" to be within the medical and administrative jurisdiction overseen by Kean. [2] The Chief Surgeon did indeed offer significant assistance, and was an early convert to Carlos Finlay's mosquito theory of transmission, which the Yellow Fever Board's experiments ultimately proved true in the late autumn and winter of 1900-1901. As early as October 13, 1900 -- after the Board's preliminary work, but before the final convincing demonstrations -- Kean issued \"Circular No. 8,\" concerning the latest scholarship on the mosquito vector for disease. [3] The circular contained a set of instructions for the entire command on mosquito eradication. Kean subsequently served as quartermaster and financial administrator for the famous series of yellow fever experiments at Camp Lazear and, for the rest of his life, Kean remained a strong proponent of the Commission's conclusions. He worked tirelessly not only to apply them in the field, but also to accord proper public recognition to the Commission's work.","In addition to his career as a sanitarian, Kean organized the department of military relief of the American Red Cross, and during World War One served as Chief of the U. S. Ambulance Service with the French Army and Deputy Chief Surgeon of the American forces. France named him an Officier de la Légion d'Honneur in recognition for these services. Cuban authorities as well offered Kean recognition with the grand cross of the Order of Merit Carlos J. Finlay, and he received both a Distinguished Service Medal from the United States government and the Gorgas Medal from the Association of Military Surgeons. For a decade after his retirement from active duty, Kean edited this last organization's medical journal,The Military Surgeon, and served on the Surgeon General's editorial board for the multi-volume history of the medical department in World War One. A great-grandson of Thomas Jefferson, Kean also took a seat with the government commission established to build the Jefferson Memorial in Washington, D.C. He held charter membership in the Walter Reed Memorial Association, and remained active in its affairs until his death in 1950.","Sources:","[1] Telegram from Philip Showalter Hench and Mary Hench to Cornelia Knox Kean, September 5, 1950, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 06501173.\n      [2] Letter from Jefferson Randolph Kean to Philip Showalter Hench, October 31, 1939, Hench Reed Yellow Fever Collection, accession number: 06282022.\n      [3] Military Orders to Commanding Officers, October 15, 1900, Hench Reed Yellow Fever Collection, accession number: 02140001.","Philip Showalter Hench (February 28, 1896 - March 30, 1965) was a U.S. physician who in 1950 was awarded the Nobel Prize for Physiology and Medicine for his role in the discovery of the hormone cortisone. In addition to his medical research, Hench spent almost three decades of his life studying the history of the U.S. Army Yellow Fever Commission and became a leading authority in the subject.","Philip Showalter Hench was born in Pittsburgh, Pennsylvania, the son of Jacob Bixler Hench and Clara Showalter. After attending local schools, Hench entered Lafayette College and graduated from the school 1916 with a Bachelor of Arts. Hench completed his medical degree at the University of Pittsburgh in 1920, and subsequently entered a residency program at St. Francis Hospital, Pittsburgh. His association with the Mayo Clinic began in 1921 as a fellow at the institution. Two years later he would become an assistant at the clinic, and then, in 1926, he would be made the head of its Department of Rheumatic Diseases After pursuing post-graduate study in Germany in 1928-1929, Hench obtained a Masters of Science in Internal Medicine at the University of Minnesota in 1931, and a Doctor of Science degree from Lafayette College in 1940. Hench remained for the duration of his career at the Mayo Clinic, where his life-long passion for meticulous research and analysis brought him the Nobel Prize for Physiology and Medicine in 1950, which he shared with Edward C. Kendall and Tadeus Reichstein, for the discovery of cortisone.","The same persistence and determination present in his professional life is also evident in Hench's research on the U. S. Army Yellow Fever Commission's famous experiments. \"As a physician particularly interested in medical history,\" he stated to experiment volunteer John J. Moran in 1937, \"I have been long interested in the story of the yellow fever work in John J. Moran, Ralph C. Hutchison, Havana.\" [1] So began a remarkable odyssey. At the request of his friend Ralph Cooper Hutchison, then president of Washington and Jefferson College, Hench had written Moran to gather information for the dedication of the College's new chemistry building, named for Commission member and former Washington and Jefferson student Jesse W. Lazear. Hench also began a correspondence with another of the yellow fever experiment's original volunteers, John R. Kissinger. Moran's and Kissinger's recollections proved so intriguing that Hench initially offered to edit and publish them. However, in the course of his research Hench discovered that much general information on the topic was inaccurate. Conflicting assertions concerning the participants and unverified claims by medical and governmental authorities in the United States and Cuba -- often politically motivated -- clouded interpretation of the facts. \"May I suggest,\" Moran consequently urged in 1938, \"that a clearing up of the REED-FINLAY-CONQUEST-OF-YELLOW-FEVER, or an effort to do so, on your part, is a task far more pressing than publishing the Kissinger-Moran stories or memoirs.\" [2] Hench resolved to document every aspect of the \"Conquest of Yellow-Fever\" and to write a much needed accurate and comprehensive history.","For the next two decades, Hench tirelessly combed through public archive collections and personal papers in the United States and Cuba. He met and interviewed surviving participants of the experiments and others associated with the project, as well as family members of the Yellow Fever Commission. He sought out physicians and scientists who had worked with the principal players or who had applied the results in the campaign to eradicate yellow fever. He identified and photographed sites associated with the yellow fever story, and he successfully petitioned politicians in the United States and Cuba to commemorate the work. In the process, Hench became the trusted friend and advisor of many of these same individuals, and they, in turn, presented him with much of the surviving original material for safekeeping.","In short, Hench came to be the world's expert on the yellow fever story and the steward of thousands of original letters and documents. His premature death at age 69 found him still hoping to uncover important missing evidence, his book unwritten. Hench's widow Mary Kahler Hench gave his yellow fever collection to the University of Virginia, Walter Reed's alma mater, and this extensive personal archive forms the most detailed and accurate record available on the Conquest of Yellow Fever.","Sources:","[1] Letter from Philip S. Hench to John J. Moran, 6 July 1937, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 03419001.\n      [2] Letter from John J. Moran to Philip S. Hench, 30 October 1938, Hench Reed Yellow Fever Collection, accession number: 03476001.","Materials from the following series were initially deposited at the University of Virginia's Alderman Library. In 1982, they were moved to the Claude Moore Health Sciences Library under the terms of a gift agreement that required the transferral of Mary K. Hench's donation to the library when adequate storage space for the collection could be found there.","Series I. Jesse W. Lazear\n      Series II. Henry Rose Carter\n      Series III. Walter Reed\n      Series IV. Philip Showalter Hench\n      Series V. Maps\n      Series VI. Alphabetical files\n      Series VII. Truby-Kean-Hench\n      Series VIII. Miscellany\n      Series IX. Photographs\n      Series X. Negatives\n      Series XI. Reprints\n      Series XIII. Reed family additions\n      Series XV. Laura Wood","Materials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were initially deposited in the HAM/TMC and were a part of the Philip S. Hench papers. In 1991, the materials were transferred from HAM/TMC to the Claude Moore Health Sciences Library after both repositories agreed that it would be more appropriate to include them in the Philip S. Hench Walter Reed Yellow Fever Collection.","Materials from Series XVI. Edward Hook additions were transferred from the Papers of Dr. Edward Watson Hook, Jr. to the Philip S. Hench Walter Reed Yellow Fever Collection around the late 1990s and early 2000s.","Processed by:\n        Historical Collections Staff","Mary K. Hench's donation arrived in Charlottesville in a number of large crates which were packed much as the collection had been found in Philip Showalter Hench's home in Rochester, Minnesota. Some confusion about Dr. Hench's filing order had been created while the collection was packed for shipping, and thus the Manuscripts Department of the University of Virginia Library found it necessary to perform some sorting and arrangement to make the collection more accessible.","Around 1968, William Bennett Bean was hired by the University of Virginia as a visiting scholar in residence to begin work on a new biography of Walter Reed. Dr. Bean found that the order of the collection was not such that he could readily use it for biographical purposes. He employed a former assistant in the Manuscripts Department, sought and received permission to refile the collection, and had his assistant perform this task. The refiling of the collection had been finished by the fall of 1969, but Bean and his assistant had no time to prepare a finding aid.","In the fall of 1969 Donna L. Purvis of the Manuscripts Department staff began writing the first edition of the collection's finding aid. During this project, Mrs. Purvis found some problems with Dr. Bean's description and arrangement of the collection and felt that it was necessary to reprocess parts of it.","Around 1990 staff members in the Claude Moore Health Sciences Library processed additions to the collection donated by Philip Showalter Hench's son, P. Kahler Hench.","Between 1999 and 2004, the Claude Moore Health Sciences Library digitized a significant portion of the collection and made the digitized files available to users in an online exhibit. During this project, over 8,000 items from the collection were scanned, transcribed, and described at the item level. Metadata for the digitized items was recorded in XML files using the TEI 2 standard.","In 2001, the Claude Moore Health Sciences Library processed additions that had been made to the collection since 1982, excepting the materials donated by P. Kahler Hench. Staff members also processed significant portions of Mary K. Hench's original donation that had not been described in the first edition of the collection finding aid. This work led to the development of a second edition finding aid that was coded in EAD and ingested into the Virginia Heritage database. This finding aid contained both new metadata and metadata that had been migrated from a Microsoft Access file.","In the 2000s the Claude Moore Health Sciences Library processed the materials in Series XV. Edward Hook additions.","In 2009, staff members in the Claude Moore Health Sciences Library processed Box 154 of the collection.","In 2013, staff members in the Claude Moore Health Sciences Library produced a third edition of the finding aid using EAD that merged collection description from four sources (the first edition finding aid, the second edition finding aid, the online exhibit, and the physical collection). When possible, metadata from the existing online exhibit's TEI files and metadata from the second edition finding aid were transformed with XSL and included in the EAD file. However, staff members sometimes found it necessary to create new metadata for the collection. The new finding aid was structured in such a way to facilitate the migration of the collection's digital files and metadata into the University of Virginia's digital repository and make it available to users via the library's online catalog.","The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audio cassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). All of these materials are arranged in 16 series: I. Jesse W. Lazear, II. Henry Rose Carter, III. Walter Reed, IV. Philip Showalter Hench, V. Maps, VI. Alphabetical files, VII. Truby-Kean-Hench, VIII. Miscellany, IX. Photographs, X. Photographic negatives, XI. Reprints, XII. Houston Academy of Medicine/Texas Medical Center additions, XIII. Reed family additions, XIV. P. Kahler Hench additions, XV. Laura Wood, and XVI. Edward Hook additions.","Series I. Jesse W. Lazear consists of materials relating to Lazear that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1800 to 1956 with the bulk of the items dating from 1863 to 1943. Much of the series consists of the correspondence of Jesse W. Lazear and his wife Mabel H. Lazear. Jesse's correspondence dates from his time as a student at Johns Hopkins University to his death in 1900. Researchers can learn a great deal about Jesse from these letters, including his relationships with friends and family, his educational background, and his professional life. Mabel's correspondence dates from the time she met Jesse to her death in 1946. This correspondence primarily concern her husband's historical legacy and a campaign to secure a pension from the U.S. government for herself and her family.","In addition to Jesse and Mabel's correspondence, the series contains other materials relating to them and their families including, but not limited to the following:","the diaries documenting the travels of Jesse and Mabel's mothers in Europe;\n      correspondence of other Lazear family members (e.g. Jesse's parents);\n      genealogical summaries and tables relating to the Lazear family;\n      legal documents (e.g. wills, certificates, deeds);\n      military records relating to Jesse;\n      certificates, reports, and other materials documenting Jesse's educational background and achievements;\n      obituaries;\n      copies of congressional bills and reports concerning the provision of a federal pension for Mabel H. Lazear;\n      newspaper articles;\n      a microscope and sets of microscope slides owned by Jesse;\n      and a medical chart that shows the progression of the yellow fever infection that killed Jesse.","Series II. Henry Rose Carter consists of materials relating to Henry Rose Carter that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1880 to 1932 with the bulk of the materials dating from 1883 to 1932. The series is particularly rich in materials that document Henry Rose Carter's professional activities in the last eleven years of his life (1914-1925). These materials include, but are not limited to the following:","correspondence with colleagues in the medical and scientific community including Rupert E. Blue, Hideyo Noguchi, Henry Hanson, Joseph A. LePrince, Frederick F. Russell, T.H.D. Griffitts, and Lunsford D. Fricks;\n      scientific, medical, and government reports relating to the study and eradication of yellow fever and malaria in North America, South America, and Africa;\n      journal articles concerning the study and eradication of yellow fever and malaria;\n      research notes written by Henry Rose Carter;\n      and photographs of Henry Rose Carter at work and with professional colleagues.","Series II. also contains correspondence between Henry Rose Carter and members of his family that date from 1880 to 1925. The family members with whom Henry corresponds most frequently in this series are his mother, Emma Coleman Carter; his wife, Laura Eugenia Hook Carter; his daughter, Laura Armistead Carter; and his son, Henry Rose Carter, Jr. These letters are not only a rich source of information about Carter's personal views and family life, they also provide valuable insights into his professional activities such as his experiences aboard vessels and in ports while working for the U.S. Marine Hospital Service and his public health work in Cuba, Panama, and Peru.","In addition to the materials that were produced during Henry Rose Carter's lifetime, the Series II. contains materials that were produced between 1925 and 1940 (after Henry Rose Carter's death) including, but not limited to the following:","copies of obituaries for Henry Rose Carter;\n      condolence letters for Henry Rose Carter's family after Henry's death;\n      and the correspondence of Laura Armistead Carter relating to her father and other members of the Carter family.","Series III. Walter Reed consists of materials that document the life of Walter Reed as well as the work and legacy of the U.S. Army Yellow Fever Commission. Items in the series date from 1806 to around 1955 with the bulk of the items dating from 1874 to 1936. The series is particularly rich in materials that document the professional and personal life of Walter Reed from 1874 to his death in 1902. These materials include, but are not limited to the following:","correspondence between Walter Reed and members of his immediate family that cover a wide range of topics including Reed's courtship of Emilie Lawrence Reed, family life, Walter Reed's work in the Western United States, and Walter Reed's work in Cuba;\n      military records relating to Walter Reed including military orders for Reed, Reed's performance reviews, and reports of Reed's work for army officials;\n      Walter Reed's correspondence with professional colleagues including members of the U.S. Army Yellow Fever Commission, military doctors, and medical researchers interested in the study of yellow fever;\n      medical records (e.g. fever charts of experiment participants), military orders, administrative records, reports, and publications documenting the results of the U.S. Army Yellow Fever Commission's experiments in Cuba;\n      articles announcing the death of Walter Reed;\n      and the shoulder boards from Walter Reed's U.S. Army uniform.","In addition to the above items, Series III. contains materials that document campaigns, spanning from 1902 to 1937, to publicly honor members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments. These materials include, but are not limited to the following:","articles and editorials relating to efforts to memorialize and provide pensions for members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments;\n      biographical sketches of members of the U.S. Army Yellow Fever Commission and experiment participants;\n      records relating to the Walter Reed Memorial Association (e.g. correspondence, donor lists);\n      copies of Congressional bills and resolutions to honor members of the U.S. Army Yellow Fever Commission and experiment participants;\n      and letters, reviews, and other materials relating to the production of Sidney Coe Howard's play,Yellow Jack.","Finally, Series III. also consists of materials that document the history of yellow fever during the nineteenth and early twentieth century. These materials include, but are not limited to the following:","items (e.g. correspondence, reports, reviews, and articles) relating to U.S. efforts to eradicate yellow fever in the Panama Canal Zone;\n      materials (e.g. correspondence, reports, and articles) documenting early twentieth century efforts to eradicate yellow fever in Peru;\n      scientific reports and publications related to the study and eradication of yellow fever and malaria;\n      and newspaper articles describing various outbreaks of yellow fever epidemics.","Series IV. Philip Showalter Hench primarily consists of materials that Hench created or collected while researching the U.S. Army Yellow Fever Commission. Items in this series date from around 1850 to around 1865 with the bulk of the items dating from 1937 to 1960. Researchers who are studying the yellow fever experiments will be particularly interested in the materials (e.g. interviews, autobiographies) that document first-hand accounts of the events surrounding the experiments. Other researchers may be interested in items that document Hench's role in shaping public memory of the commission and its experiments. The materials in this series include, but are not limited to the following:","Hench's correspondence and interviews with participants in the yellow fever experiments and their families including: Emilie Lawrence Reed, Emilie M. (Blossom) Reed, Walter Lawrence Reed, John J. Moran, Albert E. Truby, Jefferson Randolph Kean, John H. Andrus, and John R. Kissinger;\n      autobiographical accounts of the experiment's participants and their families;\n      notes, reports, correspondence and other materials relating to Hench's search for the original site of Camp Lazear in Cuba;\n      correspondence with Cuban government officials and members of the scientific community relating to Hench's campaign to build a Camp Lazear memorial;\n      correspondence and other materials relating to ceremonies honoring Jesse W. Lazear at Washington and Jefferson College;\n      newspaper articles, magazine articles, and other printed matter concerning the yellow fever experiments and its participants;\n      drafts of speeches and presentations Hench gave on the history of the yellow fever experiments to various audiences;\n      meeting minutes and other materials that document Hench's relationship with and participation in the Walter Reed Memorial Association;\n      scripts for radio programs relating to the yellow fever experiments;\n      notes, outlines, lists, correspondence, and other materials that document Hench's research about the yellow fever experiments and a book he had planned to write on the subject;\n      and the gold medal that Congress posthumously awarded to Walter Reed for his work with yellow fever.","Series V. Maps primarily consists of maps and floor plans that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1960 with the bulk of the items dating from 1899 to 1951. The maps and floor plans often include annotations and illustrate a wide range of locations including, but not limited to the following:","Havana and its environs;\n      Cuba;\n      sites associated with the yellow fever experiments;\n      and military installations in the United States.","In addition to the maps and floor plans, Series V. also consists of a few newspaper and magazine clippings that contain information relating to the yellow fever experiments.","Series VI. Alphabetical files primarily consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1860 to around 1966 with the bulk of the items dating from 1940 to 1956. All of these items have been arranged thematically into biographical files. Each file contains materials created by or relating to people who were either involved with the yellow fever experiments or aided Philip Showalter Hench in his research of the subject. These people include, but are not limited to: John J. Moran, Carlos E. Finlay, Laura Wood Roper, Mabel Lazear, Clara Maas, John R. Kissinger, Roger Post Ames, James C. Carroll, and Carlos J. Finlay. The files are arranged alphabetically by the last names of the individuals listed on the files and it is unclear whether the overall arrangement was made by Hench or by staff members at the University of Virginia. The biographical files contain a wide range of different materials that pertain to the individuals listed on the files. These materials include, but are not limited to the following:","correspondence between Philip Showalter Hench and the individuals;\n      other correspondence;\n      newspaper and magazine clippings;\n      unpublished manuscripts;\n      biographical and autobiographical accounts;\n      transcripts of oral history interviews that were conducted by Philip Showalter Hench;\n      and copies of medical charts for volunteers in the yellow fever experiments that shows the progression of the disease.","In addition to the materials that Hench created or collected during his lifetime, the biographical files in Series VI. also contain items that were added by staff at the University of Virginia Library during the late 1960s and early 1970s.","Series VII. Truby-Kean-Hench primarily consists of materials relating to Albert E. Truby and Jefferson Randolph Kean that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1879 to around 1960 with the bulk of the items dating from 1900 to 1954. These items include, but are not limited to the following:","correspondence of Jefferson Randolph Kean dating from 1900 to 1950 that relates to his personal life, the yellow fever experiments, public health initiatives, his publications, the legacy of the yellow fever experiments, Kean's work in World War I, and other topics;\n      Philip Showalter Hench's correspondence with people related to the yellow fever experiments, particularly Albert E. Truby and Jefferson Randolph Kean primarily from between 1940 and 1955;\n      a scrapbook and other materials that relate to Truby's book,Memoir of Walter Reed: the Yellow Fever Episode;\n      and Philip Showalter Hench's interviews and questionnaires for Kean and Truby from the 1940s.","In addition to the materials relating to Kean and Truby, Series VII. also includes the following:","notes from Philip Showalter Hench's research of the yellow fever experiments;\n      the recollections, autobiographies, and reports of other people involved with the yellow fever experiments including John Andrus and A.S. Pinto;\n      articles and clippings related to the yellow fever experiments;\n      a short biography of Lemuel S. Reed;\n      and a sketch Philip Showalter Hench made of a proposed museum at the Camp Lazear site.","Series VIII. Miscellany consists of oversize and miscellaneous materials in the Philip S. Hench Walter Reed yellow fever collection that were, for various reasons, not included in any of the other series in the collection. Items in this series date from around 1849 to 1982 with the bulk of the materials dating from 1885 to 1974. These materials include, but are not limited to the following:","informed consent agreements for volunteers in the yellow fever experiments;\n      diplomas and certificates for Walter Reed and Jesse W. Lazear;\n      copies and sketches of Dean Cornwell's painting,Conquerors of Yellow Fever;\n      artifacts, including a wooden board from Camp Lazear and a U.S. flag;\n      copies of correspondence, reports, medical records, and military orders from the U.S. National Archives relating to the yellow fever experiments;\n      manuscripts and related notes for published works and research relating to Walter Reed and the yellow fever experiments;\n      correspondence of Philip Showalter Hench from circa 1940 to 1966;\n      articles and clippings relating to the yellow fever experiments, the experiments' participants, and the Philip S. Hench Walter Reed yellow fever collection;\n      correspondence of Atcheson Laughlin Hench and members of the University of Virginia community relating to the Philip S. Hench Walter Reed yellow fever collection;\n      items that document the provenance and custodial history of some materials in the Philip S. Hench Walter Reed yellow fever collection;\n      photographs relating to Cuba and the yellow fever experiments;\n      notes for photographs and photographic negatives housed in Series IX. and Series X. of this collection.","Series IX. Photographs consists primarily of photographs that Philip Showalter Hench created and collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1966 with the bulk of the items dating from around 1870 to around 1960. The subjects shown in the photographs include, but are not limited to the following:","physicians, military personnel, nurses, and volunteers associated with the experiments including Walter Reed, Jesse W. Lazear, Jefferson Randolph Kean, and Aristides Agramonte;\n      family members of people associated with the yellow fever experiments including their spouses, children, and grandchildren.\n      Camp Lazear, Camp Columbia, and other locations in Cuba related to the yellow fever experiments between 1900 and 1960;\n      the U.S.S.Maineand the Spanish-American War;\n      aerial views of Havana, Cuba and its environs from the 1940s and 1950s;\n      scenes of daily life in Cuba generally from between 1898 and 1960;\n      the 1952 dedication of the Camp Lazear National Monument in Cuba;\n      the creation and unveiling of Dean Cornwell's painting,Conquerors of Yellow Fever;\n      still scenes from the movies,Yellow JackandJezebel;\n      other events and works of art commemorating the work of the participants in the yellow fever experiments;\n      documents and maps that Philip Showalter Hench copied for his research;\n      and Philip Showalter Hench and his family.","Series IX. also includes a watercolor that was painted by Emilie Lawrence Reed.","Series X. Photographic negatives consists of a mix of original and copy negatives that Philip Showalter Hench collected while researching the yellow fever experiments. Although the original images recorded on the negatives date from between the 1860s and the 1960s, it appears that the negatives themselves were produced during a narrower time frame, most likely between 1930 and 1966.","The negatives in Series X. record images associated with the yellow fever experiments and many of them are related to photographic prints found in Series VIII. Where a match between a negative and a print from these series has been made, the negative number has been written on the folder of the print in the physical collection. Finally, the negatives are generally arranged in numerical order by identification numbers that were most likely assigned by Philip Showalter Hench.","Series XI. Reprints consists of reprints and photocopies of journal articles, book extracts, book reviews and other published works that were primarily collected by Philip Showalter Hench while researching the yellow fever experiments. Items in this series date from 1856 to 1971 and cover a wide range of topics related to the study and eradication of yellow fever, including, but not limited to the following:","the results of the U.S. Army Yellow Fever Commission's work in Cuba;\n      biographical accounts of various people who had an association with the yellow fever experiments;\n      the research of people associated with the experiments including Walter Reed, Jesse W. Lazear, Aristides Agramonte, and James Carroll;\n      scientific and medical research related to yellow fever and malaria;\n      and events honoring the work of those involved with the yellow fever experiments.","Series XII. Houston Academy of Medicine/Texas Medical Center additions consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1901 to around 1966. These materials were originally a part of the Philip S. Hench papers in the John P. McGovern Historical Collections and Research Center at the Texas Medical Center Library, but they were transferred to the University of Virginia in 1991. These items include, but are not limited to the following:","correspondence between Philip Showalter Hench and people connected with the yellow fever experiments including John J. Moran and Walter Reed's children;\n      newspaper clippings relating to the death or commemoration of individuals associated with the yellow fever experiments;\n      photographs of the Camp Lazear Memorial, everyday scenes in Cuba, and John J. Moran;\n      and journal articles, booklets, and other printed matter relating to the yellow fever experiments and its participants.","Series XIII. Reed family additions consists of materials relating to the yellow fever experiments that several different donors gave to the University of Virginia. Items in the series date from around 1850 to 1967 with the bulk of the items dating from 1868 to 1949. The largest portion of the series is comprised of correspondence written by Walter Reed and his family between 1877 and 1902 that provide insights into their relationships and personal lives.","In addition to the Reed family's correspondence, the series also contains other materials relating to the Reed family and the yellow fever experiments including, but not limited to the following:","a flag that was flown over Camp Lazear;\n      newspaper clippings and articles relating to the yellow fever experiments;\n      a chemistry notebook that was owned by Walter Reed;\n      correspondence of and works by Philip Showalter Hench;\n      an inventory of materials in Series XIII. and information about their accession into the Claude Moore Health Sciences Library;\n      and materials from an exhibit on the yellow fever experiments that was hosted in Alderman Library at the University of Virginia.","Series XIV. P. Kahler Hench additions consists of original and photocopied materials that Philip Showalter Hench's son, P. Kahler Hench, donated to the University of Virginia in 1988 and 1989. Items in the series date from around 1860 to 1965 with the bulk of the materials dating from 1898 to 1965. Most of these items were collected or created by Philip Showalter Hench while researching the yellow fever experiments. These items include the following:","the correspondence of experiment participants;\n      correspondence between Philip Showalter Hench and the experiment participants;\n      correspondence between Philip Showalter Hench and families of the experiment participants;\n      press clippings relating to the experiments and the experiment participants;\n      oral history interviews conducted by Philip Showalter Hench;\n      scientific articles related to the study of yellow fever;\n      photographs of Havana, Camp Columbia, and Camp Lazear;\n      genealogical tables and summaries for the family of Jesse W. Lazear;\n      autobiographical accounts written by experiment participants;\n      unpublished manuscripts;\n      artifacts (e.g. a wooden board) from Camp Lazear;\n      Philip Showalter Hench's research notes.","Series XIV. also contains correspondence and financial records that record the transfer of collection items from the Reed family to Philip Showalter Hench and later from the Hench family to the University of Virginia.","Series XV. Laura Wood primarily consists of Laura Wood's correspondence relating to her research for a Walter Reed biography that she wrote. The series also includes, but is not limited to the following materials:","photocopies of two letters written by Walter Reed;\n      a journal article by George Sternberg;\n      and a short work that Laura Wood wrote about Walter Reed entitled,Walter Reed and yellow Fever.","Items in Series XV. date from 1875 to 1946 with the bulk of the items dating from 1941 to 1946.","Series XVI. Edward Hook additions consists of copies of letters, articles, and photographs relating to the yellow fever experiments that had been collected by Edward W. Hook, Jr, a professor of medicine at the University of Virginia. The bulk of this series is comprised of copies of a small collection of James Carroll's correspondence. The original versions of Carroll's correspondence are not housed at the University of Virginia. In addition to the Carroll letters, this series also includes, but is not limited to the following:","photographs of Walter Reed and others related to the yellow fever experiments;\n      copies of some of Theodore E. Woodward's works relating to James Carroll and yellow fever;\n      and exhibition materials.","Items in Series XVI. date from around 1880 to around 1998 with the bulk of the items dating from 1898 to 1901.","Copyright restrictions may apply for some materials in the collection.","The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audiocassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). Most of the materials in the collection were collected or created by Nobel laureate Philip Showalter Hench while researching the history of the U.S. Army Yellow Fever Commission.","Claude Moore Health Sciences Library","Collection is predominantly in English; other materials in the collection are in Spanish, French, and Portuguese."],"collection_title_tesim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"collection_ssim":["Philip S. Hench Walter Reed Yellow Fever collection, 1800/1998, bulk 1863/1974"],"level_ssm":["collection"],"level_ssim":["Collection"],"unitid_ssm":["MS.1","Archival Resource Key","/repositories/7/resources/1710"],"unitid_tesim":["MS.1","Archival Resource Key","/repositories/7/resources/1710"],"repository_ssm":["University of Virginia, Special Collections Dept."],"repository_ssim":["University of Virginia, Special Collections Dept."],"creator_corpname_ssim":["Claude Moore Health Sciences Library"],"creators_ssim":["Claude Moore Health Sciences Library"],"access_terms_ssm":["Copyright restrictions may apply for some materials in the collection."],"acqinfo_ssim":["Materials from the following series were donated to the University of Virginia's Alderman Library in the fall of 1966 and the summer of 1970 by Philip Showalter Hench's widow, Mary Kahler Hench, with the approval of his estate:","Series I. Jesse W. Lazear\n      Series II. Henry Rose Carter\n      Series III. Walter Reed\n      Series IV. Philip Showalter Hench\n      Series V. Maps\n      Series VI. Alphabetical files\n      Series VII. Truby-Kean-Hench\n      Series VIII. Miscellany\n      Series IX. Photographs\n      Series X. Negatives\n      Series XI. Reprints","Materials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were donated to the HAM/TMC by Philip Showalter Hench as a small part of a larger collection of materials.","Materials from Series XIII. Reed family additions were donated by various individuals to Alderman Library between 1947 and 1972. Box 139, Folder 1 contains a list that describes each of these donations in detail.","Materials from Series XIV. P. Kahler Hench were donated to the Claude Moore Health Sciences Library by Philip Showalter Hench's son, P. Kahler Hench, in 1988 and 1989.","Materials from Series XV. Laura Wood were most likely donated to Alderman Library between 1972 and 1982.","Materials from Series XVI. Edward Hook additions were donated to the Claude Moore Health Sciences Library as a part of the Papers of Dr. Edward Watson Hook, Jr."],"access_subjects_ssim":["Human Experimentation","Military Medicine","Physicians","Public health","Tropical medicine","Yellow Fever"],"access_subjects_ssm":["Human Experimentation","Military Medicine","Physicians","Public health","Tropical medicine","Yellow Fever"],"has_online_content_ssim":["false"],"extent_ssm":["67 Linear Feet 154 boxes"],"extent_tesim":["67 Linear Feet 154 boxes"],"date_range_isim":[1800,1801,1802,1803,1804,1805,1806,1807,1808,1809,1810,1811,1812,1813,1814,1815,1816,1817,1818,1819,1820,1821,1822,1823,1824,1825,1826,1827,1828,1829,1830,1831,1832,1833,1834,1835,1836,1837,1838,1839,1840,1841,1842,1843,1844,1845,1846,1847,1848,1849,1850,1851,1852,1853,1854,1855,1856,1857,1858,1859,1860,1861,1862,1863,1864,1865,1866,1867,1868,1869,1870,1871,1872,1873,1874,1875,1876,1877,1878,1879,1880,1881,1882,1883,1884,1885,1886,1887,1888,1889,1890,1891,1892,1893,1894,1895,1896,1897,1898,1899,1900,1901,1902,1903,1904,1905,1906,1907,1908,1909,1910,1911,1912,1913,1914,1915,1916,1917,1918,1919,1920,1921,1922,1923,1924,1925,1926,1927,1928,1929,1930,1931,1932,1933,1934,1935,1936,1937,1938,1939,1940,1941,1942,1943,1944,1945,1946,1947,1948,1949,1950,1951,1952,1953,1954,1955,1956,1957,1958,1959,1960,1961,1962,1963,1964,1965,1966,1967,1968,1969,1970,1971,1972,1973,1974,1975,1976,1977,1978,1979,1980,1981,1982,1983,1984,1985,1986,1987,1988,1989,1990,1991,1992,1993,1994,1995,1996,1997,1998],"accessrestrict_html_tesm":["\u003cp\u003eThere are no restrictions on user access to any of the materials in the collection except where noted in the container list.\u003c/p\u003e  "],"accessrestrict_heading_ssm":["Access"],"accessrestrict_tesim":["There are no restrictions on user access to any of the materials in the collection except where noted in the container list."],"arrangement_html_tesm":["\u003cp\u003eThe Philip S. Hench Walter Reed Yellow Fever Collection is organized in 16 series:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003eI. Jesse W. Lazear\u003c/item\u003e\n      \u003citem\u003eII. Henry Rose Carter\u003c/item\u003e\n      \u003citem\u003eIII. Walter Reed\u003c/item\u003e\n      \u003citem\u003eIV. Philip Showalter Hench\u003c/item\u003e\n      \u003citem\u003eV. Maps\u003c/item\u003e\n      \u003citem\u003eVI. Alphabetical files\u003c/item\u003e\n      \u003citem\u003eVII. Truby-Kean-Hench\u003c/item\u003e\n      \u003citem\u003eVIII. Miscellany\u003c/item\u003e\n      \u003citem\u003eIX. Photographs\u003c/item\u003e\n      \u003citem\u003eX. Photographic negatives\u003c/item\u003e\n      \u003citem\u003eXI. Reprints\u003c/item\u003e\n      \u003citem\u003eXII. Houston Academy of Medicine/Texas Medical Center additions\u003c/item\u003e\n      \u003citem\u003eXIII. Reed family additions\u003c/item\u003e\n      \u003citem\u003eXIV. P. Kahler Hench additions\u003c/item\u003e\n      \u003citem\u003eXV. Laura Wood\u003c/item\u003e\n      \u003citem\u003eXVI. Edward Hook additions\u003c/item\u003e\n    \u003c/list\u003e\n  "],"arrangement_heading_ssm":["Organization of the Collection"],"arrangement_tesim":["The Philip S. Hench Walter Reed Yellow Fever Collection is organized in 16 series:","I. Jesse W. Lazear\n      II. Henry Rose Carter\n      III. Walter Reed\n      IV. Philip Showalter Hench\n      V. Maps\n      VI. Alphabetical files\n      VII. Truby-Kean-Hench\n      VIII. Miscellany\n      IX. Photographs\n      X. Photographic negatives\n      XI. Reprints\n      XII. Houston Academy of Medicine/Texas Medical Center additions\n      XIII. Reed family additions\n      XIV. P. Kahler Hench additions\n      XV. Laura Wood\n      XVI. Edward Hook additions"],"bioghist_heading_ssm":["Historical Information for the U.S. Army Yellow Fever Commission","Biographical Information for Walter Reed","Biographical Information for Jesse W. Lazear","Biographical Information for Henry Rose Carter","Biographical Information for Jefferson Randolph Kean","Biographical Information for Philip Showalter Hench"],"bioghist_tesim":["The U.S. Army Yellow Fever Commission (1900-1901) was a board of physicians that the U.S. government formed in order to determine how yellow fever was transmitted between hosts. Ultimately, the commission's experiments in Cuba proved that mosquitoes transmit yellow fever--a discovery that would spur successful campaigns to control and eradicate yellow fever throughout much of the globe.","When Major Walter Reed and Acting Assistant Surgeons James Carroll, Aristides Agramonte, and Jesse Lazear gathered on the porch of the Columbia Barracks Hospital in June of 1900, they became the fourth successive board of U.S. medical officers to grapple with the appalling plague that was yellow fever.","The persistence of this disease across the Cuban archipelago and its periodic re-emergence along the coastlines and great river drainages of the Americas was taking countless thousands of lives. Lack of precise knowledge as to its cause and transmission had augmented yellow fever's extraordinarily high mortality rate and had given rise to quarantine regulations which constituted substantial impediments to efficient regional trade. Endemic in the tropics, yellow fever imposed high humanitarian and economic costs upon the entire region. Specialists regarded Cuba as one of the principal foci of the disease, and the island consequently attracted considerable attention from the medical sciences.","In 1879, one year after a devastating epidemic swept up the Mississippi valley from New Orleans, Tulane University Professor Stanford E. Chaille led the first investigatory commission to Havana, Rio de Janeiro, and the West Indies. The Chaille Commission remained in Havana three months, and its members -- including George Miller Sternberg, who became Surgeon General of the Army, and Juan Guiteras, later Director of Public Health for Havana -- consulted with Cuban scientist Carlos J. Finlay. They concluded that the causal agent for yellow fever was possibly a living entity in the atmosphere, an assertion which set Finlay on the path to the mosquito theory he developed in 1881.","Louis Pasteur's foundational and highly successful work in modern immunology in 1880 and 1881 gave a renewed impetus to investigations aimed at discovering the \"yellow fever germ.\" Over the middle years of the 1880s several scientists advanced different theories, all readily refuted by bacteriological work Sternberg undertook in Brazil and Mexico in 1887 and again in Havana in 1888 and 1889. In 1897, Italian scientist Giuseppe Sanarelli argued thatBacillus icteroideswas the culprit, and the following year a third scientific team sailed to Cuba for additional tests. Eugene Wasdin and Henry D. Geddings appeared to confirm Sanarelli's assertion, though Sternberg, by then Surgeon General, remained skeptical.","Despite Wasdin and Geddings' insistence, theB. icteroidestheory garnered significant opposition. In fact, a few months before the third commission's report reached the public, Walter Reed and James Carroll -- Reed's assistant at the Columbian University (later George Washington University) bacteriology laboratories in Washington, D.C. -- published a thorough refutation of theicteroidesproposal: the bacteria was not a unique cause of yellow fever, but a variety of the hog cholera bacillus, \"a secondary invader in yellow fever,\" Reed determined, unrelated to its etiology. [1] Dispute continued, however, and when Sternberg organized the fourth investigatory board, he charged Reed and his associates to settle theB. icteroidesquestion once and for all, then to proceed with analysis of other blood cultures and intestinal flora from yellow fever cases.","Reed and Carroll had considerable experience in bacteriological analysis, and, Sternberg reasoned, might well be able to find the specific agent of the disease. Aristides Agramonte, a Cuban scientist who had worked in Reed's lab at the Columbian University in 1898, was also an accomplished bacteriologist; he had identifiedB. icteroidesin tissue samples from cases other than yellow fever, providing further evidence opposed to Sanarelli's thesis. Jesse Lazear, a scientist from Johns Hopkins University in Baltimore, Maryland, had joined the Army Medical Corps to study tropical diseases at their point of origin; he received orders for Cuba in February 1900. Lazear impressed Reed with his abilities when the two men became acquainted in March. No doubt with Reed's advice, Sternberg assembled a crack team -- all experienced in scientific research, but each with interests as diverse as their temperaments. The mix of talent and personalities generated spectacular results.","What causes yellow fever? This simple, even obvious question had dictated yellow fever research for over two decades, and so it guided Reed in organizing the work of the commission.Bacillus icteroidesand other bacteriological sampling dominated their work for the first months. \"Reed and Carroll have been at that for a long time,\" Lazear wrote with some impatience to his wife on August 23, \". . . I would rather try to find the germ without bothering about Sanarelli.\" [2] Again and again, tests for the bacteria proved negative, and at the same time, perplexing cases of yellow fever were developing in the region. Agramonte and Reed investigated an epidemic at Pinar del Rio, 110 miles southwest of Havana; Lazear followed later to collect more specimens, and he also assessed the situation at Guanjay thirty miles southwest. To \"my very great surprise,\" Reed admitted, the specific circumstances of the appearance and development of these cases gave strong evidence against the widely-accepted notion that the excreta of patients spread the disease. The theory of fomites -- infection from contaminated clothing and bedding -- and indeed even infection from airborne particles seemed altogether untrue. \"At this stage of our investigation,\" Reed concluded, \". . . the time had arrived when the plan of our work should be radically changed.\" [3] The fundamental question underwent a subtle but critical transformation: from what causes yellow fever to what transmits it. A clear and accurate understanding of how the disease was spread would open a new avenue to its specific cause.","\"Personally, I feel that only can experimentation on human beings serve to clear the field for further effective work,\" Reed stated to Surgeon General Sternberg, who concurred. [4] Evidence gathering around them pointed strongly to an intermediate host, and the Commission resolved to test Carlos Finlay's mosquito theory -- then not generally accepted -- on human volunteers. Nine times from August 11 to August 25, 1900, mosquitoes landed on the arms of volunteers and proceeded to feed. Nine times the results were negative. On August 27, Lazear placed a mosquito on the doubting Dr. Carroll, and four days later on William J. Dean, a soldier designated XY in the \"Preliminary Note.\" [5] Both promptly developed yellow fever. Significantly, their mosquitoes had fed on cases within the initial three days of an attack and had been allowed to ripen for at least twelve days before the inoculations. Carroll vitiated the results of his experimental sickness by traveling off the post to Havana, a contaminated zone, even as Reed, ecstatic, wrote from Washington in a confidential letter: \"Did the Mosquito do it?\" [6] Dean's case seemed to prove it, since he claimed not to have left the garrison before becoming ill. Lazear also developed a case of yellow fever, almost certainly experimental in origin, though he never revealed the actual circumstances of his inoculation. His severe bout of fever took a fatal turn on September 25, 1900.","Nevertheless, these results could not have been more dramatic or convincing for the Commission. Reed quickly assembled a \"Preliminary Note,\" which he presented to the annual meeting of the American Public Health Association in Indianapolis, Indiana, October 23, 1900. After initial consultations in Cuba with General Leonard Wood, military governor of the island, and with Surgeon General Sternberg in Washington, he returned to Cuba with authorization and funding to design and carry forward a fully defensible series of experiments. His aim was confirmation of the mosquito theory and invalidation of the long-held belief in fomites.","On open terrain beyond the precincts of Columbia Barracks -- the American military base just west of Havana near the adjacent suburban towns of Quemados and Marianao (also called Quemados de Marianao) -- Reed established the quarantined experimental station. Camp Lazear, as the Commission dedicated it, took form in the rolling fields of the Finca San Jose, on the farm of Dr. Ignacio Rojas, who leased the land to the Americans. Here Reed designed two small wood-frame buildings, each 14 by 20 feet, for the experimental work, and nearby raised a group of seven tents for the accommodation and support of the volunteers. The buildings faced each other across a small swale, about 80 yards apart, and stood 75 yards from the tent encampment. Building Number One, called the Infected Clothing Building, was a single room tightly constructed to contain as much foul air as possible. A small stove kept the temperature and humidity at tropical levels, and carefully attached screening secured the pair of doorways in a vestibule against intrusion by mosquitoes. Wooden blinds on two small sealed windows shielded the room from direct sun. Building Number Two, the Infected Mosquito Building, contained a principal room, divided into two sections by a floor-to-ceiling wire mesh screen. A door direct to the exterior let into one section, while a vestibule with a solid exterior door and pair of successive screened doors opened to the other, so configured to keep infected mosquitoes inside that section alone. The spare furnishings in both sections -- cots with bedding -- were steam sterilized. Windows exposed the entire room to the clean, steady ocean breezes and to sunlight. Like the doorways, they were carefully screened. A secondary room attached to the building but not communicating with the experimental spaces sheltered the small, heated laboratory where the Commission members raised and stored the mosquitoes to be used.","These two experimental buildings presented alternate environments -- one conspicuously clean and well ventilated, the other filthy and fetid. Contemporary theories of disease held that yellow fever developed in unclean conditions, and consequently much time and money had been devoted to sanitation projects. Workers steamed clothing, burned sulphur in ships' holds, and thoroughly scrubbed surfaces with disinfectant. In cases of severe epidemic, entire buildings presumed to be infected were set afire along with their contents. Thus the extraordinary -- and intentional -- paradox of the Commission's experimental regime: Reed expected yellow fever to develop not in the unsanitary environment, but in the one thought to be most healthful.","Camp Lazear went into quarantine the day of its completion, November 20, 1900, with a command of four immune and nine non-immune individuals, all save one U.S. Army personnel. Soon a group of recent Spanish immigrants to Cuba augmented the non-immune numbers, bringing the resident total to about twenty. Reed strictly controlled access to the camp and ordered regular temperature recording for each volunteer to eliminate any unanticipated source of infection and to identify the onset of any case of yellow fever as early as possible. As a result, non-immunes were barred from returning should they leave the precinct, and two of the Spaniards who developed intermittent fevers shortly after arrival were immediately transferred with their baggage to Columbia Barracks Hospital. The immune members of the detachment oversaw medical treatments and drove the teams of mules that pulled supply wagons and the ambulance. Experimentation did not begin until each volunteer had passed the incubation period for yellow fever in perfect health.","Reed took as much care with the design of the experimental protocol as he had with the configuration of the camp and its buildings. Each evening, the occupants of the infected clothing building unpacked trunks and boxes of bed linens and blankets, nightshirts and other clothing recently worn and soiled by cases from the wards of Columbia Barracks Hospital and Las Animas Hospital in Havana. These they shook out and spread around the room to permeate the atmosphere. The stench was overpowering. Yellow fever causes severe internal hemorrhaging, and its unfortunate victims often suffer from black vomit and other bloody discharges. One routine delivery proved so putrid the volunteers \"retreated from the house,\" Reed stated. \"They pluckily returned, however, within a short time, and spent the night as usual.\" [7] In two succeeding trials the protocol became progressively more daring , as the volunteers then wore the clothing and slept on the mattresses used by yellow fever patients, and finally put towels on their bedding smeared with blood drawn from cases in the early stages of an attack. Each morning, the volunteers carefully repacked the rank, encrusted materials into boxes and emerged to an adjacent tent where they spent the day quarantined from the rest of the company. Three trials of twenty days each involved seven men altogether, lead by Robert P. Cooke, a physician in the Army Medical Corps. None developed yellow fever.","The Commission's mosquito experiments proceeded in four series. First, Reed sought to demonstrate that mosquitoes of the varietyCulex fasciata(later calledStegomyia fasciata, and later stillAedes aegypti) could in fact transmit yellow fever, as Carlos J. Finlay had argued and the initial experiments at Camp Columbia strongly suggested. Here the Commission members simply applied infected mosquitoes contained in test tubes or jars to the skin of the initial volunteers. Success in these tests raised a number of questions, each one addressed in the subsequent series:","How could a building become infected?\n      When does a mosquito develop the ability to transmit the disease?\n      Over what length of time can a mosquito retain this capacity to infect?","The second series consequently employed the specialized \"Infected Mosquito Building\" to indicate how a structure could be considered infected with yellow fever. This experiment required two groups of volunteers, one to be inoculated and another to serve as controls. \"Loaded\" mosquitoes, as the men called them, were released into the screened section of Building Two -- on the side with the protected vestibule entry. One or more non-immune men then entered the opposite section of the room through the direct exterior door, and lay down on bunks adjacent to the wire mesh screen in the center of the room. Now the young man to be inoculated walked through the vestibule into the mosquito side of the room and proceeded to lie on a bunk adjacent to the wire screen separating him from the controls. The inoculation volunteer remained in the building for about twenty minutes -- enough time to suffer several mosquito bites -- he then exited to a quarantine tent outside. The controls spent the remainder of the evening and night in the uninfected side of the room, and indeed returned to sleep in the room for as many as eighteen more nights. As Reed stated, absence of yellow fever in the controls showed \"that the essential factor in the infection of a building with yellow fever is the presence therein of [infected] mosquitoes,\" and nothing more. [8] The degree of sanitation, so long considered critical, was utterly irrelevant.","The third series of mosquito experiments confirmed what Henry Rose Carter, of the U.S. Public Health Service, called the \"period of extrinsic incubation,\" [9] the length of time required for secondary cases of yellow fever to develop after an initial intrusion of the disease into a locality. In this series, a single volunteer underwent three successive inoculations by the same mosquitoes, each group of inoculations interrupted by a period of time equal in length to the typical incubation period of the disease in humans, about five days. In this manner, the volunteer's illness could be specifically attributed to a single inoculation group. The use of the same mosquitoes and the same volunteer concurrently demonstrated that no peculiar personal immunity was at play, since logic dictates that a person susceptible to yellow fever on day 17 of a mosquito's contamination -- as happened in the experiment -- could not have been immune to yellow fever on day 11 or day 4. It was thus only the mosquito's capacity to infect which changed, and that occurred no less than 11 days after contamination.","The duration of time over which these \"fully ripened\" mosquitoes remained infective comprised the fourth series of experiments. For this series the Commission kept alive a group of infected mosquitoes for as long as possible, and proceeded to inoculate three volunteers -- on the 39th, 51st, and 57th day after contamination. Each developed yellow fever. A fourth volunteer declined to be bitten on day 65, and the last two mosquitoes of the group, \"deprived of further opportunity to feed on human blood\" [10] expired on day 69 and day 71, clear evidence that even a sparsely populated region may retain the potential for new infections more than two months after the first appearance of the disease.","Although it went unrecorded in the published papers, Reed organized a supplemental experiment to test another species of mosquito.Culex pungensfailed to transmit yellow fever to at least one volunteer and probably to a second. Reed's preliminary conclusions indicated thatCulex fasciatawas the only species capable of transmitting yellow fever. [11]","A last experimental regime involved subcutaneous injections of blood from positive cases of yellow fever to presumed non-immunes. Reed devised these tests to confirm the presence of the yellow fever agent in the blood of a victim during the first days of an attack, and, more importantly, to settle theBacillus icteroidesquestion. The same blood cultures which produced yellow fever in four volunteers also failed to grow anyB. icteroides, conclusively invalidating Sanarelli's claim.","Altogether, the mosquito inoculations and the blood injections produced fourteen cases of yellow fever. All made a full recovery.","Notwithstanding the decisive medical victory -- as Reed declared, \"aside from the antitoxin of Diptheria and Koch's discovery of the tubercle bacillus, it will be regarded as the most important piece of work, scientifically, during the 19th century\" [12] -- success at Camp Lazear unfolded in its own time. Initially, Reed observed, \"the results obtained at this station were not encouraging.\" [13] The first inoculations of four volunteers over a period of two weeks proved disconcertingly negative each time. Then, on December 5, 1900, private John R. Kissinger presented his arm to the mosquitoes, and late in the evening on December 8, suffered the first chills of \"a well-marked attack of yellow fever.\" [14] Three more men in rapid succession fell victim to the insects -- Spanish volunteers Antonio Benigno, Nicanor Fernandez, and Vicente Presedo. The force of the conclusions was evident to everyone:","\"It can readily be imagined,\" Reed empathetically and wryly described in his first presentation of the experiments, \"that the concurrence of 4 cases of yellow fever in our small command of 12 non-immunes within the space of 1 week, while giving rise to feelings of exultation in the hearts of the experimenters, in view of the vast importance attaching to these results, might inspire quite other sentiments in the bosoms of those who had previously consented to submit themselves to the mosquito's bite. In fact, several of our good-natured Spanish friends who had jokingly compared our mosquitoes to 'the little flies that buzzed harmlessly about their tables,' suddenly appeared to lose all interest in the progress of science, and, forgetting for the moment even their own personal aggrandizement, incontinently severed their connection with Camp Lazear. Personally, while lamenting to some extent their departure, I could not but feel that in placing themselves beyond our control they were exercising the soundest judgment.\"","\"In striking contrast,\" Reed continued, the anxiety of the fomites volunteers began to melt into relief. \"[T]he countenances of these men, which had before borne the serious aspect of those who were bravely facing an unseen foe, suddenly took on the glad expression of 'schoolboys let out for a holiday,' and from this time their contempt for 'fomites' could not find sufficient expression. Thus illustrating once more, gentlemen, the old adage that familiarity, even with fomites, may breed contempt.\" [15]","The question of human experimentation was indeed a serious one -- unavoidable, in actuality, as Reed had stated the previous summer to Surgeon General Sternberg. When the Commission first considered a trial of Finlay's mosquito theory, Reed, Carroll, and Lazear agreed to experiment on themselves. Agramonte, a native Cuban, had acquired immunity as a child. Doubtless Finlay's experience of many unsuccessful inoculations communicated that positive results would not be forthcoming rapidly, so before the first series of inoculations began under Lazear's direction at Columbia Barracks, Reed left Cuba for Washington, where he completed a monumental report on typhoid fever among the army corps -- left unfinished by the sudden death of co-author Edward O. Shakespeare. Carroll and Lazear both sickened while Reed was in Washington, and Lazear, young and strong, had no reason to anticipate that his case would be fatal. Reed was shocked at Lazear's death, and because of his own age -- 49, a decade and a half older than Lazear and a dozen years older than Carroll -- he resolved not to inoculate himself when he returned to Cuba on October 4, 1900. The point had already been amply demonstrated, and only a rigidly controlled experimental regime would establish the necessary proof. Carroll, however, remained embittered about this for the remainder of his life, though he evidently never communicated his objections directly to Reed.","That initial series of mosquito inoculations was probably accomplished without formal documentation of informed consent. Indeed, the experiments may also have been carried forward without the full knowledge of the commanding officer of Camp Columbia, and Reed consequently shielded the identity of Private William J. Dean, the second positive experimental case, behind the pseudonym \"XY\" in the \"Preliminary Note.\" No such potentially troublesome problems arose for the experimental series at Camp Lazear; Reed obtained prior support from all of the appropriate authorities in the military and the administration, even including the Spanish Consul to Cuba. With the advice of the Commission and others, he drafted what is now one of the oldest series of extant informed consent documents. The surviving examples are in Spanish with English translations, and were signed by volunteers Antonio Benigno and Vicente Presedo, and a third with the mark of Nicanor Fernandez, who was illiterate.","The documents take the form of a contract between individual volunteers and the Commission, represented by Reed. At least 25 years old, each volunteer explicitly consented to participate, and balanced the certainty of contracting yellow fever in the general population against the risks of developing an experimental case, followed by expert and timely medical care. The volunteers agreed to remain at Camp Lazear for the duration of the experiments, and as a reward for participation would receive $100 \"in American gold,\" with an additional hundred-dollar supplement for contracting yellow fever. These payments could be assigned to a survivor, and the volunteers agreed to forfeit any remuneration in cases of desertion.","For the American participants no consent documents appear to survive, though in contemporary letters Reed assured his correspondents that the Commission obtained written consent from all the volunteers. The record of expenses for Camp Lazear -- maintained by Reed's friend and colleague in the medical corps, Jefferson Randolph Kean -- indicates that the same schedule of payments for participation and sickness applied to the Americans as well. Volunteers who participated in the fomites tests and in addition the later series of blood injections and the single trial of an alternative species of mosquito also earned $100 each plus the $100 supplement if yellow fever developed. Two Americans declined these gratuities, as Kean termed them, Dr. Robert P. Cooke, of the fomites tests, and John J. Moran, who had recently received an honorable discharge from the service, and was the only American civilian to participate. His was the fourth case of yellow fever to develop from mosquito inoculation. Moran eventually settled in Cuba, where he managed the Havana offices of the Sun Oil Company, and late in life became a close friend of Philip S. Hench. Together the two men rediscovered the site of Camp Lazear in 1940 -- Building Number One still intact -- and successfully lobbied the Cuban government to memorialize there the work of Finlay and the American Commission in the conquest of yellow fever.","Reed informally commemorated his own experiences at Camp Lazear by commissioning a group photograph, evidently taken there shortly before he left Cuba in February 1901. A more important event occurred on the sixth of that month when Reed presented the results of the Camp Lazear yellow fever experiments to a great ovation at the Pan-American Medical Congress in Havana. Three days later he set sail for the United States, and once landed, drafted the Congress paper asThe Etiology of Yellow Fever -- An Additional Note, published immediately in theJournal of the American Medical Association. [16]","Though his correspondence intimates a great appreciation for Cuba, Reed never returned to the warm, sunny shores of the island freed of a dreadful plague. Carroll stayed behind at Camp Lazear through February to complete the last experimental series officially bearing the imprimatur of the Yellow Fever Commission, and returned to Washington soon after March first. [17] The Medical Corps retained the lease on Camp Lazear against the possibility of continuing experiments another season, and Carroll, in fact, returned to Havana in August 1901 for a final experimental series, though he did not make use of Camp Lazear. This work involved at least three volunteers at Las Animas Hospital, Havana, who submitted to blood injections. Carroll's assignment aimed at a greater understanding of the yellow fever agent, and he proved that blood drawn from active cases of yellow fever remained virulent even after passing through fine bacteria filters. In addition, by heating contaminated blood which had previously caused cases of yellow fever, Carroll rendered it non-infective -- thereby establishing that this filterable entity, though sub-microscopic, was demonstrably present in the bloodstream. Carroll wrapped up the series in October and returned home to stay. [18] In Cuba, J. Randolph Kean made the last rental payments to Signore Rojas on October 9, 1901, and Camp Lazear, for more than a generation, slipped out of the realm of memory.","Sources:","[1] Walter Reed and James Carroll,Bacillus Icteroides and Bacillus Cholerae Suis -- A Preliminary Note,Medical News(29 April 1899), reprinted in: United States Senate Document No. 822,Yellow Fever, A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 55.\n      [2] Letter from Jesse W. Lazear to Mabel Houston Lazear, 23 August 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00341001.\n      [3] Walter Reed, \"The Propagation of Yellow Fever -- Observations Based on Recent Researches,\" in United States Senate Document No. 822,Yellow Fever A Compilation of Various Publications(Washington: Government Printing Office, 1911), p. 94.\n      [4] Letter from Walter Reed to George M. Sternberg, 24 July 1900, Hench Reed Yellow Fever Collection, accession number: 02064001.\n      [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note,Proceedings of the Twenty-eighth Annual Meeting of the American Public Health AssociationIndianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n      [6] Letter from Walter Reed to James Carroll, 7 September 1900, Edward Hook Additions to the Philip S. Hench Walter Reed Yellow Fever Collection: James Carroll Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 15312004. The originals of these letters remain in a private collection.\n      [7] Walter Reed, James Carroll, Aristides Agramonte,The Etiology of Yellow Fever -- An Additional Note,Journal of the American Medical Association36 (16 February 1901): 431-440, reprinted in: Senate Document No. 822, p. 84.\n      [8] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n      [9] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n      [10] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 101.\n      [11]Culex fasciatawas reclassified shortly after the experiments asStegomyiaand later becameAedes aegypti.\n      [12] Letter to from Walter Reed to Emilie Lawrence Reed, 9 December 1900, Hench Reed Collection, accession number: 02231001.\n      [13] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 97.\n      [14] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 98.\n      [15] Walter Reed,The Propagation of Yellow Fever -- Observations Based on Recent Researches, in Senate Document No. 822, p. 99.\n      [16] Please see note [7].\n      [17] The Commission reported these concluding experiments in: Walter Reed, James Carroll, Aristides Agramonte,Experimental Yellow Fever,American MedicineII (6 July 1901) 1: 15-23.\n      [18] Walter Reed, James Carroll,The Etiology of Yellow Fever (A Supplemental Note),American MedicineIII (22 February 1902) 8: 301-305.","Walter Reed (September 13, 1851 - November 22, 1902) was a U.S. Army physician who led the army's Yellow Fever Commission 1900 and 1901. Experiments conducted by the commission confirmed a theory that yellow fever is transmitted by mosquitoes--a discovery that led to the control and eradication of this disease across much of the globe. Reed would receive much of the credit for the work of the commission because of his role as its leader, and, long after his death in 1902, he would be widely celebrated as a heroic figure in the fields of public health and medical research.","Reed spent his first days in a small house which served as the parsonage for a Methodist congregation in Gloucester County, Virginia, where his father was minister.  Lemuel Sutton Reed and Pharaba White Reed welcomed young Walter into the family on September 13, 1851;  he was the youngest of their five children.  The Reeds moved to other Virginia parishes during Walter's childhood, and just after the close of the Civil War, transferred to the town of Charlottesville.  That move in 1866 placed Walter in the orbit of the University of Virginia, which he entered a year later at age sixteen under the care of his older brother Christopher, also a student at the University.  Reed attended two year-long sessions, the second devoted entirely to the medical curriculum, and he completed an M.D. degree on July 1, 1869, as one of the youngest students to graduate in the history of the medical school.","At that time the School of Medicine at the University offered little opportunity for direct clinical experience, so Reed subsequently enrolled at the Bellevue Hospital Medical College, in Manhattan, New York.  There he obtained a second M.D. degree in 1870.  Reed interned at a number of hospitals in the New York metropolitan area, including the Infants' Hospital on Randall's Island and the Brooklyn City Hospital.  In 1873, he assumed the position of assistant sanitary officer for the Brooklyn Board of Health.  The large and diverse population of New York, with its many immigrant communities and dense, tenement housing, provided countless medical cases to treat and study;  these served to expose Reed to the vital importance of public health, and developed in him a lifelong interest in the field.  Yet the frenetic life of the great cities began to pall after a few years: \"Here the ever bustling day is crowded into the busy night; nor can we draw the line of separation between the two,\"[1] he wrote to Emilie Lawrence, of Murfreesboro, North Carolina, later to become Mrs. Walter Reed.  Their courtship letters reveal much of his maturing character, interests, and philosophy of life.  Increasing responsibilities with the Board of Health precluded opening a private practice, and Reed's youth proved a barrier in a culture given to offering respect more to the appearance of maturity than to its actual demonstration. Reed consequently resolved to join the Army Medical Corps, both for the professional opportunities it offered immediately and for the modest financial security it could provide to a young man without independent means.  He passed the qualifying examinations in January 1875 and proceeded to his first assignment at the military base on Willet's Point, New York Harbor.","Reed remained in the Medical Corps for the rest of his life, spending many years of the '70s, '80s, and early '90s at difficult postings in the American West.  The first of these -- to the Arizona Territory -- began in the late spring of 1876, and indeed hurried along his wedding to Emilie Lawrence, on April 25, shortly before his departure.  She joined him the following November, and bore two children at frontier posts, a son Walter Lawrence and a daughter Emilie, called Blossom.","Reed's other western assignments included forts in Nebraska, Dakota Territory, and Minnesota, with two eastern interludes at Baltimore, Maryland and another at Mount Vernon Barracks, Alabama.  During the second of these tours in Baltimore -- over the 1890-1891 academic year -- Reed completed advanced coursework in pathology and bacteriology in the Johns Hopkins University Hospital Pathology Laboratory.  When he returned from his last western appointment in 1893, Reed joined the faculty of the Army Medical School in Washington, D.C., where he held the professorship of Bacteriology and Clinical Microscopy.  He also became curator of the Army Medical Museum and joined the faculty of the Columbian University in Washington (later the George Washington University).  In addition, Reed maintained close ties with professor William Welch and other leading lights in the scientific community he had come to know at Hopkins a few years earlier.","Beyond his teaching responsibilities for the Army and the Columbian University programs, Reed actively pursued medical research projects.  A bibliography of his publications finds entries from 1892 to the year of his untimely death a decade later, and the subjects he investigated range from erysipelas to cholera, typhoid, malaria, and yellow fever, among others.[2]   In 1896, a research trip to investigate an outbreak of smallpox took him to Key West, and there he developed a close friendship with Jefferson Randolph Kean, a fellow Virginian and colleague in the Medical Corps ten years his junior.  When Reed traveled to Cuba in 1899 to study typhoid in the army encampments of the U.S. forces, Kean was already there, and Kean was still in Cuba when Reed returned as the head of the Army board charged by Surgeon General George Miller Sternberg to examine tropical diseases including yellow fever.  Kean and his first wife Louise were great supporters of the U.S. Army Yellow Fever Commission's work, and Kean in fact served as quartermaster for the famous series of experiments at Camp Lazear.  After the dramatic and conclusive success of those experiments, Kean actively -- though unsuccessfully -- promoted Reed's candidacy for Surgeon General.","Reed continued to speak and publish on yellow fever after his return from Cuba in 1901, receiving honorary degrees from Harvard and the University of Michigan in recognition of his seminal work.  In November 1902, Reed developed what had been for him recurring gastro-intestinal trouble.  This time, however, his appendix ruptured, and surgery came too late to save him from the peritonitis which developed.  He died on November 23, 1902, almost two years to the day from the opening of Camp Lazear and the stunning experimental victory there.  Kean remained a champion of his deceased friend's role in the conquest of yellow fever.  He organized the Walter Reed Memorial Association, to provide support for Reed's family and to build a suitable memorial, and was instrumental in lobbying the United States Congress to establish the Yellow Fever Roll of Honor.  In 1929, Congress mandated the annual publication of the Roll in theArmy Register, and struck a series Congressional Gold Medals saluting the Commission members and the young Americans who bravely suffered experimental yellow fever a generation before.","Sources:","[1] Letter from Walter Reed to Emilie Lawrence, 18 July 1874, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 01605001.\n      [2] The bibliography of Reed's scientific papers may be found in: Howard Atwood Kelly,Walter Reed and Yellow Fever(New York: McClure, Phillips and Co., 1906), pp. 281-283. Kelly's complete biography of Reed is contained on this Web site.","Jesse William Lazear (May 2, 1866 - September 26, 1900) was a physician who was a member of the U.S. Army Yellow Fever Commission in 1900. Lazear's death from yellow fever at the outset of the commission's work in Cuba would lead to his elevation as a martyr for medical science in the eyes of many during the twentieth century.","\"I rather think I am on the track of the real germ,\" Jesse W. Lazear wrote his wife from Cuba on September 8, 1900.[1] Seventeen days later, the fulminating case of yellow fever Lazear had contracted just over a week after writing Mabel H. Lazear suddenly ended the young scientist's life. He was 34 years old. Unlike so many other yellow fever fatalities, however, this one would lead to a direct and highly successful assault on the disease itself. Yellow fever's ascendancy, endemic in Cuba, was about to be undermined.","Lazear had reported to Camp Columbia, Cuba in February 1900 for duty as an acting assistant surgeon with the U. S. Army Corps stationed on the island. Here he undertook bacteriological study of tropical diseases, particularly malaria and yellow fever, and in May he was named to the Army board charged with \"pursuing scientific investigations with reference to the infectious diseases prevalent on the island of Cuba.\"[2]","These orders placed him officially in the company of Walter Reed, James Carroll, and Aristides Agramonte -- the U.S. Army Yellow Fever Commission -- though Lazear had already met Reed the preceding March on a project to evaluate the efficacy of electrozone, a disinfectant made from seawater collected off the Cuban coast. While Reed was in Cuba that March, Lazear discussed with him the recent discovery of British scientist Sir Ronald Ross concerning the mosquito vector for malaria. At Johns Hopkins Hospital in Baltimore, where he was first a medical resident and later in charge of the clinical laboratory, Lazear had followed Ross's accomplishments with great interest, and pursued field work and experimentation on theAnophelesmosquito with fellow Hopkins scientist William S. Thayer. Lazear was thus the only member of the Commission who had experience with mosquito work, and was consequently the most open to the possible verity of Cuban scientist Carlos Juan Finlay's theory of mosquito transmission for yellow fever.","The record is apparently silent as to when Lazear first visited Finlay. Certainly by late June Lazear was beginning to grow mosquito larvae acquired from Finlay's laboratory, the first specimens brought to him by Henry Rose Carter, of the United States Public Health Service.[3] Not long after arriving in Cuba Lazear met Carter, whose own observations on yellow fever strongly suggested an intermediate host in the spread of the disease. However, Army Surgeon General George Miller Sternberg, who organized the Yellow Fever Commission, first charged the board members to investigate the relationship ofBacillus icteroidesto yellow fever -- proposed by the Italian Scientist Giuseppe Sanarelli as the actual cause of the disease. \"Dr. Reed had been in the old discussion over Sanarelli's bacillus and he still works on that subject,\" Lazear wrote his wife in July, \"I am not all interested in it but want to do work which may lead to the discovery of the real organism.\"[4] Soon he would have the opportunity. The relatively quick failure of the Bacillus icteroides inquiry opened the door to what became the ground-breaking mosquito work, and Lazear was well placed to begin.","The project started in earnest on August 1, 1900. In a small pocket notebook Lazear noted the preparatory work of raising and infecting mosquitoes, and subsequently recorded the series of eleven experimental inoculations made from the 11th to the 31st of August, the last two producing cases of full-blown yellow fever. These two positive cases developed from mosquitoes allowed to ripen over a period of 12 days, and this was Lazear's crucial discovery. The epidemiological pattern was thus entirely consistent with Carter's observations of a delay between the primary and secondary outbreaks of yellow fever in an epidemic, and, in addition, explained why Finlay's experiments had been largely unsuccessful -- he had not waited long enough before inoculating his subjects.","Although Lazear never directly admitted to experimenting on himself, when Reed reviewed Lazear's sketchy notations he evidently found entries strongly suggesting Lazear's case was not accidental, as officially reported. Unfortunately, the little notebook so crucial to the preparation of the Commission's famous initial paper,The Etiology of Yellow Fever -- A Preliminary Note[5], vanished from Reed's Washington office after his own untimely death in 1902. Still, Lazear's invaluable contribution to the Commission's victory was widely recognized and elicited tributes from many quarters: \"He was a splendid, brave fellow,\" Reed said of his young colleague, \" and I lament his loss more than words can tell; but his death was not in vain- His name will live in the history of those who have benefited humanity.\" [6] \"His death was a sacrifice to scientific research of the highest character,\" stated General Leonard Wood, military Governor of Cuba.[7] \"Your husband was a martyr in the noblest of causes,\" Dr. L. O. Howard wrote to Mabel Lazear, \"and I am proud to have known him. . . . His work contributed towards one of the greatest discoveries of the century, the results of which will be of invaluable benefit to mankind.\"[8] And so they were. Though Lazear's one-year-old son and newborn daughter never knew their father, they grew up in a world liberated -- almost in its entirety -- from the disease that killed him.","[1] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 8 September 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00344001.","Sources:","[2] Military Orders for Walter Reed, James Carroll, Aristides Agramonte, and Jesse W. Lazear, 24 May 1900, Hench Reed Collection, accession number 02019001.\n      [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n      [4] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 15 July 1900, Hench Reed Collection, accession number: 00334001.\n      [5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,The Etiology of Yellow Fever -- A Preliminary Note, Proceedings of the Twenty-eighth Annual Meeting of the American Public Health Association Indianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\n      [6] Letter from Walter Reed to Emilie Lawrence Reed, 6 October 1900, Hench Reed Collection, accession number: 02135001.\n      [7] Letter from Leonard Wood to the Adjutant-General, United States Army, November 1900, Hench Reed Collection, accession number: 00375002.\n      [8] Letter from Leland Ossian Howard to Mabel Houston Lazear, 7 February 1901, Hench Reed Collection, accession number: 00388001.","Henry Rose Carter (August 25, 1852 - September 14, 1925) was a prominent physician in the U.S. Public Health Service who was a leading authority in the transmission and control of tropical diseases, particularly yellow fever and malaria. During his long career as a sanitarian, Carter undertook campaigns to investigate and control the spread of tropical diseases in Cuba, the Panama Canal Zone, the Southeastern United States, and Peru.","Like Walter Reed and Jefferson Randolph Kean, Henry Rose Carter was a native Virginian and a graduate of the University of Virginia. Carter obtained a civil engineering degree from Virginia in 1873 and also undertook post-graduate work in mathematics and applied chemistry the next year. Subsequently, however, Carter's interests turned towards medicine, and he completed a medical degree at the University of Maryland in 1879. The same year Assistant Surgeon Carter joined the Marine Hospital Service -- later the United States Public Health Service -- and the young surgeon rose steadily through the ranks, ultimately attaining the position of Assistant Surgeon General in 1915.","Carter's initial assignments with the Hospital Service placed him at the center of the yellow fever maelstrom. In 1879 he was detailed to Memphis and other Southern cities, then in the throes of a second year of devastating epidemics. Here began, as his colleague T. H. D. Griffitts observed, Carter's \"lifelong interest in the epidemiology and control of yellow fever.\"[1] After several years of clinical practice in various Marine hospitals, Carter resumed a direct confrontation with yellow fever when his orders for duty with the Gulf Coast Maritime Quarantine assigned him to Ship Island, Mississippi, in 1888. Here and at subsequent quarantine station postings around the Gulf, he quietly championed a thorough review and rationalization of quarantine policies, with a view toward establishing uniform regulation, more thorough disinfection of vessels, and minimized interference with naval commerce. Crucial to the success of these activities was Carter's attention to the incubation period of yellow fever, which his on-site observations indicated to vary between 5 and 7 days. At the time the official literature stated with far less precision a variance of between 1 and 14 days; Carter's work consequently greatly increased the efficiency and effectiveness of quarantine operations.","Nevertheless, yellow fever continued to menace the temperate coastline of the United States, and Carter ably directed the Health Service's epidemiological control efforts in numerous threatened regions. In conjunction with this sanitary work for the 1898 season, Carter made detailed notes on the development of yellow fever at Orwood and Taylor, Mississippi. The isolation of these communities enabled him to identify more reliably the phenomenon of a delay between the initial cases of yellow fever in a locality and the subsequent appearance of secondary infection -- a delay two to four times longer than the incubation period of the disease in an infected person. Carter called this interval between the primary and secondary cases \"the period of extrinsic incubation,\" and he defined its \"usual limits . . . [as ranging] from ten to seventeen days.\"[2]","Before he was able to publish his conclusions, Carter took the helm of the quarantine service in war-time Cuba. There, in 1900, he met U. S. Army Yellow Fever Commission member Jesse Lazear. Carter had finally arranged for his paper's publication that year in theNew Orleans Medical and Surgical Journal, and gave a draft to Lazear. \"If these dates are correct,\" Carter later recalled Lazear saying, \"it spells a living host.\"[3] The theory of mosquito transmission long advanced by Cuban scientist Carlos J. Finlay began to seem more likely. And indeed it was. The Commission's experiments in 1900-1901 irrefutably proved the mosquito vector and established the extrinsic incubation period at twelve days. Shortly after these successes Reed saluted Carter, \"I know of no one more competent to pass judgment on all that pertains to the subject of yellow fever. You must not forget that your own work in Mississippi did more to impress me with the importance of an intermediate host than everything else put to-gether.\"[4]","Carter's long and distinguished sanitary career took him to the Panama Canal Zone in 1904, where he served as Chief Quarantine Officer and Chief of Hospitals for five years. He undertook detailed investigations and control measures of malaria in North Carolina and elsewhere in the South, and became a founder of the National Malaria Committee. With the support of the Rockefeller Foundation International Health Board, he undertook additional investigation and control measures for yellow fever in Central and South America. His expertise recommended him to the Peruvian government, which named Carter Sanitary Advisor in 1920-1921. Health problems at the end of his life compelled Carter to withdraw from active fieldwork, though he remained a highly valued consultant to the Health Board and a much-beloved and respected teacher for a new generation of sanitarians. Carter closed his career researching and writing the manuscript that his daughter Laura Armistead Carter edited and published posthumously in 1931:Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.[5]","Sources:","[1] T. H. D. Griffitts,Henry Rose Carter: The Scientist and the Man,Southern Medical Journal32 (August 1939) 8: 842.\n      [2] Henry Rose Carter,A Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation,Medical Record59 (15 June 1901) 24: 937.\n      [3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\n      [4] Letter from Walter Reed to Henry Rose Carter, 26 February 1901, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 02447001.\n      [5] Carter, Henry Rose.Yellow Fever: An Epidemiological and Historical Study of its Place of Origin.Baltimore: The Williams and Wilkins Company, 1931.","Jefferson Randolph Kean (June 27, 1860 - September 4, 1950) was a U.S. Army physician who was a leading authority in sanitation, public health, and tropical diseases. Later in his career, Kean would become widely recognized for his role in organizing and administering medical services for the U.S. armed forces during World War I.","\"He possessed one of the keenest, most scholarly minds I've ever encountered,\" recalled Nobel Prize winner Philip S. Hench of Jefferson Randolph Kean. [1] Kean and Hench shared an abiding interest in the work of the United States Army Yellow Fever Commission -- Kean, as a contemporary and supporter, and Hench, as a scholar and scientist intent on accurate historical documentation. On the advice of yellow fever experiment volunteer John J. Moran, Hench first wrote Kean in 1939. From that initial contact developed a close friendship which would last for the remainder of their lives. Kean entrusted Hench not only with numerous period documents, including original letters, accounts, fever charts, and other items, but also with the freely-given counsel and insight of a trusted friend.","Like Walter Reed and Henry Rose Carter before him, Jefferson Randolph Kean was an alumnus of the University of Virginia, completing the medical program there in 1883. Kean joined the U.S. Army Medical Corps in 1884, and after forty years in the service, retired with the rank of Colonel. Congress awarded him a promotion to Brigadier General, retired, in 1930. The early years of Kean's career passed in medical postings in the American West, and no doubt offered him experiences similar to those of Walter Reed, whom he met not on the frontier, but in Florida in 1896. Kean became an expert in tropical diseases and sanitation during his five-year assignment in the Florida tropics, an expertise which served him well over two terms of service later in Cuba. During the Spanish-American War and subsequent U. S. occupation of Cuba, Kean was Chief Surgeon for the Department of Havana, then Superintendent of the Department of Charities -- from 1898 to 1902. After a four-year interlude as an assistant to the Surgeon General in Washington, D.C., Kean again returned to Cuba as an advisor to the Department of Sanitation from 1906-1909.","Kean himself stated: \"Reed and I were good friends before the Yellow Fever Board came to Cuba in June 1900, and [Reed] located himself at Marianao, 8 miles S. W. of Havana,\" to be within the medical and administrative jurisdiction overseen by Kean. [2] The Chief Surgeon did indeed offer significant assistance, and was an early convert to Carlos Finlay's mosquito theory of transmission, which the Yellow Fever Board's experiments ultimately proved true in the late autumn and winter of 1900-1901. As early as October 13, 1900 -- after the Board's preliminary work, but before the final convincing demonstrations -- Kean issued \"Circular No. 8,\" concerning the latest scholarship on the mosquito vector for disease. [3] The circular contained a set of instructions for the entire command on mosquito eradication. Kean subsequently served as quartermaster and financial administrator for the famous series of yellow fever experiments at Camp Lazear and, for the rest of his life, Kean remained a strong proponent of the Commission's conclusions. He worked tirelessly not only to apply them in the field, but also to accord proper public recognition to the Commission's work.","In addition to his career as a sanitarian, Kean organized the department of military relief of the American Red Cross, and during World War One served as Chief of the U. S. Ambulance Service with the French Army and Deputy Chief Surgeon of the American forces. France named him an Officier de la Légion d'Honneur in recognition for these services. Cuban authorities as well offered Kean recognition with the grand cross of the Order of Merit Carlos J. Finlay, and he received both a Distinguished Service Medal from the United States government and the Gorgas Medal from the Association of Military Surgeons. For a decade after his retirement from active duty, Kean edited this last organization's medical journal,The Military Surgeon, and served on the Surgeon General's editorial board for the multi-volume history of the medical department in World War One. A great-grandson of Thomas Jefferson, Kean also took a seat with the government commission established to build the Jefferson Memorial in Washington, D.C. He held charter membership in the Walter Reed Memorial Association, and remained active in its affairs until his death in 1950.","Sources:","[1] Telegram from Philip Showalter Hench and Mary Hench to Cornelia Knox Kean, September 5, 1950, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 06501173.\n      [2] Letter from Jefferson Randolph Kean to Philip Showalter Hench, October 31, 1939, Hench Reed Yellow Fever Collection, accession number: 06282022.\n      [3] Military Orders to Commanding Officers, October 15, 1900, Hench Reed Yellow Fever Collection, accession number: 02140001.","Philip Showalter Hench (February 28, 1896 - March 30, 1965) was a U.S. physician who in 1950 was awarded the Nobel Prize for Physiology and Medicine for his role in the discovery of the hormone cortisone. In addition to his medical research, Hench spent almost three decades of his life studying the history of the U.S. Army Yellow Fever Commission and became a leading authority in the subject.","Philip Showalter Hench was born in Pittsburgh, Pennsylvania, the son of Jacob Bixler Hench and Clara Showalter. After attending local schools, Hench entered Lafayette College and graduated from the school 1916 with a Bachelor of Arts. Hench completed his medical degree at the University of Pittsburgh in 1920, and subsequently entered a residency program at St. Francis Hospital, Pittsburgh. His association with the Mayo Clinic began in 1921 as a fellow at the institution. Two years later he would become an assistant at the clinic, and then, in 1926, he would be made the head of its Department of Rheumatic Diseases After pursuing post-graduate study in Germany in 1928-1929, Hench obtained a Masters of Science in Internal Medicine at the University of Minnesota in 1931, and a Doctor of Science degree from Lafayette College in 1940. Hench remained for the duration of his career at the Mayo Clinic, where his life-long passion for meticulous research and analysis brought him the Nobel Prize for Physiology and Medicine in 1950, which he shared with Edward C. Kendall and Tadeus Reichstein, for the discovery of cortisone.","The same persistence and determination present in his professional life is also evident in Hench's research on the U. S. Army Yellow Fever Commission's famous experiments. \"As a physician particularly interested in medical history,\" he stated to experiment volunteer John J. Moran in 1937, \"I have been long interested in the story of the yellow fever work in John J. Moran, Ralph C. Hutchison, Havana.\" [1] So began a remarkable odyssey. At the request of his friend Ralph Cooper Hutchison, then president of Washington and Jefferson College, Hench had written Moran to gather information for the dedication of the College's new chemistry building, named for Commission member and former Washington and Jefferson student Jesse W. Lazear. Hench also began a correspondence with another of the yellow fever experiment's original volunteers, John R. Kissinger. Moran's and Kissinger's recollections proved so intriguing that Hench initially offered to edit and publish them. However, in the course of his research Hench discovered that much general information on the topic was inaccurate. Conflicting assertions concerning the participants and unverified claims by medical and governmental authorities in the United States and Cuba -- often politically motivated -- clouded interpretation of the facts. \"May I suggest,\" Moran consequently urged in 1938, \"that a clearing up of the REED-FINLAY-CONQUEST-OF-YELLOW-FEVER, or an effort to do so, on your part, is a task far more pressing than publishing the Kissinger-Moran stories or memoirs.\" [2] Hench resolved to document every aspect of the \"Conquest of Yellow-Fever\" and to write a much needed accurate and comprehensive history.","For the next two decades, Hench tirelessly combed through public archive collections and personal papers in the United States and Cuba. He met and interviewed surviving participants of the experiments and others associated with the project, as well as family members of the Yellow Fever Commission. He sought out physicians and scientists who had worked with the principal players or who had applied the results in the campaign to eradicate yellow fever. He identified and photographed sites associated with the yellow fever story, and he successfully petitioned politicians in the United States and Cuba to commemorate the work. In the process, Hench became the trusted friend and advisor of many of these same individuals, and they, in turn, presented him with much of the surviving original material for safekeeping.","In short, Hench came to be the world's expert on the yellow fever story and the steward of thousands of original letters and documents. His premature death at age 69 found him still hoping to uncover important missing evidence, his book unwritten. Hench's widow Mary Kahler Hench gave his yellow fever collection to the University of Virginia, Walter Reed's alma mater, and this extensive personal archive forms the most detailed and accurate record available on the Conquest of Yellow Fever.","Sources:","[1] Letter from Philip S. Hench to John J. Moran, 6 July 1937, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 03419001.\n      [2] Letter from John J. Moran to Philip S. Hench, 30 October 1938, Hench Reed Yellow Fever Collection, accession number: 03476001."],"custodhist_html_tesm":["\u003cp\u003eMaterials from the following series were initially deposited at the University of Virginia's Alderman Library. In 1982, they were moved to the Claude Moore Health Sciences Library under the terms of a gift agreement that required the transferral of Mary K. Hench's donation to the library when adequate storage space for the collection could be found there.\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003eSeries I. Jesse W. Lazear\u003c/item\u003e\n      \u003citem\u003eSeries II. Henry Rose Carter\u003c/item\u003e\n      \u003citem\u003eSeries III. Walter Reed\u003c/item\u003e\n      \u003citem\u003eSeries IV. Philip Showalter Hench\u003c/item\u003e\n      \u003citem\u003eSeries V. Maps\u003c/item\u003e\n      \u003citem\u003eSeries VI. Alphabetical files\u003c/item\u003e\n      \u003citem\u003eSeries VII. Truby-Kean-Hench\u003c/item\u003e\n      \u003citem\u003eSeries VIII. Miscellany\u003c/item\u003e\n      \u003citem\u003eSeries IX. Photographs\u003c/item\u003e\n      \u003citem\u003eSeries X. Negatives\u003c/item\u003e\n      \u003citem\u003eSeries XI. Reprints\u003c/item\u003e\n      \u003citem\u003eSeries XIII. Reed family additions\u003c/item\u003e\n      \u003citem\u003eSeries XV. Laura Wood\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eMaterials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were initially deposited in the HAM/TMC and were a part of the Philip S. Hench papers. In 1991, the materials were transferred from HAM/TMC to the Claude Moore Health Sciences Library after both repositories agreed that it would be more appropriate to include them in the Philip S. Hench Walter Reed Yellow Fever Collection.\u003c/p\u003e","\u003cp\u003e Materials from Series XVI. Edward Hook additions were transferred from the Papers of Dr. Edward Watson Hook, Jr. to the Philip S. Hench Walter Reed Yellow Fever Collection around the late 1990s and early 2000s.\u003c/p\u003e  "],"custodhist_heading_ssm":["Custodial History"],"custodhist_tesim":["Materials from the following series were initially deposited at the University of Virginia's Alderman Library. In 1982, they were moved to the Claude Moore Health Sciences Library under the terms of a gift agreement that required the transferral of Mary K. Hench's donation to the library when adequate storage space for the collection could be found there.","Series I. Jesse W. Lazear\n      Series II. Henry Rose Carter\n      Series III. Walter Reed\n      Series IV. Philip Showalter Hench\n      Series V. Maps\n      Series VI. Alphabetical files\n      Series VII. Truby-Kean-Hench\n      Series VIII. Miscellany\n      Series IX. Photographs\n      Series X. Negatives\n      Series XI. Reprints\n      Series XIII. Reed family additions\n      Series XV. Laura Wood","Materials from Series XII. Houston Academy of Medicine/Texas Medical Center (HAM/TMC) were initially deposited in the HAM/TMC and were a part of the Philip S. Hench papers. In 1991, the materials were transferred from HAM/TMC to the Claude Moore Health Sciences Library after both repositories agreed that it would be more appropriate to include them in the Philip S. Hench Walter Reed Yellow Fever Collection.","Materials from Series XVI. Edward Hook additions were transferred from the Papers of Dr. Edward Watson Hook, Jr. to the Philip S. Hench Walter Reed Yellow Fever Collection around the late 1990s and early 2000s."],"odd_html_tesm":["\u003clist type=\"deflist\"\u003e\n      \u003cdefitem\u003e\n        \u003clabel\u003eProcessed by:\u003c/label\u003e\n        \u003citem\u003eHistorical Collections Staff\u003c/item\u003e\n      \u003c/defitem\u003e\n    \u003c/list\u003e\n  "],"odd_heading_ssm":["General"],"odd_tesim":["Processed by:\n        Historical Collections Staff"],"prefercite_html_tesm":["\u003cp\u003ePhilip S. Hench Walter Reed Yellow Fever Collection, 1800-1998, MS-1, Claude Moore Health Sciences Library, Historical Collections and Services, University of Virginia\u003c/p\u003e  "],"prefercite_tesim":["Philip S. Hench Walter Reed Yellow Fever Collection, 1800-1998, MS-1, Claude Moore Health Sciences Library, Historical Collections and Services, University of Virginia"],"processinfo_html_tesm":["\u003cp\u003eMary K. Hench's donation arrived in Charlottesville in a number of large crates which were packed much as the collection had been found in Philip Showalter Hench's home in Rochester, Minnesota. Some confusion about Dr. Hench's filing order had been created while the collection was packed for shipping, and thus the Manuscripts Department of the University of Virginia Library found it necessary to perform some sorting and arrangement to make the collection more accessible.\u003c/p\u003e","\u003cp\u003e Around 1968, William Bennett Bean was hired by the University of Virginia as a visiting scholar in residence to begin work on a new biography of Walter Reed. Dr. Bean found that the order of the collection was not such that he could readily use it for biographical purposes. He employed a former assistant in the Manuscripts Department, sought and received permission to refile the collection, and had his assistant perform this task. The refiling of the collection had been finished by the fall of 1969, but Bean and his assistant had no time to prepare a finding aid.\u003c/p\u003e","\u003cp\u003e In the fall of 1969 Donna L. Purvis of the Manuscripts Department staff began writing the first edition of the collection's finding aid. During this project, Mrs. Purvis found some problems with Dr. Bean's description and arrangement of the collection and felt that it was necessary to reprocess parts of it.\u003c/p\u003e","\u003cp\u003e Around 1990 staff members in the Claude Moore Health Sciences Library processed additions to the collection donated by Philip Showalter Hench's son, P. Kahler Hench.\u003c/p\u003e","\u003cp\u003e Between 1999 and 2004, the Claude Moore Health Sciences Library digitized a significant portion of the collection and made the digitized files available to users in an online exhibit. During this project, over 8,000 items from the collection were scanned, transcribed, and described at the item level. Metadata for the digitized items was recorded in XML files using the TEI 2 standard.\u003c/p\u003e","\u003cp\u003e In 2001, the Claude Moore Health Sciences Library processed additions that had been made to the collection since 1982, excepting the materials donated by P. Kahler Hench. Staff members also processed significant portions of Mary K. Hench's original donation that had not been described in the first edition of the collection finding aid. This work led to the development of a second edition finding aid that was coded in EAD and ingested into the Virginia Heritage database. This finding aid contained both new metadata and metadata that had been migrated from a Microsoft Access file.\u003c/p\u003e","\u003cp\u003e In the 2000s the Claude Moore Health Sciences Library processed the materials in Series XV. Edward Hook additions.\u003c/p\u003e","\u003cp\u003e In 2009, staff members in the Claude Moore Health Sciences Library processed Box 154 of the collection.\u003c/p\u003e","\u003cp\u003e In 2013, staff members in the Claude Moore Health Sciences Library produced a third edition of the finding aid using EAD that merged collection description from four sources (the first edition finding aid, the second edition finding aid, the online exhibit, and the physical collection). When possible, metadata from the existing online exhibit's TEI files and metadata from the second edition finding aid were transformed with XSL and included in the EAD file. However, staff members sometimes found it necessary to create new metadata for the collection. The new finding aid was structured in such a way to facilitate the migration of the collection's digital files and metadata into the University of Virginia's digital repository and make it available to users via the library's online catalog.\u003c/p\u003e  "],"processinfo_heading_ssm":["Processing History"],"processinfo_tesim":["Mary K. Hench's donation arrived in Charlottesville in a number of large crates which were packed much as the collection had been found in Philip Showalter Hench's home in Rochester, Minnesota. Some confusion about Dr. Hench's filing order had been created while the collection was packed for shipping, and thus the Manuscripts Department of the University of Virginia Library found it necessary to perform some sorting and arrangement to make the collection more accessible.","Around 1968, William Bennett Bean was hired by the University of Virginia as a visiting scholar in residence to begin work on a new biography of Walter Reed. Dr. Bean found that the order of the collection was not such that he could readily use it for biographical purposes. He employed a former assistant in the Manuscripts Department, sought and received permission to refile the collection, and had his assistant perform this task. The refiling of the collection had been finished by the fall of 1969, but Bean and his assistant had no time to prepare a finding aid.","In the fall of 1969 Donna L. Purvis of the Manuscripts Department staff began writing the first edition of the collection's finding aid. During this project, Mrs. Purvis found some problems with Dr. Bean's description and arrangement of the collection and felt that it was necessary to reprocess parts of it.","Around 1990 staff members in the Claude Moore Health Sciences Library processed additions to the collection donated by Philip Showalter Hench's son, P. Kahler Hench.","Between 1999 and 2004, the Claude Moore Health Sciences Library digitized a significant portion of the collection and made the digitized files available to users in an online exhibit. During this project, over 8,000 items from the collection were scanned, transcribed, and described at the item level. Metadata for the digitized items was recorded in XML files using the TEI 2 standard.","In 2001, the Claude Moore Health Sciences Library processed additions that had been made to the collection since 1982, excepting the materials donated by P. Kahler Hench. Staff members also processed significant portions of Mary K. Hench's original donation that had not been described in the first edition of the collection finding aid. This work led to the development of a second edition finding aid that was coded in EAD and ingested into the Virginia Heritage database. This finding aid contained both new metadata and metadata that had been migrated from a Microsoft Access file.","In the 2000s the Claude Moore Health Sciences Library processed the materials in Series XV. Edward Hook additions.","In 2009, staff members in the Claude Moore Health Sciences Library processed Box 154 of the collection.","In 2013, staff members in the Claude Moore Health Sciences Library produced a third edition of the finding aid using EAD that merged collection description from four sources (the first edition finding aid, the second edition finding aid, the online exhibit, and the physical collection). When possible, metadata from the existing online exhibit's TEI files and metadata from the second edition finding aid were transformed with XSL and included in the EAD file. However, staff members sometimes found it necessary to create new metadata for the collection. The new finding aid was structured in such a way to facilitate the migration of the collection's digital files and metadata into the University of Virginia's digital repository and make it available to users via the library's online catalog."],"scopecontent_html_tesm":["\u003cp\u003eThe Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audio cassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). All of these materials are arranged in 16 series: I. Jesse W. Lazear, II. Henry Rose Carter, III. Walter Reed, IV. Philip Showalter Hench, V. Maps, VI. Alphabetical files, VII. Truby-Kean-Hench, VIII. Miscellany, IX. Photographs, X. Photographic negatives, XI. Reprints, XII. Houston Academy of Medicine/Texas Medical Center additions, XIII. Reed family additions, XIV. P. Kahler Hench additions, XV. Laura Wood, and XVI. Edward Hook additions.\u003c/p\u003e","\u003cp\u003e Series I. Jesse W. Lazear consists of materials relating to Lazear that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1800 to 1956 with the bulk of the items dating from 1863 to 1943. Much of the series consists of the correspondence of Jesse W. Lazear and his wife Mabel H. Lazear. Jesse's correspondence dates from his time as a student at Johns Hopkins University to his death in 1900. Researchers can learn a great deal about Jesse from these letters, including his relationships with friends and family, his educational background, and his professional life. Mabel's correspondence dates from the time she met Jesse to her death in 1946. This correspondence primarily concern her husband's historical legacy and a campaign to secure a pension from the U.S. government for herself and her family.\u003c/p\u003e","\u003cp\u003e In addition to Jesse and Mabel's correspondence, the series contains other materials relating to them and their families including, but not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ethe diaries documenting the travels of Jesse and Mabel's mothers in Europe;\u003c/item\u003e\n      \u003citem\u003ecorrespondence of other Lazear family members (e.g. Jesse's parents);\u003c/item\u003e\n      \u003citem\u003egenealogical summaries and tables relating to the Lazear family;\u003c/item\u003e\n      \u003citem\u003elegal documents (e.g. wills, certificates, deeds);\u003c/item\u003e\n      \u003citem\u003emilitary records relating to Jesse;\u003c/item\u003e\n      \u003citem\u003ecertificates, reports, and other materials documenting Jesse's educational background and achievements;\u003c/item\u003e\n      \u003citem\u003eobituaries;\u003c/item\u003e\n      \u003citem\u003ecopies of congressional bills and reports concerning the provision of a federal pension for Mabel H. Lazear;\u003c/item\u003e\n      \u003citem\u003enewspaper articles;\u003c/item\u003e\n      \u003citem\u003ea microscope and sets of microscope slides owned by Jesse;\u003c/item\u003e\n      \u003citem\u003eand a medical chart that shows the progression of the yellow fever infection that killed Jesse.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries II. Henry Rose Carter consists of materials relating to Henry Rose Carter that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1880 to 1932 with the bulk of the materials dating from 1883 to 1932. The series is particularly rich in materials that document Henry Rose Carter's professional activities in the last eleven years of his life (1914-1925). These materials include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ecorrespondence with colleagues in the medical and scientific community including Rupert E. Blue, Hideyo Noguchi, Henry Hanson, Joseph A. LePrince, Frederick F. Russell, T.H.D. Griffitts, and Lunsford D. Fricks;\u003c/item\u003e\n      \u003citem\u003escientific, medical, and government reports relating to the study and eradication of yellow fever and malaria in North America, South America, and Africa;\u003c/item\u003e\n      \u003citem\u003ejournal articles concerning the study and eradication of yellow fever and malaria;\u003c/item\u003e\n      \u003citem\u003eresearch notes written by Henry Rose Carter;\u003c/item\u003e\n      \u003citem\u003eand photographs of Henry Rose Carter at work and with professional colleagues.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries II. also contains correspondence between Henry Rose Carter and members of his family that date from 1880 to 1925. The family members with whom Henry corresponds most frequently in this series are his mother, Emma Coleman Carter; his wife, Laura Eugenia Hook Carter; his daughter, Laura Armistead Carter; and his son, Henry Rose Carter, Jr. These letters are not only a rich source of information about Carter's personal views and family life, they also provide valuable insights into his professional activities such as his experiences aboard vessels and in ports while working for the U.S. Marine Hospital Service and his public health work in Cuba, Panama, and Peru.\u003c/p\u003e","\u003cp\u003e In addition to the materials that were produced during Henry Rose Carter's lifetime, the Series II. contains materials that were produced between 1925 and 1940 (after Henry Rose Carter's death) including, but not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ecopies of obituaries for Henry Rose Carter;\u003c/item\u003e\n      \u003citem\u003econdolence letters for Henry Rose Carter's family after Henry's death;\u003c/item\u003e\n      \u003citem\u003eand the correspondence of Laura Armistead Carter relating to her father and other members of the Carter family.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries III. Walter Reed consists of materials that document the life of Walter Reed as well as the work and legacy of the U.S. Army Yellow Fever Commission. Items in the series date from 1806 to around 1955 with the bulk of the items dating from 1874 to 1936. The series is particularly rich in materials that document the professional and personal life of Walter Reed from 1874 to his death in 1902. These materials include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ecorrespondence between Walter Reed and members of his immediate family that cover a wide range of topics including Reed's courtship of Emilie Lawrence Reed, family life, Walter Reed's work in the Western United States, and Walter Reed's work in Cuba;\u003c/item\u003e\n      \u003citem\u003emilitary records relating to Walter Reed including military orders for Reed, Reed's performance reviews, and reports of Reed's work for army officials;\u003c/item\u003e\n      \u003citem\u003eWalter Reed's correspondence with professional colleagues including members of the U.S. Army Yellow Fever Commission, military doctors, and medical researchers interested in the study of yellow fever;\u003c/item\u003e\n      \u003citem\u003emedical records (e.g. fever charts of experiment participants), military orders, administrative records, reports, and publications documenting the results of the U.S. Army Yellow Fever Commission's experiments in Cuba;\u003c/item\u003e\n      \u003citem\u003earticles announcing the death of Walter Reed;\u003c/item\u003e\n      \u003citem\u003eand the shoulder boards from Walter Reed's U.S. Army uniform.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eIn addition to the above items, Series III. contains materials that document campaigns, spanning from 1902 to 1937, to publicly honor members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments. These materials include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003earticles and editorials relating to efforts to memorialize and provide pensions for members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments;\u003c/item\u003e\n      \u003citem\u003ebiographical sketches of members of the U.S. Army Yellow Fever Commission and experiment participants;\u003c/item\u003e\n      \u003citem\u003erecords relating to the Walter Reed Memorial Association (e.g. correspondence, donor lists);\u003c/item\u003e\n      \u003citem\u003ecopies of Congressional bills and resolutions to honor members of the U.S. Army Yellow Fever Commission and experiment participants;\u003c/item\u003e\n      \u003citem\u003eand letters, reviews, and other materials relating to the production of Sidney Coe Howard's play,\u003ctitle render=\"italic\"\u003eYellow Jack\u003c/title\u003e.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eFinally, Series III. also consists of materials that document the history of yellow fever during the nineteenth and early twentieth century. These materials include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003eitems (e.g. correspondence, reports, reviews, and articles) relating to U.S. efforts to eradicate yellow fever in the Panama Canal Zone;\u003c/item\u003e\n      \u003citem\u003ematerials (e.g. correspondence, reports, and articles) documenting early twentieth century efforts to eradicate yellow fever in Peru;\u003c/item\u003e\n      \u003citem\u003escientific reports and publications related to the study and eradication of yellow fever and malaria;\u003c/item\u003e\n      \u003citem\u003eand newspaper articles describing various outbreaks of yellow fever epidemics.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries IV. Philip Showalter Hench primarily consists of materials that Hench created or collected while researching the U.S. Army Yellow Fever Commission. Items in this series date from around 1850 to around 1865 with the bulk of the items dating from 1937 to 1960. Researchers who are studying the yellow fever experiments will be particularly interested in the materials (e.g. interviews, autobiographies) that document first-hand accounts of the events surrounding the experiments. Other researchers may be interested in items that document Hench's role in shaping public memory of the commission and its experiments. The materials in this series include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003eHench's correspondence and interviews with participants in the yellow fever experiments and their families including: Emilie Lawrence Reed, Emilie M. (Blossom) Reed, Walter Lawrence Reed, John J. Moran, Albert E. Truby, Jefferson Randolph Kean, John H. Andrus, and John R. Kissinger;\u003c/item\u003e\n      \u003citem\u003eautobiographical accounts of the experiment's participants and their families;\u003c/item\u003e\n      \u003citem\u003enotes, reports, correspondence and other materials relating to Hench's search for the original site of Camp Lazear in Cuba;\u003c/item\u003e\n      \u003citem\u003ecorrespondence with Cuban government officials and members of the scientific community relating to Hench's campaign to build a Camp Lazear memorial;\u003c/item\u003e\n      \u003citem\u003ecorrespondence and other materials relating to ceremonies honoring Jesse W. Lazear at Washington and Jefferson College;\u003c/item\u003e\n      \u003citem\u003enewspaper articles, magazine articles, and other printed matter concerning the yellow fever experiments and its participants;\u003c/item\u003e\n      \u003citem\u003edrafts of speeches and presentations Hench gave on the history of the yellow fever experiments to various audiences;\u003c/item\u003e\n      \u003citem\u003emeeting minutes and other materials that document Hench's relationship with and participation in the Walter Reed Memorial Association;\u003c/item\u003e\n      \u003citem\u003escripts for radio programs relating to the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003enotes, outlines, lists, correspondence, and other materials that document Hench's research about the yellow fever experiments and a book he had planned to write on the subject;\u003c/item\u003e\n      \u003citem\u003eand the gold medal that Congress posthumously awarded to Walter Reed for his work with yellow fever.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries V. Maps primarily consists of maps and floor plans that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1960 with the bulk of the items dating from 1899 to 1951. The maps and floor plans often include annotations and illustrate a wide range of locations including, but not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003eHavana and its environs;\u003c/item\u003e\n      \u003citem\u003eCuba;\u003c/item\u003e\n      \u003citem\u003esites associated with the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003eand military installations in the United States.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eIn addition to the maps and floor plans, Series V. also consists of a few newspaper and magazine clippings that contain information relating to the yellow fever experiments.\u003c/p\u003e","\u003cp\u003e Series VI. Alphabetical files primarily consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1860 to around 1966 with the bulk of the items dating from 1940 to 1956. All of these items have been arranged thematically into biographical files. Each file contains materials created by or relating to people who were either involved with the yellow fever experiments or aided Philip Showalter Hench in his research of the subject. These people include, but are not limited to: John J. Moran, Carlos E. Finlay, Laura Wood Roper, Mabel Lazear, Clara Maas, John R. Kissinger, Roger Post Ames, James C. Carroll, and Carlos J. Finlay. The files are arranged alphabetically by the last names of the individuals listed on the files and it is unclear whether the overall arrangement was made by Hench or by staff members at the University of Virginia. The biographical files contain a wide range of different materials that pertain to the individuals listed on the files. These materials include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ecorrespondence between Philip Showalter Hench and the individuals;\u003c/item\u003e\n      \u003citem\u003eother correspondence;\u003c/item\u003e\n      \u003citem\u003enewspaper and magazine clippings;\u003c/item\u003e\n      \u003citem\u003eunpublished manuscripts;\u003c/item\u003e\n      \u003citem\u003ebiographical and autobiographical accounts;\u003c/item\u003e\n      \u003citem\u003etranscripts of oral history interviews that were conducted by Philip Showalter Hench;\u003c/item\u003e\n      \u003citem\u003eand copies of medical charts for volunteers in the yellow fever experiments that shows the progression of the disease.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eIn addition to the materials that Hench created or collected during his lifetime, the biographical files in Series VI. also contain items that were added by staff at the University of Virginia Library during the late 1960s and early 1970s.\u003c/p\u003e","\u003cp\u003e Series VII. Truby-Kean-Hench primarily consists of materials relating to Albert E. Truby and Jefferson Randolph Kean that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1879 to around 1960 with the bulk of the items dating from 1900 to 1954. These items include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ecorrespondence of Jefferson Randolph Kean dating from 1900 to 1950 that relates to his personal life, the yellow fever experiments, public health initiatives, his publications, the legacy of the yellow fever experiments, Kean's work in World War I, and other topics;\u003c/item\u003e\n      \u003citem\u003ePhilip Showalter Hench's correspondence with people related to the yellow fever experiments, particularly Albert E. Truby and Jefferson Randolph Kean primarily from between 1940 and 1955;\u003c/item\u003e\n      \u003citem\u003ea scrapbook and other materials that relate to Truby's book,\u003ctitle render=\"italic\"\u003eMemoir of Walter Reed: the Yellow Fever Episode\u003c/title\u003e;\u003c/item\u003e\n      \u003citem\u003eand Philip Showalter Hench's interviews and questionnaires for Kean and Truby from the 1940s.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eIn addition to the materials relating to Kean and Truby, Series VII. also includes the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003enotes from Philip Showalter Hench's research of the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ethe recollections, autobiographies, and reports of other people involved with the yellow fever experiments including John Andrus and A.S. Pinto;\u003c/item\u003e\n      \u003citem\u003earticles and clippings related to the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ea short biography of Lemuel S. Reed;\u003c/item\u003e\n      \u003citem\u003eand a sketch Philip Showalter Hench made of a proposed museum at the Camp Lazear site.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries VIII. Miscellany consists of oversize and miscellaneous materials in the Philip S. Hench Walter Reed yellow fever collection that were, for various reasons, not included in any of the other series in the collection. Items in this series date from around 1849 to 1982 with the bulk of the materials dating from 1885 to 1974. These materials include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003einformed consent agreements for volunteers in the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ediplomas and certificates for Walter Reed and Jesse W. Lazear;\u003c/item\u003e\n      \u003citem\u003ecopies and sketches of Dean Cornwell's painting,\u003ctitle render=\"italic\"\u003eConquerors of Yellow Fever\u003c/title\u003e;\u003c/item\u003e\n      \u003citem\u003eartifacts, including a wooden board from Camp Lazear and a U.S. flag;\u003c/item\u003e\n      \u003citem\u003ecopies of correspondence, reports, medical records, and military orders from the U.S. National Archives relating to the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003emanuscripts and related notes for published works and research relating to Walter Reed and the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ecorrespondence of Philip Showalter Hench from circa 1940 to 1966;\u003c/item\u003e\n      \u003citem\u003earticles and clippings relating to the yellow fever experiments, the experiments' participants, and the Philip S. Hench Walter Reed yellow fever collection;\u003c/item\u003e\n      \u003citem\u003ecorrespondence of Atcheson Laughlin Hench and members of the University of Virginia community relating to the Philip S. Hench Walter Reed yellow fever collection;\u003c/item\u003e\n      \u003citem\u003eitems that document the provenance and custodial history of some materials in the Philip S. Hench Walter Reed yellow fever collection;\u003c/item\u003e\n      \u003citem\u003ephotographs relating to Cuba and the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003enotes for photographs and photographic negatives housed in Series IX. and Series X. of this collection.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries IX. Photographs consists primarily of photographs that Philip Showalter Hench created and collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1966 with the bulk of the items dating from around 1870 to around 1960. The subjects shown in the photographs include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ephysicians, military personnel, nurses, and volunteers associated with the experiments including Walter Reed, Jesse W. Lazear, Jefferson Randolph Kean, and Aristides Agramonte;\u003c/item\u003e\n      \u003citem\u003efamily members of people associated with the yellow fever experiments including their spouses, children, and grandchildren.\u003c/item\u003e\n      \u003citem\u003eCamp Lazear, Camp Columbia, and other locations in Cuba related to the yellow fever experiments between 1900 and 1960;\u003c/item\u003e\n      \u003citem\u003ethe U.S.S.\u003cemph render=\"italic\"\u003eMaine\u003c/emph\u003eand the Spanish-American War;\u003c/item\u003e\n      \u003citem\u003eaerial views of Havana, Cuba and its environs from the 1940s and 1950s;\u003c/item\u003e\n      \u003citem\u003escenes of daily life in Cuba generally from between 1898 and 1960;\u003c/item\u003e\n      \u003citem\u003ethe 1952 dedication of the Camp Lazear National Monument in Cuba;\u003c/item\u003e\n      \u003citem\u003ethe creation and unveiling of Dean Cornwell's painting,\u003ctitle render=\"italic\"\u003eConquerors of Yellow Fever\u003c/title\u003e;\u003c/item\u003e\n      \u003citem\u003estill scenes from the movies,\u003ctitle render=\"italic\"\u003eYellow Jack\u003c/title\u003eand\u003ctitle render=\"italic\"\u003eJezebel\u003c/title\u003e;\u003c/item\u003e\n      \u003citem\u003eother events and works of art commemorating the work of the participants in the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003edocuments and maps that Philip Showalter Hench copied for his research;\u003c/item\u003e\n      \u003citem\u003eand Philip Showalter Hench and his family.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries IX. also includes a watercolor that was painted by Emilie Lawrence Reed.\u003c/p\u003e","\u003cp\u003e Series X. Photographic negatives consists of a mix of original and copy negatives that Philip Showalter Hench collected while researching the yellow fever experiments. Although the original images recorded on the negatives date from between the 1860s and the 1960s, it appears that the negatives themselves were produced during a narrower time frame, most likely between 1930 and 1966.\u003c/p\u003e","\u003cp\u003e The negatives in Series X. record images associated with the yellow fever experiments and many of them are related to photographic prints found in Series VIII. Where a match between a negative and a print from these series has been made, the negative number has been written on the folder of the print in the physical collection. Finally, the negatives are generally arranged in numerical order by identification numbers that were most likely assigned by Philip Showalter Hench.\u003c/p\u003e","\u003cp\u003e Series XI. Reprints consists of reprints and photocopies of journal articles, book extracts, book reviews and other published works that were primarily collected by Philip Showalter Hench while researching the yellow fever experiments. Items in this series date from 1856 to 1971 and cover a wide range of topics related to the study and eradication of yellow fever, including, but not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ethe results of the U.S. Army Yellow Fever Commission's work in Cuba;\u003c/item\u003e\n      \u003citem\u003ebiographical accounts of various people who had an association with the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ethe research of people associated with the experiments including Walter Reed, Jesse W. Lazear, Aristides Agramonte, and James Carroll;\u003c/item\u003e\n      \u003citem\u003escientific and medical research related to yellow fever and malaria;\u003c/item\u003e\n      \u003citem\u003eand events honoring the work of those involved with the yellow fever experiments.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries XII. Houston Academy of Medicine/Texas Medical Center additions consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1901 to around 1966. These materials were originally a part of the Philip S. Hench papers in the John P. McGovern Historical Collections and Research Center at the Texas Medical Center Library, but they were transferred to the University of Virginia in 1991. These items include, but are not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ecorrespondence between Philip Showalter Hench and people connected with the yellow fever experiments including John J. Moran and Walter Reed's children;\u003c/item\u003e\n      \u003citem\u003enewspaper clippings relating to the death or commemoration of individuals associated with the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ephotographs of the Camp Lazear Memorial, everyday scenes in Cuba, and John J. Moran;\u003c/item\u003e\n      \u003citem\u003eand journal articles, booklets, and other printed matter relating to the yellow fever experiments and its participants.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries XIII. Reed family additions consists of materials relating to the yellow fever experiments that several different donors gave to the University of Virginia. Items in the series date from around 1850 to 1967 with the bulk of the items dating from 1868 to 1949. The largest portion of the series is comprised of correspondence written by Walter Reed and his family between 1877 and 1902 that provide insights into their relationships and personal lives.\u003c/p\u003e","\u003cp\u003e In addition to the Reed family's correspondence, the series also contains other materials relating to the Reed family and the yellow fever experiments including, but not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ea flag that was flown over Camp Lazear;\u003c/item\u003e\n      \u003citem\u003enewspaper clippings and articles relating to the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ea chemistry notebook that was owned by Walter Reed;\u003c/item\u003e\n      \u003citem\u003ecorrespondence of and works by Philip Showalter Hench;\u003c/item\u003e\n      \u003citem\u003ean inventory of materials in Series XIII. and information about their accession into the Claude Moore Health Sciences Library;\u003c/item\u003e\n      \u003citem\u003eand materials from an exhibit on the yellow fever experiments that was hosted in Alderman Library at the University of Virginia.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries XIV. P. Kahler Hench additions consists of original and photocopied materials that Philip Showalter Hench's son, P. Kahler Hench, donated to the University of Virginia in 1988 and 1989. Items in the series date from around 1860 to 1965 with the bulk of the materials dating from 1898 to 1965. Most of these items were collected or created by Philip Showalter Hench while researching the yellow fever experiments. These items include the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ethe correspondence of experiment participants;\u003c/item\u003e\n      \u003citem\u003ecorrespondence between Philip Showalter Hench and the experiment participants;\u003c/item\u003e\n      \u003citem\u003ecorrespondence between Philip Showalter Hench and families of the experiment participants;\u003c/item\u003e\n      \u003citem\u003epress clippings relating to the experiments and the experiment participants;\u003c/item\u003e\n      \u003citem\u003eoral history interviews conducted by Philip Showalter Hench;\u003c/item\u003e\n      \u003citem\u003escientific articles related to the study of yellow fever;\u003c/item\u003e\n      \u003citem\u003ephotographs of Havana, Camp Columbia, and Camp Lazear;\u003c/item\u003e\n      \u003citem\u003egenealogical tables and summaries for the family of Jesse W. Lazear;\u003c/item\u003e\n      \u003citem\u003eautobiographical accounts written by experiment participants;\u003c/item\u003e\n      \u003citem\u003eunpublished manuscripts;\u003c/item\u003e\n      \u003citem\u003eartifacts (e.g. a wooden board) from Camp Lazear;\u003c/item\u003e\n      \u003citem\u003ePhilip Showalter Hench's research notes.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eSeries XIV. also contains correspondence and financial records that record the transfer of collection items from the Reed family to Philip Showalter Hench and later from the Hench family to the University of Virginia.\u003c/p\u003e","\u003cp\u003e Series XV. Laura Wood primarily consists of Laura Wood's correspondence relating to her research for a Walter Reed biography that she wrote. The series also includes, but is not limited to the following materials:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ephotocopies of two letters written by Walter Reed;\u003c/item\u003e\n      \u003citem\u003ea journal article by George Sternberg;\u003c/item\u003e\n      \u003citem\u003eand a short work that Laura Wood wrote about Walter Reed entitled,\u003ctitle render=\"italic\"\u003eWalter Reed and yellow Fever\u003c/title\u003e.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eItems in Series XV. date from 1875 to 1946 with the bulk of the items dating from 1941 to 1946.\u003c/p\u003e","\u003cp\u003e Series XVI. Edward Hook additions consists of copies of letters, articles, and photographs relating to the yellow fever experiments that had been collected by Edward W. Hook, Jr, a professor of medicine at the University of Virginia. The bulk of this series is comprised of copies of a small collection of James Carroll's correspondence. The original versions of Carroll's correspondence are not housed at the University of Virginia. In addition to the Carroll letters, this series also includes, but is not limited to the following:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003ephotographs of Walter Reed and others related to the yellow fever experiments;\u003c/item\u003e\n      \u003citem\u003ecopies of some of Theodore E. Woodward's works relating to James Carroll and yellow fever;\u003c/item\u003e\n      \u003citem\u003eand exhibition materials.\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eItems in Series XVI. date from around 1880 to around 1998 with the bulk of the items dating from 1898 to 1901.\u003c/p\u003e  "],"scopecontent_heading_ssm":["Scope and Content Information"],"scopecontent_tesim":["The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audio cassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). All of these materials are arranged in 16 series: I. Jesse W. Lazear, II. Henry Rose Carter, III. Walter Reed, IV. Philip Showalter Hench, V. Maps, VI. Alphabetical files, VII. Truby-Kean-Hench, VIII. Miscellany, IX. Photographs, X. Photographic negatives, XI. Reprints, XII. Houston Academy of Medicine/Texas Medical Center additions, XIII. Reed family additions, XIV. P. Kahler Hench additions, XV. Laura Wood, and XVI. Edward Hook additions.","Series I. Jesse W. Lazear consists of materials relating to Lazear that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1800 to 1956 with the bulk of the items dating from 1863 to 1943. Much of the series consists of the correspondence of Jesse W. Lazear and his wife Mabel H. Lazear. Jesse's correspondence dates from his time as a student at Johns Hopkins University to his death in 1900. Researchers can learn a great deal about Jesse from these letters, including his relationships with friends and family, his educational background, and his professional life. Mabel's correspondence dates from the time she met Jesse to her death in 1946. This correspondence primarily concern her husband's historical legacy and a campaign to secure a pension from the U.S. government for herself and her family.","In addition to Jesse and Mabel's correspondence, the series contains other materials relating to them and their families including, but not limited to the following:","the diaries documenting the travels of Jesse and Mabel's mothers in Europe;\n      correspondence of other Lazear family members (e.g. Jesse's parents);\n      genealogical summaries and tables relating to the Lazear family;\n      legal documents (e.g. wills, certificates, deeds);\n      military records relating to Jesse;\n      certificates, reports, and other materials documenting Jesse's educational background and achievements;\n      obituaries;\n      copies of congressional bills and reports concerning the provision of a federal pension for Mabel H. Lazear;\n      newspaper articles;\n      a microscope and sets of microscope slides owned by Jesse;\n      and a medical chart that shows the progression of the yellow fever infection that killed Jesse.","Series II. Henry Rose Carter consists of materials relating to Henry Rose Carter that Philip Showalter Hench collected while researching the yellow fever experiments. Items in this series date from around 1880 to 1932 with the bulk of the materials dating from 1883 to 1932. The series is particularly rich in materials that document Henry Rose Carter's professional activities in the last eleven years of his life (1914-1925). These materials include, but are not limited to the following:","correspondence with colleagues in the medical and scientific community including Rupert E. Blue, Hideyo Noguchi, Henry Hanson, Joseph A. LePrince, Frederick F. Russell, T.H.D. Griffitts, and Lunsford D. Fricks;\n      scientific, medical, and government reports relating to the study and eradication of yellow fever and malaria in North America, South America, and Africa;\n      journal articles concerning the study and eradication of yellow fever and malaria;\n      research notes written by Henry Rose Carter;\n      and photographs of Henry Rose Carter at work and with professional colleagues.","Series II. also contains correspondence between Henry Rose Carter and members of his family that date from 1880 to 1925. The family members with whom Henry corresponds most frequently in this series are his mother, Emma Coleman Carter; his wife, Laura Eugenia Hook Carter; his daughter, Laura Armistead Carter; and his son, Henry Rose Carter, Jr. These letters are not only a rich source of information about Carter's personal views and family life, they also provide valuable insights into his professional activities such as his experiences aboard vessels and in ports while working for the U.S. Marine Hospital Service and his public health work in Cuba, Panama, and Peru.","In addition to the materials that were produced during Henry Rose Carter's lifetime, the Series II. contains materials that were produced between 1925 and 1940 (after Henry Rose Carter's death) including, but not limited to the following:","copies of obituaries for Henry Rose Carter;\n      condolence letters for Henry Rose Carter's family after Henry's death;\n      and the correspondence of Laura Armistead Carter relating to her father and other members of the Carter family.","Series III. Walter Reed consists of materials that document the life of Walter Reed as well as the work and legacy of the U.S. Army Yellow Fever Commission. Items in the series date from 1806 to around 1955 with the bulk of the items dating from 1874 to 1936. The series is particularly rich in materials that document the professional and personal life of Walter Reed from 1874 to his death in 1902. These materials include, but are not limited to the following:","correspondence between Walter Reed and members of his immediate family that cover a wide range of topics including Reed's courtship of Emilie Lawrence Reed, family life, Walter Reed's work in the Western United States, and Walter Reed's work in Cuba;\n      military records relating to Walter Reed including military orders for Reed, Reed's performance reviews, and reports of Reed's work for army officials;\n      Walter Reed's correspondence with professional colleagues including members of the U.S. Army Yellow Fever Commission, military doctors, and medical researchers interested in the study of yellow fever;\n      medical records (e.g. fever charts of experiment participants), military orders, administrative records, reports, and publications documenting the results of the U.S. Army Yellow Fever Commission's experiments in Cuba;\n      articles announcing the death of Walter Reed;\n      and the shoulder boards from Walter Reed's U.S. Army uniform.","In addition to the above items, Series III. contains materials that document campaigns, spanning from 1902 to 1937, to publicly honor members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments. These materials include, but are not limited to the following:","articles and editorials relating to efforts to memorialize and provide pensions for members of the U.S. Army Yellow Fever Commission and those who participated in the commission's experiments;\n      biographical sketches of members of the U.S. Army Yellow Fever Commission and experiment participants;\n      records relating to the Walter Reed Memorial Association (e.g. correspondence, donor lists);\n      copies of Congressional bills and resolutions to honor members of the U.S. Army Yellow Fever Commission and experiment participants;\n      and letters, reviews, and other materials relating to the production of Sidney Coe Howard's play,Yellow Jack.","Finally, Series III. also consists of materials that document the history of yellow fever during the nineteenth and early twentieth century. These materials include, but are not limited to the following:","items (e.g. correspondence, reports, reviews, and articles) relating to U.S. efforts to eradicate yellow fever in the Panama Canal Zone;\n      materials (e.g. correspondence, reports, and articles) documenting early twentieth century efforts to eradicate yellow fever in Peru;\n      scientific reports and publications related to the study and eradication of yellow fever and malaria;\n      and newspaper articles describing various outbreaks of yellow fever epidemics.","Series IV. Philip Showalter Hench primarily consists of materials that Hench created or collected while researching the U.S. Army Yellow Fever Commission. Items in this series date from around 1850 to around 1865 with the bulk of the items dating from 1937 to 1960. Researchers who are studying the yellow fever experiments will be particularly interested in the materials (e.g. interviews, autobiographies) that document first-hand accounts of the events surrounding the experiments. Other researchers may be interested in items that document Hench's role in shaping public memory of the commission and its experiments. The materials in this series include, but are not limited to the following:","Hench's correspondence and interviews with participants in the yellow fever experiments and their families including: Emilie Lawrence Reed, Emilie M. (Blossom) Reed, Walter Lawrence Reed, John J. Moran, Albert E. Truby, Jefferson Randolph Kean, John H. Andrus, and John R. Kissinger;\n      autobiographical accounts of the experiment's participants and their families;\n      notes, reports, correspondence and other materials relating to Hench's search for the original site of Camp Lazear in Cuba;\n      correspondence with Cuban government officials and members of the scientific community relating to Hench's campaign to build a Camp Lazear memorial;\n      correspondence and other materials relating to ceremonies honoring Jesse W. Lazear at Washington and Jefferson College;\n      newspaper articles, magazine articles, and other printed matter concerning the yellow fever experiments and its participants;\n      drafts of speeches and presentations Hench gave on the history of the yellow fever experiments to various audiences;\n      meeting minutes and other materials that document Hench's relationship with and participation in the Walter Reed Memorial Association;\n      scripts for radio programs relating to the yellow fever experiments;\n      notes, outlines, lists, correspondence, and other materials that document Hench's research about the yellow fever experiments and a book he had planned to write on the subject;\n      and the gold medal that Congress posthumously awarded to Walter Reed for his work with yellow fever.","Series V. Maps primarily consists of maps and floor plans that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1960 with the bulk of the items dating from 1899 to 1951. The maps and floor plans often include annotations and illustrate a wide range of locations including, but not limited to the following:","Havana and its environs;\n      Cuba;\n      sites associated with the yellow fever experiments;\n      and military installations in the United States.","In addition to the maps and floor plans, Series V. also consists of a few newspaper and magazine clippings that contain information relating to the yellow fever experiments.","Series VI. Alphabetical files primarily consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1860 to around 1966 with the bulk of the items dating from 1940 to 1956. All of these items have been arranged thematically into biographical files. Each file contains materials created by or relating to people who were either involved with the yellow fever experiments or aided Philip Showalter Hench in his research of the subject. These people include, but are not limited to: John J. Moran, Carlos E. Finlay, Laura Wood Roper, Mabel Lazear, Clara Maas, John R. Kissinger, Roger Post Ames, James C. Carroll, and Carlos J. Finlay. The files are arranged alphabetically by the last names of the individuals listed on the files and it is unclear whether the overall arrangement was made by Hench or by staff members at the University of Virginia. The biographical files contain a wide range of different materials that pertain to the individuals listed on the files. These materials include, but are not limited to the following:","correspondence between Philip Showalter Hench and the individuals;\n      other correspondence;\n      newspaper and magazine clippings;\n      unpublished manuscripts;\n      biographical and autobiographical accounts;\n      transcripts of oral history interviews that were conducted by Philip Showalter Hench;\n      and copies of medical charts for volunteers in the yellow fever experiments that shows the progression of the disease.","In addition to the materials that Hench created or collected during his lifetime, the biographical files in Series VI. also contain items that were added by staff at the University of Virginia Library during the late 1960s and early 1970s.","Series VII. Truby-Kean-Hench primarily consists of materials relating to Albert E. Truby and Jefferson Randolph Kean that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1879 to around 1960 with the bulk of the items dating from 1900 to 1954. These items include, but are not limited to the following:","correspondence of Jefferson Randolph Kean dating from 1900 to 1950 that relates to his personal life, the yellow fever experiments, public health initiatives, his publications, the legacy of the yellow fever experiments, Kean's work in World War I, and other topics;\n      Philip Showalter Hench's correspondence with people related to the yellow fever experiments, particularly Albert E. Truby and Jefferson Randolph Kean primarily from between 1940 and 1955;\n      a scrapbook and other materials that relate to Truby's book,Memoir of Walter Reed: the Yellow Fever Episode;\n      and Philip Showalter Hench's interviews and questionnaires for Kean and Truby from the 1940s.","In addition to the materials relating to Kean and Truby, Series VII. also includes the following:","notes from Philip Showalter Hench's research of the yellow fever experiments;\n      the recollections, autobiographies, and reports of other people involved with the yellow fever experiments including John Andrus and A.S. Pinto;\n      articles and clippings related to the yellow fever experiments;\n      a short biography of Lemuel S. Reed;\n      and a sketch Philip Showalter Hench made of a proposed museum at the Camp Lazear site.","Series VIII. Miscellany consists of oversize and miscellaneous materials in the Philip S. Hench Walter Reed yellow fever collection that were, for various reasons, not included in any of the other series in the collection. Items in this series date from around 1849 to 1982 with the bulk of the materials dating from 1885 to 1974. These materials include, but are not limited to the following:","informed consent agreements for volunteers in the yellow fever experiments;\n      diplomas and certificates for Walter Reed and Jesse W. Lazear;\n      copies and sketches of Dean Cornwell's painting,Conquerors of Yellow Fever;\n      artifacts, including a wooden board from Camp Lazear and a U.S. flag;\n      copies of correspondence, reports, medical records, and military orders from the U.S. National Archives relating to the yellow fever experiments;\n      manuscripts and related notes for published works and research relating to Walter Reed and the yellow fever experiments;\n      correspondence of Philip Showalter Hench from circa 1940 to 1966;\n      articles and clippings relating to the yellow fever experiments, the experiments' participants, and the Philip S. Hench Walter Reed yellow fever collection;\n      correspondence of Atcheson Laughlin Hench and members of the University of Virginia community relating to the Philip S. Hench Walter Reed yellow fever collection;\n      items that document the provenance and custodial history of some materials in the Philip S. Hench Walter Reed yellow fever collection;\n      photographs relating to Cuba and the yellow fever experiments;\n      notes for photographs and photographic negatives housed in Series IX. and Series X. of this collection.","Series IX. Photographs consists primarily of photographs that Philip Showalter Hench created and collected while researching the yellow fever experiments. Items in this series date from around 1846 to around 1966 with the bulk of the items dating from around 1870 to around 1960. The subjects shown in the photographs include, but are not limited to the following:","physicians, military personnel, nurses, and volunteers associated with the experiments including Walter Reed, Jesse W. Lazear, Jefferson Randolph Kean, and Aristides Agramonte;\n      family members of people associated with the yellow fever experiments including their spouses, children, and grandchildren.\n      Camp Lazear, Camp Columbia, and other locations in Cuba related to the yellow fever experiments between 1900 and 1960;\n      the U.S.S.Maineand the Spanish-American War;\n      aerial views of Havana, Cuba and its environs from the 1940s and 1950s;\n      scenes of daily life in Cuba generally from between 1898 and 1960;\n      the 1952 dedication of the Camp Lazear National Monument in Cuba;\n      the creation and unveiling of Dean Cornwell's painting,Conquerors of Yellow Fever;\n      still scenes from the movies,Yellow JackandJezebel;\n      other events and works of art commemorating the work of the participants in the yellow fever experiments;\n      documents and maps that Philip Showalter Hench copied for his research;\n      and Philip Showalter Hench and his family.","Series IX. also includes a watercolor that was painted by Emilie Lawrence Reed.","Series X. Photographic negatives consists of a mix of original and copy negatives that Philip Showalter Hench collected while researching the yellow fever experiments. Although the original images recorded on the negatives date from between the 1860s and the 1960s, it appears that the negatives themselves were produced during a narrower time frame, most likely between 1930 and 1966.","The negatives in Series X. record images associated with the yellow fever experiments and many of them are related to photographic prints found in Series VIII. Where a match between a negative and a print from these series has been made, the negative number has been written on the folder of the print in the physical collection. Finally, the negatives are generally arranged in numerical order by identification numbers that were most likely assigned by Philip Showalter Hench.","Series XI. Reprints consists of reprints and photocopies of journal articles, book extracts, book reviews and other published works that were primarily collected by Philip Showalter Hench while researching the yellow fever experiments. Items in this series date from 1856 to 1971 and cover a wide range of topics related to the study and eradication of yellow fever, including, but not limited to the following:","the results of the U.S. Army Yellow Fever Commission's work in Cuba;\n      biographical accounts of various people who had an association with the yellow fever experiments;\n      the research of people associated with the experiments including Walter Reed, Jesse W. Lazear, Aristides Agramonte, and James Carroll;\n      scientific and medical research related to yellow fever and malaria;\n      and events honoring the work of those involved with the yellow fever experiments.","Series XII. Houston Academy of Medicine/Texas Medical Center additions consists of materials that Philip Showalter Hench created or collected while researching the yellow fever experiments. Items in this series date from around 1901 to around 1966. These materials were originally a part of the Philip S. Hench papers in the John P. McGovern Historical Collections and Research Center at the Texas Medical Center Library, but they were transferred to the University of Virginia in 1991. These items include, but are not limited to the following:","correspondence between Philip Showalter Hench and people connected with the yellow fever experiments including John J. Moran and Walter Reed's children;\n      newspaper clippings relating to the death or commemoration of individuals associated with the yellow fever experiments;\n      photographs of the Camp Lazear Memorial, everyday scenes in Cuba, and John J. Moran;\n      and journal articles, booklets, and other printed matter relating to the yellow fever experiments and its participants.","Series XIII. Reed family additions consists of materials relating to the yellow fever experiments that several different donors gave to the University of Virginia. Items in the series date from around 1850 to 1967 with the bulk of the items dating from 1868 to 1949. The largest portion of the series is comprised of correspondence written by Walter Reed and his family between 1877 and 1902 that provide insights into their relationships and personal lives.","In addition to the Reed family's correspondence, the series also contains other materials relating to the Reed family and the yellow fever experiments including, but not limited to the following:","a flag that was flown over Camp Lazear;\n      newspaper clippings and articles relating to the yellow fever experiments;\n      a chemistry notebook that was owned by Walter Reed;\n      correspondence of and works by Philip Showalter Hench;\n      an inventory of materials in Series XIII. and information about their accession into the Claude Moore Health Sciences Library;\n      and materials from an exhibit on the yellow fever experiments that was hosted in Alderman Library at the University of Virginia.","Series XIV. P. Kahler Hench additions consists of original and photocopied materials that Philip Showalter Hench's son, P. Kahler Hench, donated to the University of Virginia in 1988 and 1989. Items in the series date from around 1860 to 1965 with the bulk of the materials dating from 1898 to 1965. Most of these items were collected or created by Philip Showalter Hench while researching the yellow fever experiments. These items include the following:","the correspondence of experiment participants;\n      correspondence between Philip Showalter Hench and the experiment participants;\n      correspondence between Philip Showalter Hench and families of the experiment participants;\n      press clippings relating to the experiments and the experiment participants;\n      oral history interviews conducted by Philip Showalter Hench;\n      scientific articles related to the study of yellow fever;\n      photographs of Havana, Camp Columbia, and Camp Lazear;\n      genealogical tables and summaries for the family of Jesse W. Lazear;\n      autobiographical accounts written by experiment participants;\n      unpublished manuscripts;\n      artifacts (e.g. a wooden board) from Camp Lazear;\n      Philip Showalter Hench's research notes.","Series XIV. also contains correspondence and financial records that record the transfer of collection items from the Reed family to Philip Showalter Hench and later from the Hench family to the University of Virginia.","Series XV. Laura Wood primarily consists of Laura Wood's correspondence relating to her research for a Walter Reed biography that she wrote. The series also includes, but is not limited to the following materials:","photocopies of two letters written by Walter Reed;\n      a journal article by George Sternberg;\n      and a short work that Laura Wood wrote about Walter Reed entitled,Walter Reed and yellow Fever.","Items in Series XV. date from 1875 to 1946 with the bulk of the items dating from 1941 to 1946.","Series XVI. Edward Hook additions consists of copies of letters, articles, and photographs relating to the yellow fever experiments that had been collected by Edward W. Hook, Jr, a professor of medicine at the University of Virginia. The bulk of this series is comprised of copies of a small collection of James Carroll's correspondence. The original versions of Carroll's correspondence are not housed at the University of Virginia. In addition to the Carroll letters, this series also includes, but is not limited to the following:","photographs of Walter Reed and others related to the yellow fever experiments;\n      copies of some of Theodore E. Woodward's works relating to James Carroll and yellow fever;\n      and exhibition materials.","Items in Series XVI. date from around 1880 to around 1998 with the bulk of the items dating from 1898 to 1901."],"userestrict_html_tesm":["\u003cp\u003eCopyright restrictions may apply for some materials in the collection.\u003c/p\u003e  "],"userestrict_heading_ssm":["Copyright Status"],"userestrict_tesim":["Copyright restrictions may apply for some materials in the collection."],"abstract_html_tesm":["\u003cabstract id=\"aspace_98fe81a152b4be0b7388b1814ffaf4bd\"\u003eThe Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audiocassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). Most of the materials in the collection were collected or created by Nobel laureate Philip Showalter Hench while researching the history of the U.S. Army Yellow Fever Commission.\u003c/abstract\u003e\n    "],"abstract_tesim":["The Philip S. Hench Walter Reed Yellow Fever Collection documents the work of the U.S. Army Yellow Fever Commission, the legacy of the commission's discoveries, the lives of individuals who were connected to the commission, and twentieth century campaigns to shape public memory of the commission. Items in the collection date from 1800 to 1998, with the bulk of the items dating from 1864 to 1974. A wide range of formats are represented in the collection including, but not limited to the following: articles, artifacts, audiocassettes, bills (legislative records), biographies, charts (graphic documents), correspondence, diaries, editorials, interviews, journals (periodicals), magazines, maps, medical records, military records, negatives (photographic), notes, photographs, reports, reprints, scrapbooks, and speeches. Unique materials in the collection are supplemented with copies of original documents and photographs housed in other institutions (e.g. the U.S. National Archives). Most of the materials in the collection were collected or created by Nobel laureate Philip Showalter Hench while researching the history of the U.S. Army Yellow Fever Commission."],"corpname_ssim":["Claude Moore Health Sciences Library"],"names_ssim":["Claude Moore Health Sciences Library"],"language_ssim":["Collection is predominantly in English; other materials in the collection are in Spanish, French, and Portuguese."],"descrules_ssm":["Describing Archives: A Content Standard"],"total_component_count_is":10452,"online_item_count_is":0,"component_level_isim":[0],"sort_isi":0,"timestamp":"2026-08-14T22:54:59.526Z","bioghist_html_tesm":["\u003cp\u003eThe U.S. Army Yellow Fever Commission (1900-1901) was a board of physicians that the U.S. government formed in order to determine how yellow fever was transmitted between hosts. Ultimately, the commission's experiments in Cuba proved that mosquitoes transmit yellow fever--a discovery that would spur successful campaigns to control and eradicate yellow fever throughout much of the globe.\u003c/p\u003e","\u003cp\u003e When Major Walter Reed and Acting Assistant Surgeons James Carroll, Aristides Agramonte, and Jesse Lazear gathered on the porch of the Columbia Barracks Hospital in June of 1900, they became the fourth successive board of U.S. medical officers to grapple with the appalling plague that was yellow fever.\u003c/p\u003e","\u003cp\u003e The persistence of this disease across the Cuban archipelago and its periodic re-emergence along the coastlines and great river drainages of the Americas was taking countless thousands of lives. Lack of precise knowledge as to its cause and transmission had augmented yellow fever's extraordinarily high mortality rate and had given rise to quarantine regulations which constituted substantial impediments to efficient regional trade. Endemic in the tropics, yellow fever imposed high humanitarian and economic costs upon the entire region. Specialists regarded Cuba as one of the principal foci of the disease, and the island consequently attracted considerable attention from the medical sciences.\u003c/p\u003e","\u003cp\u003e In 1879, one year after a devastating epidemic swept up the Mississippi valley from New Orleans, Tulane University Professor Stanford E. Chaille led the first investigatory commission to Havana, Rio de Janeiro, and the West Indies. The Chaille Commission remained in Havana three months, and its members -- including George Miller Sternberg, who became Surgeon General of the Army, and Juan Guiteras, later Director of Public Health for Havana -- consulted with Cuban scientist Carlos J. Finlay. They concluded that the causal agent for yellow fever was possibly a living entity in the atmosphere, an assertion which set Finlay on the path to the mosquito theory he developed in 1881.\u003c/p\u003e","\u003cp\u003e Louis Pasteur's foundational and highly successful work in modern immunology in 1880 and 1881 gave a renewed impetus to investigations aimed at discovering the \"yellow fever germ.\" Over the middle years of the 1880s several scientists advanced different theories, all readily refuted by bacteriological work Sternberg undertook in Brazil and Mexico in 1887 and again in Havana in 1888 and 1889. In 1897, Italian scientist Giuseppe Sanarelli argued that\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003ewas the culprit, and the following year a third scientific team sailed to Cuba for additional tests. Eugene Wasdin and Henry D. Geddings appeared to confirm Sanarelli's assertion, though Sternberg, by then Surgeon General, remained skeptical.\u003c/p\u003e","\u003cp\u003e Despite Wasdin and Geddings' insistence, the\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003etheory garnered significant opposition. In fact, a few months before the third commission's report reached the public, Walter Reed and James Carroll -- Reed's assistant at the Columbian University (later George Washington University) bacteriology laboratories in Washington, D.C. -- published a thorough refutation of the\u003cemph render=\"italic\"\u003eicteroides\u003c/emph\u003eproposal: the bacteria was not a unique cause of yellow fever, but a variety of the hog cholera bacillus, \"a secondary invader in yellow fever,\" Reed determined, unrelated to its etiology. [1] Dispute continued, however, and when Sternberg organized the fourth investigatory board, he charged Reed and his associates to settle the\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003equestion once and for all, then to proceed with analysis of other blood cultures and intestinal flora from yellow fever cases.\u003c/p\u003e","\u003cp\u003e Reed and Carroll had considerable experience in bacteriological analysis, and, Sternberg reasoned, might well be able to find the specific agent of the disease. Aristides Agramonte, a Cuban scientist who had worked in Reed's lab at the Columbian University in 1898, was also an accomplished bacteriologist; he had identified\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003ein tissue samples from cases other than yellow fever, providing further evidence opposed to Sanarelli's thesis. Jesse Lazear, a scientist from Johns Hopkins University in Baltimore, Maryland, had joined the Army Medical Corps to study tropical diseases at their point of origin; he received orders for Cuba in February 1900. Lazear impressed Reed with his abilities when the two men became acquainted in March. No doubt with Reed's advice, Sternberg assembled a crack team -- all experienced in scientific research, but each with interests as diverse as their temperaments. The mix of talent and personalities generated spectacular results.\u003c/p\u003e","\u003cp\u003e What causes yellow fever? This simple, even obvious question had dictated yellow fever research for over two decades, and so it guided Reed in organizing the work of the commission.\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003eand other bacteriological sampling dominated their work for the first months. \"Reed and Carroll have been at that for a long time,\" Lazear wrote with some impatience to his wife on August 23, \". . . I would rather try to find the germ without bothering about Sanarelli.\" [2] Again and again, tests for the bacteria proved negative, and at the same time, perplexing cases of yellow fever were developing in the region. Agramonte and Reed investigated an epidemic at Pinar del Rio, 110 miles southwest of Havana; Lazear followed later to collect more specimens, and he also assessed the situation at Guanjay thirty miles southwest. To \"my very great surprise,\" Reed admitted, the specific circumstances of the appearance and development of these cases gave strong evidence against the widely-accepted notion that the excreta of patients spread the disease. The theory of fomites -- infection from contaminated clothing and bedding -- and indeed even infection from airborne particles seemed altogether untrue. \"At this stage of our investigation,\" Reed concluded, \". . . the time had arrived when the plan of our work should be radically changed.\" [3] The fundamental question underwent a subtle but critical transformation: from what causes yellow fever to what transmits it. A clear and accurate understanding of how the disease was spread would open a new avenue to its specific cause.\u003c/p\u003e","\u003cp\u003e \"Personally, I feel that only can experimentation on human beings serve to clear the field for further effective work,\" Reed stated to Surgeon General Sternberg, who concurred. [4] Evidence gathering around them pointed strongly to an intermediate host, and the Commission resolved to test Carlos Finlay's mosquito theory -- then not generally accepted -- on human volunteers. Nine times from August 11 to August 25, 1900, mosquitoes landed on the arms of volunteers and proceeded to feed. Nine times the results were negative. On August 27, Lazear placed a mosquito on the doubting Dr. Carroll, and four days later on William J. Dean, a soldier designated XY in the \"Preliminary Note.\" [5] Both promptly developed yellow fever. Significantly, their mosquitoes had fed on cases within the initial three days of an attack and had been allowed to ripen for at least twelve days before the inoculations. Carroll vitiated the results of his experimental sickness by traveling off the post to Havana, a contaminated zone, even as Reed, ecstatic, wrote from Washington in a confidential letter: \"Did the Mosquito do it?\" [6] Dean's case seemed to prove it, since he claimed not to have left the garrison before becoming ill. Lazear also developed a case of yellow fever, almost certainly experimental in origin, though he never revealed the actual circumstances of his inoculation. His severe bout of fever took a fatal turn on September 25, 1900.\u003c/p\u003e","\u003cp\u003e Nevertheless, these results could not have been more dramatic or convincing for the Commission. Reed quickly assembled a \"Preliminary Note,\" which he presented to the annual meeting of the American Public Health Association in Indianapolis, Indiana, October 23, 1900. After initial consultations in Cuba with General Leonard Wood, military governor of the island, and with Surgeon General Sternberg in Washington, he returned to Cuba with authorization and funding to design and carry forward a fully defensible series of experiments. His aim was confirmation of the mosquito theory and invalidation of the long-held belief in fomites.\u003c/p\u003e","\u003cp\u003e On open terrain beyond the precincts of Columbia Barracks -- the American military base just west of Havana near the adjacent suburban towns of Quemados and Marianao (also called Quemados de Marianao) -- Reed established the quarantined experimental station. Camp Lazear, as the Commission dedicated it, took form in the rolling fields of the Finca San Jose, on the farm of Dr. Ignacio Rojas, who leased the land to the Americans. Here Reed designed two small wood-frame buildings, each 14 by 20 feet, for the experimental work, and nearby raised a group of seven tents for the accommodation and support of the volunteers. The buildings faced each other across a small swale, about 80 yards apart, and stood 75 yards from the tent encampment. Building Number One, called the Infected Clothing Building, was a single room tightly constructed to contain as much foul air as possible. A small stove kept the temperature and humidity at tropical levels, and carefully attached screening secured the pair of doorways in a vestibule against intrusion by mosquitoes. Wooden blinds on two small sealed windows shielded the room from direct sun. Building Number Two, the Infected Mosquito Building, contained a principal room, divided into two sections by a floor-to-ceiling wire mesh screen. A door direct to the exterior let into one section, while a vestibule with a solid exterior door and pair of successive screened doors opened to the other, so configured to keep infected mosquitoes inside that section alone. The spare furnishings in both sections -- cots with bedding -- were steam sterilized. Windows exposed the entire room to the clean, steady ocean breezes and to sunlight. Like the doorways, they were carefully screened. A secondary room attached to the building but not communicating with the experimental spaces sheltered the small, heated laboratory where the Commission members raised and stored the mosquitoes to be used.\u003c/p\u003e","\u003cp\u003e These two experimental buildings presented alternate environments -- one conspicuously clean and well ventilated, the other filthy and fetid. Contemporary theories of disease held that yellow fever developed in unclean conditions, and consequently much time and money had been devoted to sanitation projects. Workers steamed clothing, burned sulphur in ships' holds, and thoroughly scrubbed surfaces with disinfectant. In cases of severe epidemic, entire buildings presumed to be infected were set afire along with their contents. Thus the extraordinary -- and intentional -- paradox of the Commission's experimental regime: Reed expected yellow fever to develop not in the unsanitary environment, but in the one thought to be most healthful.\u003c/p\u003e","\u003cp\u003e Camp Lazear went into quarantine the day of its completion, November 20, 1900, with a command of four immune and nine non-immune individuals, all save one U.S. Army personnel. Soon a group of recent Spanish immigrants to Cuba augmented the non-immune numbers, bringing the resident total to about twenty. Reed strictly controlled access to the camp and ordered regular temperature recording for each volunteer to eliminate any unanticipated source of infection and to identify the onset of any case of yellow fever as early as possible. As a result, non-immunes were barred from returning should they leave the precinct, and two of the Spaniards who developed intermittent fevers shortly after arrival were immediately transferred with their baggage to Columbia Barracks Hospital. The immune members of the detachment oversaw medical treatments and drove the teams of mules that pulled supply wagons and the ambulance. Experimentation did not begin until each volunteer had passed the incubation period for yellow fever in perfect health.\u003c/p\u003e","\u003cp\u003e Reed took as much care with the design of the experimental protocol as he had with the configuration of the camp and its buildings. Each evening, the occupants of the infected clothing building unpacked trunks and boxes of bed linens and blankets, nightshirts and other clothing recently worn and soiled by cases from the wards of Columbia Barracks Hospital and Las Animas Hospital in Havana. These they shook out and spread around the room to permeate the atmosphere. The stench was overpowering. Yellow fever causes severe internal hemorrhaging, and its unfortunate victims often suffer from black vomit and other bloody discharges. One routine delivery proved so putrid the volunteers \"retreated from the house,\" Reed stated. \"They pluckily returned, however, within a short time, and spent the night as usual.\" [7] In two succeeding trials the protocol became progressively more daring , as the volunteers then wore the clothing and slept on the mattresses used by yellow fever patients, and finally put towels on their bedding smeared with blood drawn from cases in the early stages of an attack. Each morning, the volunteers carefully repacked the rank, encrusted materials into boxes and emerged to an adjacent tent where they spent the day quarantined from the rest of the company. Three trials of twenty days each involved seven men altogether, lead by Robert P. Cooke, a physician in the Army Medical Corps. None developed yellow fever.\u003c/p\u003e","\u003cp\u003e The Commission's mosquito experiments proceeded in four series. First, Reed sought to demonstrate that mosquitoes of the variety\u003cemph render=\"italic\"\u003eCulex fasciata\u003c/emph\u003e(later called\u003cemph render=\"italic\"\u003eStegomyia fasciata\u003c/emph\u003e, and later still\u003cemph render=\"italic\"\u003eAedes aegypti\u003c/emph\u003e) could in fact transmit yellow fever, as Carlos J. Finlay had argued and the initial experiments at Camp Columbia strongly suggested. Here the Commission members simply applied infected mosquitoes contained in test tubes or jars to the skin of the initial volunteers. Success in these tests raised a number of questions, each one addressed in the subsequent series:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003eHow could a building become infected?\u003c/item\u003e\n      \u003citem\u003eWhen does a mosquito develop the ability to transmit the disease?\u003c/item\u003e\n      \u003citem\u003eOver what length of time can a mosquito retain this capacity to infect?\u003c/item\u003e\n    \u003c/list\u003e\n","\u003cp\u003eThe second series consequently employed the specialized \"Infected Mosquito Building\" to indicate how a structure could be considered infected with yellow fever. This experiment required two groups of volunteers, one to be inoculated and another to serve as controls. \"Loaded\" mosquitoes, as the men called them, were released into the screened section of Building Two -- on the side with the protected vestibule entry. One or more non-immune men then entered the opposite section of the room through the direct exterior door, and lay down on bunks adjacent to the wire mesh screen in the center of the room. Now the young man to be inoculated walked through the vestibule into the mosquito side of the room and proceeded to lie on a bunk adjacent to the wire screen separating him from the controls. The inoculation volunteer remained in the building for about twenty minutes -- enough time to suffer several mosquito bites -- he then exited to a quarantine tent outside. The controls spent the remainder of the evening and night in the uninfected side of the room, and indeed returned to sleep in the room for as many as eighteen more nights. As Reed stated, absence of yellow fever in the controls showed \"that the essential factor in the infection of a building with yellow fever is the presence therein of [infected] mosquitoes,\" and nothing more. [8] The degree of sanitation, so long considered critical, was utterly irrelevant.\u003c/p\u003e","\u003cp\u003e The third series of mosquito experiments confirmed what Henry Rose Carter, of the U.S. Public Health Service, called the \"period of extrinsic incubation,\" [9] the length of time required for secondary cases of yellow fever to develop after an initial intrusion of the disease into a locality. In this series, a single volunteer underwent three successive inoculations by the same mosquitoes, each group of inoculations interrupted by a period of time equal in length to the typical incubation period of the disease in humans, about five days. In this manner, the volunteer's illness could be specifically attributed to a single inoculation group. The use of the same mosquitoes and the same volunteer concurrently demonstrated that no peculiar personal immunity was at play, since logic dictates that a person susceptible to yellow fever on day 17 of a mosquito's contamination -- as happened in the experiment -- could not have been immune to yellow fever on day 11 or day 4. It was thus only the mosquito's capacity to infect which changed, and that occurred no less than 11 days after contamination.\u003c/p\u003e","\u003cp\u003e The duration of time over which these \"fully ripened\" mosquitoes remained infective comprised the fourth series of experiments. For this series the Commission kept alive a group of infected mosquitoes for as long as possible, and proceeded to inoculate three volunteers -- on the 39th, 51st, and 57th day after contamination. Each developed yellow fever. A fourth volunteer declined to be bitten on day 65, and the last two mosquitoes of the group, \"deprived of further opportunity to feed on human blood\" [10] expired on day 69 and day 71, clear evidence that even a sparsely populated region may retain the potential for new infections more than two months after the first appearance of the disease.\u003c/p\u003e","\u003cp\u003e Although it went unrecorded in the published papers, Reed organized a supplemental experiment to test another species of mosquito.\u003cemph render=\"italic\"\u003eCulex pungens\u003c/emph\u003efailed to transmit yellow fever to at least one volunteer and probably to a second. Reed's preliminary conclusions indicated that\u003cemph render=\"italic\"\u003eCulex fasciata\u003c/emph\u003ewas the only species capable of transmitting yellow fever. [11]\u003c/p\u003e","\u003cp\u003e A last experimental regime involved subcutaneous injections of blood from positive cases of yellow fever to presumed non-immunes. Reed devised these tests to confirm the presence of the yellow fever agent in the blood of a victim during the first days of an attack, and, more importantly, to settle the\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003equestion. The same blood cultures which produced yellow fever in four volunteers also failed to grow any\u003cemph render=\"italic\"\u003eB. icteroides\u003c/emph\u003e, conclusively invalidating Sanarelli's claim.\u003c/p\u003e","\u003cp\u003e Altogether, the mosquito inoculations and the blood injections produced fourteen cases of yellow fever. All made a full recovery.\u003c/p\u003e","\u003cp\u003e Notwithstanding the decisive medical victory -- as Reed declared, \"aside from the antitoxin of Diptheria and Koch's discovery of the tubercle bacillus, it will be regarded as the most important piece of work, scientifically, during the 19th century\" [12] -- success at Camp Lazear unfolded in its own time. Initially, Reed observed, \"the results obtained at this station were not encouraging.\" [13] The first inoculations of four volunteers over a period of two weeks proved disconcertingly negative each time. Then, on December 5, 1900, private John R. Kissinger presented his arm to the mosquitoes, and late in the evening on December 8, suffered the first chills of \"a well-marked attack of yellow fever.\" [14] Three more men in rapid succession fell victim to the insects -- Spanish volunteers Antonio Benigno, Nicanor Fernandez, and Vicente Presedo. The force of the conclusions was evident to everyone:\u003c/p\u003e","\u003cp\u003e \"It can readily be imagined,\" Reed empathetically and wryly described in his first presentation of the experiments, \"that the concurrence of 4 cases of yellow fever in our small command of 12 non-immunes within the space of 1 week, while giving rise to feelings of exultation in the hearts of the experimenters, in view of the vast importance attaching to these results, might inspire quite other sentiments in the bosoms of those who had previously consented to submit themselves to the mosquito's bite. In fact, several of our good-natured Spanish friends who had jokingly compared our mosquitoes to 'the little flies that buzzed harmlessly about their tables,' suddenly appeared to lose all interest in the progress of science, and, forgetting for the moment even their own personal aggrandizement, incontinently severed their connection with Camp Lazear. Personally, while lamenting to some extent their departure, I could not but feel that in placing themselves beyond our control they were exercising the soundest judgment.\"\u003c/p\u003e","\u003cp\u003e \"In striking contrast,\" Reed continued, the anxiety of the fomites volunteers began to melt into relief. \"[T]he countenances of these men, which had before borne the serious aspect of those who were bravely facing an unseen foe, suddenly took on the glad expression of 'schoolboys let out for a holiday,' and from this time their contempt for 'fomites' could not find sufficient expression. Thus illustrating once more, gentlemen, the old adage that familiarity, even with fomites, may breed contempt.\" [15]\u003c/p\u003e","\u003cp\u003e The question of human experimentation was indeed a serious one -- unavoidable, in actuality, as Reed had stated the previous summer to Surgeon General Sternberg. When the Commission first considered a trial of Finlay's mosquito theory, Reed, Carroll, and Lazear agreed to experiment on themselves. Agramonte, a native Cuban, had acquired immunity as a child. Doubtless Finlay's experience of many unsuccessful inoculations communicated that positive results would not be forthcoming rapidly, so before the first series of inoculations began under Lazear's direction at Columbia Barracks, Reed left Cuba for Washington, where he completed a monumental report on typhoid fever among the army corps -- left unfinished by the sudden death of co-author Edward O. Shakespeare. Carroll and Lazear both sickened while Reed was in Washington, and Lazear, young and strong, had no reason to anticipate that his case would be fatal. Reed was shocked at Lazear's death, and because of his own age -- 49, a decade and a half older than Lazear and a dozen years older than Carroll -- he resolved not to inoculate himself when he returned to Cuba on October 4, 1900. The point had already been amply demonstrated, and only a rigidly controlled experimental regime would establish the necessary proof. Carroll, however, remained embittered about this for the remainder of his life, though he evidently never communicated his objections directly to Reed.\u003c/p\u003e","\u003cp\u003e That initial series of mosquito inoculations was probably accomplished without formal documentation of informed consent. Indeed, the experiments may also have been carried forward without the full knowledge of the commanding officer of Camp Columbia, and Reed consequently shielded the identity of Private William J. Dean, the second positive experimental case, behind the pseudonym \"XY\" in the \"Preliminary Note.\" No such potentially troublesome problems arose for the experimental series at Camp Lazear; Reed obtained prior support from all of the appropriate authorities in the military and the administration, even including the Spanish Consul to Cuba. With the advice of the Commission and others, he drafted what is now one of the oldest series of extant informed consent documents. The surviving examples are in Spanish with English translations, and were signed by volunteers Antonio Benigno and Vicente Presedo, and a third with the mark of Nicanor Fernandez, who was illiterate.\u003c/p\u003e","\u003cp\u003e The documents take the form of a contract between individual volunteers and the Commission, represented by Reed. At least 25 years old, each volunteer explicitly consented to participate, and balanced the certainty of contracting yellow fever in the general population against the risks of developing an experimental case, followed by expert and timely medical care. The volunteers agreed to remain at Camp Lazear for the duration of the experiments, and as a reward for participation would receive $100 \"in American gold,\" with an additional hundred-dollar supplement for contracting yellow fever. These payments could be assigned to a survivor, and the volunteers agreed to forfeit any remuneration in cases of desertion.\u003c/p\u003e","\u003cp\u003e For the American participants no consent documents appear to survive, though in contemporary letters Reed assured his correspondents that the Commission obtained written consent from all the volunteers. The record of expenses for Camp Lazear -- maintained by Reed's friend and colleague in the medical corps, Jefferson Randolph Kean -- indicates that the same schedule of payments for participation and sickness applied to the Americans as well. Volunteers who participated in the fomites tests and in addition the later series of blood injections and the single trial of an alternative species of mosquito also earned $100 each plus the $100 supplement if yellow fever developed. Two Americans declined these gratuities, as Kean termed them, Dr. Robert P. Cooke, of the fomites tests, and John J. Moran, who had recently received an honorable discharge from the service, and was the only American civilian to participate. His was the fourth case of yellow fever to develop from mosquito inoculation. Moran eventually settled in Cuba, where he managed the Havana offices of the Sun Oil Company, and late in life became a close friend of Philip S. Hench. Together the two men rediscovered the site of Camp Lazear in 1940 -- Building Number One still intact -- and successfully lobbied the Cuban government to memorialize there the work of Finlay and the American Commission in the conquest of yellow fever.\u003c/p\u003e","\u003cp\u003e Reed informally commemorated his own experiences at Camp Lazear by commissioning a group photograph, evidently taken there shortly before he left Cuba in February 1901. A more important event occurred on the sixth of that month when Reed presented the results of the Camp Lazear yellow fever experiments to a great ovation at the Pan-American Medical Congress in Havana. Three days later he set sail for the United States, and once landed, drafted the Congress paper as\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- An Additional Note\u003c/title\u003e, published immediately in the\u003ctitle render=\"italic\"\u003eJournal of the American Medical Association\u003c/title\u003e. [16]\u003c/p\u003e","\u003cp\u003e Though his correspondence intimates a great appreciation for Cuba, Reed never returned to the warm, sunny shores of the island freed of a dreadful plague. Carroll stayed behind at Camp Lazear through February to complete the last experimental series officially bearing the imprimatur of the Yellow Fever Commission, and returned to Washington soon after March first. [17] The Medical Corps retained the lease on Camp Lazear against the possibility of continuing experiments another season, and Carroll, in fact, returned to Havana in August 1901 for a final experimental series, though he did not make use of Camp Lazear. This work involved at least three volunteers at Las Animas Hospital, Havana, who submitted to blood injections. Carroll's assignment aimed at a greater understanding of the yellow fever agent, and he proved that blood drawn from active cases of yellow fever remained virulent even after passing through fine bacteria filters. In addition, by heating contaminated blood which had previously caused cases of yellow fever, Carroll rendered it non-infective -- thereby establishing that this filterable entity, though sub-microscopic, was demonstrably present in the bloodstream. Carroll wrapped up the series in October and returned home to stay. [18] In Cuba, J. Randolph Kean made the last rental payments to Signore Rojas on October 9, 1901, and Camp Lazear, for more than a generation, slipped out of the realm of memory.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003e[1] Walter Reed and James Carroll,\u003ctitle render=\"doublequote\"\u003eBacillus Icteroides and Bacillus Cholerae Suis -- A Preliminary Note\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eMedical News\u003c/title\u003e(29 April 1899), reprinted in: United States Senate Document No. 822,\u003ctitle render=\"italic\"\u003eYellow Fever, A Compilation of Various Publications\u003c/title\u003e(Washington: Government Printing Office, 1911), p. 55.\u003c/item\u003e\n      \u003citem\u003e[2] Letter from Jesse W. Lazear to Mabel Houston Lazear, 23 August 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00341001.\u003c/item\u003e\n      \u003citem\u003e[3] Walter Reed, \"The Propagation of Yellow Fever -- Observations Based on Recent Researches,\" in United States Senate Document No. 822,\u003ctitle render=\"italic\"\u003eYellow Fever A Compilation of Various Publications\u003c/title\u003e(Washington: Government Printing Office, 1911), p. 94.\u003c/item\u003e\n      \u003citem\u003e[4] Letter from Walter Reed to George M. Sternberg, 24 July 1900, Hench Reed Yellow Fever Collection, accession number: 02064001.\u003c/item\u003e\n      \u003citem\u003e[5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- A Preliminary Note\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eProceedings of the Twenty-eighth Annual Meeting of the American Public Health Association\u003c/title\u003eIndianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\u003c/item\u003e\n      \u003citem\u003e[6] Letter from Walter Reed to James Carroll, 7 September 1900, Edward Hook Additions to the Philip S. Hench Walter Reed Yellow Fever Collection: James Carroll Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 15312004. The originals of these letters remain in a private collection.\u003c/item\u003e\n      \u003citem\u003e[7] Walter Reed, James Carroll, Aristides Agramonte,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- An Additional Note\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eJournal of the American Medical Association\u003c/title\u003e36 (16 February 1901): 431-440, reprinted in: Senate Document No. 822, p. 84.\u003c/item\u003e\n      \u003citem\u003e[8] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 99.\u003c/item\u003e\n      \u003citem\u003e[9] Henry Rose Carter,\u003ctitle render=\"doublequote\"\u003eA Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eMedical Record\u003c/title\u003e59 (15 June 1901) 24: 937.\u003c/item\u003e\n      \u003citem\u003e[10] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 101.\u003c/item\u003e\n      \u003citem\u003e[11]\u003cemph render=\"italic\"\u003eCulex fasciata\u003c/emph\u003ewas reclassified shortly after the experiments as\u003cemph render=\"italic\"\u003eStegomyia\u003c/emph\u003eand later became\u003cemph render=\"italic\"\u003eAedes aegypti.\u003c/emph\u003e\u003c/item\u003e\n      \u003citem\u003e[12] Letter to from Walter Reed to Emilie Lawrence Reed, 9 December 1900, Hench Reed Collection, accession number: 02231001.\u003c/item\u003e\n      \u003citem\u003e[13] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 97.\u003c/item\u003e\n      \u003citem\u003e[14] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 98.\u003c/item\u003e\n      \u003citem\u003e[15] Walter Reed,\u003ctitle render=\"doublequote\"\u003eThe Propagation of Yellow Fever -- Observations Based on Recent Researches\u003c/title\u003e, in Senate Document No. 822, p. 99.\u003c/item\u003e\n      \u003citem\u003e[16] Please see note [7].\u003c/item\u003e\n      \u003citem\u003e[17] The Commission reported these concluding experiments in: Walter Reed, James Carroll, Aristides Agramonte,\u003ctitle render=\"doublequote\"\u003eExperimental Yellow Fever\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eAmerican Medicine\u003c/title\u003eII (6 July 1901) 1: 15-23.\u003c/item\u003e\n      \u003citem\u003e[18] Walter Reed, James Carroll,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever (A Supplemental Note)\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eAmerican Medicine\u003c/title\u003eIII (22 February 1902) 8: 301-305.\u003c/item\u003e\n    \u003c/list\u003e\n  ","\u003cp\u003eWalter Reed (September 13, 1851 - November 22, 1902) was a U.S. Army physician who led the army's Yellow Fever Commission 1900 and 1901. Experiments conducted by the commission confirmed a theory that yellow fever is transmitted by mosquitoes--a discovery that led to the control and eradication of this disease across much of the globe. Reed would receive much of the credit for the work of the commission because of his role as its leader, and, long after his death in 1902, he would be widely celebrated as a heroic figure in the fields of public health and medical research.\u003c/p\u003e","\u003cp\u003e Reed spent his first days in a small house which served as the parsonage for a Methodist congregation in Gloucester County, Virginia, where his father was minister.  Lemuel Sutton Reed and Pharaba White Reed welcomed young Walter into the family on September 13, 1851;  he was the youngest of their five children.  The Reeds moved to other Virginia parishes during Walter's childhood, and just after the close of the Civil War, transferred to the town of Charlottesville.  That move in 1866 placed Walter in the orbit of the University of Virginia, which he entered a year later at age sixteen under the care of his older brother Christopher, also a student at the University.  Reed attended two year-long sessions, the second devoted entirely to the medical curriculum, and he completed an M.D. degree on July 1, 1869, as one of the youngest students to graduate in the history of the medical school.\u003c/p\u003e","\u003cp\u003e At that time the School of Medicine at the University offered little opportunity for direct clinical experience, so Reed subsequently enrolled at the Bellevue Hospital Medical College, in Manhattan, New York.  There he obtained a second M.D. degree in 1870.  Reed interned at a number of hospitals in the New York metropolitan area, including the Infants' Hospital on Randall's Island and the Brooklyn City Hospital.  In 1873, he assumed the position of assistant sanitary officer for the Brooklyn Board of Health.  The large and diverse population of New York, with its many immigrant communities and dense, tenement housing, provided countless medical cases to treat and study;  these served to expose Reed to the vital importance of public health, and developed in him a lifelong interest in the field.  Yet the frenetic life of the great cities began to pall after a few years: \"Here the ever bustling day is crowded into the busy night; nor can we draw the line of separation between the two,\"[1] he wrote to Emilie Lawrence, of Murfreesboro, North Carolina, later to become Mrs. Walter Reed.  Their courtship letters reveal much of his maturing character, interests, and philosophy of life.  Increasing responsibilities with the Board of Health precluded opening a private practice, and Reed's youth proved a barrier in a culture given to offering respect more to the appearance of maturity than to its actual demonstration. Reed consequently resolved to join the Army Medical Corps, both for the professional opportunities it offered immediately and for the modest financial security it could provide to a young man without independent means.  He passed the qualifying examinations in January 1875 and proceeded to his first assignment at the military base on Willet's Point, New York Harbor.\u003c/p\u003e","\u003cp\u003e Reed remained in the Medical Corps for the rest of his life, spending many years of the '70s, '80s, and early '90s at difficult postings in the American West.  The first of these -- to the Arizona Territory -- began in the late spring of 1876, and indeed hurried along his wedding to Emilie Lawrence, on April 25, shortly before his departure.  She joined him the following November, and bore two children at frontier posts, a son Walter Lawrence and a daughter Emilie, called Blossom.\u003c/p\u003e","\u003cp\u003e Reed's other western assignments included forts in Nebraska, Dakota Territory, and Minnesota, with two eastern interludes at Baltimore, Maryland and another at Mount Vernon Barracks, Alabama.  During the second of these tours in Baltimore -- over the 1890-1891 academic year -- Reed completed advanced coursework in pathology and bacteriology in the Johns Hopkins University Hospital Pathology Laboratory.  When he returned from his last western appointment in 1893, Reed joined the faculty of the Army Medical School in Washington, D.C., where he held the professorship of Bacteriology and Clinical Microscopy.  He also became curator of the Army Medical Museum and joined the faculty of the Columbian University in Washington (later the George Washington University).  In addition, Reed maintained close ties with professor William Welch and other leading lights in the scientific community he had come to know at Hopkins a few years earlier.\u003c/p\u003e","\u003cp\u003e Beyond his teaching responsibilities for the Army and the Columbian University programs, Reed actively pursued medical research projects.  A bibliography of his publications finds entries from 1892 to the year of his untimely death a decade later, and the subjects he investigated range from erysipelas to cholera, typhoid, malaria, and yellow fever, among others.[2]   In 1896, a research trip to investigate an outbreak of smallpox took him to Key West, and there he developed a close friendship with Jefferson Randolph Kean, a fellow Virginian and colleague in the Medical Corps ten years his junior.  When Reed traveled to Cuba in 1899 to study typhoid in the army encampments of the U.S. forces, Kean was already there, and Kean was still in Cuba when Reed returned as the head of the Army board charged by Surgeon General George Miller Sternberg to examine tropical diseases including yellow fever.  Kean and his first wife Louise were great supporters of the U.S. Army Yellow Fever Commission's work, and Kean in fact served as quartermaster for the famous series of experiments at Camp Lazear.  After the dramatic and conclusive success of those experiments, Kean actively -- though unsuccessfully -- promoted Reed's candidacy for Surgeon General.\u003c/p\u003e","\u003cp\u003e Reed continued to speak and publish on yellow fever after his return from Cuba in 1901, receiving honorary degrees from Harvard and the University of Michigan in recognition of his seminal work.  In November 1902, Reed developed what had been for him recurring gastro-intestinal trouble.  This time, however, his appendix ruptured, and surgery came too late to save him from the peritonitis which developed.  He died on November 23, 1902, almost two years to the day from the opening of Camp Lazear and the stunning experimental victory there.  Kean remained a champion of his deceased friend's role in the conquest of yellow fever.  He organized the Walter Reed Memorial Association, to provide support for Reed's family and to build a suitable memorial, and was instrumental in lobbying the United States Congress to establish the Yellow Fever Roll of Honor.  In 1929, Congress mandated the annual publication of the Roll in the\u003ctitle render=\"italic\"\u003eArmy Register\u003c/title\u003e, and struck a series Congressional Gold Medals saluting the Commission members and the young Americans who bravely suffered experimental yellow fever a generation before.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003e[1] Letter from Walter Reed to Emilie Lawrence, 18 July 1874, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 01605001.\u003c/item\u003e\n      \u003citem\u003e[2] The bibliography of Reed's scientific papers may be found in: Howard Atwood Kelly,\u003ctitle render=\"italic\"\u003eWalter Reed and Yellow Fever\u003c/title\u003e(New York: McClure, Phillips and Co., 1906), pp. 281-283. Kelly's complete biography of Reed is contained on this Web site.\u003c/item\u003e\n    \u003c/list\u003e\n  ","\u003cp\u003eJesse William Lazear (May 2, 1866 - September 26, 1900) was a physician who was a member of the U.S. Army Yellow Fever Commission in 1900. Lazear's death from yellow fever at the outset of the commission's work in Cuba would lead to his elevation as a martyr for medical science in the eyes of many during the twentieth century.\u003c/p\u003e","\u003cp\u003e \"I rather think I am on the track of the real germ,\" Jesse W. Lazear wrote his wife from Cuba on September 8, 1900.[1] Seventeen days later, the fulminating case of yellow fever Lazear had contracted just over a week after writing Mabel H. Lazear suddenly ended the young scientist's life. He was 34 years old. Unlike so many other yellow fever fatalities, however, this one would lead to a direct and highly successful assault on the disease itself. Yellow fever's ascendancy, endemic in Cuba, was about to be undermined.\u003c/p\u003e","\u003cp\u003e Lazear had reported to Camp Columbia, Cuba in February 1900 for duty as an acting assistant surgeon with the U. S. Army Corps stationed on the island. Here he undertook bacteriological study of tropical diseases, particularly malaria and yellow fever, and in May he was named to the Army board charged with \"pursuing scientific investigations with reference to the infectious diseases prevalent on the island of Cuba.\"[2]\u003c/p\u003e","\u003cp\u003e These orders placed him officially in the company of Walter Reed, James Carroll, and Aristides Agramonte -- the U.S. Army Yellow Fever Commission -- though Lazear had already met Reed the preceding March on a project to evaluate the efficacy of electrozone, a disinfectant made from seawater collected off the Cuban coast. While Reed was in Cuba that March, Lazear discussed with him the recent discovery of British scientist Sir Ronald Ross concerning the mosquito vector for malaria. At Johns Hopkins Hospital in Baltimore, where he was first a medical resident and later in charge of the clinical laboratory, Lazear had followed Ross's accomplishments with great interest, and pursued field work and experimentation on the\u003cemph render=\"italic\"\u003eAnopheles\u003c/emph\u003emosquito with fellow Hopkins scientist William S. Thayer. Lazear was thus the only member of the Commission who had experience with mosquito work, and was consequently the most open to the possible verity of Cuban scientist Carlos Juan Finlay's theory of mosquito transmission for yellow fever.\u003c/p\u003e","\u003cp\u003e The record is apparently silent as to when Lazear first visited Finlay. Certainly by late June Lazear was beginning to grow mosquito larvae acquired from Finlay's laboratory, the first specimens brought to him by Henry Rose Carter, of the United States Public Health Service.[3] Not long after arriving in Cuba Lazear met Carter, whose own observations on yellow fever strongly suggested an intermediate host in the spread of the disease. However, Army Surgeon General George Miller Sternberg, who organized the Yellow Fever Commission, first charged the board members to investigate the relationship of\u003cemph render=\"italic\"\u003eBacillus icteroides\u003c/emph\u003eto yellow fever -- proposed by the Italian Scientist Giuseppe Sanarelli as the actual cause of the disease. \"Dr. Reed had been in the old discussion over Sanarelli's bacillus and he still works on that subject,\" Lazear wrote his wife in July, \"I am not all interested in it but want to do work which may lead to the discovery of the real organism.\"[4] Soon he would have the opportunity. The relatively quick failure of the Bacillus icteroides inquiry opened the door to what became the ground-breaking mosquito work, and Lazear was well placed to begin.\u003c/p\u003e","\u003cp\u003e The project started in earnest on August 1, 1900. In a small pocket notebook Lazear noted the preparatory work of raising and infecting mosquitoes, and subsequently recorded the series of eleven experimental inoculations made from the 11th to the 31st of August, the last two producing cases of full-blown yellow fever. These two positive cases developed from mosquitoes allowed to ripen over a period of 12 days, and this was Lazear's crucial discovery. The epidemiological pattern was thus entirely consistent with Carter's observations of a delay between the primary and secondary outbreaks of yellow fever in an epidemic, and, in addition, explained why Finlay's experiments had been largely unsuccessful -- he had not waited long enough before inoculating his subjects.\u003c/p\u003e","\u003cp\u003e Although Lazear never directly admitted to experimenting on himself, when Reed reviewed Lazear's sketchy notations he evidently found entries strongly suggesting Lazear's case was not accidental, as officially reported. Unfortunately, the little notebook so crucial to the preparation of the Commission's famous initial paper,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- A Preliminary Note\u003c/title\u003e[5], vanished from Reed's Washington office after his own untimely death in 1902. Still, Lazear's invaluable contribution to the Commission's victory was widely recognized and elicited tributes from many quarters: \"He was a splendid, brave fellow,\" Reed said of his young colleague, \" and I lament his loss more than words can tell; but his death was not in vain- His name will live in the history of those who have benefited humanity.\" [6] \"His death was a sacrifice to scientific research of the highest character,\" stated General Leonard Wood, military Governor of Cuba.[7] \"Your husband was a martyr in the noblest of causes,\" Dr. L. O. Howard wrote to Mabel Lazear, \"and I am proud to have known him. . . . His work contributed towards one of the greatest discoveries of the century, the results of which will be of invaluable benefit to mankind.\"[8] And so they were. Though Lazear's one-year-old son and newborn daughter never knew their father, they grew up in a world liberated -- almost in its entirety -- from the disease that killed him.\u003c/p\u003e","\u003cp\u003e [1] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 8 September 1900, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 00344001.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003e[2] Military Orders for Walter Reed, James Carroll, Aristides Agramonte, and Jesse W. Lazear, 24 May 1900, Hench Reed Collection, accession number 02019001.\u003c/item\u003e\n      \u003citem\u003e[3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\u003c/item\u003e\n      \u003citem\u003e[4] Letter fragment from Jesse W. Lazear to Mabel Houston Lazear, 15 July 1900, Hench Reed Collection, accession number: 00334001.\u003c/item\u003e\n      \u003citem\u003e[5] Walter Reed, James Carroll, Aristides Agramonte, Jesse W. Lazear,\u003ctitle render=\"doublequote\"\u003eThe Etiology of Yellow Fever -- A Preliminary Note,\u003c/title\u003e \u003ctitle render=\"italic\"\u003eProceedings of the Twenty-eighth Annual Meeting of the American Public Health Association Indianapolis, Indiana, 22, 23, 24, 25, and 26 October 1900.\u003c/title\u003e\u003c/item\u003e\n      \u003citem\u003e[6] Letter from Walter Reed to Emilie Lawrence Reed, 6 October 1900, Hench Reed Collection, accession number: 02135001.\u003c/item\u003e\n      \u003citem\u003e[7] Letter from Leonard Wood to the Adjutant-General, United States Army, November 1900, Hench Reed Collection, accession number: 00375002.\u003c/item\u003e\n      \u003citem\u003e[8] Letter from Leland Ossian Howard to Mabel Houston Lazear, 7 February 1901, Hench Reed Collection, accession number: 00388001.\u003c/item\u003e\n    \u003c/list\u003e\n  ","\u003cp\u003eHenry Rose Carter (August 25, 1852 - September 14, 1925) was a prominent physician in the U.S. Public Health Service who was a leading authority in the transmission and control of tropical diseases, particularly yellow fever and malaria. During his long career as a sanitarian, Carter undertook campaigns to investigate and control the spread of tropical diseases in Cuba, the Panama Canal Zone, the Southeastern United States, and Peru.\u003c/p\u003e","\u003cp\u003e Like Walter Reed and Jefferson Randolph Kean, Henry Rose Carter was a native Virginian and a graduate of the University of Virginia. Carter obtained a civil engineering degree from Virginia in 1873 and also undertook post-graduate work in mathematics and applied chemistry the next year. Subsequently, however, Carter's interests turned towards medicine, and he completed a medical degree at the University of Maryland in 1879. The same year Assistant Surgeon Carter joined the Marine Hospital Service -- later the United States Public Health Service -- and the young surgeon rose steadily through the ranks, ultimately attaining the position of Assistant Surgeon General in 1915.\u003c/p\u003e","\u003cp\u003e Carter's initial assignments with the Hospital Service placed him at the center of the yellow fever maelstrom. In 1879 he was detailed to Memphis and other Southern cities, then in the throes of a second year of devastating epidemics. Here began, as his colleague T. H. D. Griffitts observed, Carter's \"lifelong interest in the epidemiology and control of yellow fever.\"[1] After several years of clinical practice in various Marine hospitals, Carter resumed a direct confrontation with yellow fever when his orders for duty with the Gulf Coast Maritime Quarantine assigned him to Ship Island, Mississippi, in 1888. Here and at subsequent quarantine station postings around the Gulf, he quietly championed a thorough review and rationalization of quarantine policies, with a view toward establishing uniform regulation, more thorough disinfection of vessels, and minimized interference with naval commerce. Crucial to the success of these activities was Carter's attention to the incubation period of yellow fever, which his on-site observations indicated to vary between 5 and 7 days. At the time the official literature stated with far less precision a variance of between 1 and 14 days; Carter's work consequently greatly increased the efficiency and effectiveness of quarantine operations.\u003c/p\u003e","\u003cp\u003e Nevertheless, yellow fever continued to menace the temperate coastline of the United States, and Carter ably directed the Health Service's epidemiological control efforts in numerous threatened regions. In conjunction with this sanitary work for the 1898 season, Carter made detailed notes on the development of yellow fever at Orwood and Taylor, Mississippi. The isolation of these communities enabled him to identify more reliably the phenomenon of a delay between the initial cases of yellow fever in a locality and the subsequent appearance of secondary infection -- a delay two to four times longer than the incubation period of the disease in an infected person. Carter called this interval between the primary and secondary cases \"the period of extrinsic incubation,\" and he defined its \"usual limits . . . [as ranging] from ten to seventeen days.\"[2]\u003c/p\u003e","\u003cp\u003e Before he was able to publish his conclusions, Carter took the helm of the quarantine service in war-time Cuba. There, in 1900, he met U. S. Army Yellow Fever Commission member Jesse Lazear. Carter had finally arranged for his paper's publication that year in the\u003ctitle render=\"italic\"\u003eNew Orleans Medical and Surgical Journal\u003c/title\u003e, and gave a draft to Lazear. \"If these dates are correct,\" Carter later recalled Lazear saying, \"it spells a living host.\"[3] The theory of mosquito transmission long advanced by Cuban scientist Carlos J. Finlay began to seem more likely. And indeed it was. The Commission's experiments in 1900-1901 irrefutably proved the mosquito vector and established the extrinsic incubation period at twelve days. Shortly after these successes Reed saluted Carter, \"I know of no one more competent to pass judgment on all that pertains to the subject of yellow fever. You must not forget that your own work in Mississippi did more to impress me with the importance of an intermediate host than everything else put to-gether.\"[4]\u003c/p\u003e","\u003cp\u003e Carter's long and distinguished sanitary career took him to the Panama Canal Zone in 1904, where he served as Chief Quarantine Officer and Chief of Hospitals for five years. He undertook detailed investigations and control measures of malaria in North Carolina and elsewhere in the South, and became a founder of the National Malaria Committee. With the support of the Rockefeller Foundation International Health Board, he undertook additional investigation and control measures for yellow fever in Central and South America. His expertise recommended him to the Peruvian government, which named Carter Sanitary Advisor in 1920-1921. Health problems at the end of his life compelled Carter to withdraw from active fieldwork, though he remained a highly valued consultant to the Health Board and a much-beloved and respected teacher for a new generation of sanitarians. Carter closed his career researching and writing the manuscript that his daughter Laura Armistead Carter edited and published posthumously in 1931:\u003ctitle render=\"italic\"\u003eYellow Fever: An Epidemiological and Historical Study of its Place of Origin.\u003c/title\u003e[5]\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003e[1] T. H. D. Griffitts,\u003ctitle render=\"doublequote\"\u003eHenry Rose Carter: The Scientist and the Man\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eSouthern Medical Journal\u003c/title\u003e32 (August 1939) 8: 842.\u003c/item\u003e\n      \u003citem\u003e[2] Henry Rose Carter,\u003ctitle render=\"doublequote\"\u003eA Note on the Spread of Yellow Fever in Houses, Extrinsic Incubation\u003c/title\u003e,\u003ctitle render=\"italic\"\u003eMedical Record\u003c/title\u003e59 (15 June 1901) 24: 937.\u003c/item\u003e\n      \u003citem\u003e[3] \"Conversation between Drs. Carter, Thayer, and Parker,\" 1924, Henry Rose Carter Papers, Claude Moore Health Sciences Library, Department of Historical Collections and Services, Box 1.\u003c/item\u003e\n      \u003citem\u003e[4] Letter from Walter Reed to Henry Rose Carter, 26 February 1901, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 02447001.\u003c/item\u003e\n      \u003citem\u003e[5] Carter, Henry Rose.\u003ctitle render=\"italic\"\u003eYellow Fever: An Epidemiological and Historical Study of its Place of Origin.\u003c/title\u003eBaltimore: The Williams and Wilkins Company, 1931.\u003c/item\u003e\n    \u003c/list\u003e\n  ","\u003cp\u003eJefferson Randolph Kean (June 27, 1860 - September 4, 1950) was a U.S. Army physician who was a leading authority in sanitation, public health, and tropical diseases. Later in his career, Kean would become widely recognized for his role in organizing and administering medical services for the U.S. armed forces during World War I.\u003c/p\u003e","\u003cp\u003e \"He possessed one of the keenest, most scholarly minds I've ever encountered,\" recalled Nobel Prize winner Philip S. Hench of Jefferson Randolph Kean. [1] Kean and Hench shared an abiding interest in the work of the United States Army Yellow Fever Commission -- Kean, as a contemporary and supporter, and Hench, as a scholar and scientist intent on accurate historical documentation. On the advice of yellow fever experiment volunteer John J. Moran, Hench first wrote Kean in 1939. From that initial contact developed a close friendship which would last for the remainder of their lives. Kean entrusted Hench not only with numerous period documents, including original letters, accounts, fever charts, and other items, but also with the freely-given counsel and insight of a trusted friend.\u003c/p\u003e","\u003cp\u003e Like Walter Reed and Henry Rose Carter before him, Jefferson Randolph Kean was an alumnus of the University of Virginia, completing the medical program there in 1883. Kean joined the U.S. Army Medical Corps in 1884, and after forty years in the service, retired with the rank of Colonel. Congress awarded him a promotion to Brigadier General, retired, in 1930. The early years of Kean's career passed in medical postings in the American West, and no doubt offered him experiences similar to those of Walter Reed, whom he met not on the frontier, but in Florida in 1896. Kean became an expert in tropical diseases and sanitation during his five-year assignment in the Florida tropics, an expertise which served him well over two terms of service later in Cuba. During the Spanish-American War and subsequent U. S. occupation of Cuba, Kean was Chief Surgeon for the Department of Havana, then Superintendent of the Department of Charities -- from 1898 to 1902. After a four-year interlude as an assistant to the Surgeon General in Washington, D.C., Kean again returned to Cuba as an advisor to the Department of Sanitation from 1906-1909.\u003c/p\u003e","\u003cp\u003e Kean himself stated: \"Reed and I were good friends before the Yellow Fever Board came to Cuba in June 1900, and [Reed] located himself at Marianao, 8 miles S. W. of Havana,\" to be within the medical and administrative jurisdiction overseen by Kean. [2] The Chief Surgeon did indeed offer significant assistance, and was an early convert to Carlos Finlay's mosquito theory of transmission, which the Yellow Fever Board's experiments ultimately proved true in the late autumn and winter of 1900-1901. As early as October 13, 1900 -- after the Board's preliminary work, but before the final convincing demonstrations -- Kean issued \"Circular No. 8,\" concerning the latest scholarship on the mosquito vector for disease. [3] The circular contained a set of instructions for the entire command on mosquito eradication. Kean subsequently served as quartermaster and financial administrator for the famous series of yellow fever experiments at Camp Lazear and, for the rest of his life, Kean remained a strong proponent of the Commission's conclusions. He worked tirelessly not only to apply them in the field, but also to accord proper public recognition to the Commission's work.\u003c/p\u003e","\u003cp\u003e In addition to his career as a sanitarian, Kean organized the department of military relief of the American Red Cross, and during World War One served as Chief of the U. S. Ambulance Service with the French Army and Deputy Chief Surgeon of the American forces. France named him an Officier de la Légion d'Honneur in recognition for these services. Cuban authorities as well offered Kean recognition with the grand cross of the Order of Merit Carlos J. Finlay, and he received both a Distinguished Service Medal from the United States government and the Gorgas Medal from the Association of Military Surgeons. For a decade after his retirement from active duty, Kean edited this last organization's medical journal,\u003ctitle render=\"italic\"\u003eThe Military Surgeon\u003c/title\u003e, and served on the Surgeon General's editorial board for the multi-volume history of the medical department in World War One. A great-grandson of Thomas Jefferson, Kean also took a seat with the government commission established to build the Jefferson Memorial in Washington, D.C. He held charter membership in the Walter Reed Memorial Association, and remained active in its affairs until his death in 1950.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003e[1] Telegram from Philip Showalter Hench and Mary Hench to Cornelia Knox Kean, September 5, 1950, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 06501173.\u003c/item\u003e\n      \u003citem\u003e[2] Letter from Jefferson Randolph Kean to Philip Showalter Hench, October 31, 1939, Hench Reed Yellow Fever Collection, accession number: 06282022.\u003c/item\u003e\n      \u003citem\u003e[3] Military Orders to Commanding Officers, October 15, 1900, Hench Reed Yellow Fever Collection, accession number: 02140001.\u003c/item\u003e\n    \u003c/list\u003e\n  ","\u003cp\u003ePhilip Showalter Hench (February 28, 1896 - March 30, 1965) was a U.S. physician who in 1950 was awarded the Nobel Prize for Physiology and Medicine for his role in the discovery of the hormone cortisone. In addition to his medical research, Hench spent almost three decades of his life studying the history of the U.S. Army Yellow Fever Commission and became a leading authority in the subject.\u003c/p\u003e","\u003cp\u003e Philip Showalter Hench was born in Pittsburgh, Pennsylvania, the son of Jacob Bixler Hench and Clara Showalter. After attending local schools, Hench entered Lafayette College and graduated from the school 1916 with a Bachelor of Arts. Hench completed his medical degree at the University of Pittsburgh in 1920, and subsequently entered a residency program at St. Francis Hospital, Pittsburgh. His association with the Mayo Clinic began in 1921 as a fellow at the institution. Two years later he would become an assistant at the clinic, and then, in 1926, he would be made the head of its Department of Rheumatic Diseases After pursuing post-graduate study in Germany in 1928-1929, Hench obtained a Masters of Science in Internal Medicine at the University of Minnesota in 1931, and a Doctor of Science degree from Lafayette College in 1940. Hench remained for the duration of his career at the Mayo Clinic, where his life-long passion for meticulous research and analysis brought him the Nobel Prize for Physiology and Medicine in 1950, which he shared with Edward C. Kendall and Tadeus Reichstein, for the discovery of cortisone.\u003c/p\u003e","\u003cp\u003e The same persistence and determination present in his professional life is also evident in Hench's research on the U. S. Army Yellow Fever Commission's famous experiments. \"As a physician particularly interested in medical history,\" he stated to experiment volunteer John J. Moran in 1937, \"I have been long interested in the story of the yellow fever work in John J. Moran, Ralph C. Hutchison, Havana.\" [1] So began a remarkable odyssey. At the request of his friend Ralph Cooper Hutchison, then president of Washington and Jefferson College, Hench had written Moran to gather information for the dedication of the College's new chemistry building, named for Commission member and former Washington and Jefferson student Jesse W. Lazear. Hench also began a correspondence with another of the yellow fever experiment's original volunteers, John R. Kissinger. Moran's and Kissinger's recollections proved so intriguing that Hench initially offered to edit and publish them. However, in the course of his research Hench discovered that much general information on the topic was inaccurate. Conflicting assertions concerning the participants and unverified claims by medical and governmental authorities in the United States and Cuba -- often politically motivated -- clouded interpretation of the facts. \"May I suggest,\" Moran consequently urged in 1938, \"that a clearing up of the REED-FINLAY-CONQUEST-OF-YELLOW-FEVER, or an effort to do so, on your part, is a task far more pressing than publishing the Kissinger-Moran stories or memoirs.\" [2] Hench resolved to document every aspect of the \"Conquest of Yellow-Fever\" and to write a much needed accurate and comprehensive history.\u003c/p\u003e","\u003cp\u003e For the next two decades, Hench tirelessly combed through public archive collections and personal papers in the United States and Cuba. He met and interviewed surviving participants of the experiments and others associated with the project, as well as family members of the Yellow Fever Commission. He sought out physicians and scientists who had worked with the principal players or who had applied the results in the campaign to eradicate yellow fever. He identified and photographed sites associated with the yellow fever story, and he successfully petitioned politicians in the United States and Cuba to commemorate the work. In the process, Hench became the trusted friend and advisor of many of these same individuals, and they, in turn, presented him with much of the surviving original material for safekeeping.\u003c/p\u003e","\u003cp\u003e In short, Hench came to be the world's expert on the yellow fever story and the steward of thousands of original letters and documents. His premature death at age 69 found him still hoping to uncover important missing evidence, his book unwritten. Hench's widow Mary Kahler Hench gave his yellow fever collection to the University of Virginia, Walter Reed's alma mater, and this extensive personal archive forms the most detailed and accurate record available on the Conquest of Yellow Fever.\u003c/p\u003e","\u003cp\u003e Sources:\u003c/p\u003e    ","\u003clist type=\"ordered\"\u003e\n      \u003citem\u003e[1] Letter from Philip S. Hench to John J. Moran, 6 July 1937, Philip S. Hench Walter Reed Yellow Fever Collection, Claude Moore Health Sciences Library, Department of Historical Collections and Services, accession number: 03419001.\u003c/item\u003e\n      \u003citem\u003e[2] Letter from John J. Moran to Philip S. Hench, 30 October 1938, Hench Reed Yellow Fever Collection, accession number: 03476001.\u003c/item\u003e\n    \u003c/list\u003e\n  "]}]}},"label":"Breadcrumbs"}}},"links":{"self":"https://arvasarchive.org/catalog/viu_repositories_7_resources_1710_c04"}},{"id":"viu_viu00044_c03_c07","type":null,"attributes":{"title":"Sermon Notes, 1827/1863","breadcrumbs":{"id":"https://arvasarchive.org/catalog/viu_viu00044_c03_c07#breadcrumbs","type":"document_value","attributes":{"value":{"ref_ssi":"viu_viu00044_c03_c07","ref_ssm":["viu_viu00044_c03_c07"],"id":"viu_viu00044_c03_c07","ead_ssi":"viu_viu00044","_root_":"viu_viu00044","_nest_parent_":"viu_viu00044_c03","parent_ssi":"viu_viu00044_c03","parent_ssim":["Bondurant-Morrison Family Papers \n 1787-1936","Papers of Rev. James Morrison"],"parent_ids_ssim":["viu_viu00044","viu_viu00044_c03"],"title_filing_ssi":"Sermon Notes","title_ssm":["Sermon Notes"],"title_tesim":["Sermon Notes"],"normalized_title_ssm":["Sermon Notes, 1827/1863"],"text":["Sermon Notes, 1827/1863","Bondurant-Morrison Family Papers \n 1787-1936","Papers of Rev. James Morrison","Box Box 32"],"parent_unittitles_ssm":["Bondurant-Morrison Family Papers \n 1787-1936","Papers of Rev. James Morrison"],"parent_unittitles_tesim":["Bondurant-Morrison Family Papers \n 1787-1936","Papers of Rev. James Morrison"],"normalized_date_ssm":["1827/1863"],"unitdate_other_ssim":["1827-1863, n.d."],"component_level_isim":[2],"sort_isi":100,"repository_ssim":["University of Virginia, Special Collections Dept."],"collection_ssim":["Bondurant-Morrison Family Papers \n 1787-1936"],"extent_ssm":["(6 folders)"],"extent_tesim":["(6 folders)"],"containers_ssim":["Box Box 32"],"has_online_content_ssim":["false"],"child_component_count_isi":0,"parent_access_restrict_tesm":["Collection is open to research."],"parent_access_terms_tesm":["See the \n            \n            University of Virginia Library’s use policy."],"date_range_isim":[1827,1828,1829,1830,1831,1832,1833,1834,1835,1836,1837,1838,1839,1840,1841,1842,1843,1844,1845,1846,1847,1848,1849,1850,1851,1852,1853,1854,1855,1856,1857,1858,1859,1860,1861,1862,1863],"_nest_path_":"/components#2/components#6","timestamp":"2026-08-14T22:55:15.948Z","collection":{"numFound":1,"start":0,"numFoundExact":true,"docs":[{"id":"viu_viu00044","ead_ssi":"viu_viu00044","_root_":"viu_viu00044","_nest_parent_":"viu_viu00044","ead_source_url_ssi":"data/uva-sc/viu00044.xml","title_ssm":["Bondurant-Morrison Family Papers \n 1787-1936"],"title_tesim":["Bondurant-Morrison Family Papers \n 1787-1936"],"normalized_title_ssm":["Bondurant-Morrison Family Papers \n 1787-1936"],"text":["Bondurant-Morrison Family Papers \n 1787-1936","3918","16,000 items","Collection is open to research.","Funded in part by a grant from the National Endowment\n            for the Humanities","This collection consist of ca. 16,000 items, 1787-1936, and\n         contains the papers of the \n         Bondurant familyof \n         Buckingham County, Virginia, and the \n         Morrison familyof \n         Rockbridge County, Virginiawho were\n         related through the marriage of \n         Alexander Joseph Bondurantand \n         Emily MacFarland Morrisonin 1859. \n         Alexander J. Bondurantand \n         Emily (Morrison) Bondurantwere the chief\n         correspondents in this collection. \n         Alexander J. Bondurant(1836-1910) was a \n         Confederatesoldier, farmer, politician,\n         superintendent of \n         Buckingham County, Va.schools, professor\n         of agriculture at \n         Auburn University, and tobacco consultant\n         to the government of \n         Australia. His father, \n         Thomas Moseley Bondurant(1797-1862), was\n         a landowner, member of the board of trustees of \n         Hampden-Sydney College, a soldier in the\n         War of 1812, a member of the \n         Virginia Senate, and one of the founders\n         of the \n         Richmond Whig. His oldest son, \n         Alexander Lee Bondurant(1865-1937) was\n         professor of Latin and head of the graduate school of the \n         University of Mississippi.","Emily MacFarland Morrison(b. 1837) was\n         the daughter of Rev. \n         James Morrisonand \n         Frances (Brown) Morrisonof \n         Rockbridge County, Va.A copy of her\n         reminiscences can be found in the Rare Books collection (F 231\n         .B65 1944 1962ed). The \n         Morrison familymaterial consists chiefly of\n         the papers of Rev. \n         James Morrison(1797-1870), including\n         correspondence concerning his family, his congregation, and\n         the \n         Presbyterian Church; also included are\n         his seminary and sermon notes from 1815-1874, and diaries and\n         account books for his home, \n         Bellevue.","Subjects included in this collection are farms in \n         Buckingham Co., Va., family affairs, the\n         Civil War, school administration in \n         Buckingham Co., \n         Auburn University, the \n         University of Virginia, mining and\n         mineral rights in \n         Virginia, immigrant land schemes in \n         Virginia, including the \n         James River Valley Immigrant Societyand\n         the \n         Virginia Land and Immigrant Company, \n         Virginiaand national politics, tobacco\n         culture in \n         Australiaand the southern \n         United States, Rev. \n         James Morrison's education at the \n         University of North Carolina, his\n         pastorates in \n         North Carolinaand \n         Virginia, the \n         Presbyterian Churchin the South, and the \n         Bellevue Schoolin \n         Rockbridge County, Virginia.","Most of the personal correspondence in the collection is\n         concerned with family matters. A great deal of the letters\n         discussed agriculture with regard to the family farms,\n         especially \n         Variety Shade, and \n         Alexander J. Bondurant's various\n         agricultural positions and interests. AJB's letters from \n         Australiato various family members\n         spanned the period from 1896 to 1901. These contain some\n         information on agriculture and the culture of \n         Australia. Some of the letters from \n         Charles W. Dabneyto \n         A.J. Bondurant(1881-1898) discuss iron\n         ore and mineral rights in \n         Virginiaas well as agriculture.","The Civil War and its affects is another subject to be\n         found in the correspondence. Letters from \n         Emily (Morrison) Bondurantto \n         Alexander J. Bondurantmention her\n         brothers' war activities and posts (29 Jul, 8 Aug, and 11 Aug\n         1862; 6 [Apr] and 22 Apr 1863; 1 Mar, 28 Mar, 5 Apr 1865). A\n         13 May 1863 letter from \n         Thomas Lee Bondurantto \n         A.J.Bondurantmentions the reaction to the\n         death of General \n         Thomas \"Stonewall\" Jackson. Letters to \n         E.M. Bondurantfrom \n         A.J. Bondurantmention the war and his\n         desire to support the army (12 Apr, 27 Apr, 26 May 1863). Rev.\n         James Morrisonalso wrote to his daughter \n         E.M. Bondurantabout the war and her\n         brother, \n         Samuel Morrison's appointment as a\n         surgeon in the army (5 Nov 1861, 23 May 1865). Letters to Rev.\n         James Morrisonmention the early rumblings\n         of the Civil War and rumors of secession (25 Jul, 20 Oct, 9\n         Nov, 4 Dec 1860), as well as letters from his sons telling of\n         their posts (20 Feb, 4 Dec 1863; 14 Jan, 21 May 1863).","Politics is also a prominent subject in some of the\n         correspondence. The \n         Bondurantswere active in the publishing\n         of the \n         Richmond Whig(est. 1824) and it is\n         mentioned in a few letters. \n         E.M. Bondurantto \n         A.J. Bondurantmentions that \n         George [P. Bondurant](1838-1886) wanted\n         to leave the management of the paper to \n         A.J. Bondurant. \n         Thomas M. Bondurantmentions the paper in\n         a letter (19 Nov 1857) to his son \n         A.J. Bondurant. A letter from \n         George P. Bondurantto his father \n         A.J. Bondurantmentions the \n         Whigagain and the \n         Bondurantinterests in the paper (22 Mar\n         1896). Local and national politics is found in several letters\n         from \n         E.M. Bondurantto \n         A.J. Bondurant(26 Jul, 27 Sep, 8, 11, 31\n         Oct 1896). Letters from \n         Alexander Lee Bondurantto his father \n         A.J. Bondurantmention local politics and\n         the race for the legislature (25 Oct 1887, 7 May 1889). \n         Thomas M. Bondurantwas also concerned\n         with local politics; a letter from \n         J.T. Bocockmentions Sen. \n         Floodand local tax collecting practices\n         and the justice system and how they could be changed (8 Jan\n         1834).","Religion and the \n         Presbyterian Churchis also a prominent\n         subject in the correspondence of Rev. \n         James Morrison, pastor of \n         New Providence Presbyterian Church, \n         Rockbridge County, Virginia. The letters\n         from Rev. \n         Elam J. Morrisonfrom Rev. \n         James Morrison(1820-1826) are concerned\n         with family matters, friends in the ministry, questions and\n         and advice about the ministry, the Presbytery and synods.\n         Letters to Rev. \n         James Morrison(1813-1863, n.d.) contain\n         many similar topics and include family letters and letters\n         from friends and relatives in the ministry.","See the \n            \n            University of Virginia Library’s use policy.","University of Virginia. Library. Special\n            Collections Dept.","University of Virginia","Confederate","Auburn University","Hampden-Sydney College","Virginia Senate","Richmond Whig","University of Mississippi","Presbyterian Church","Bellevue","James River Valley Immigrant Society","Virginia Land and Immigrant Company","University of North Carolina","Bellevue School","Variety Shade","Whig","New Providence Presbyterian Church","Bondurant family","Morrison family","Bondurant","William Harrison","William G. Harrison","Alexander Joseph Bondurant","Emily MacFarland Morrison","Alexander J. Bondurant","Emily (Morrison) Bondurant","Thomas Moseley Bondurant","Alexander Lee Bondurant","James Morrison","Frances (Brown) Morrison","Charles W. Dabney","A.J. Bondurant","Thomas Lee Bondurant","A.J.Bondurant","Thomas \"Stonewall\" Jackson","E.M. Bondurant","Samuel Morrison","Bondurants","George [P. Bondurant]","Thomas M. Bondurant","George P. Bondurant","J.T. Bocock","Flood","Elam J. Morrison","English"],"collection_title_tesim":["Bondurant-Morrison Family Papers \n 1787-1936"],"collection_ssim":["Bondurant-Morrison Family Papers \n 1787-1936"],"level_ssm":["collection"],"level_ssim":["Collection"],"unitid_ssm":["3918"],"unitid_tesim":["3918"],"repository_ssm":["University of Virginia, Special Collections Dept."],"repository_ssim":["University of Virginia, Special Collections Dept."],"creator_ssm":["William Harrison"],"creator_ssim":["William Harrison"],"creator_persname_ssim":["William Harrison","William G. Harrison","Alexander Joseph Bondurant","Emily MacFarland Morrison","Alexander J. Bondurant","Emily (Morrison) Bondurant","Thomas Moseley Bondurant","Alexander Lee Bondurant","James Morrison","Frances (Brown) Morrison","Charles W. Dabney","A.J. Bondurant","Thomas Lee Bondurant","A.J.Bondurant","Thomas \"Stonewall\" Jackson","E.M. Bondurant","Samuel Morrison","Bondurants","George [P. Bondurant]","Thomas M. Bondurant","George P. Bondurant","J.T. Bocock","Flood","Elam J. Morrison"],"creator_corpname_ssim":["University of Virginia. Library. Special\n            Collections Dept.","University of Virginia","Confederate","Auburn University","Hampden-Sydney College","Virginia Senate","Richmond Whig","University of Mississippi","Presbyterian Church","Bellevue","James River Valley Immigrant Society","Virginia Land and Immigrant Company","University of North Carolina","Bellevue School","Variety Shade","Whig","New Providence Presbyterian Church"],"creator_famname_ssim":["Bondurant family","Morrison family","Bondurant"],"creators_ssim":["William Harrison","William G. Harrison","Alexander Joseph Bondurant","Emily MacFarland Morrison","Alexander J. Bondurant","Emily (Morrison) Bondurant","Thomas Moseley Bondurant","Alexander Lee Bondurant","James Morrison","Frances (Brown) Morrison","Charles W. Dabney","A.J. Bondurant","Thomas Lee Bondurant","A.J.Bondurant","Thomas \"Stonewall\" Jackson","E.M. Bondurant","Samuel Morrison","Bondurants","George [P. Bondurant]","Thomas M. Bondurant","George P. Bondurant","J.T. Bocock","Flood","Elam J. Morrison","University of Virginia. Library. Special\n            Collections Dept.","University of Virginia","Confederate","Auburn University","Hampden-Sydney College","Virginia Senate","Richmond Whig","University of Mississippi","Presbyterian Church","Bellevue","James River Valley Immigrant Society","Virginia Land and Immigrant Company","University of North Carolina","Bellevue School","Variety Shade","Whig","New Providence Presbyterian Church","Bondurant family","Morrison family","Bondurant"],"access_terms_ssm":["See the \n            \n            University of Virginia Library’s use policy."],"acqinfo_ssim":["This collection was deposited to the Library by \n            William G. Harrison, of the \n            University of Virginia, on May 14,\n            1952."],"has_online_content_ssim":["false"],"physdesc_tesim":["16,000 items"],"accessrestrict_html_tesm":["\u003cp\u003eCollection is open to research.\u003c/p\u003e\n      "],"accessrestrict_heading_ssm":["Access Restrictions"],"accessrestrict_tesim":["Collection is open to research."],"prefercite_html_tesm":["\u003cp\u003eBondurant-Morrison Family\n            Papers, Accession 3918, Special Collections Department, University of\n         Virginia Library\u003c/p\u003e\n      "],"prefercite_tesim":["Bondurant-Morrison Family\n            Papers, Accession 3918, Special Collections Department, University of\n         Virginia Library"],"processinfo_html_tesm":["\u003cp\u003eFunded in part by a grant from the National Endowment\n            for the Humanities\u003c/p\u003e\n      "],"processinfo_heading_ssm":["Funding Note"],"processinfo_tesim":["Funded in part by a grant from the National Endowment\n            for the Humanities"],"scopecontent_html_tesm":["\u003cp\u003eThis collection consist of ca. 16,000 items, 1787-1936, and\n         contains the papers of the \n         \u003cfamname\u003eBondurant family\u003c/famname\u003eof \n         \u003cgeogname\u003eBuckingham County, Virginia\u003c/geogname\u003e, and the \n         \u003cfamname\u003eMorrison family\u003c/famname\u003eof \n         \u003cgeogname\u003eRockbridge County, Virginia\u003c/geogname\u003ewho were\n         related through the marriage of \n         \u003cpersname\u003eAlexander Joseph Bondurant\u003c/persname\u003eand \n         \u003cpersname\u003eEmily MacFarland Morrison\u003c/persname\u003ein 1859. \n         \u003cpersname\u003eAlexander J. Bondurant\u003c/persname\u003eand \n         \u003cpersname\u003eEmily (Morrison) Bondurant\u003c/persname\u003ewere the chief\n         correspondents in this collection. \n         \u003cpersname\u003eAlexander J. Bondurant\u003c/persname\u003e(1836-1910) was a \n         \u003ccorpname\u003eConfederate\u003c/corpname\u003esoldier, farmer, politician,\n         superintendent of \n         \u003cgeogname\u003eBuckingham County, Va.\u003c/geogname\u003eschools, professor\n         of agriculture at \n         \u003ccorpname\u003eAuburn University\u003c/corpname\u003e, and tobacco consultant\n         to the government of \n         \u003cgeogname\u003eAustralia\u003c/geogname\u003e. His father, \n         \u003cpersname\u003eThomas Moseley Bondurant\u003c/persname\u003e(1797-1862), was\n         a landowner, member of the board of trustees of \n         \u003ccorpname\u003eHampden-Sydney College\u003c/corpname\u003e, a soldier in the\n         War of 1812, a member of the \n         \u003ccorpname\u003eVirginia Senate\u003c/corpname\u003e, and one of the founders\n         of the \n         \u003ccorpname\u003eRichmond Whig\u003c/corpname\u003e. His oldest son, \n         \u003cpersname\u003eAlexander Lee Bondurant\u003c/persname\u003e(1865-1937) was\n         professor of Latin and head of the graduate school of the \n         \u003ccorpname\u003eUniversity of Mississippi\u003c/corpname\u003e.\u003c/p\u003e\n      ","\u003cp\u003e\u003cpersname\u003eEmily MacFarland Morrison\u003c/persname\u003e(b. 1837) was\n         the daughter of Rev. \n         \u003cpersname\u003eJames Morrison\u003c/persname\u003eand \n         \u003cpersname\u003eFrances (Brown) Morrison\u003c/persname\u003eof \n         \u003cgeogname\u003eRockbridge County, Va.\u003c/geogname\u003eA copy of her\n         reminiscences can be found in the Rare Books collection (F 231\n         .B65 1944 1962ed). The \n         \u003cfamname\u003eMorrison family\u003c/famname\u003ematerial consists chiefly of\n         the papers of Rev. \n         \u003cpersname\u003eJames Morrison\u003c/persname\u003e(1797-1870), including\n         correspondence concerning his family, his congregation, and\n         the \n         \u003ccorpname\u003ePresbyterian Church\u003c/corpname\u003e; also included are\n         his seminary and sermon notes from 1815-1874, and diaries and\n         account books for his home, \n         \u003ccorpname\u003eBellevue\u003c/corpname\u003e.\u003c/p\u003e\n      ","\u003cp\u003eSubjects included in this collection are farms in \n         \u003cgeogname\u003eBuckingham Co., Va.\u003c/geogname\u003e, family affairs, the\n         Civil War, school administration in \n         \u003cgeogname\u003eBuckingham Co.\u003c/geogname\u003e, \n         \u003ccorpname\u003eAuburn University\u003c/corpname\u003e, the \n         \u003ccorpname\u003eUniversity of Virginia\u003c/corpname\u003e, mining and\n         mineral rights in \n         \u003cgeogname\u003eVirginia\u003c/geogname\u003e, immigrant land schemes in \n         \u003cgeogname\u003eVirginia\u003c/geogname\u003e, including the \n         \u003ccorpname\u003eJames River Valley Immigrant Society\u003c/corpname\u003eand\n         the \n         \u003ccorpname\u003eVirginia Land and Immigrant Company\u003c/corpname\u003e, \n         \u003cgeogname\u003eVirginia\u003c/geogname\u003eand national politics, tobacco\n         culture in \n         \u003cgeogname\u003eAustralia\u003c/geogname\u003eand the southern \n         \u003cgeogname\u003eUnited States\u003c/geogname\u003e, Rev. \n         \u003cpersname\u003eJames Morrison\u003c/persname\u003e's education at the \n         \u003ccorpname\u003eUniversity of North Carolina\u003c/corpname\u003e, his\n         pastorates in \n         \u003cgeogname\u003eNorth Carolina\u003c/geogname\u003eand \n         \u003cgeogname\u003eVirginia\u003c/geogname\u003e, the \n         \u003ccorpname\u003ePresbyterian Church\u003c/corpname\u003ein the South, and the \n         \u003ccorpname\u003eBellevue School\u003c/corpname\u003ein \n         \u003cgeogname\u003eRockbridge County, Virginia\u003c/geogname\u003e.\u003c/p\u003e\n      ","\u003cp\u003eMost of the personal correspondence in the collection is\n         concerned with family matters. A great deal of the letters\n         discussed agriculture with regard to the family farms,\n         especially \n         \u003ccorpname\u003eVariety Shade\u003c/corpname\u003e, and \n         \u003cpersname\u003eAlexander J. Bondurant\u003c/persname\u003e's various\n         agricultural positions and interests. AJB's letters from \n         \u003cgeogname\u003eAustralia\u003c/geogname\u003eto various family members\n         spanned the period from 1896 to 1901. These contain some\n         information on agriculture and the culture of \n         \u003cgeogname\u003eAustralia\u003c/geogname\u003e. Some of the letters from \n         \u003cpersname\u003eCharles W. Dabney\u003c/persname\u003eto \n         \u003cpersname\u003eA.J. Bondurant\u003c/persname\u003e(1881-1898) discuss iron\n         ore and mineral rights in \n         \u003cgeogname\u003eVirginia\u003c/geogname\u003eas well as agriculture.\u003c/p\u003e\n      ","\u003cp\u003eThe Civil War and its affects is another subject to be\n         found in the correspondence. Letters from \n         \u003cpersname\u003eEmily (Morrison) Bondurant\u003c/persname\u003eto \n         \u003cpersname\u003eAlexander J. Bondurant\u003c/persname\u003emention her\n         brothers' war activities and posts (29 Jul, 8 Aug, and 11 Aug\n         1862; 6 [Apr] and 22 Apr 1863; 1 Mar, 28 Mar, 5 Apr 1865). A\n         13 May 1863 letter from \n         \u003cpersname\u003eThomas Lee Bondurant\u003c/persname\u003eto \n         \u003cpersname\u003eA.J.Bondurant\u003c/persname\u003ementions the reaction to the\n         death of General \n         \u003cpersname\u003eThomas \"Stonewall\" Jackson\u003c/persname\u003e. Letters to \n         \u003cpersname\u003eE.M. Bondurant\u003c/persname\u003efrom \n         \u003cpersname\u003eA.J. Bondurant\u003c/persname\u003emention the war and his\n         desire to support the army (12 Apr, 27 Apr, 26 May 1863). Rev.\n         \u003cpersname\u003eJames Morrison\u003c/persname\u003ealso wrote to his daughter \n         \u003cpersname\u003eE.M. Bondurant\u003c/persname\u003eabout the war and her\n         brother, \n         \u003cpersname\u003eSamuel Morrison\u003c/persname\u003e's appointment as a\n         surgeon in the army (5 Nov 1861, 23 May 1865). Letters to Rev.\n         \u003cpersname\u003eJames Morrison\u003c/persname\u003emention the early rumblings\n         of the Civil War and rumors of secession (25 Jul, 20 Oct, 9\n         Nov, 4 Dec 1860), as well as letters from his sons telling of\n         their posts (20 Feb, 4 Dec 1863; 14 Jan, 21 May 1863).\u003c/p\u003e\n      ","\u003cp\u003ePolitics is also a prominent subject in some of the\n         correspondence. The \n         \u003cpersname\u003eBondurants\u003c/persname\u003ewere active in the publishing\n         of the \n         \u003ccorpname\u003eRichmond Whig\u003c/corpname\u003e(est. 1824) and it is\n         mentioned in a few letters. \n         \u003cpersname\u003eE.M. Bondurant\u003c/persname\u003eto \n         \u003cpersname\u003eA.J. Bondurant\u003c/persname\u003ementions that \n         \u003cpersname\u003eGeorge [P. Bondurant]\u003c/persname\u003e(1838-1886) wanted\n         to leave the management of the paper to \n         \u003cpersname\u003eA.J. Bondurant\u003c/persname\u003e. \n         \u003cpersname\u003eThomas M. Bondurant\u003c/persname\u003ementions the paper in\n         a letter (19 Nov 1857) to his son \n         \u003cpersname\u003eA.J. Bondurant\u003c/persname\u003e. A letter from \n         \u003cpersname\u003eGeorge P. Bondurant\u003c/persname\u003eto his father \n         \u003cpersname\u003eA.J. Bondurant\u003c/persname\u003ementions the \n         \u003ccorpname\u003eWhig\u003c/corpname\u003eagain and the \n         \u003cfamname\u003eBondurant\u003c/famname\u003einterests in the paper (22 Mar\n         1896). Local and national politics is found in several letters\n         from \n         \u003cpersname\u003eE.M. Bondurant\u003c/persname\u003eto \n         \u003cpersname\u003eA.J. Bondurant\u003c/persname\u003e(26 Jul, 27 Sep, 8, 11, 31\n         Oct 1896). Letters from \n         \u003cpersname\u003eAlexander Lee Bondurant\u003c/persname\u003eto his father \n         \u003cpersname\u003eA.J. Bondurant\u003c/persname\u003emention local politics and\n         the race for the legislature (25 Oct 1887, 7 May 1889). \n         \u003cpersname\u003eThomas M. Bondurant\u003c/persname\u003ewas also concerned\n         with local politics; a letter from \n         \u003cpersname\u003eJ.T. Bocock\u003c/persname\u003ementions Sen. \n         \u003cpersname\u003eFlood\u003c/persname\u003eand local tax collecting practices\n         and the justice system and how they could be changed (8 Jan\n         1834).\u003c/p\u003e\n      ","\u003cp\u003eReligion and the \n         \u003ccorpname\u003ePresbyterian Church\u003c/corpname\u003eis also a prominent\n         subject in the correspondence of Rev. \n         \u003cpersname\u003eJames Morrison\u003c/persname\u003e, pastor of \n         \u003ccorpname\u003eNew Providence Presbyterian Church\u003c/corpname\u003e, \n         \u003cgeogname\u003eRockbridge County, Virginia\u003c/geogname\u003e. The letters\n         from Rev. \n         \u003cpersname\u003eElam J. Morrison\u003c/persname\u003efrom Rev. \n         \u003cpersname\u003eJames Morrison\u003c/persname\u003e(1820-1826) are concerned\n         with family matters, friends in the ministry, questions and\n         and advice about the ministry, the Presbytery and synods.\n         Letters to Rev. \n         \u003cpersname\u003eJames Morrison\u003c/persname\u003e(1813-1863, n.d.) contain\n         many similar topics and include family letters and letters\n         from friends and relatives in the ministry.\u003c/p\u003e\n    "],"scopecontent_heading_ssm":["Scope and Content"],"scopecontent_tesim":["This collection consist of ca. 16,000 items, 1787-1936, and\n         contains the papers of the \n         Bondurant familyof \n         Buckingham County, Virginia, and the \n         Morrison familyof \n         Rockbridge County, Virginiawho were\n         related through the marriage of \n         Alexander Joseph Bondurantand \n         Emily MacFarland Morrisonin 1859. \n         Alexander J. Bondurantand \n         Emily (Morrison) Bondurantwere the chief\n         correspondents in this collection. \n         Alexander J. Bondurant(1836-1910) was a \n         Confederatesoldier, farmer, politician,\n         superintendent of \n         Buckingham County, Va.schools, professor\n         of agriculture at \n         Auburn University, and tobacco consultant\n         to the government of \n         Australia. His father, \n         Thomas Moseley Bondurant(1797-1862), was\n         a landowner, member of the board of trustees of \n         Hampden-Sydney College, a soldier in the\n         War of 1812, a member of the \n         Virginia Senate, and one of the founders\n         of the \n         Richmond Whig. His oldest son, \n         Alexander Lee Bondurant(1865-1937) was\n         professor of Latin and head of the graduate school of the \n         University of Mississippi.","Emily MacFarland Morrison(b. 1837) was\n         the daughter of Rev. \n         James Morrisonand \n         Frances (Brown) Morrisonof \n         Rockbridge County, Va.A copy of her\n         reminiscences can be found in the Rare Books collection (F 231\n         .B65 1944 1962ed). The \n         Morrison familymaterial consists chiefly of\n         the papers of Rev. \n         James Morrison(1797-1870), including\n         correspondence concerning his family, his congregation, and\n         the \n         Presbyterian Church; also included are\n         his seminary and sermon notes from 1815-1874, and diaries and\n         account books for his home, \n         Bellevue.","Subjects included in this collection are farms in \n         Buckingham Co., Va., family affairs, the\n         Civil War, school administration in \n         Buckingham Co., \n         Auburn University, the \n         University of Virginia, mining and\n         mineral rights in \n         Virginia, immigrant land schemes in \n         Virginia, including the \n         James River Valley Immigrant Societyand\n         the \n         Virginia Land and Immigrant Company, \n         Virginiaand national politics, tobacco\n         culture in \n         Australiaand the southern \n         United States, Rev. \n         James Morrison's education at the \n         University of North Carolina, his\n         pastorates in \n         North Carolinaand \n         Virginia, the \n         Presbyterian Churchin the South, and the \n         Bellevue Schoolin \n         Rockbridge County, Virginia.","Most of the personal correspondence in the collection is\n         concerned with family matters. A great deal of the letters\n         discussed agriculture with regard to the family farms,\n         especially \n         Variety Shade, and \n         Alexander J. Bondurant's various\n         agricultural positions and interests. AJB's letters from \n         Australiato various family members\n         spanned the period from 1896 to 1901. These contain some\n         information on agriculture and the culture of \n         Australia. Some of the letters from \n         Charles W. Dabneyto \n         A.J. Bondurant(1881-1898) discuss iron\n         ore and mineral rights in \n         Virginiaas well as agriculture.","The Civil War and its affects is another subject to be\n         found in the correspondence. Letters from \n         Emily (Morrison) Bondurantto \n         Alexander J. Bondurantmention her\n         brothers' war activities and posts (29 Jul, 8 Aug, and 11 Aug\n         1862; 6 [Apr] and 22 Apr 1863; 1 Mar, 28 Mar, 5 Apr 1865). A\n         13 May 1863 letter from \n         Thomas Lee Bondurantto \n         A.J.Bondurantmentions the reaction to the\n         death of General \n         Thomas \"Stonewall\" Jackson. Letters to \n         E.M. Bondurantfrom \n         A.J. Bondurantmention the war and his\n         desire to support the army (12 Apr, 27 Apr, 26 May 1863). Rev.\n         James Morrisonalso wrote to his daughter \n         E.M. Bondurantabout the war and her\n         brother, \n         Samuel Morrison's appointment as a\n         surgeon in the army (5 Nov 1861, 23 May 1865). Letters to Rev.\n         James Morrisonmention the early rumblings\n         of the Civil War and rumors of secession (25 Jul, 20 Oct, 9\n         Nov, 4 Dec 1860), as well as letters from his sons telling of\n         their posts (20 Feb, 4 Dec 1863; 14 Jan, 21 May 1863).","Politics is also a prominent subject in some of the\n         correspondence. The \n         Bondurantswere active in the publishing\n         of the \n         Richmond Whig(est. 1824) and it is\n         mentioned in a few letters. \n         E.M. Bondurantto \n         A.J. Bondurantmentions that \n         George [P. Bondurant](1838-1886) wanted\n         to leave the management of the paper to \n         A.J. Bondurant. \n         Thomas M. Bondurantmentions the paper in\n         a letter (19 Nov 1857) to his son \n         A.J. Bondurant. A letter from \n         George P. Bondurantto his father \n         A.J. Bondurantmentions the \n         Whigagain and the \n         Bondurantinterests in the paper (22 Mar\n         1896). Local and national politics is found in several letters\n         from \n         E.M. Bondurantto \n         A.J. Bondurant(26 Jul, 27 Sep, 8, 11, 31\n         Oct 1896). Letters from \n         Alexander Lee Bondurantto his father \n         A.J. Bondurantmention local politics and\n         the race for the legislature (25 Oct 1887, 7 May 1889). \n         Thomas M. Bondurantwas also concerned\n         with local politics; a letter from \n         J.T. Bocockmentions Sen. \n         Floodand local tax collecting practices\n         and the justice system and how they could be changed (8 Jan\n         1834).","Religion and the \n         Presbyterian Churchis also a prominent\n         subject in the correspondence of Rev. \n         James Morrison, pastor of \n         New Providence Presbyterian Church, \n         Rockbridge County, Virginia. The letters\n         from Rev. \n         Elam J. Morrisonfrom Rev. \n         James Morrison(1820-1826) are concerned\n         with family matters, friends in the ministry, questions and\n         and advice about the ministry, the Presbytery and synods.\n         Letters to Rev. \n         James Morrison(1813-1863, n.d.) contain\n         many similar topics and include family letters and letters\n         from friends and relatives in the ministry."],"userestrict_html_tesm":["\u003cp\u003eSee the \n            \u003cextref type=\"simple\" href=\"https://www.library.virginia.edu/policies/use-of-materials\"\u003e\n            University of Virginia Library’s use policy.\u003c/extref\u003e\u003c/p\u003e\n      "],"userestrict_heading_ssm":["Use Restrictions"],"userestrict_tesim":["See the \n            \n            University of Virginia Library’s use policy."],"physloc_html_tesm":["\u003cphysloc\u003e\u003c/physloc\u003e\n      "],"corpname_ssim":["University of Virginia. Library. Special\n            Collections Dept.","University of Virginia","Confederate","Auburn University","Hampden-Sydney College","Virginia Senate","Richmond Whig","University of Mississippi","Presbyterian Church","Bellevue","James River Valley Immigrant Society","Virginia Land and Immigrant Company","University of North Carolina","Bellevue School","Variety Shade","Whig","New Providence Presbyterian Church"],"famname_ssim":["Bondurant family","Morrison family","Bondurant"],"persname_ssim":["William Harrison","William G. Harrison","Alexander Joseph Bondurant","Emily MacFarland Morrison","Alexander J. Bondurant","Emily (Morrison) Bondurant","Thomas Moseley Bondurant","Alexander Lee Bondurant","James Morrison","Frances (Brown) Morrison","Charles W. Dabney","A.J. Bondurant","Thomas Lee Bondurant","A.J.Bondurant","Thomas \"Stonewall\" Jackson","E.M. Bondurant","Samuel Morrison","Bondurants","George [P. Bondurant]","Thomas M. Bondurant","George P. Bondurant","J.T. Bocock","Flood","Elam J. Morrison"],"names_ssim":["University of Virginia. Library. Special\n            Collections Dept.","University of Virginia","Confederate","Auburn University","Hampden-Sydney College","Virginia Senate","Richmond Whig","University of Mississippi","Presbyterian Church","Bellevue","James River Valley Immigrant Society","Virginia Land and Immigrant Company","University of North Carolina","Bellevue School","Variety Shade","Whig","New Providence Presbyterian Church","Bondurant family","Morrison family","Bondurant","William Harrison","William G. Harrison","Alexander Joseph Bondurant","Emily MacFarland Morrison","Alexander J. Bondurant","Emily (Morrison) Bondurant","Thomas Moseley Bondurant","Alexander Lee Bondurant","James Morrison","Frances (Brown) Morrison","Charles W. Dabney","A.J. Bondurant","Thomas Lee Bondurant","A.J.Bondurant","Thomas \"Stonewall\" Jackson","E.M. Bondurant","Samuel Morrison","Bondurants","George [P. Bondurant]","Thomas M. Bondurant","George P. Bondurant","J.T. Bocock","Flood","Elam J. Morrison"],"language_ssim":["English"],"total_component_count_is":268,"online_item_count_is":0,"component_level_isim":[0],"sort_isi":0,"timestamp":"2026-08-14T22:55:15.948Z"}]}},"label":"Breadcrumbs"}}},"links":{"self":"https://arvasarchive.org/catalog/viu_viu00044_c03_c07"}},{"id":"viu_viu01145_c242","type":"Item","attributes":{"title":"S.[?] Goodwin to Dabney S. Carr, 1839","abstract_or_scope":{"id":"https://arvasarchive.org/catalog/viu_viu01145_c242#abstract_or_scope","type":"document_value","attributes":{"value":"\u003cp\u003e[has had a conversation with Mr. Barney who promises that nothing further on an unnamed subject would be published in \u003cspan type=\"simple\"\u003eThe Patriot\u003c/span\u003e]\u003c/p\u003e","label":"Abstract Or Scope"}},"breadcrumbs":{"id":"https://arvasarchive.org/catalog/viu_viu01145_c242#breadcrumbs","type":"document_value","attributes":{"value":{"ref_ssi":"viu_viu01145_c242","ref_ssm":["viu_viu01145_c242"],"id":"viu_viu01145_c242","ead_ssi":"viu_viu01145","_root_":"viu_viu01145","_nest_parent_":"viu_viu01145","parent_ssi":"viu_viu01145","parent_ssim":["Carr-Cary Family Papers \n 1785-1839"],"parent_ids_ssim":["viu_viu01145"],"title_filing_ssi":"S.[?] Goodwin to Dabney S. Carr","title_ssm":["S.[?] Goodwin to Dabney S. Carr"],"title_tesim":["S.[?] Goodwin to Dabney S. Carr"],"normalized_title_ssm":["S.[?] Goodwin to Dabney S. Carr, 1839"],"text":["S.[?] Goodwin to Dabney S. Carr, 1839","Carr-Cary Family Papers \n 1785-1839","Box Box 3","[has had a conversation with Mr. Barney who promises\n               that nothing further on an unnamed subject would be\n               published in \n               The Patriot]"],"parent_unittitles_ssm":["Carr-Cary Family Papers \n 1785-1839"],"parent_unittitles_tesim":["Carr-Cary Family Papers \n 1785-1839"],"normalized_date_ssm":["1839"],"unitdate_other_ssim":["1839 Apr 1"],"level_ssm":["Item"],"level_ssim":["Item"],"component_level_isim":[1],"sort_isi":242,"repository_ssim":["University of Virginia, Special Collections Dept."],"collection_ssim":["Carr-Cary Family Papers \n 1785-1839"],"containers_ssim":["Box Box 3"],"has_online_content_ssim":["false"],"child_component_count_isi":0,"parent_access_restrict_tesm":["Collection is open to research."],"parent_access_terms_tesm":["See the \n            \n            University of Virginia Library’s use policy."],"date_range_isim":[1839],"scopecontent_html_tesm":["\u003cp\u003e[has had a conversation with Mr. Barney who promises\n               that nothing further on an unnamed subject would be\n               published in \n               \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Patriot\u003c/title\u003e\u003c/bibref\u003e]\u003c/p\u003e\n        "],"scopecontent_tesim":["[has had a conversation with Mr. Barney who promises\n               that nothing further on an unnamed subject would be\n               published in \n               The Patriot]"],"_nest_path_":"/components#241","timestamp":"2026-08-14T22:56:40.321Z","collection":{"numFound":1,"start":0,"numFoundExact":true,"docs":[{"id":"viu_viu01145","ead_ssi":"viu_viu01145","_root_":"viu_viu01145","_nest_parent_":"viu_viu01145","ead_source_url_ssi":"data/uva-sc/viu01145.xml","title_ssm":["Carr-Cary Family Papers \n 1785-1839"],"title_tesim":["Carr-Cary Family Papers \n 1785-1839"],"normalized_title_ssm":["Carr-Cary Family Papers \n 1785-1839"],"text":["Carr-Cary Family Papers \n 1785-1839","1231","ca. 285 items","Collection is open to research.","Funded in part by a grant from the National Endowment\n            for the Humanities","This collection consists of the papers of the \n         Carr familyof \" \n         Carrsbrook\", \n         Albemarle County, and the \n         Cary familyof \" \n         Carysbrook, \" \n         Fluvanna County, Virginia, 1785-1839, ca.\n         285 items (2.5 Hollinger boxes, 1 linear foot), including\n         chiefly correspondence, but also manuscripts of obituaries,\n         poetry, and debates, and financial documents. The papers\n         include correspondence between \n         Peter Carr(1770-1815), nephew of \n         Thomas Jefferson, \n         Hester \"Hetty\" Smith Stevenson\n         Carr(1767-1834), \n         George Pitt Stevenson(d.1819), \n         Dabney S. Carr(1802-1854), \n         Maria Jefferson Carr(1804-1825), \n         Jane Margaret Carr Cary(1809-1903), \n         Wilson Miles Cary(1806-1877), \n         Wilson Jefferson Cary(1784-1823), and \n         Virginia Randolph Cary(1786-1852), with\n         other members of the \n         Jefferson, \n         Randolph, \n         Carr, and \n         Caryfamilies.","All Thomas Jefferson correspondence has been transferred to\n         the Thomas Jefferson Papers and is not listed in this guide.\n         The Jefferson letters are included in the calendar \n         The Jefferson Papers of the University of\n            Virginiacompiled by Constance E. Thurlow and Francis L.\n         Berkeley, Jr. available in the Special Collections Reading\n         Room and on the Special Collections web page under Digital\n         Resources \u0026 Exhibitions -Guides to the Collections.","Topics include family and social news of \n         Charlottesville, Virginia, and \n         Baltimore, Maryland, agricultural matters\n         and plantation life; relationships between slaves and their\n         owners; family advice, education and study of law; the\n         increasing financial distress of the period and other\n         financial matters of the family; religious thought; local and\n         national politics; scattered references to the \n         University of Virginiaand Thomas\n         Jefferson; with genealogical notes by \n         Wilson Miles Cary.","Topics also include proposed and subsequent sale of\n         Carrsbrook; the sale, hire, and purchase of family slaves;\n         Hetty Carr's move to Baltimore; a fight between \n         Charles Lewis Bankheadand \n         Thomas Jefferson Randolphand its after\n         effects; \n         John Addison Carr's career in the navy;\n         concern for dental care; the controversial proposal of either\n         a lottery ora subscription for the financial relief of Thomas\n         Jefferson; and travel to \n         Florida. The papers also contain\n         correspondence, 1793-1807, of \n         Thomas Mann Randolph(1768-1828,\n         son-in-law of Thomas Jefferson, concerning agricultural and\n         social matters; the possible engagement of \n         John Leslieas a tutor for the \n         Randolph family; a letter, 1802, from\n         Thomas Mann Randolph to Peter Carr concerning his plans to\n         respond to \n         James Thomson Callender's accusation\n         against Thomas Jefferson, and his decision not to do so; and a\n         letter, 1826, from Thomas Jefferson Randolph (1792-1875)\n         concerning Thomas Jefferson's death and desire for keeping his\n         father from misusing money from Jefferson's estate.","The papers also contain a letter, 1797, from \n         George Washingtoncommenting on the\n         divisive nature of politics and on political attacks aimed at\n         him; a letter, 1800, from \n         James Monroeregarding the hire of slaves\n         and financial matters; a statement, 1814, by \n         Anne Cary Randolph Bankheadon Thomas\n         Jefferson Randolph's courtship and marriage to \n         Jane Hollins Nicholas(1798-1871); an\n         obituary, 1815, of Peter Carr by \n         William Wirt; two student essays by Peter\n         Carr; and poems by \n         Virginia Randolph Cary.","Financial documents consist of receipts for payments of\n         fees for Peter Carr at \n         William \u0026 Mary College; receipts for\n         payments of fees related to the education of D. Terrell and\n         George P. Stevenson; Peter Carr's account with \n         Hollins \u0026 McBlairof Baltimore; a\n         receipt for blacksmith work; Hetty Carr's memorandum\n         concerning money due her from Robert Carter Nicholas from a\n         plantation in \n         Louisiana; accounts of Mrs. Virginia\n         Cary; and an account of the estate of Wilson J. Cary.","Sources for information about the Carr \u0026 Cary families\n         include: \n         The Virginia Carysby Fairfax Harrison, \n         The Carr Family Recordsby Edson I. Carr, and \n         The Carrs of Albemarlea University of Virginia History Thesis by Elizabeth\n         Dabney Coleman.","See the \n            \n            University of Virginia Library’s use policy.","University of Virginia. Library. Special\n            Collections Dept.","Carrsbrook","Carysbrook","University of Virginia","William \u0026 Mary College","Hollins \u0026 McBlair","Carr family","Cary family","Jefferson","Randolph","Carr","Cary","Randolph family","Peter Carr","Thomas Jefferson","Hester \"Hetty\" Smith Stevenson\n         Carr","George Pitt Stevenson","Dabney S. Carr","Maria Jefferson Carr","Jane Margaret Carr Cary","Wilson Miles Cary","Wilson Jefferson Cary","Virginia Randolph Cary","Charles Lewis Bankhead","Thomas Jefferson Randolph","John Addison Carr","Thomas Mann Randolph","John Leslie","James Thomson Callender","George Washington","James Monroe","Anne Cary Randolph Bankhead","Jane Hollins Nicholas","William Wirt","English"],"collection_title_tesim":["Carr-Cary Family Papers \n 1785-1839"],"collection_ssim":["Carr-Cary Family Papers \n 1785-1839"],"level_ssm":["collection"],"level_ssim":["Collection"],"unitid_ssm":["1231"],"unitid_tesim":["1231"],"repository_ssm":["University of Virginia, Special Collections Dept."],"repository_ssim":["University of Virginia, Special Collections Dept."],"creator_persname_ssim":["Peter Carr","Thomas Jefferson","Hester \"Hetty\" Smith Stevenson\n         Carr","George Pitt Stevenson","Dabney S. Carr","Maria Jefferson Carr","Jane Margaret Carr Cary","Wilson Miles Cary","Wilson Jefferson Cary","Virginia Randolph Cary","Charles Lewis Bankhead","Thomas Jefferson Randolph","John Addison Carr","Thomas Mann Randolph","John Leslie","James Thomson Callender","George Washington","James Monroe","Anne Cary Randolph Bankhead","Jane Hollins Nicholas","William Wirt"],"creator_corpname_ssim":["University of Virginia. Library. Special\n            Collections Dept.","Carrsbrook","Carysbrook","University of Virginia","William \u0026 Mary College","Hollins \u0026 McBlair"],"creator_famname_ssim":["Carr family","Cary family","Jefferson","Randolph","Carr","Cary","Randolph family"],"creators_ssim":["Peter Carr","Thomas Jefferson","Hester \"Hetty\" Smith Stevenson\n         Carr","George Pitt Stevenson","Dabney S. Carr","Maria Jefferson Carr","Jane Margaret Carr Cary","Wilson Miles Cary","Wilson Jefferson Cary","Virginia Randolph Cary","Charles Lewis Bankhead","Thomas Jefferson Randolph","John Addison Carr","Thomas Mann Randolph","John Leslie","James Thomson Callender","George Washington","James Monroe","Anne Cary Randolph Bankhead","Jane Hollins Nicholas","William Wirt","University of Virginia. Library. Special\n            Collections Dept.","Carrsbrook","Carysbrook","University of Virginia","William \u0026 Mary College","Hollins \u0026 McBlair","Carr family","Cary family","Jefferson","Randolph","Carr","Cary","Randolph family"],"access_terms_ssm":["See the \n            \n            University of Virginia Library’s use policy."],"acqinfo_ssim":["These papers were purchased for the Tracy W. McGregor\n            Collection by the University of Virginia Library, from Mrs.\n            Fairfax Harrison, Fauquier County, Virginia, on September\n            1, 1941."],"has_online_content_ssim":["false"],"physdesc_tesim":["ca. 285 items"],"accessrestrict_html_tesm":["\u003cp\u003eCollection is open to research.\u003c/p\u003e\n      "],"accessrestrict_heading_ssm":["Access Restrictions"],"accessrestrict_tesim":["Collection is open to research."],"prefercite_html_tesm":["\u003cp\u003eCarr-Cary Family\n            Papers, Accession 1231, Special Collections Department, University of\n         Virginia Library\u003c/p\u003e\n      "],"prefercite_tesim":["Carr-Cary Family\n            Papers, Accession 1231, Special Collections Department, University of\n         Virginia Library"],"processinfo_html_tesm":["\u003cp\u003eFunded in part by a grant from the National Endowment\n            for the Humanities\u003c/p\u003e\n      "],"processinfo_heading_ssm":["Funding Note"],"processinfo_tesim":["Funded in part by a grant from the National Endowment\n            for the Humanities"],"scopecontent_html_tesm":["\u003cp\u003eThis collection consists of the papers of the \n         \u003cfamname\u003eCarr family\u003c/famname\u003eof \" \n         \u003ccorpname\u003eCarrsbrook\u003c/corpname\u003e\", \n         \u003cgeogname\u003eAlbemarle County\u003c/geogname\u003e, and the \n         \u003cfamname\u003eCary family\u003c/famname\u003eof \" \n         \u003ccorpname\u003eCarysbrook\u003c/corpname\u003e, \" \n         \u003cgeogname\u003eFluvanna County, Virginia\u003c/geogname\u003e, 1785-1839, ca.\n         285 items (2.5 Hollinger boxes, 1 linear foot), including\n         chiefly correspondence, but also manuscripts of obituaries,\n         poetry, and debates, and financial documents. The papers\n         include correspondence between \n         \u003cpersname\u003ePeter Carr\u003c/persname\u003e(1770-1815), nephew of \n         \u003cpersname\u003eThomas Jefferson\u003c/persname\u003e, \n         \u003cpersname normal=\"Hetty Carr\"\u003eHester \"Hetty\" Smith Stevenson\n         Carr\u003c/persname\u003e(1767-1834), \n         \u003cpersname\u003eGeorge Pitt Stevenson\u003c/persname\u003e(d.1819), \n         \u003cpersname\u003eDabney S. Carr\u003c/persname\u003e(1802-1854), \n         \u003cpersname\u003eMaria Jefferson Carr\u003c/persname\u003e(1804-1825), \n         \u003cpersname\u003eJane Margaret Carr Cary\u003c/persname\u003e(1809-1903), \n         \u003cpersname\u003eWilson Miles Cary\u003c/persname\u003e(1806-1877), \n         \u003cpersname\u003eWilson Jefferson Cary\u003c/persname\u003e(1784-1823), and \n         \u003cpersname\u003eVirginia Randolph Cary\u003c/persname\u003e(1786-1852), with\n         other members of the \n         \u003cfamname\u003eJefferson\u003c/famname\u003e, \n         \u003cfamname\u003eRandolph\u003c/famname\u003e, \n         \u003cfamname\u003eCarr\u003c/famname\u003e, and \n         \u003cfamname\u003eCary\u003c/famname\u003efamilies.\u003c/p\u003e\n      ","\u003cp\u003eAll Thomas Jefferson correspondence has been transferred to\n         the Thomas Jefferson Papers and is not listed in this guide.\n         The Jefferson letters are included in the calendar \n         \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Jefferson Papers of the University of\n            Virginia\u003c/title\u003e\u003c/bibref\u003ecompiled by Constance E. Thurlow and Francis L.\n         Berkeley, Jr. available in the Special Collections Reading\n         Room and on the Special Collections web page under Digital\n         Resources \u0026amp; Exhibitions -Guides to the Collections.\u003c/p\u003e\n      ","\u003cp\u003eTopics include family and social news of \n         \u003cgeogname\u003eCharlottesville, Virginia\u003c/geogname\u003e, and \n         \u003cgeogname\u003eBaltimore, Maryland\u003c/geogname\u003e, agricultural matters\n         and plantation life; relationships between slaves and their\n         owners; family advice, education and study of law; the\n         increasing financial distress of the period and other\n         financial matters of the family; religious thought; local and\n         national politics; scattered references to the \n         \u003ccorpname\u003eUniversity of Virginia\u003c/corpname\u003eand Thomas\n         Jefferson; with genealogical notes by \n         \u003cpersname\u003eWilson Miles Cary\u003c/persname\u003e.\u003c/p\u003e\n      ","\u003cp\u003eTopics also include proposed and subsequent sale of\n         Carrsbrook; the sale, hire, and purchase of family slaves;\n         Hetty Carr's move to Baltimore; a fight between \n         \u003cpersname\u003eCharles Lewis Bankhead\u003c/persname\u003eand \n         \u003cpersname\u003eThomas Jefferson Randolph\u003c/persname\u003eand its after\n         effects; \n         \u003cpersname\u003eJohn Addison Carr\u003c/persname\u003e's career in the navy;\n         concern for dental care; the controversial proposal of either\n         a lottery ora subscription for the financial relief of Thomas\n         Jefferson; and travel to \n         \u003cgeogname\u003eFlorida\u003c/geogname\u003e. The papers also contain\n         correspondence, 1793-1807, of \n         \u003cpersname\u003eThomas Mann Randolph\u003c/persname\u003e(1768-1828,\n         son-in-law of Thomas Jefferson, concerning agricultural and\n         social matters; the possible engagement of \n         \u003cpersname\u003eJohn Leslie\u003c/persname\u003eas a tutor for the \n         \u003cfamname\u003eRandolph family\u003c/famname\u003e; a letter, 1802, from\n         Thomas Mann Randolph to Peter Carr concerning his plans to\n         respond to \n         \u003cpersname\u003eJames Thomson Callender\u003c/persname\u003e's accusation\n         against Thomas Jefferson, and his decision not to do so; and a\n         letter, 1826, from Thomas Jefferson Randolph (1792-1875)\n         concerning Thomas Jefferson's death and desire for keeping his\n         father from misusing money from Jefferson's estate.\u003c/p\u003e\n      ","\u003cp\u003eThe papers also contain a letter, 1797, from \n         \u003cpersname\u003eGeorge Washington\u003c/persname\u003ecommenting on the\n         divisive nature of politics and on political attacks aimed at\n         him; a letter, 1800, from \n         \u003cpersname\u003eJames Monroe\u003c/persname\u003eregarding the hire of slaves\n         and financial matters; a statement, 1814, by \n         \u003cpersname\u003eAnne Cary Randolph Bankhead\u003c/persname\u003eon Thomas\n         Jefferson Randolph's courtship and marriage to \n         \u003cpersname\u003eJane Hollins Nicholas\u003c/persname\u003e(1798-1871); an\n         obituary, 1815, of Peter Carr by \n         \u003cpersname\u003eWilliam Wirt\u003c/persname\u003e; two student essays by Peter\n         Carr; and poems by \n         \u003cpersname\u003eVirginia Randolph Cary\u003c/persname\u003e.\u003c/p\u003e\n      ","\u003cp\u003eFinancial documents consist of receipts for payments of\n         fees for Peter Carr at \n         \u003ccorpname\u003eWilliam \u0026amp; Mary College\u003c/corpname\u003e; receipts for\n         payments of fees related to the education of D. Terrell and\n         George P. Stevenson; Peter Carr's account with \n         \u003ccorpname\u003eHollins \u0026amp; McBlair\u003c/corpname\u003eof Baltimore; a\n         receipt for blacksmith work; Hetty Carr's memorandum\n         concerning money due her from Robert Carter Nicholas from a\n         plantation in \n         \u003cgeogname\u003eLouisiana\u003c/geogname\u003e; accounts of Mrs. Virginia\n         Cary; and an account of the estate of Wilson J. Cary.\u003c/p\u003e\n      ","\u003cp\u003eSources for information about the Carr \u0026amp; Cary families\n         include: \n         \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Virginia Carys\u003c/title\u003e\u003c/bibref\u003eby Fairfax Harrison, \n         \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Carr Family Records\u003c/title\u003e\u003c/bibref\u003eby Edson I. Carr, and \n         \u003cbibref type=\"simple\" href=\"\"\u003e\u003ctitle type=\"simple\" href=\"\"\u003eThe Carrs of Albemarle\u003c/title\u003e\u003c/bibref\u003ea University of Virginia History Thesis by Elizabeth\n         Dabney Coleman.\u003c/p\u003e\n    "],"scopecontent_heading_ssm":["Scope and Content"],"scopecontent_tesim":["This collection consists of the papers of the \n         Carr familyof \" \n         Carrsbrook\", \n         Albemarle County, and the \n         Cary familyof \" \n         Carysbrook, \" \n         Fluvanna County, Virginia, 1785-1839, ca.\n         285 items (2.5 Hollinger boxes, 1 linear foot), including\n         chiefly correspondence, but also manuscripts of obituaries,\n         poetry, and debates, and financial documents. The papers\n         include correspondence between \n         Peter Carr(1770-1815), nephew of \n         Thomas Jefferson, \n         Hester \"Hetty\" Smith Stevenson\n         Carr(1767-1834), \n         George Pitt Stevenson(d.1819), \n         Dabney S. Carr(1802-1854), \n         Maria Jefferson Carr(1804-1825), \n         Jane Margaret Carr Cary(1809-1903), \n         Wilson Miles Cary(1806-1877), \n         Wilson Jefferson Cary(1784-1823), and \n         Virginia Randolph Cary(1786-1852), with\n         other members of the \n         Jefferson, \n         Randolph, \n         Carr, and \n         Caryfamilies.","All Thomas Jefferson correspondence has been transferred to\n         the Thomas Jefferson Papers and is not listed in this guide.\n         The Jefferson letters are included in the calendar \n         The Jefferson Papers of the University of\n            Virginiacompiled by Constance E. Thurlow and Francis L.\n         Berkeley, Jr. available in the Special Collections Reading\n         Room and on the Special Collections web page under Digital\n         Resources \u0026 Exhibitions -Guides to the Collections.","Topics include family and social news of \n         Charlottesville, Virginia, and \n         Baltimore, Maryland, agricultural matters\n         and plantation life; relationships between slaves and their\n         owners; family advice, education and study of law; the\n         increasing financial distress of the period and other\n         financial matters of the family; religious thought; local and\n         national politics; scattered references to the \n         University of Virginiaand Thomas\n         Jefferson; with genealogical notes by \n         Wilson Miles Cary.","Topics also include proposed and subsequent sale of\n         Carrsbrook; the sale, hire, and purchase of family slaves;\n         Hetty Carr's move to Baltimore; a fight between \n         Charles Lewis Bankheadand \n         Thomas Jefferson Randolphand its after\n         effects; \n         John Addison Carr's career in the navy;\n         concern for dental care; the controversial proposal of either\n         a lottery ora subscription for the financial relief of Thomas\n         Jefferson; and travel to \n         Florida. The papers also contain\n         correspondence, 1793-1807, of \n         Thomas Mann Randolph(1768-1828,\n         son-in-law of Thomas Jefferson, concerning agricultural and\n         social matters; the possible engagement of \n         John Leslieas a tutor for the \n         Randolph family; a letter, 1802, from\n         Thomas Mann Randolph to Peter Carr concerning his plans to\n         respond to \n         James Thomson Callender's accusation\n         against Thomas Jefferson, and his decision not to do so; and a\n         letter, 1826, from Thomas Jefferson Randolph (1792-1875)\n         concerning Thomas Jefferson's death and desire for keeping his\n         father from misusing money from Jefferson's estate.","The papers also contain a letter, 1797, from \n         George Washingtoncommenting on the\n         divisive nature of politics and on political attacks aimed at\n         him; a letter, 1800, from \n         James Monroeregarding the hire of slaves\n         and financial matters; a statement, 1814, by \n         Anne Cary Randolph Bankheadon Thomas\n         Jefferson Randolph's courtship and marriage to \n         Jane Hollins Nicholas(1798-1871); an\n         obituary, 1815, of Peter Carr by \n         William Wirt; two student essays by Peter\n         Carr; and poems by \n         Virginia Randolph Cary.","Financial documents consist of receipts for payments of\n         fees for Peter Carr at \n         William \u0026 Mary College; receipts for\n         payments of fees related to the education of D. Terrell and\n         George P. Stevenson; Peter Carr's account with \n         Hollins \u0026 McBlairof Baltimore; a\n         receipt for blacksmith work; Hetty Carr's memorandum\n         concerning money due her from Robert Carter Nicholas from a\n         plantation in \n         Louisiana; accounts of Mrs. Virginia\n         Cary; and an account of the estate of Wilson J. Cary.","Sources for information about the Carr \u0026 Cary families\n         include: \n         The Virginia Carysby Fairfax Harrison, \n         The Carr Family Recordsby Edson I. Carr, and \n         The Carrs of Albemarlea University of Virginia History Thesis by Elizabeth\n         Dabney Coleman."],"userestrict_html_tesm":["\u003cp\u003eSee the \n            \u003cextref type=\"simple\" href=\"https://www.library.virginia.edu/policies/use-of-materials\"\u003e\n            University of Virginia Library’s use policy.\u003c/extref\u003e\u003c/p\u003e\n      "],"userestrict_heading_ssm":["Use Restrictions"],"userestrict_tesim":["See the \n            \n            University of Virginia Library’s use policy."],"physloc_html_tesm":["\u003cphysloc\u003e\u003c/physloc\u003e\n      "],"corpname_ssim":["University of Virginia. Library. 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